AP Georgopoulos
Nov 1, 1982; 2:1527-1537
Articles

Plasticity in the subcortical motor basal ganglia–thalamo–cerebellar network plays a key role in the acquisition and control of long-term memory for new procedural skills, from the formation of population trajectories controlling trained motor skills in the striatum to the adaptation of sensorimotor maps in the cerebellum. However, recent findings demonstrate the involvement of a wider cortical and subcortical brain network in the consolidation and control of well-trained actions, including a brain region traditionally associated with declarative memory—the hippocampus. Here, we probe which role these subcortical areas play in skilled motor sequence control, from sequence feature selection during planning to their integration during sequence execution. An fMRI dataset (N = 24; 14 females) collected after participants learnt to produce four finger press sequences entirely from memory with high movement and timing accuracy over several days was examined for both changes in BOLD activity and their informational content in subcortical regions of interest. Although there was a widespread activity increase in effector-related striatal, thalamic, and cerebellar regions, in particular during sequence execution, the associated activity did not contain information on the motor sequence identity. In contrast, hippocampal activity increased during planning and predicted the order of the upcoming sequence of movements. Our findings suggest that the hippocampus preorders movements for skilled action sequences, thus contributing to the higher-order control of skilled movements that require flexible retrieval. These findings challenge the traditional taxonomy of episodic and procedural memory and carry implications for the rehabilitation of individuals with neurodegenerative disorders.

The Tripartite organizations (FAO, OIE, WHO) invite partners to join public discussion on the establishment of the AMR Multi-Stakeholder Partnership Platform.

http://j.mp/196BLpQ From her salon in Maryland, Camille Reed sees more black women embracing natural hair

A blockbuster exhibition in Paris is showcasing 500 artifacts and artworks in honor of the Surrealist Manifesto, which sparked a new artistic style that spread around the world

Designed in SOLIDWORKS software, this lowriding sport machine becomes nimble highrider on demand

See how to use CVOL to navigate volatile markets with its unique methodology and comprehensive suite of metrics.

God prepared the team in Argentina for OM Latin America’s new focus on mobilisation, even before they knew what it was.

A former dancer uses her choreography skills to plan her students' movement through the classroom.

Following Donald Trump's victory in the US presidential elections, a new trend has emerged on social media platforms called the 'MATGA movement'.

Los Angeles CA (SPX) Nov 09, 2024
Data from NISAR will improve our understanding of such phenomena as earthquakes, volcanoes, and landslides, as well as damage to infrastructure. Earth's surface is in a state of continuous motion, although often unnoticed. Scientists have utilized satellite and ground-based technology to observe movements linked to geological events such as earthquakes, landslides, and volcanic activity. A

Donald Trump’s performance in the 2024 election surpassed expectations, with the candidate winning the key battleground states of Pennsylvania, North Carolina and Georgia and picking up larger shares of more diverse segments of the electorate, including Black and Latino male voters. Keeanga-Yamahtta Taylor, a professor of African American studies at Princeton University, says the blame lies squarely on the Harris campaign, which refused to differentiate itself from unpopular incumbent President Joe Biden. “The problem here is with the leadership of the Democratic Party,” adds John Nichols, national affairs correspondent for The Nation. Nichols and Taylor discuss how Democrats “demobilized” young voters and grassroots organizers, to their electoral detriment. “Donald Trump, as a president who has very few guardrails, has the potential to take horrific actions,” says Nichols. For those seeking to oppose him, says Taylor, “There’s a lot of rebuilding that has to be done.”

Namikawa appears as young Count Piast in 8th episode on Saturday

Following Donald Trump's victory in the US presidential elections, a new trend has emerged on social media platforms called the 'MATGA movement'.

Manchester : Manchester University Press, [2018]

Manchester : Manchester University Press, [2017]

Oakland, CA : AK Press ; [Albany, NY] : Institute for Anarchist Studies, [2015]

Manchester : Manchester University Press, [2016]

New Brunswick, NJ : Rutgers University Press, [2023]

The green building drive is gaining momentum with real estate developers and the Indian Green Building Council joining hands for projects

Scintillating Odissi dance presentations highlighted the inextricable symbiosis of yoga and dance

Vinitha Nedungadi has imaginatively enlarged the repertoire in Mohiniyattam by adapting literary works and poetry in the dance form.

The second documentary in our Future Cities strand takes a closer look at how the maker movement has been appropriated in Shenzhen.

Ugandan Climate Activist, Vanessa Nakate joins us at WIRED Live 2020 to discuss the threat of climate change on Africa, its impact on communities across the continent and how we can tackle the pace of climate change via grassroots climate movements. "While Africa endures an ever-growing list of climate change disasters, you wouldn't know it from watching the news."

Peter Mui, founder of Fixit Clinic, discusses the right-to-repair movement and encourages us to fix and tinker with the products we buy instead of tossing them in landfills. He also speaks on the Fixit Clinic, where anyone can bring their broken electronics and get them repaired, with the goal of reducing waste and encouraging people to hang on to their tools and gadgets for as long as possible.

The 19-year-old State-level gymnast from Madurai suffered shoulder dislocation twice

‘The marginalised who have taken small loans and repaid as much they could are being made easy targets by banks, while big defaulters are left free,’ says Anti-SARFAESI official

The latest series of abstract collages by SG Vasudev, one of the founder-members of Chennai’s Cholamandal Artists Village, takes inspiration from his past work

With growing cultural homogenisation and divisive ideologies in India, the movement must step up the fight for social justice, equality and rationalism

National Bureau of Economic Research

Wolters Kluwer

While the issue with the of TOS has been addressedsorted out, the trailers are still facing delays in the scanning centre

The airport logged 1,538 air traffic movements, significantly up from 1,433 in September 2024

What does Chi Udaka bring to The Hindu November Fest? Here’s what show co-creators Ian Cleworth and Anandavalli and Shakuhachi Grand Master Riley Lee say

According to the Home Ministry's guidelines on the lockdown educational institutions, coaching centres, air travel and train services will continue to remain suspended

This year’s festival features nine events including walks, installations, talks and performances, presented at historic sites and archives across Kolkata

Source: www.reuters.com - Saturday, May 09, 2020
Malaysia's government extended the time frame for movement and business curbs by another four weeks to June 9, amid a gradual reopening of economic activity stunted by the coronavirus pandemic.

Russian Imperial Movement, based in St. Petersburg, is increasingly expanding its outreach beyond Russia through the establishment of transnational networks with likeminded neo-Nazis and white supremacist groups, experts warn

Nov. 15 - How much pressure is the Anna Hazare movement really putting on the Indian government. Professor Ashutosh Varshney of Brown University analyzes.