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Computer Scientist Explains One Concept in 5 Levels of Difficulty

Moravec's paradox is the observation that many things that are difficult to do for robots to do come easily to humans, and vice versa. Stanford University professor Chelsea Finn has been tasked to explain this concept to 5 different people; a child, a teen, a college student, a grad student, and an expert.




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UMass Professor Explains the Internet in 5 Levels of Difficulty

The internet is the most technically complex system humanity has ever built. Jim Kurose, Professor at UMass Amherst, has been challenged to explain the internet to 5 different people; a child, a teen, a college student, a grad student, and an expert.




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Mathematician Explains Infinity in 5 Levels of Difficulty

While the concept of infinity may seem mysterious, mathematicians have developed processes to reason the strange properties of infinity. Mathematician Emily Riehl has been challenged to explain infinity to 5 different people; a child, a teen, a college student, a grad student, and an expert. Director: Maya Dangerfield Producer: Wendi Jonassen Director of Photography: Ben Finkel Editor: Louville Moore Host: Emily Riehl Level 1: Samira Sardella Level 2: Eris Busey Level 3: Yoni Singer Level 4: Elliot Lehrer Level 5: Adriana Salerno Line Producer: Joseph Buscemi Associate Producer: Paul Gulyas Production Manager: Eric Martinez Production Coordinator: Fernando Davila Camera Operator: Larry Greenblatt Gaffer: Randy Feldman Audio: Ken Pexton Production Assistant: Andrea Hines Hair/Makeup Artist: Haki Pope Johns Post Production Supervisor: Alexa Deutsch Post Production Coordinator: Ian Bryant Supervising Editor: Doug Larsen Assistant Editor: Paul Tael




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Theoretical Physicist Explains Time in 5 Levels of Difficulty

Time: the most familiar, and most mysterious quality of the physical universe. Theoretical physicist Brian Greene, PhD, has been challenged to explain the nature of time to 5 different people; a child, a teen, a college student, a grad student, and an expert. Director: Maya Dangerfield Producer: Wendi Jonassen Field Producer: Katherine Wzorek Director of Photography: Charlie Jordan Editor: Shandor Garrison Host: Brian Greene Level 1: Kayla Martini Level 2: Maria Guseva Level 3: Zain Kamal Level 4: Alexander Novara Level 5: Massimo Porrati Line Producer: Joseph Buscemi Associate Producer: Paul Gulyas Production Manager: Eric Martinez Production Coordinator: Fernando Davila Casting Producer: Nick Sawyer Camera Operator: Britney Berger Gaffer: Gautam Kadian Audio: Brett Van Deusen Production Assistant: Nicole Gaitan Hair/Makeup Artist: Yev Write-Mason Post Production Supervisor: Alexa Deutsch Post Production Coordinator: Ian Bryant Supervising Editor: Doug Larsen Assistant Editor: Andy Morell




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MIT Professor Explains Nuclear Fusion in 5 Levels of Difficulty

Nuclear fusion underpins some of the most basic processes in our universe and holds the promise of virtually limitless, clean, carbon-free energy. Dr. Anne White, Professor of Nuclear Science and Engineering at The Massachusetts Institute of Technology, has been challenged to explain the nature of nuclear fusion to 5 different people; a child, a teen, a college student, a grad student, and an expert.




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Harvard Professor Explains Algorithms in 5 Levels of Difficulty

From the physical world to the virtual world, algorithms are seemingly everywhere. David J. Malan, Professor of Computer Science at Harvard University, has been challenged to explain the science of algorithms to 5 different people; a child, a teen, a college student, a grad student, and an expert. Director: Wendi Jonassen Director of Photography: Zach Eisen Editor: Louville Moore Host: David J. Malan Guests: Level 1: Addison Vincent Level 2: Lexi Kemmer Level 3: Patricia Guirao Level 4: Mahi Shafiullah Level 5: Chris Wiggins Creative Producer: Maya Dangerfield Line Producer: Joseph Buscemi Associate Producer: Paul Gulyas; Kameryn Hamilton Production Manager: D. Eric Martinez Production Coordinator: Fernando Davila Casting Producer: Vanessas Brown; Nicholas Sawyer Camera Operator: Brittany Berger Gaffer: Gautam Kadian Sound Mixer: Lily Van Leeuwen Production Assistant: Ryan Coppola Hair & Make-Up: Yev Wright-Mason Post Production Supervisor: Alexa Deutsch Post Production Coordinator: Ian Bryant Supervising Editor: Doug Larsen Assistant Editor: Lauren Worona




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Chess Pro Explains Chess in 5 Levels of Difficulty (ft. GothamChess)

Chess has been around for centuries, but remains a challenging, ever-evolving game to this day. Levy Rozman a.k.a. GothamChess has been challenged to explain the game of chess to 5 different people; a novice, an intermediate, a semi-pro, a grandmaster and an AI programmer.Director: Maya DangerfieldDirector of Photography: Charlie JordanEditor: Robby MasseyHost: Levy RozmanGuest: Level 1: Riyae Park; Level 2: Jeffrey Kim; Level 3: Tani Adewumi; Level 4: Irina Krush; Level 5: Siddartha SenCreative Producer: Wendi JonassenLine Producer: Joseph BuscemiAssociate Producer: Paul Gulyas; Kameryn HamiltonProduction Manager: D. Eric MartinezProduction Coordinator: Fernando DavilaCasting Producer: Vanessa Brown; Nicholas SawyerCamera Operator: Brittany BergerGaffer: Rebecca Van Der MeulenSound Mixer: Lily Van LeeuwenProduction Assistant: Ryan CoppolaHair & Make-Up: Yev Write-MasonPost Production Supervisor: Alexa DeutschPost Production Coordinator: Ian BryantSupervising Editor: Doug LarsenAssistant Editor: Billy Ward




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Anupam Kher On IFFI Row: Shameful!

'If the Holocaust was right, then the exodus of Kashmiri Pandits is also right.'




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Shrivalli and McGiffin pair in the quarterfinals




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IFFI 2016: all eyes on S. Korea

What makes South Korean cinema so special on the global map? With a great line-up of its contemporary films, IFFI's 47th edition, could be the place to find the answer




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The Sniffing Bear / directed by: Co Hoedeman ; produced by: Thérèse Descary ; production agency: National Film Board of Canada (Montreal)

Montreal : National Film Board of Canada, 2008




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Structure determination of difficult-to-crystallize organic molecules by co-crystallization of a phosphorylated macrocycle

Org. Chem. Front., 2024, 11,6358-6366
DOI: 10.1039/D4QO01498G, Research Article
Heng Li, Zhijin Li, Juli Jiang, Chen Lin, Leyong Wang
This work reported that 37 different difficult-to-crystallize guest molecules were co-crystallized with the host macrocycle F[3]A1-[P(O)Ph]3 at room temperature, and the molecular structures of the guests could be determined by SCXRD.
The content of this RSS Feed (c) The Royal Society of Chemistry




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'Difficult to keep up with Ranveer'

Ranveer is loud, but not shrill, notes Subhash K Jha.As in singing, in acting holding your pitch in the higher notes is a Himalayan task.Ranveer resides on the highest notes of the musical mountain and still manages to be coherent, fluent and persuasive.




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Gala Dalí in the company of ‘difficult’ women

2024 seems to be the year museums are making room for the narratives of misunderstood women — from Yoko Ono and Naomi Campbell, to Salvador Dalí’s wife and muse




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T20 World Cup: Taking cricket to America involves a difficult culture transfer

It might be politically incorrect to say this, but America isn’t ready to embrace cricket yet




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Why some cuvettes are difficult to come by

A spot shortage of the analytical sample holder affects some scientists




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The difficult search for the right recipe in cancer immunotherapy

With so many ingredients on hand, can the oncology community figure out how to sensibly and efficiently combine checkpoint inhibitors with other drugs?




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Nathan Redmond: 'It's difficult to post a TikTok video if you've lost 1-0' | David Hytner

The Covid-19 lockdown has given the midfielder the chance to show his acting skills outside the Southampton changing room

Nathan Redmond hustles towards the camera, suited up, fedora jauntily perched and when he starts to lip-sync, the voice is that of Carter – the character played by Chris Tucker in Rush Hour 3. It is the scene involving him, Master Yu and Mi and, for those who have not seen it, has Carter getting into a word-play tangle as he questions Yu and Mi. “Who are you? Yu. No, not me, you. Yes, I am Yu.” It goes from there.

Related: 'People's lives depend on it': the sacked English defender left in limbo | Sid Lowe

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How Theresa May’s exit compares with other difficult departures from No 10

The Guardian’s former political editor revisits humiliating prime ministerial resignations from Robert Peel to David Cameron

Both Brexit camps claim Sir Robert Peel, the Tory moderniser whose 1846 resignation crisis most resembles May’s. But he had succeeded where she failed. Determined to cut food prices for industrial workers, Peel pushed through repeal of protectionist Corn Laws with opposition help. In retaliation, rightwing enemies defeated his Irish Coercion bill. Peel resisted Queen Victoria’s appeal to stay, but grateful crowds cheered him as he walked to the Commons to resign. He slipped out by a side door, but was spotted and cheered home. Divided Tories lost office for 20 years.

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Gambling on US equities is becoming more difficult

Deglobalisation should make investors think twice about betting on index tracker funds




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Covid-19: Assam has stepped into most difficult times, says health minister Himanta Biswa Sarma




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Emirates to raise debt as it braces for most difficult months ever

The state-owned airline, which suspended regular passenger flights in March reported a 21% rise in profit for its financial year that ended on March 31





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Steep difficulty curve




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Indian Immunologicals, Griffith University of Australia developing vaccine against Covid-19

IIL is already working with Griffith University for conducting R&D of Zika virus vaccine which is currently at pre-clinical toxicology testing stage.






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U.S. Supreme Court Makes More Difficult Expropriation Lawsuits Against Foreign States

The United States Supreme Court has made it more difficult for plaintiffs to sue foreign states in US courts under the exception to sovereign immunity applicable to “any case . . . in which rights in property taken in violation of international law ...




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Grateful hikers return to Griffith Park: 'Like being set free'

'Like being set free:' Grateful hikers returning to Griffith Park




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Rosena Allin-Khan: 'If Matt Hancock found my tone difficult, that's on him'

The Labour MP and A&E doctor on her run-in with the health secretary and her shifts on the hospital frontline

When Rosena Allin-Khan stood up in the House of Commons last Tuesday to address the health secretary, Matt Hancock, she anticipated being stonewalled. She didn’t expect to become the story.

In her other life, the MP for Tooting is an A&E doctor and intensive care specialist and has been working 12-hour hospital shifts throughout the pandemic. Allin-Khan reported that the government’s failures were contributing to a greater loss of life and she wanted answers on its testing strategy. The health secretary awkwardly responded by suggesting that Allin-Khan’s testimony was untrue and moreover, that she “might do well to take a leaf out of the shadow secretary of state’s book in terms of tone”.

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Labour migration: Germany is open to graduates but immigration is difficult for medium-skilled workers

Germany is one of the OECD countries with the lowest barriers to immigration for high-skilled workers. However, long-term labour migration is low in comparison with other countries.




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Labour migration: Germany is open to graduates but immigration is difficult for medium-skilled workers

Germany is one of the OECD countries with the lowest barriers to immigration for high-skilled workers. However, long-term labour migration is low in comparison with other countries.




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Labour migration: Germany is open to graduates but immigration is difficult for medium-skilled workers

Germany is one of the OECD countries with the lowest barriers to immigration for high-skilled workers. However, long-term labour migration is low in comparison with other countries.




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Education Indicators in Focus 13 - How difficult is it to move from school to work?

In some countries, an increasing number of young people are neither in employment, nor in education or training (NEET). A high proportion of NEETs is an indicator of a difficult transition between school and work.




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Webinar video recording on Finding Alternatives to Per- and Polyfluoroalkyl Substances of Concern: A Difficult and Continuing Challenge

On Thursday 26 September 2019, the OECD discussed "Finding Alternatives to Per- and Polyfluoroalkyl Substances of Concern: A Difficult and Continuing Challenge" with the participation of W.L. Gore & Associates, Inc. Presenters shared efforts, successes and challenges in eliminating per and polyfluorinated chemicals of environmental concern from the life cycle of consumer products.




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It's capricious and difficult but there's no denying Pinot Noir is worth celebrating

Happy Pinot Noir Day (yes, it really is a thing). I'm up for a bit of veneration - any excuse to celebrate the good things in life, and Pinot Noir is among the best




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'A very difficult shot': Yuvraj Singh shares video of him hitting six over covers




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Facing difficulties due to non-availability of farm labour, say Amritsar farmers




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Why is interoperability between the two fields of chemical crystallography and protein crystallography so difficult?

The interoperability of chemical and biological crystallographic data is a key challenge to research and its application to pharmaceutical design. Research attempting to combine data from the two disciplines, small-molecule or chemical crystallography (CX) and macromolecular crystallography (MX), will face unique challenges including variations in terminology, software development, file format and databases which differ significantly from CX to MX. This perspective overview spans the two disciplines and originated from the investigation of protein binding to model radiopharmaceuticals. The opportunities of interlinked research while utilizing the two databases of the CSD (Cambridge Structural Database) and the PDB (Protein Data Bank) will be highlighted. The advantages of software that can handle multiple file formats and the circuitous route to convert organometallic small-molecule structural data for use in protein refinement software will be discussed. In addition some pointers to avoid being shipwrecked will be shared, such as the care which must be taken when interpreting data precision involving small molecules versus proteins.




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A practical overview of molecular replacement: Clostridioides difficile PilA1, a difficult case study

Many biologists are now routinely seeking to determine the three-dimensional structures of their proteins of choice, illustrating the importance of this knowledge, but also of the simplification and streamlining of structure-determination processes. Despite the fact that most software packages offer simple pipelines, for the non-expert navigating the outputs and understanding the key aspects can be daunting. Here, the structure determination of the type IV pili (TFP) protein PilA1 from Clostridioides difficile is used to illustrate the different steps involved, the key decision criteria and important considerations when using the most common pipelines and software. Molecular-replacement pipelines within CCP4i2 are presented to illustrate the more commonly used processes. Previous knowledge of the biology and structure of TFP pilins, particularly the presence of a long, N-terminal α-helix required for pilus formation, allowed informed decisions to be made during the structure-determination strategy. The PilA1 structure was finally successfully determined using ARCIMBOLDO and the ab initio MR strategy used is described.




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Off-Ramp blog posts moving to spiffier dwellings

; Credit: John Rabe

John Rabe

Dear Off-Ramp fans,

What is a blog, after all? Words and images.

And what is a radio story on the web? Words, images, and sound.

Can't they live together in harmony? We say YES.

And with that in mind, we're killing the Off-Ramp blog page.  

But don't fear; we're not cutting back on content: everything that would have found a home here - Marc Haefele's art reviews, recommendations for fun events, etc. -- will now be on the regular web page of the Off-Ramp radio show

All the old blog entries will continue to stay on this page as an archive, like Catherine Deneuve's fading vampire lovers in The Hunger.

This content is from Southern California Public Radio. View the original story at SCPR.org.




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Richard Johnson believes it is now more difficult than ever for Watford to bring players through the youth academy and into the Premier League

Richard Johnson believes that it is a tall order for any top-flight club, not just Watford, to hand homegrown players from the academy a chance to play in the Premier League due to what is at stake in financial and sporting terms.




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11 of the most difficult ultramarathons in the world

A regular marathon will sound like an easy warm-up compared to these crazy yet compelling endurance races.



  • Fitness & Well-Being

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What is C. difficile?

C. difficile is a harmful bacterium that produces toxins that attack the lining of the intestine. The superbug has exploded in growth over the decades.



  • Fitness & Well-Being

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The Hunt helps online shoppers with difficult-to-find items

If you've ever had trouble finding something online, a new website is here to help.



  • Natural Beauty & Fashion

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Development of bomb-sniffing cyborg locusts officially underway

The Office of Naval Research hopes to harness locusts' powerful sense of smell to protect soldiers on the battlefield.



  • Research & Innovations

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For a quick lesson on gene editing or blockchain, there's Five Levels of Difficulty

Wired's video series, 'Five Levels of Difficulty,' challenges an expert to explain a complicated concept to people at five levels of expertise — and it's cool.



  • Research & Innovations

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Charles Randell to replace John Griffith-Jones as chair of the FCA

Randell to take up role on 1 April.




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The Ultimate Guide to Dealing With Difficult People: 'Jackass Whisperer' Scott Stratten on Marketing Smarts [Podcast]

Scott Stratten, co-owner of UnMarketing and co-author of The Jackass Whisperer, shares tips for addressing bad behavior at work, at home, and online.




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Edward M. Griffin Presented with the Albert Nelson Marquis Lifetime Achievement Award by Marquis Who's Who

Dr. Griffin has been endorsed by Marquis Who's Who as a leader in the field of education