x-cardiac, a leader in AI-based medical devices for the prediction of postoperative complications after cardiac surgery, is pleased to announce the successful MDR (Medical Device Regulation) certification of its new x-cardiac-platform.

PRZOOM - Newswire (press release) - Tue, 12 Nov 2024 00:00:00 -0500, Chicago IL United States - Strategic Consolidation Offers Expanded Cybersecurity Suite of Market-Leading MDR, EDR, Offensive Security, DFIR, and Threat Intelligence - Trustwave.com / Cybereason.com

Martin Prescher
Dec 1, 2020; 61:1605-1616
Research Articles

ABCB4/MDR3 is located in the canalicular membrane of hepatocytes and translocates PC-lipids from the cytoplasmic to the extracellular leaflet. ABCB4 is an ATP-dependent transporter that reduces the harsh detergent effect of the bile salts by counteracting self-digestion. To do so, ABCB4 provides PC lipids for extraction into bile. PC lipids account for 40% of the entire pool of lipids in the canalicular membrane with an unknown distribution over both leaflets. Extracted PC lipids end up in so-called mixed micelles. Mixed micelles are composed of phospholipids, bile salts, and cholesterol. Ninety to ninety-five percent of the phospholipids are members of the PC family, but only a subset of mainly 16.0-18:1 PC and 16:0-18:2 PC variants are present. To elucidate whether ABCB4 is the key discriminator in this enrichment of specific PC lipids, we used in vitro studies to identify crucial determinants in substrate selection. We demonstrate that PC-lipid moieties alone are insufficient for stimulating ABCB4 ATPase activity, and that at least two acyl chains and the backbone itself are required for a productive interaction. The nature of the fatty acids, like length or saturation has a quantitative impact on the ATPase activity. Our data demonstrate a two-step enrichment and protective function of ABCB4 to mitigate the harsh detergent effect of the bile salts, because ABCB4 can translocate more than just the PC-lipid variants found in bile.

EMDR therapy, also known as Eye Movement Desensitization and Reprocessing therapy, is an integrative and all-inclusive psychotherapy model used to treat mental conditions and trauma. This approach has been researched extensively in recent years and confirmed to be an effective way to tackle mental challenges. EMDR therapy was reportedly developed in the 1980’s by an […]

The post What are The Different Phases of EMDR Therapy? first appeared on What is Psychology?.

Read the in depth Review of Sony MDR-MV1 Audio Video. Know detailed info about Sony MDR-MV1 configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

The RNTCP currently treats patients without knowing their resistance profile: JMM

Finance minister Nirmala Sitharaman in the FY20 Budget abolished MDR charges for all merchants having a turnover of over Rs 50 crore which would lead the payment companies taking a hit on their margins.

“We would appreciate it if the Finance Ministry could approach the RBI or the respective authorities to direct NBFCs and Banks to waive off DBD (dealer by down) and MDR (merchant discount rate) charges to retailers on paper finance and on digital transactions for at least 6 months post lockdown,” All India Mobile Retailers Association said in a letter to finance minister Nirmala Sitharaman.

Pottercast is back for conclumdrum conjuration as they attempt to answer your burning questions from the Wizarding World!

Episode 268 — Conjuring Conclumdrums

Pottercast is hosted by Melissa Anelli, John Noe, Frankie Franco, and Zack Luye.

Find the latest episode and explore Pottercast interviews, discussions and more at Pottercast.com

Visit the-leaky-cauldron.org for the latest and greatest from Harry Potter's Wizarding World.

According to the Pradhan Mantri Jan Dhan Yojana (PMJDY) website, the total number of RuPay cards issued so far stands at over 290 million.

MedTech Europe has issued a statement welcoming the delay for enforcing the European Medical Devices Regulation (EU MDR), and asking for similar action for the In Vitro Diagnostic Regulation (IVDR).

Maurits Lugard, a partner, Josefine Sommer, a senior associate, and Anouchka Hoffman, an associate, at Sidley Austin, examines the consequences that come with the delay of the application of EU Medical Devices Regulation by one year.

The European Medical Device Regulation (EU MDR) will come into effect on 26th May 2021, a year later than originally planned.

The MDCG just published a joint implementation plan regarding the MDR. Here is my summary and analysis. It’s not a happy story. Not the IVDR This implementation plan is not about the IVDR, and the fact that it is not about the IVDR is information in itself. It means that the MDCG is not even […]

I have blogged before about the effects and possibilities of the Corrigendum of December 2019 for class I medical devices. I refer you to that blog for the background to this discussion, which covers the mechanics of timing. The draft corrigendum discussed in that blog was adopted as described.  The new guidance The MDCG has […]

What is this recommendation about? Obviously this recommendation is an attempt of the Commission to manage administative barriers to placing PPE (personal protective equipment) and medical devices on the market that would be needed in the struggle to get the current Covid-19 pandemic under control. In my view you can also see this as a […]

After a statement on a press conference today by Stefan De keersmaecker that had many people very excited quickly, the official announcement came later in the afternoon: Here is what I think about this development. Work on a proposal ongoing The Commission announced that ‘work on a proposal to postpone the date of application’. This tells […]

On Friday 3 April 2020 it finally happened: the Commission proposal for amendment of the MDR to defer the date of application with a year that everyone was waiting for and was in the works for some time was finally published. As I have heard from many directions immediately after the announcement of the proposal being […]

It’s always a risk to put out a theory about legislative oversight after a Sherlock Homes investigation that eliminates all other options as I did in my last blog about the MDR amendment proposal. Recent development seem to confirm that I was right in assuming that not touching the two dates of application of 26 […]

With the overwhelming vote in the Parliament in favor of the Commission proposal to amend the MDR it is politically basically a done deal now that the MDR will be amended. After the vote there were people that immediately stated that the amendment was formally approved – not so. We are looking at law making […]

Schubert, Sarah Joanne, author

Online Resource

Interview with Christina Vandenbroucke-Grauls, MD, PhD, author of Evaluation of the Association Between Gastric Acid Suppression and Risk of Intestinal Colonization With Multidrug-Resistant Microorganisms: A Systematic Review and Meta-analysis, and Todd Campbell Lee, MD MPH, author of Deprescribing Proton Pump Inhibitors: Overcoming Resistance