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Assembly of ionic supramolecular polymers using a decacationic pillar[5]arene to noncovalently crosslink hyaluronic acid for short DNA delivery

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00447G, Research Article
Qian Li, Danying Ma, Yue-Yang Liu, Hui Wang, Wei Zhou, Dan-Wei Zhang, Zhan-Ting Li
A multicationic pillar[5]arene noncovalently crosslinks hyaluronic acid to afford ionic supramolecular polymers for intramolecular delivery of short DNA.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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InPost CEO on Q3 results: we are relentlessly focused on delivering

InPost Group has announced it’s Q3 24 results this morning, featuring significant gains in volumes, sales and profitability, as well as continued expansion of its locker network in all key markets.




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India vs Pakistan Tussle Leads To Cancellation Of Champions Trophy Launch

A chatter emerged that South Africa could be a viable alternative to organise next year's Champions Trophy but no such discussion happened in the International Cricket Council on Tuesday





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Rosslyn Chapel - the 12 great mysteries - What's the meaning of carvings of American plants that predate Columbus' 1492 A.D. discovery of America? - Exotic plants featured in the chapel's carving include maize (corn) and aloe vera - One theory

Rosslyn Chapel, just outside Edinburgh, has been a holy place for centuries. Its name means either "point of a waterfall" or "ancient knowledge down the line" depending on who you ask. -- What is the chapel's link with Freemasons? Apparently Sir William St Clair claimed patronage of the masons - a link passed and strengthened through the generations and evidenced in two seventeenth century charters. In 1736, Sir William Sinclair became the first Scottish Grand Master at the Grand Lodge of Scotland in Edinburgh. By the 1690s, the bond between the Sinclairs and the masons was commented in a celebrated letter. ... Who is the leering green man engraved more than 120 times in the chapel? Carvings of a bearded green man appear in many religious settings in much of the world, but few have as many as Rosslyn. There are many theories about who the green man was. Some say it was either John the Baptist or Hercules. He is depicted as a Robin Hood-type figure, sometimes alternatively named Jack-in-the-green or Jack-in-the-Tree. He also may have been Celtic fertility god or a tree spirit. ... Who is the man with the gash on his head? Rumour suggests that he might be the smited apprentice of pillar fame. However, he could also be Freemasonry's legendary figure, Hiram Abiff, the martyred architect of King Solomon's Temple. Academic symbologists say it could just as easily express a classic archetype of sacrifice and rebirth. ... What do the 213 mysterious cube carvings mean? The mystical symbols carved into the stone ceiling of the chapel have confused historians for generations. But recently music scientists who believe they are part of a musical notation system are making efforts to decode the signs. The series of lines and dots are thought to represent shapes created by sand on a musical instrument during the vibrations caused by sound.



  • Christian Church History Study
  • 2. 313 A.D. to 1521 A.D. - Revised Rome and the Holy Roman Empire

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Contending for Truth: Exposed: Tim LaHaye, Chuck Missler, Jerry Falwell, Sun Myung Moon, Rick Santorum, Newt Gingrich, Benny Hinn, Kathryn Kuhlman, Paul Crouch, Chuck Smith, Hal Lindsey, Rick Joyner, The Pope, TBN, Calvary Chapel, CNP, Knights of Malta &a

Welcome to the new Contending for Truth website! We are excited to have an opportunity to streamline the site, focusing more on the content and delivering the teachings to you. God Bless you, Dr. Scott Johnson.




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Contending for Truth: Exposed: Tim LaHaye, Chuck Missler, Jerry Falwell, Sun Myung Moon, Rick Santorum, Newt Gingrich, Benny Hinn, Kathryn Kuhlman, Paul Crouch, Chuck Smith, Hal Lindsey, Rick Joyner, The Pope, TBN, Calvary Chapel, CNP, Knights of Malta &a

Welcome to the new Contending for Truth website! We are excited to have an opportunity to streamline the site, focusing more on the content and delivering the teachings to you. God Bless you, Dr. Scott Johnson.




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Contending for Truth: Exposed: Tim LaHaye, Chuck Missler, Jerry Falwell, Sun Myung Moon, Rick Santorum, Newt Gingrich, Benny Hinn, Kathryn Kuhlman, Paul Crouch, Chuck Smith, Hal Lindsey, Rick Joyner, The Pope, TBN, Calvary Chapel, CNP, Knights of Malta &a

Welcome to the new Contending for Truth website! We are excited to have an opportunity to streamline the site, focusing more on the content and delivering the teachings to you. God Bless you, Dr. Scott Johnson.




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Contending for Truth: Exposed: Tim LaHaye, Chuck Missler, Jerry Falwell, Sun Myung Moon, Rick Santorum, Newt Gingrich, Benny Hinn, Kathryn Kuhlman, Paul Crouch, Chuck Smith, Hal Lindsey, Rick Joyner, The Pope, TBN, Calvary Chapel, CNP, Knights of Malta &a

Welcome to the new Contending for Truth website! We are excited to have an opportunity to streamline the site, focusing more on the content and delivering the teachings to you. God Bless you, Dr. Scott Johnson.




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LibreSSL 4.0.0 Released

The LibreSSL project, a closely associated subproject of the OpenBSD project, has announced the availability of their new stable release, LibreSSL 4.0.0, which comes with a number of improvements and a sprinkling of fixes.

The release announcement reads,

Subject:    LibreSSL 4.0.0 Released
From:       Brent Cook <busterb () gmail ! com>

We have released LibreSSL 4.0.0, which will be arriving in the
LibreSSL directory of your local OpenBSD mirror soon. This is the
first stable release for the 4.0.x branch, also available with OpenBSD 7.6

It includes the following change from LibreSSL 3.9.2:

  * Portable changes
    - Added initial Emscripten support in CMake builds.
    - Removed timegm() compatibility layer since all uses were replaced
      with OPENSSL_timegm(). Cleaned up the corresponding test harness.
    - The mips32 platform is no longer actively supported.
    - Fixed Windows support for dates beyond 2038.

Read more…




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Krytyczna podatność w Fortinet FortiOS SSL-VPN (CVE-2022-42475)

Fortinet opublikował informację o krytycznej podatności CVE-2022-42475 pozwalającej na zdalne wykonanie kodu bez uwierzytelniania w module SSL-VPN (sslvpnd) dla FortiOS. Podatność była aktywnie wykorzystywana w atakach jeszcze zanim jej istnienie zostało ujawnione.




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Win10 BrightnessSlider 1.8.11 (Freeware)

Win10 BrightnessSlider adds a Monitor Brightness icon to on Taskbar Tray that lets you adjust the brightness of your monitor(s) with a simple slider. If you use multiple monito....




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Haftstrafe für Ärztin wegen angeblicher Russland-Kritik - ohne Beweise

Kritik an Russlands Krieg gegen die Ukraine wird von der russischen Justiz hart bestraft. Nun muss eine Ärztin für Jahre in Haft, weil sie der Ukraine angeblich ein Recht auf Selbstverteidigung zugestand. Beweise dafür gibt es nicht.




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Ukraine-Liveblog: ++ Kiew: Russland plant Angriff an Südfront ++

Russland bereitet ukrainischen Angaben zufolge einen Angriff an der südlichen Front vor. US-Außenminister Blinken reist am Mittwoch nach Brüssel, um über die Lage in der Ukraine zu beraten. Die Entwicklungen vom Dienstag zum Nachlesen.




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Comodo Points to High Assurance SSL as Fix for Phishing




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Russland greift ISIS-Stellungen an

Russische Kriegsschiffe haben am 20. November Cruise Missiles auf Ziele in Syrien abgefeuert und dabei sieben islamistische Stellungen in den nördlich Provincen Raqqa, Idlib and Aleppo getroffen. Col Patrick Ryder kritisierte, bei den russischen Angriffen würden auch gemäßigte syrische Oppositionsgruppe in Mitleidenschaft gezogen. Die Nachrichtensender BBC und Channel 4 veröffentlichten ...




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The Crossland Team is Back at Keller Williams Realty Austin SW Market Center

And the real estate journey continues … Sylvia and I started Crossland Real Estate in Jan 1993, and remained independent until we sold our property management portfolio in 2004 and “retired” for a year. We didn’t actually formally retire … more of a sabbatical … as we were still in our 40s with kids 9 and 12. But we did take a year off from active real estate “production”. We weren’t sure whether we wanted to remain in real estate forever or not. I started a telecom services company and dabbled in Business Brokerage, both of which were interesting pursuits worthy of a full effort, and which I could have succeeded at doing, but after some time off from the daily real estate routine, something happened… The phone rang. It was Real Estate. It wanted us back. Sometimes distance from something brings perspective and a renewed appreciation of it. So, ... Read more



  • Austin Real Estate
  • Business and Technology

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Der Einmarsch der Ukraine in Kursk/Russland – Was soll er bringen?

Dr. Alexander von Paleske ---- 19.8. 2024 Der ukrainischen Armee ist ein Überraschungsschlag gelungen: sie ist 30-40km auf russisches Gebiet im Raum Kursk vorgedrungen. Viele Unterstützer der Ukraine sehen jetzt offenbar die Möglichkeit, Russland eine schwere Niederlage beizubringen, die möglicherweise auch zum Sturz des russischen Präsidenten Putin führen könne. Welche Kriegsziele? Da die Ukraine Russland nicht erobern will - und kann - stellt sich die Frage nach den ukrainischen Kriegszielen....




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How to Make Your WordPress Website Secure (SSL) in 6 Steps

If you've looked into search engine optimization as a promotional technique for your website, you have likely come across the advice to make your website secure (having an https:// appear in front of your URLs instead of http://). Google has been very vocal in pushing for all websites to make the move to being secure,…

The post How to Make Your WordPress Website Secure (SSL) in 6 Steps appeared first on Sugarrae.




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Oberesslingen - Stuttgart BMX Jam Series





We jammed diligently with our friends from the Stuttgart BMX Jam Series in the legendary Oberesslingen skate park. Our bro @sm1ley captured the BMX session in moving pictures. Be sure to check out the @bmxjamseries Instagram page for the next session.

Enjoy the video, your kunstform BMX Shop Team!

Video & Edit by: Miguel Smajli




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Populations of grassland butterflies decline almost 50 &#37; over two decades

By http://www.eea.europa.eu/

Grassland butterflies have declined dramatically between 1990 and 2011. This has been caused by intensifying agriculture and a failure to properly manage grassland ecosystems, according to a report from the European Environment Agency (EEA).

The fall in grassland butterfly numbers is particularly worrying, according to the report, because these butterflies are considered to be representative indicators of trends observed for most other terrestrial insects, which together form around two thirds of the world’s species. This means that butterflies are useful indicators of biodiversity and the general health of ecosystems.
Seventeen butterfly species are examined in 'The European Grassland Butterfly Indicator: 1990–2011’, comprising seven widespread and 10 specialist species. Of the 17 species, eight have declined in Europe, two have remained stable and one increased. For six species the trend is uncertain.
Butterflies examined in the report include the Common Blue (Polyommatus icarus), which has declined significantly, the Orangetip (Anthocharis cardamines), which seems to be stable since 1990, and the Lulworth Skipper (Thymelicus acteon), which shows an uncertain trend over the last two decades.
Hans Bruyninckx, EEA Executive Director, said: "This dramatic decline in grassland butterflies should ring alarm bells – in general Europe’s grassland habitats are shrinking. If we fail to maintain these habitats we could lose many of these species forever. We must recognise the importance of butterflies and other insects – the pollination they carry out is essential for both natural ecosystems and agriculture." more...




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Dissemination meeting with MsMonina, Brussles

Dissemination meeting with MsMonina, Brussles (26 November 2013)

 

 





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Israel Relentlessly Destroying Hezbollah &amp; Hamas | CBN NewsWatch October 30, 202

Israel says it's reduced Hezbollah's rocket supply by 80%, and warns that if Iran strikes again then Israel could hit more valuable Iranian targets next time, Israel captures hundreds of Hamas terrorists, and Israel responds to international ...




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‘Needlessly delayed’

Does the rulemaking process delay potential lifesaving rules, or is it necessary to ensure the promulgation of the best rules possible? A Senate subcommittee listens to the debate.




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Genetec Helps Organizations Move Seamlessly From Incident Response to Investigations

This integration enables users to move seamlessly from incident response to investigation from within a single interface.




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Chomps Names Tim Bosslet as CFO

In his previous roles at Chomps, Bosslet served as senior director of finance, VP of finance and senior VP of finance.





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Officials say rapper Nipsey Hussle shot and killed at 33

Nipsey Hussle, a respected rapper who earned a Grammy nomination this year for his major-label debut, was fatally shot outside his clothing store, authorities said.




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Investigation of fast and efficient lossless compression algorithms for macromolecular crystallography experiments

Structural biology experiments benefit significantly from state-of-the-art synchrotron data collection. One can acquire macromolecular crystallography (MX) diffraction data on large-area photon-counting pixel-array detectors at framing rates exceeding 1000 frames per second, using 200 Gbps network connectivity, or higher when available. In extreme cases this represents a raw data throughput of about 25 GB s−1, which is nearly impossible to deliver at reasonable cost without compression. Our field has used lossless compression for decades to make such data collection manageable. Many MX beamlines are now fitted with DECTRIS Eiger detectors, all of which are delivered with optimized compression algorithms by default, and they perform well with current framing rates and typical diffraction data. However, better lossless compression algorithms have been developed and are now available to the research community. Here one of the latest and most promising lossless compression algorithms is investigated on a variety of diffraction data like those routinely acquired at state-of-the-art MX beamlines.




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Marquis Who's Who Selects Michael P. Kessler for Expertise in Forensic Science, Forensic Intelligence, and Law Enforcement

Mr. Michael P. Kessler is noted for his contributions to the forensic sciences and forensic operations




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Dennis Kessler Joins DevBlink AI as Non-Executive Director

Global Top 100 Innovator in Data & Analytics Strengthens devBlink AI Board




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Share & Record Any Audio Wirelessly: The first Auracast™ Transceiver to reinvent your smart life

VOCE provides the most easy way solution to enable Auracast™ service.




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MovPilot Netflix Video Downloader Released to Boost Netflix Videos Offline Streaming in A Hassle-free Way

"The Netflix Video Downloader launched by MovPilot has offered a hassle-free way to bypass all official limitations and download Netflix videos in HD quality without hassle."




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Marquis Who's Who Honors Michael Kessler, JD, for Expertise in Energy Law

Michael Kessler, JD, is honored for his work as a leading expert in regulatory matters




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Funwhole Announces the Launch of a Highly Innovative Steampunk Vintage Car. The vehicle not only allows for free opening of doors and boarding but also effortlessly navigates between day and night

Highlights of the product introduction.




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Useful Tips to Help You Optimize Your Search Engine Performance Effortlessly

Search engine optimization (SEO) has become a critical factor in driving traffic, enhancing visibility, and improving website performance. Whether you’re a seasoned marketer or a business owner, refining your SEO strategies is a necessity to stay ahead of competitors. When you focus on key aspects like keyword research, content creation, and technical SEO, you can […]

The post Useful Tips to Help You Optimize Your Search Engine Performance Effortlessly appeared first on Designer Daily: graphic and web design blog.




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Hassler Honored with 2015 Contractor of the Year Award

Hassler Heating and Air Conditioning Inc. of El Cerrito, California, was named the 2015 Home Upgrade Program Contractor of the Year by PG&E and Energy Upgrade California.




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How to make a minimal HTTPS request with ncat --ssl with explicit HTTP content?

Posted by Ciro Santilli OurBigBook via dev on Sep 17

Hello, I was trying for fun to make an HTTPS request with explicit hand-written HTTP content.

Something analogous to:

printf 'GET / HTTP/1.1 Host: example.com ' | ncat example.com 80

but for HTTPS. After Googling one of the tools that I found that seemed it might do the job was ncat from the nmap
project, so I tried:

printf 'GET / HTTP/1.1 Host: example.com ' | ncat --ssl example.com 443

an that works...




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SE Radio 598: Jonathan Crossland on the AMMERSE Framework

Jonathan Crossland, software architect, author, and business owner, joins host Jeff Doolittle for a conversation about the AMMERSE framework of design principles. They start by discussing the agile manifesto as a statement of values, and Jonathan shares his perspective based on his experience as a software developer and business owner. They then explore the three layers of the AMMERSE framework and how they help business and engineering leaders to align their values, thereby improving their ability to collaborate and reach common goals. Brought to you by IEEE Computer Society and IEEE Software magazine.




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¡RESCATEN EL TITANIC!, de Clive Cussler (Javier Vergara, 1985)

Título:
¡Rescaten el Titanic!
Autor: Clive Cussler (1931-2020)
Título original: Raise the Titanic! (1976) Nº 3 en la serie “Dirk Pitt”
Traducción: Ariel Bignami
Editor: Javier Vergara Editor (Buenos Aires)
Fecha de edición: 1985-09
Descripción física: 389, 2 p.; 13,5x22 cm.
ISBN: 978-950-15-0056-1 (950-15-0056-X)
Estructura: preludio, 5 partes, 82 capítulos, “Ajuste de cuentas”
Información sobre impresión:
Esta edición terminó de imprimirse en la COMPAÑÍA IMPRESORA ARGENTINA S.A.
Alsina 2049/61 - Buenos Aires - Rep. Argentina en el mes de setiembre de 1985
 
Información de cubierta:
EL DESCUBRIMIENTO DEL TITANIC
FICCIÓN QUE HOY ES REALIDAD
 
Información de contracubierta:
La acción del bestseller del año tiene lugar en 1988. El Proyecto Siciliano es el plan del siglo. Nada más importante desde la bomba atómica. Su éxito significará levantar una red protectora sobre todo el país, protegiéndolo de cualquier ataque exterior. Pero se necesita bizanio, carísimo elemento, que ya no se da en la naturaleza. El único bizanio que hay en el mundo está sepultado en el “Titanic”, hundido en 1912 y que yace en el fondo del mar, a más de dos millas de profundidad.

La crítica dijo:
“Extraordinario suspenso, salta de una emoción a otra, mantiene al lector tan cautivo, que nadie quiere que llegue el final”.
Publishers Weekly

¡Rescaten el Titanic! es suspenso en su mejor sentido. Será tal vez el éxito del año”.
San Francisco Chronicle

“Cussler imaginó con genio y creó con perfección”.
Philadelphia Inquirer
 
MI COMENTARIO:
Un verdadero clásico en la literatura de espionaje y de aventura moderna, ¡Rescaten el Titanic! fue la tercera novela del escritor Clive Cussler sobre Dirk Pitt, agente de NUMA (National Underwater & Marine Agency), pero la primera que tuvo un gran éxito a nivel mundial, y que terminó por consolidar a la serie como una de las mejores del género, que ya va por el libro nº 27, The Corsican Shadow, publicado en 2023 por Dirk Cussler, hijo de Clive y continuador de sus novelas.
El presidente de EEUU autoriza y sostiene el “Proyecto Siciliano”, un esquema ultrasecreto funcionando a espaldas del Congreso y de la opinión pública, que busca dotar a su país de la invulnerabilidad frente a un posible ataque misilístico de la URSS. Para lograr su objetivo, necesita imperiosamente de bizanio, un mineral rarísimo que sólo pudo hallarse en el Ártico ruso. Se descubre que un cargamento de bizanio pudo haber sido transportado en el Titanic, famoso barco hundido en 1912. Contrareloj, se monta una operación dirigida por Dirk Pitt para llevarlo a la superficie y arrástralo hasta el puerto de Nueva York. Sin embargo, la KGB logró infiltrar a dos espías en el contingente de rescate, que recurren incluso al asesinato para malograr la misión. Sólo la poderosa mente de Pitt puede resolver este misterio y evitar una catástrofe.
Cussler crea a un héroe sólido, hecho a sí mismo, inteligente, intuitivo, seductor, misterioso. Un lobo solitario que sabe hacer su trabajo y que quiere lo mejor para su país. La novela tiene un fuerte espíritu de restauración post-Watergate. Más allá de los fallos, hasta de los delitos del pasado reciente, Pitt encarna la necesidad de que EEUU prosiga su lucha por la libertad y contra el imperio soviético. Hay una escena muy ilustrativa: la viuda de uno de los mineros que trabajaron en la búsqueda del bizanio a principios del siglo XX es contactada por la inteligencia norteamericana para que brinde alguna pista sobre dónde puede estar. Al principio se niega. Le dicen que tiene una llamada telefónica. Después de atender, pregunta emocionada si es cierto que el que la llamó fue el presidente de EEUU para pedirle su colaboración. Cussler reflota no sólo al Titanic, sino al sentimiento patriótico que su país tenía muy dañado a finales de los 70. Lo hace apelando tanto al cultivo de las viejas tradiciones de camaradería y de esfuerzo que crearon a la gran república del Norte, así como a la tecnología militar y marina, que tiene que priorizarse, incluso sobre las preocupaciones sociales. Cussler quiere ganar porque lo cree justo, y así lo demuestra en una gran novela de acción, de misterio y de pasión.

ADAPTACIONES AL CINE Y LA TV:
Ver mi entrada > Cine de espías: DIRK PITT



  • AD ADAPTACIONES AL CINE Y LA TV
  • AD MIS COMENTARIOS
  • AU CLIVE CUSSLER
  • ED JAVIER VERGARA
  • GE NOVELA
  • PE DIRK PITT

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How Apple solved the wireless lossless audio problem with the USB-C AirPods Pro

The USB-C AirPods Pro are the first earbuds to be capable of wireless lossless audio. #airpods #losslessaudio #earbuds



  • Tech Trends and Commentaries

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Ecology and Conservation of Mountaintop grasslands in Brazil

Location: Electronic Resource- 




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Geologic explorer's guide to the Sheyenne National Grassland

Location: Sciences Library Library- QE150.S44F75 2001




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Secured Web Page (SSL)

Secure Sockets Layer (SSL) secures safe passage of credit card information, user names, passwords, and other sensitive e-commerce transactions.

Newlook Marketing promise to protect your personal information. Any page at newlook.com.sg that asks you for personal information is highly secured and encripted with SSL 128-bit encryption. This will prevent any third party servers from tapping the information.




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GSV Hopelessly Optimistic But Still Right

Machines of Loving Grace Anthropic CEO Dario Amodei publishes a 14,000-word post on How AI Could Transform the World for the Better, detailing how the 5-10 years following availability of an "Expert-Level Science and Engineering" AI, or "country of geniuses in a datacenter" will play out advances in biology, (Amodei's specialty,) neuroscience, economic development, governance, and work and meaning. Amodei draws on Iain M. Bank's MeFi Favorite the Culture as he concludes: "I think the Culture's values are a winning strategy because they're the sum of a million small decisions that have clear moral force and that tend to pull everyone together onto the same side. Basic human intuitions of fairness, cooperation, curiosity, and autonomy are hard to argue with, and are cumulative in a way that our more destructive impulses often aren't. [...] These simple intuitions, if taken to their logical conclusion, lead eventually to rule of law, democracy, and Enlightenment values. If not inevitably, then at least as a statistical tendency, this is where humanity was already headed. AI simply offers an opportunity to get us there more quickly—to make the logic starker and the destination clearer. Banks, most previously on the Blue: [1][2] via The Verge/Decoder




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Looking for foreign travel without the hassle? Hop in the car and head north

There's been a tremendous uptick in travel abroad since the lifting of COVID-related restrictions…




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Capturing and sharing dazzling photos of the natural world is Stacy Gessler's calling

In January 2024, Stacy Gessler found herself outdoors in below-freezing temperatures at Yellowstone National Park, waiting for just the right sliver of a second to photograph scenes of a pack of wolves as they went about their day…



  • Health & Home/Lifestyle

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Spokane's relentlessly gigging Snacks at Midnight shows off its eclectic rock sound on What You Think You Want

Sometimes it can be tough when you get the musical munchies yet struggle to figure out what exactly fits your sonic taste in the moment…




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GitHub - sjdonado/idonthavespotify: Effortlessly convert Spotify links to your preferred streaming service

sjdonado/idonthavespotify: Effortlessly convert Spotify links to your preferred streaming service https://ift.tt/dH4YICR music, streaming, spotify, tools




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Mum's 'ome-made froot cake, perfick fer pusslin'!

WendyHarris1955 posted a photo:

unbranded
plywood (basswood)
175 pieces
280 x 350 mm

TED: "I fink this lickle cat an' tiger pussle's cute. It's got pussycat wimsys an' it's shaped, so it's gonna be a keeper. The wobbly edj wuz a bit fiddly an' I 'ad to check the pikchur to make shure I 'ad it rite, but uvverwise it's a good'un.
That peece of cake I'm abowt to eat is Mum's 'ome-made froot cake spredd wiv butter - s'nice cuz she puts whisky in it. That's the cake, not the butter!"