The use of substituted fused pyrimidinones and dihydropyrimidinones of the formula (I) or salts thereof where the radicals of the formula (I) are each as defined in the description, for enhancing stress tolerance in plants to abiotic stress, and for invigorating plant growth and/or for increasing plant yield.

New phenylamidines are described, having general formula (I): and their use for the control of phytopathogenic fungi.

Disclosed is a humidity indicator which contains no heavy metal and has good visibility of a color change that occurs when the humidity is increased. The humidity indicator can be produced by applying an aqueous coating comprising a leuco dye, an acidic compound which is in a solid state at ambient temperature, a deliquescent substance and an aqueous resin emulsion onto a substrate such as a resin film, a nonwoven fabric or a paper, and heating and drying the resulting product.

The present invention features compounds having the Formula (Ia) and (Ib) (e.g., a compound of any of Formulas ((Ia-2)-(Ia-21)), including other tautomers, stereoisomers, E/Z stereoisomers, prodrugs, pharmaceutically acceptable salts, and compositions thereof. The invention also features methods for treating or preventing pain (e.g., neuropathic pain), inflammation, or epilepsy in a patient by administering an effective amount of a compound of Formula (Ia) or (Ib). The invention also features a method for treating or preventing pain (e.g., neuropathic pain), inflammation, or epilepsy in a patient that includes administering to a patient in need thereof an effective amount of a compound of Formula (IIa) or (IIb) (e.g., a compound of any of Formulas ((IIa-2)-(IIa-6)). The compounds described herein (e.g., a compound of Formulas (Ia), (Ib), (IIa), or (IIb)) can also be used as anticonvulsants.

A battery pack dehumidifier system for controlling the relative humidity within a battery pack enclosure is provided, the dehumidifier system including a desiccant that absorbs/adsorbs water vapor from the battery pack enclosure. The system heats and reactivates the desiccant at predetermined time intervals or when the humidity within the system reaches a preset level, thereby allowing the desiccant to regain its potential for absorbing/adsorbing water vapor.

Dehumidifying cooling apparatus and method are provided for an electronics rack. The apparatus includes an air-to-liquid heat exchanger disposed at an air inlet or outlet side of the rack and positioned for air passing through the electronics rack to pass across the heat exchanger. The heat exchanger is in fluid communication with a coolant loop for passing coolant therethrough at a temperature below a dew point temperature of the air passing across the heat exchanger so that air passing across the heat exchanger is dehumidified and cooled. A condensate collector, disposed below the heat exchanger, collects liquid condensate from the dehumidifying of air passing through the electronics rack, wherein the heat exchanger includes a plurality of sloped surfaces configured to facilitate drainage of liquid condensate from the heat exchanger to the condensate collector.

An adaptive algorithm based battery-powered long distance wireless temperature and humidity sensor module. The sensor module uses an adaptive algorithm to transmit data on an event basis and/or a reduced basis to extend battery life to more than 10 years. It also uses a low power wireless transmitter which has frequency of sub-1 GHz and an effective transfer distance of up to 250 meters, a low power temperature and humidity sensor, and a long lasting lithium battery which has shelf life of 20 years.

An aerosol delivery system has a nebulizer and a humidifier providing a gas flow to the nebulizer. A controller varies humidity level of the gas flow to the nebulizer so that if the nebulizer is not operating it has about 100% humidity and it is operating the value is less to allow for the humidification effect of the nebulizer. The control may be achieved by dynamically varying proportions of flow through a dry branch and a humidification branch.

For music production, the velocity values with the purpose of creating dynamic percussion in cooperation with a value measuring surface (a touch screen tablet or touch screen phone) has the ability to simulate the tension of a percussion instrument thus tone values are correlated with X, Y values from a measuring surface and dynamics values are measured with velocity, all inclusive, wireless and cooperative with MIDI software.

The present invention relates to the administration of warm humidified oxygen to patients suffering with breathing problems. The present invention more specifically relates to the high flow of warm humidified oxygen to patients suffering with breathing problems or suffering with asthma.

A system provides warm, humidified gas to a patient via a patient interface. Horizontal connections can be used between the humidification chamber and conduit. To reduce the likelihood of condensate flowing back to the humidification chamber, or dead space or gases recirculation regions occurring within the gases flow path, a raised portion is positioned inside of the flow path to improve flow characteristics and to provide a barrier for condensate back flow. The raised portion also reduces the amount of condensate that is formed in the system and provides better flow characteristics for sensing purposes.

According to the present invention, there are provided a pyrimidine derivative represented by a general formula (1) indicated below, and an organic electroluminescent device comprising a pair of electrodes, and at least one organic layer sandwiched therebetween, wherein the pyrimidine derivative is used as a constituent material for the at least one organic layer. The pyrimidine derivative of the present invention is a material for a high efficiency, high durability organic electroluminescent device, is excellent in electron injection/transport performance, has hole blocking capability, and excels in characteristics.

Putting the AirTurn BT-200S-4 bluetooth foot controller to the test for hands-free DAW control.

HighLife Samples has launched the third volume in the Trance Midi Melodies series of sound packs, delivering a fresh batch of MIDI melodies and samples for Trance producers who want to get instant inspiration for their music productions. The pack includes 20 melodies and 20 bass loops in both MIDI and Wav formats (80 files […]

The post HighLife Samples releases Trance Midi Melodies Vol. 3 appeared first on rekkerd.org.

Plugin Boutique has announced an exclusive sale on reMIDI by SongWish, a MIDI sampler plugin that allows you to grab harmonies and melodies from compositions of past greats and get the most out of your royalty-free MIDI loops. If you can sample audio to help kickstart productions, why not sample midi? You can isolate melodies […]

The post Sample MIDI with SongWish’s reMIDI plugin, on sale for $19 USD appeared first on rekkerd.org.

FeelYourSound has announced the release of The Piano Sessions, a free songwriting package for producers of any genre. It contains over 26 free chord transformation presets for the ChordPotion songwriting plugin. The new presets transform the chords in your DAW into completely new piano melodies. With a few clicks, you can turn any chords into […]

The post FeelYourSound releases The Piano Sessions package with free MIDI melody generators appeared first on rekkerd.org.

The Dynamic Controls app for ROLI Dashboard turns a ROLI Lightpad Block into a highly customizable MIDI control surface, allowing you to design your own control layout using Buttons, Faders and XY Pads. Connect your Lightpad Block to the computer and launch ROLI Dashboard to load the Dynamic Controls app. Use Dashboard to edit the […]

The post Dynamic Controls 2 turns ROLI Lightpad Block into customizable MIDI control surface appeared first on rekkerd.org.

Ugritone has announced the release of KVLT Drums II: Speed Metal, a new expansion pack for the KVLT Drums II virtual drum instrument. For this new expansion, the KVLT Drums II virtual instrument has been updated with improved loading times, less CPU consumption, and tuning options. KVLT Drums II is a Drum Sample Library catered […]

The post Ugritone releases KVLT Drums II: Speed Metal, New IR & MIDI Packs and more appeared first on rekkerd.org.

Plugin Boutique has announced a sale on the Zenith by Audiaire, offering 30% off regular on the advanced MIDI processor plugin. Zenith allows any continuous controllers in a device to be modified by an independent sequencer lane, with each lane running at a unique rate and number of steps. As a feature-rich MIDI processor with […]

The post Audiaire’s Zenith MIDI controller & sequencer on sale at 30% OFF appeared first on rekkerd.org.

Control Ableton Live's EQ8 Frequency parameter with incoming MIDI notes. There are plenty of devices for MIDI mapping, this one is specifically tuned to the EQ8's Frequency parameter. It doesn't arbi...

Thanks. It just seems odd that it's exactly every 7th chromatic note. Seems like too big a coincidence. Anyway, may have to buy a new one. Cheers, CAM

Heated, humidified high-flow nasal cannula (HHHFNC) is a noninvasive mode of respiratory support that is commonly used in the majority of US NICUs. No large randomized trial has evaluated safety or efficacy of HHHFNC.

This large randomized controlled trial suggests that HHHFNC is as effective as nCPAP for noninvasive respiratory support and can be safely applied to a wide range of neonates. (Read the full article)

FreeBSD Security Advisory - The kernel driver for /dev/midistat implements a handler for read(2). This handler is not thread-safe, and a multi-threaded program can exploit races in the handler to cause it to copy out kernel memory outside the boundaries of midistat's data buffer. The races allow a program to read kernel memory within a 4GB window centered at midistat's data buffer. The buffer is allocated each time the device is opened, so an attacker is not limited to a static 4GB region of memory. On 32-bit platforms, an attempt to trigger the race may cause a page fault in kernel mode, leading to a panic.

FreeBSD Security Advisory - The kernel driver for /dev/midistat implements a handler for read(2). This handler is not thread-safe, and a multi-threaded program can exploit races in the handler to cause it to copy out kernel memory outside the boundaries of midistat's data buffer. The races allow a program to read kernel memory within a 4GB window centered at midistat's data buffer. The buffer is allocated each time the device is opened, so an attacker is not limited to a static 4GB region of memory. On 32-bit platforms, an attempt to trigger the race may cause a page fault in kernel mode, leading to a panic.

Four decades ago, we introduced a standard way of encoding digital sound. Its first ever upgrade could lead to new genres of music and ways of experiencing sound

Four decades ago, we introduced a standard way of encoding digital sound. Its first ever upgrade could lead to new genres of music and ways of experiencing sound

Four decades ago, we introduced a standard way of encoding digital sound. Its first ever upgrade could lead to new genres of music and ways of experiencing sound

Title: High Heat, Humidity Could Affect More Than 1.2 Billion People by End of Century
Category: Health News
Created: 3/24/2020 12:00:00 AM
Last Editorial Review: 3/25/2020 12:00:00 AM

ABSTRACT

Selectable markers are indispensable for genetic engineering, yet their number and variety are limited. Most selection procedures for prototrophic cells rely on the introduction of antibiotic resistance genes. New minimally invasive tools are needed to facilitate sophisticated genetic manipulations. Here, we characterized three endogenous genes in the human fungal pathogen Aspergillus fumigatus for their potential as markers for targeted genomic insertions of DNAs of interest (DOIs). Since these genes are involved in uptake and metabolization of pyrimidines, resistance to the toxic effects of prodrugs 5-fluorocytosine and 5-fluorouracil can be used to select successfully integrated DOIs. We show that DOI integration, resulting in the inactivation of these genes, caused no adverse effects with respect to nutrient requirements, stress resistance, or virulence. Beside the individual use of markers for site-directed integration of reporter cassettes, including the 17-kb penicillin biosynthetic cluster, we demonstrate their sequential use by inserting three genes encoding fluorescent proteins into a single strain for simultaneous multicolor localization microscopy. In addition to A. fumigatus, we validated the applicability of this novel toolbox in Penicillium chrysogenum and Fusarium oxysporum. Enabling multiple targeted insertions of DOIs without the necessity for exogenous markers, this technology has the potential to significantly advance genetic engineering.

IMPORTANCE This work reports the discovery of a novel genetic toolbox comprising multiple, endogenous selectable markers for targeted genomic insertions of DNAs of interest (DOIs). Marker genes encode proteins involved in 5-fluorocytosine uptake and pyrimidine salvage activities mediating 5-fluorocytosine deamination as well as 5-fluorouracil phosphoribosylation. The requirement for their genomic replacement by DOIs to confer 5-fluorocytosine or 5-fluorouracil resistance for transformation selection enforces site-specific integrations. Due to the fact that the described markers are endogenously encoded, there is no necessity for the exogenous introduction of commonly employed markers such as auxotrophy-complementing genes or antibiotic resistance cassettes. Importantly, inactivation of the described marker genes had no adverse effects on nutrient requirements, growth, or virulence of the human pathogen Aspergillus fumigatus. Given the limited number and distinct types of selectable markers available for the genetic manipulation of prototrophic strains such as wild-type strains, we anticipate that the proposed methodology will significantly advance genetic as well as metabolic engineering of fungal species.

BACKGROUND:High-flow nasal cannula (HFNC) therapy may reduce the re-intubation rate compared with conventional oxygen therapy. However, HFNC has not been sufficiently compared with conventional oxygen therapy with a heated humidifier, even though heated humidification is beneficial for facilitating airway clearance.METHODS:This study was a single-center, open-label, randomized controlled trial. We randomized subjects with respiratory failure after extubation to either HFNC group or to a large-volume humidified nebulization-based nebulizer. The primary end point was the re-intubation rate within 7 d after extubation.RESULTS:We could not recruit enough subjects for the sample size we designed, therefore, we analyzed 69 subjects (HFNC group, 30 subjects; nebulizer group, 39 subjects). The re-intubation rate within 7 d was not significantly different between the HFNC and nebulizer groups (5/30 subjects [17%] and 6/39 subjects [15%], respectively; P > .99). PaO2/set FIO2 at 24 h after extubation was also not significantly different between the respective groups (264 ± 105 mm Hg in the HFNC group vs 224 ± 53 mm Hg in the nebulizer group; P = .07).CONCLUSIONS:Compared with a large-volume nebulization-based humidifier, HFNC may not reduce the re-intubation rate within 7 d. However, because of insufficient statistical power, further studies are needed to reach a conclusion.

Manoella Gemaque Cavalcante, Cleusa Yoshiko Nagamachi, Julio Cesar Pieczarka, and Renata Coelho Rodrigues Noronha

Eukaryotic genomes exhibit substantial accumulation of repetitive DNA sequences. These sequences can participate in chromosomal reorganization events and undergo molecular cooption to interfere with the function and evolution of genomes. In turtles, repetitive DNA sequences appear to be accumulated at probable break points and may participate in events such as non-homologous recombination and chromosomal rearrangements. In this study, repeated sequences of 5S rDNA, U2 snRNA and Tc1/Mariner transposons were amplified from the genomes of the turtles, Podocnemis expansa and Podocnemis unifilis, and mapped by fluorescence in situ hybridization. Our data confirm the 2n=28 chromosomes for these species (the second lowest 2n in the order Testudines). We observe high conservation of the co-located 5S rDNA and U2 snRNA genes on a small chromosome pair (pair 13), and surmise that this represents the ancestral condition. Our analysis reveals a wide distribution of the Tc1/Mariner transposons and we discuss how the mobility of these transposons can act on karyotypic reorganization events (contributing to the 2n decrease of those species). Our data add new information for the order Testudines and provide important insights into the dynamics and organization of these sequences in the chelonian genomes.

Purpose:

Thymidine kinase 1 (TK1) is downstream to the CDK4/6 pathway, and TK activity (TKa) measured in blood is a dynamic marker of outcome in patients with advanced breast cancer (ABC). This study explores TK1 as a biomarker of palbociclib response, both in vitro and in patients with ABC.

Four decades ago, we introduced a standard way of encoding digital sound. Its first ever upgrade could lead to new genres of music and ways of experiencing sound

A new study has identified thousands of incidents of previously rare or unprecedented extreme heat/humidity combinations in parts of Asia, Africa, Australia, South America and North America, including in the US Gulf Coast region.

Events with extreme temperatures and humidity are occurring twice as often now as they were 40 years ago

-- Read more on ScientificAmerican.com

A federal court Tuesday issued a memorandum opinion and a preliminary injunction against Arthur Piner Grider, III; Asgard Avionics Corp. of Florida; and 14 other corporate defendants who operate as employee leasing companies, from violating the Internal Revenue Code.

Researchers found that temperature extremes previously thought to be rare have been recorded more than 1,000 times in 40 years.

Can one device to it all? Should it? Has its time finally come?

Events with extreme temperatures and humidity are occurring twice as often now as they were 40 years ago

-- Read more on ScientificAmerican.com

Scientists identify thousands of extreme events, suggesting stark warnings about global heating are already coming to pass

Intolerable bouts of extreme humidity and heat which could threaten human survival are on the rise across the world, suggesting that worst-case scenario warnings about the consequences of global heating are already occurring, a new study has revealed.

Related: One billion people will live in insufferable heat within 50 years – study

Researchers found that temperature extremes previously thought to be rare have been recorded more than 1,000 times in 40 years.

New study finds a growing number of places with intolerable conditions

Sunlight kills COVID-19 while warmer temperatures and humid weather significantly damage the virus, measured in terms of the virus' half-life or the time it takes to cut its potency in half, according to the latest breakthrough research from the US Department of Homeland Security's most advanced biocontainment lab, released at the White House on Thursday.

The coronavirus outbreak in the US has killed nearly 50,000 Americans and infected more than 860,000 till date. Research around the effect of temperature and humidity has been gaining traction for weeks, these are the most downloaded papers on research websites but this is the first time the US government has put an official stamp on initial results of temperature tests on COVID-19.

"Our most striking observation to date is the powerful effect that solar light appears to have on killing the virus, both on surfaces and in the air. We've seen a similar effect with both temperature and humidity as well. Increasing the temperature and humidity or both is generally less favourable to the virus," Bill Bryan, chief of the science and technology directorate at the US Department of Homeland Security, said.

In a room at 70-75F temperature with 20 per cent humidity, the half-life of the virus is about an hour, according to Bryan. "But you get outside and it cuts down to a minute and a half, very significant difference when it when it gets hit with UV rays," he said.

According to the same research, the virus' half-life on surfaces reduces dramatically with a combination increase of temperature and humidity. When the temperate is kept constant at 70-75F and only the humidity is cranked up from 20 per cent to 80 per cent, the virus' half-life is shown to crash from 18 hours to 6 hours. If the temperature is increased to 95F, the half-life sinks to barely 60 minutes.

Bryan said this testing was done at DHS' advanced biocontainment lab in Maryland, just outside the national capital. Pointing to charts with data from experiments on the COVID-19 virus, Bryan said the virus half-life plunges "drastically" with exposure to higher temperatures and even minimal exposure to humidity.

Bryan said the DHS biocontainment lab is the only one in America that has the capability to do the kind of testing that has led to the research on the virus' UV and temperature tolerance.

Bryan explained the mechanics of the COVID-19 temperature tolerance experiment in simple terms. He said the virus was first locked into a 5-gallon bucket and suspended in the air inside. "We're able to take a particle of a virus and suspend it in the air inside of this drum and hit it with various temperatures, various humidity levels, multiple different kinds of environmental conditions to include sunlight. And we're able to measure the decay of that virus while it's suspended in the air. This is how we do our aerosol testing."

"While there are many unknown links in the COVID-19 transmission chain, we believe these trends can support practical decision making to lower the risks associated with the virus," Bryan said. The DHS team has also tested the effect of bleach and isopropyl alcohol on the virus, "specifically in saliva and respiratory fluids".

"And I can tell you that bleach will kill the virus in five minutes, isopropyl alcohol will kill the virus in 30 seconds, and that's with no manipulation. No rubbing."

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Chamonix’s cable car back in business after two months, albeit with strict social-distancing measures

She recently returned from a festive family getaway to Fiji. And Storm looked sun-kissed and radiant as she attended the Cirque du Soleil press night at London's Royal Albert Hall on Wednesday.

Taking to Instagram on Monday, the former Coronation Street actress, 29, shared the photograph of herself clad in the fuchsia frock, from New Look

Amanda, 48, looked sensational as she stepped out in a vibrant jewel style gown that sheathed her lithe figure, while Alesha, 41, oozed sartorial chic in a loose blue suit.

The singer, 31, put on a stunning display as she showed off her svelte figure in a fitted grey midi dress, in snaps shared to her Instagram on Wednesday.