Israelis huddled in bomb shelters as the missiles streaked across the sky.

A day after a mass shooting in San Bernardino, California, authorities are trying to figure out why a couple would embark on a deadly killing spree.

Canopy walkway connections with structural thermal breaks support LEED Certification and contribute to an estimated annual energy cost savings of $300,000.

Boston — Injury and illness prevention efforts are most needed in Massachusetts’ transportation and warehousing industry, results of a recent analysis of workers’ compensation claims show.

The PC-5000 Series Wall-Mount Particle/Mass Monitor is a branded six-channel particulate meter that optionally incorporates sensors for additional environmental parameters such as total volatile organic compounds, carbon dioxide, temperature and relative humidity.

Advances like digitization, IoT, AI and mobile devices put mass notification directly into users’ hands, speeding up response times in emergency situations.

Washington — A State Plan covering Massachusetts’ state and local government employees is a step closer to reality after OSHA recently published a proposed rule outlining its initial approval.

Washington — A State Plan covering Massachusetts’ state and local government employees is now a reality after OSHA announced its initial approval.

Boston — Falls to a lower level were the leading a cause of fatal worker injuries in Massachusetts from 2014 to 2015, representing nearly 17 percent of the state’s workplace fatalities, according to a report released Oct. 16 by the state’s Department of Public Health.

Boston — The rate of opioid-related overdose deaths among Massachusetts workers in 2016 and 2017 rose 83.7% over the previous five-year period, with construction and agricultural occupations experiencing dramatic jumps, according to a recent report from the state’s Department of Public Health.

Boston — Unintentional overdoses accounted for more than 1 out of 4 workplace deaths in Massachusetts between 2021 and 2022, the state’s Department of Public Health reports.

Boston – Massachusetts is closer to extending OSHA protections to an estimated 400,000 public workers after the state’s House on Oct. 25 voted unanimously in favor of a bill (H. 3952) that boosts safety standards for all state and municipal government employees.

Boston — Intended to give small health care employers an “easy-to-use format” for a written exposure control plan, the Massachusetts Department of Public Health has published sample written plans for a respiratory protection program and bloodborne pathogen exposure control.

Luxury flooring brand Riva Spain opens four new "Riva Corners" in Massachusetts, showcasing their high-quality, sustainable wood products. The expansion reflects the brand's growth in the region, with business tripling over two years.

The acquisition aligns seamlessly with Amass Brands Group's overarching strategy to expand its presence in key segments of the spirits market.

This week on Basic Black: In the wake of the fatal shooting of Trayvon Martin, a look at Massachusetts' "stand your ground" proposal and recent efforts to pass or block the legislation. Also, the pending Supreme Court decision on the Obama administration's health care reform legislation: however they decide, what are the political ramifications for President Obama's re-election campaign and the impact on communities of color.

Our panel:
- Callie Crossley, host and executive editor, The Callie Crossley Show
- Kim McLarin, author and assistant professor of writing, literature, and publishing, Emerson College
- Peniel Joseph, professor of history, Tufts University
- Phillip Martin, senior reporter, WGBH Radio



(Image source via Creative Commons: xtopalopaquetl)

(June 8, 2012)

The recently published Trotter Review examines political gains made by African American politicians at the beginning of the 21st century. Also, specific essays on why Boston has not elected a black mayor while the city of Denver has done so twice, and how Deval Patrick has served the interests of black communities while not alienating the larger population.

Our panelists:
- Latoyia Edwards, anchor, New England Cable News
- Kim McLarin, assistant professor of writing, literature and publishing, Emerson College
- Phillip Martin, senior reporter, 89.7 WGBH Radio
- Ravi Perry, political science professor
- Kenneth Cooper, editor, The Trotter Review

Lect. Joshua Tepfer explains his work helping wrongfully arrested people

Cyrell Boyd is headed to treatment at the Red Wing juvenile facility for his role in the Nudieland shooting in August 2023. At a hearing Tuesday, victims spoke to him about the shooting’s impact.

Russia's gold reserves reached a new record in August as they amounted to $188.8 billion. Their share in international assets exceeded 30 percent for the first time in almost 25 years, the Central Bank of Russia said. As of September 1, 2024, Russia's international reserves grew to $613.7 billion, up from $602.05 billion as of August 1. In August, Russia increased its gold investments by 5.1 percent, bringing them to a record $188.8 billion. The previous record was set a month earlier at $179.5 billion.

A powerful solar flare that caused a massive ejection of solar matter on June 2, 2024, may cause a very string magnetic storm on Earth. The plasma cloud will reach our planet on Tuesday, June 4th. The June 2 X-class flare (the most powerful one) has become the third highest-level flare in the past 24 hours caused by active region 3697. This area caused a powerful flare in 2017 and the strongest magnetic storm since 2005. A total of five X-class flares were recorded in just three days from the moment the area appeared on the side of the Sun facing the Earth. The most dangerous flare occurred on May 29, but the ejection passed by the planet.

[Politics] :
Anchor: South Korea, the United States and Japan are conducting their second trilateral multidomain exercise in international waters south of South Korea’s Jeju Island. The U.S. Navy’s USS George Washington aircraft carrier, South Korea’s ROKS Seoae Ryu Seong-ryong destroyer and Japan’s JS Haguro ...

[more...]

Capitalism can be like a warped and extremely un-fun game of Monopoly, and most people are entering the fray much too late to get a slice of the action.

Addressing the demand for high stability of beamline instruments at the SHINE facility, a high stability mirror regulating mechanism has been developed for mirror adjustments. Active mass damping was adopted to attenuate pitch angle vibrations of mirrors caused by structural vibrations. An internal absolute velocity feedback was used to reduce the negative impact of spillover effects and to improve performance. The experiment was conducted on a prototype structure of a mirror regulating mechanism, and results showed that the vibration RMS of the pitch angle was effectively attenuated from 47 nrad to 27 nrad above 1 Hz.

President Biden signed a memorial bill to recognize the victims of the 2016 Pulse nightclub shooting and offered his condolences to people who are awaiting news on their loved ones in the wake of the deadly Surfside, Fla., partial condo collapse.

Biden — who was vice president when a 29-year-old man killed 49 people and wounded 53 more in the nightclub mass shooting — signed the bill to enshrine a monument to the dozens killed in the Latin Night massacre.

The shooting occurred at a gay nightclub in Orlando, Fla., in June 2016. The month of June is celebrated annually as LGBTQ Pride Month in the United States.

"May a president never have to sign another monument like this," Biden said.

Biden also offered his thoughts to the victims and loved ones of those affected by the catastrophic collapse this week of a Miami-Dade County condo. Authorities say four people have been declared dead and an additional 159 are considered missing in the rubble.

"I just want to say, I've spoken to Gov. [Ron] DeSantis, and we've provided all the help that they have, they need," Biden said. "We sent the best people from FEMA down there. We're going to stay with them."

This content is from Southern California Public Radio. View the original story at SCPR.org.

Source: Dr. David Nierengarten 10/29/2024

Wedbush analysts Dr. David Nierengarten, Dennis Pak, and Dr. Martin Fan, in a research report published on October 29, 2024, maintained their Outperform rating on Kiniksa Pharmaceuticals Ltd. (KNSA:NASDAQ) with a price target of US$34.00. The report follows Kiniksa's Q3 2024 earnings announcement, which showed continued strong growth for Arcalyst.

The analysts highlighted the company's strong quarterly performance, stating, "Net product revenues of US$112.2MM (+73% y/y) slightly edged out our US$112.0MM estimate. Management's updated FY revenue guidance to US$410-US$420MM (previously US$405-US$415MM) implies Q4 revenue of US$115.5-US$125.5MM (3%-12% q/q growth)."

Regarding market penetration, the analysts noted, "More than 11% of patients in KNSA's target RP population of 14,000 patients that suffer from two or more recurrences are now actively on Arcalyst therapy, compared to 9% penetration at YE23." They added, "Notably, ~45% of all new prescriptions were written by repeat prescribers, which accounted for ~25% (640) of total prescriber base."

The analysts emphasized the growing duration of therapy, stating, "Importantly, average total duration of Arcalyst therapy in RP continues to grow, increasing to ~27 months as of 3Q24 from ~23 months as of 1Q24."

Regarding the company's pipeline, the report highlighted progress with abiprubart, noting, "Abiprubart's subcutaneous formulation and potential for once-monthly dosing should provide a greater dosing convenience relative to other agents and support uptake in a crowded but large market (300,000+ patients in the U.S.A.) assuming comparable efficacy."

The analysts addressed the stock's recent performance, stating, "We think today's share action reflects overoptimistic expectations investors may have had following the outsized Q2 sequential growth over a seasonally weak Q1. Net-net, we believe Arcalyst fundamentals remain strong and view current trading levels as an attractive entry point."

Wedbush's valuation methodology is based on a sum-of-parts approach. The analysts explained, "Our PT is derived from a sum-of-parts valuation for each of the company's clinical programs: an 8x multiple to KNSA's share of estimated US sales of Arcalyst in RP in 2027 and CAPS in 2025 (discounted back by 15%), and an 8x multiple to abiprubart's estimated sales in Sjogren's disease in 2029/30 (discounted back by 35%)."

In conclusion, Wedbush's maintenance of its Outperform rating and US$34 price target reflects confidence in Kiniksa's commercial execution with Arcalyst and pipeline potential. The share price at the time of the report of US$23.76 represents a potential return of approximately 43% to the analysts' target price, suggesting a significant upside as the company continues to expand its market penetration and advance its pipeline.

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Disclosures for Wedbush, Kiniksa Pharmaceuticals, October 29, 2024

Analyst Certification We, David Nierengarten, Dennis Pak and Martin Fan, certify that the views expressed in this report accurately reflect our personal opinions and that we have not and will not, directly or indirectly, receive compensation or other payments in connection with our specific recommendations or views contained in this report.

Company Specific Disclosures This information is subject to change at any time. 1. WS makes a market in the securities of Kiniksa Pharmaceuticals.

Wedbush disclosure price charts are updated within the first fifteen days of each new calendar quarter per FINRA regulations. Price charts for companies initiated upon in the current quarter, and rating and target price changes occurring in the current quarter, will not be displayed until the following quarter. Additional information on recommended securities is available on request. Disclosure information regarding historical ratings and price targets is available: Research Disclosures *WS changed its rating system from (Strong Buy/ Buy/ Hold/ Sell) to (Outperform/ Neutral/ Underperform) on July 14, 2009. Applicable disclosure information is also available upon request by contacting the Research Department at (212) 833-1375, by email to leslie.lippai@wedbush.com. You may also submit a written request to the following: Wedbush Securities, Attn: Research Department, 142 W 57th Street, New York, NY 10019.

OTHER DISCLOSURES The information herein is based on sources that we consider reliable, but its accuracy is not guaranteed. The information contained herein is not a representation by this corporation, nor is any recommendation made herein based on any privileged information. This information is not intended to be nor should it be relied upon as a complete record or analysis: neither is it an offer nor a solicitation of an offer to sell or buy any security mentioned herein. This firm, Wedbush Securities, its officers, employees, and members of their families, or any one or more of them, and its discretionary and advisory accounts, may have a position in any security discussed herein or in related securities and may make, from time to time, purchases or sales thereof in the open market or otherwise. The information and expressions of opinion contained herein are subject to change without further notice. The herein mentioned securities may be sold to or bought from customers on a principal basis by this firm. Additional information with respect to the information contained herein may be obtained upon request. Wedbush Securities does and seeks to do business with companies covered in its research reports. Thus, investors should be aware that the firm may have a conflict of interest that could affect the objectivity of this report. Investors should consider this report as only a single factor in making their investment decision. Please see pages 3–7 of this report for analyst certification and important disclosure information. Retail Investors The information provided is for general informational purposes only and should not be considered an individual recommendation or personalized investment advice. The companies/investments mentioned may not be suitable for everyone. Each investor needs to review their own respective situation(s) before making any investment decisions. All expressions of opinion are subject to change without notice due to shifting market(s), economic or political conditions. Investment involves risks including the risk of principal. Past performance is no guarantee of future results and the opinions presented cannot be viewed as an indicator of future performance.

( Companies Mentioned: KNSA:NASDAQ, )

Infectious disease outbreaks that turn into epidemics or pandemics can kill millions of people and cause trillions of dollars of damage to economic activity, says a new report from the international, independent Commission on a Global Health Risk Framework for the Future.

The 1.3 million nursing home residents in the U.S. make up less than 0.5 percent of the nation’s population, but represent approximately 15 percent of COVID-19 related deaths to date.

A recent ISHN webinar highlighted the often-overlooked hazard of combustible dust, with expert Mark Hanson detailing the devastating consequences of ignoring this workplace threat.

OSHA investigation finds operator of three Massachusetts waterproofing contracting companies could have prevented an employee from dying in February 2024 when part of a foundation broke and fell.

As consumers are spending less on discretionary items and more on essentials, experts note that mass merchandisers are capitalizing on value, variety and services.

As consumers today work to pay their bills and buy groceries, data shows that mass merchandisers are serving as a go-to channel to stretch their dollars. 

KROHNE Inc. highlighted their OPTIMASS 1400 Coriolis mass flowmeter.

Deep Tissue Massage Expert Builds Loyal Following for Healing Massages

Part of Exner's Highly Regarded Optical Measurement Range, EXcell 231 Is Ideal for Monitoring and Trending Algal Growth

Add the products you want to your cart in advance to get at least 25% off on Amazon Prime Day

This Salon and Spa Galleria outlet in Fort Worth offers the best in a variety of massage modalities

Unprecedented Move by Toley Ranz Foundation taking its anti-bullying program to Libraries' bully-free spaces, helping kids' to learn healthy social skills, led to explosive growth into 'A Community Thrives' campaign'

Mass Shootings Anywhere Are War-like Actions Effecting Children Everywhere. Groundbreaking Pro-Social Program Teaches Coping & Life Skills Empowering Young Children From Within, with Self-Belief to Bring Bullying To An End. No Fear Toley Ranz is Here

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Everything you need to know about using a massage gun for muscle relaxation after exercise

This Salon and Spa Galleria massage center caters to everyone from athletes to the average person seeking relief

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Exploring the Unique Heating and Vibration Technology of PICOOC Heating Massage Gun for Deeper Massage and Relaxation

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2012 Luncheon Event Takes Place Thursday, September 13 from noon - 2 PM at the Boston Marriott Quincy Hotel; Tom Bergeron Comes to Pick Up His 2007 Award!

Tickets are on sale now and this event is open to the public. Dick Albert, Jim Boyd, Jack Williams, Matt Siegel, George Capalbo, Jane Christo, Joseph Ryan and others to be honored as well