Apparently tomorrow is Monday.

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As the new year brings in a new peak in COVID cases across the country, we all have a right to feel a little down in the dumps. One trend picked up by surveys earlier in the pandemic was a drop in self-reported happiness. Now, with a new year of General Social Survey data released, […]

November 9 is the 96th birthday of Harrison Ruffin Tyler, a retired chemical engineer and a historical preservationist who lives in Virginia. His claim to fame is that he is the grandson of U.S. President John Tyler, our tenth president who served in office from 1841 to 1845. That's like, 180 years ago. How is that possible?

President Tyler fathered 15 children. The thirteenth was Lyon Gardiner Tyler, born in 1853, when the former president was 63 years old. Lyon Gardiner Tyler had six children, the fifth being Harrison Ruffin Tyler, who was born in 1928 when his father was 75 years old. Therefore, a president who was born 234 years ago has a living grandchild today. 

Harrison Ruffin Tyler is also a descendant of Pocahontas and several other prominent figures from both the Revolutionary War and the Civil War. Happy Birthday, Mr. Tyler. -via Boing Boing

(Portrait of President Tyler from Wikimedia Commons)

It sure was a lovely surprise one day last fall when a representative from the Bead&Button Show called to ask if I would be interested in sending my beaded quilts for exhibition at the 2015 show in Milwaukee, WI.

Would I be interested? Of course I would!!! But since I'm more of a beader and don't have that many beaded quilts, I suggested they also contact my brother, Thom Atkins, who has made a mind-boggling number of beaded quilts in the last 10 years or so.

Brother-sister exhibition... how fun is that! You can see all 22 quilts in the Artisan Area of the Exhibition Hall if you're attending the show, May 27 - June 8. For those who can't make it, here are my quilts, the ones in the show. When you click on the first picture, you can see a slide show with full-size pictures.

It's really special how,in recent years, quilters are interested in beads, and beaders are playing with quilting, both finding ways to expand their creativity! And it's super fun to show with my bro!

Oh dear, busy me, four months since I've posted here. Lots of quilting, a little beading, some travels, and recently several sets of house guests have made "retirement" a bit of a joke. For now, since the La Conner Quilt Festival is just around the corner (October 2-4), my subject is one small exhibition on the first floor at the Museum, which is currently up, and will remain through the Festival.

Last year at the Festival (and again this year!) Sue Spargo taught workshops on her wool applique embroidery methods. Those of us who were lucky enough to get in were invited by the Museum to exhibit our finished pieces. These marvelous creations are the subject of this post. Uneven lighting makes it difficult to get good photos, so please forgive poor color or tone on some of these photos.

In case you are unfamiliar with Sue's work, below is an example of her work. Students in her class could choose to make chicks, circles, or flowers. Most chose the chicks. Eight of her students are showing their work in the current exhibit.

My vote for the most awesome-creative piece goes to Bunny Starbuck for She Has Flown the Coop! Here it is:

Having put my chicks all in neat rows similar to Sue's example, I find it amazing that Bunny's mind took the idea and made a whole different story of it... a coop full of chicks, with two in line on the roof ready to follow the one already in the air. Don't you just love the way the lines divide the space?!




Note Bunny's use of whispy yarn to suggest little chick feathers, her use of snaps for eyes, the one chick turned full front, the one with a bead-tassled braid and glasses, and the one with beaded loop fringe and a gathered yellow ribbon (?) yo-yo. I love them! I'm in awe, Bunny!

Below is Chicks on Parade by Dorie Benson. It's so fun the way they are so close together, with two of them going in a different direction, just as you might see in a little cluster of chicks. If you click the photo to enlarge it, you can see some of Dorie's excellent stitching and hand quilting!

The next one is Chicks by Glenys Baker, who not only did all 36 chicks but also made a second quilt featuring circles (shown further down). Awesome work, Glenys!

And next is Birds of a Feather Can Dance Together by Lorraine Jones. The fun of the title is matched by the fun of Lorraine's embellishments, including her border treatment. (You'll have to see this one in person, because the light from a table lamp, made the lower corner of the photo look terrible.)

I guess most of us like to "swim the other way," as you can see in the next piece, Chickadees, by Carrie Unick. I thought many of Corrie's embellishments were especially fun and creative, so I've also included a couple of detail photos.



Last of the chicks is my piece, simply named Chicks. It was so much fun, that I made another small piece (also in the exhibition), shown at the top of this post. Both are displayed in shadow-box type frames to protect them from dust and moth damage.
Glenys Baker, in one year, made not only a 36-chicks quilt (shown above), but also a 48-circles quilt, Circles. How she keeps thinking of new embellishment variations I can't imagine. Yet each of her circles is completely unique! Her choice of border fabrics is perfect for the quilt, complimenting the flow of color among the circles.


I love the fun color combinations and the way the beads enhance her embroidery on Nancy Anders' Bodacious Blooms, a joyful wall quilt if ever there was one! (Again, I couldn't quite get the color right in the photo, so you'll just have to go to the Museum to see it in person.)


The name of Roberta Roberts' flower quilt, Memories, invites us to look closely at the flower with three ladybugs. I don't know the story, but I can tell there is one here... and I love that. Her embellishments are varied and fun as well.



There you have it... 10 quilts by 8 students who learned some methods of wool applique and embroidery from Sue Spargo, last year at the La Conner Quilt Festival. I'm so grateful to be one of them!

Dear Friends, At this special time of the year, RSS Ground team would like to send you its best greetings and wish you happy holidays. We express you our sincerest appreciation for being with RSS Ground. And we thank you for making our job enthralling and enjoyable. May God bless you and may the new […]

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May this Christmas be a fitting ending to a successful year for you. May the New Year bring fresh hopes and bright beginnings!

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Here comes another year of giving thanks to all our dear customers! Happy Thanksgiving to everyone celebrating. May you enjoy this wonderful occasion and have lots of fun in the whole year ahead. We will do our best to keep RSS Ground on the highest level and continue developing it according to your needs. Thank […]

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Dear RSS Ground Users! We sincerely wish you happy holidays! May peace and prosperity always stay in your homes, May joy and happiness always follow you in your life. Merry Christmas and Happy New Year!

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This time of the year there is an urge for holidays and amusement. Halloween is one of those best occasions to take a break from your daily routine and to fully enjoy this very special night of the year. We sincerely wish you a Happy Halloween and a great holiday season. Have fun and stay […]

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We are taking this opportunity to say Thank You! We can’t express how much we appreciate you being a part of RSS Ground family. We hope our unique tools will continue to be useful to you for years to come. We usually never do this, but this time we would like to show our token […]

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Dear Friends, RSS Ground team wishes you Merry Christmas and Happy New Year! May all your current plans and projects be successful and bring you joy and happiness. We have a lot of exciting plans for 2022 and will continue developing our service to make your work online easier. Happy Holidays!

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We are welcoming this holiday season! And they are coming for you. Our spooky scary-good updates are lurking out there, but there is no need to fear because we are always working to enhance your online experience. We have just added: IFTTT integration – ability to automate posting to many more destinations and collect more targeted […]

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Traditionally, end of November is the time to be thankful, a time to remember and to embrace those who enrich our lives. Thanks to your active participation in our development process we continue to grow RSS Ground  service. This year we have added several powerful tools based on your feedback: Telegram Feeds and automated Poster, […]

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There is no perfect moment to take action for success, always strive to bring your ambition to life.  Wishing you great inspiration and success!

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Dear RSS Ground Family, As the golden leaves of autumn usher in a season of warmth and gratitude, we pause to reflect on the journey we’ve shared. Thanksgiving isn’t just a holiday—it’s a heartfelt reminder of the importance of connection, community, and the spirit of giving thanks. Today, we extend our deepest appreciation to you, […]

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The magic of the holiday season is upon us, and it’s the perfect time to reflect on the year that has flown by. Here at RSS Ground, we’ve been on an incredible journey, one that would not have been possible without you, our dedicated users. Your trust has empowered us to continuously enhance our offerings, […]

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An NPR listener is graduating soon with her MBA. She wants to know if it's OK celebrate her achievement by asking loved ones to buy her gifts from a registry, similar to what people do for weddings.

OM Guatemala distributes more than 1,000 pairs of shoes at local primary schools.

Complaints about denied claims often concern the treatment the scheme will cover for a prescribed minimum benefit.

Alumnus Pablo Lopez works to give back to Penn State and State College through his role as film production manager for the Happy Valley Adventure Bureau.

Investors holding more than a quarter of Shoprite shares opposed its executive pay, requiring SA's largest retailer to address dissenting shareholders' concerns.

“As I watched the ending scene (that lasted about three minutes) I thought about the “happy ending” notion,” says Ava. “Is it real or is it a fairy tale? A utopia created by Hollywood to give their viewers a false sense of hope in the reality of a broken world? And so, I said to myself: I believe in happy endings.”

October is National Italian American Heritage Month, a month dedicated to celebrating the distinguished cultural contributions of Americans with Italian lineage. According to the United States Census Bureau, as of 2019, more than 16 million Americans of Italian descent reside in the United States, making up the seventh largest ethnic group in the country. “Italian […]

More than 100 Delawareans, from newborns to seniors, attended story time at the Dover Public Library to wish Smokey Bear a happy 80th birthday on August 9, which marks Smokey’s official birthday.

to make yourself happy and remarkably less disturbable

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“It might feel like 2064 on the surface, but in its nostalgic, rechargeable heart, the show parties like it’s 1999.”

Tech companies are force-feeding people AI on search engines and social media platforms and there's no way to opt out. Google search, considered the gateway to the internet, is especially frustrating.

‘You deserve something better!’ Ward’s partner Nancy Xu said of result

Bill MacDonnell's paintings are on display at the Military Museums in Calgary through Remembrance Day and into 2025.

The Martian new year arrives with the Red Planet’s vernal equinox. Explaining why requires a deep dive into celestial mechanics and Earth’s calendrical history

A new survey of plan sponsors sheds light on their satisfaction with transparency at large and small pharmacy benefit managers (PBMs).

As you will see, clients remain slightly more satisfied with the perceived transparency of smaller PBMs compared with the Big Three PBMs—CVS Caremark, Express Scripts, and Optum Rx.

However, plan sponsors are dissatisfied with transparency about how both large and small PBMs make money. Smaller PBMs have an edge, but it’s narrower than you might think.

Perhaps PBMs’ clients are unable or unwilling to negotiate better deals, write more effective contracts, and switch to more satisfying relationships. Or maybe they don’t mind the current system, despite the challenges for patients. Some argue that transparency could swoop down to solve this problem. Riddle me this: Should we watch what plan sponsors say, or what they do?

Read on to see what you think of my arguments below. Then, click here to share your thoughts with the Drug Channels community.
Read more »

“Children are not small adults.” We invoke this saying, in a vague and hand-wavy manner, whenever we talk about the need to study drugs in pediatric populations. It’s an interesting idea, but it really cries out for further elaboration. If they’re not small adults, what are they? Are pediatric efficacy and safety totally uncorrelated with adult efficacy and safety? Or are children actually kind of like small adults in certain important ways?

Pediatric post-marketing studies have been completed for over 200 compounds in the years since BPCA (2002, offering a reward of 6 months extra market exclusivity/patent life to any drug conducting requested pediatric studies) and PREA (2007, giving FDA power to require pediatric studies) were enacted. I think it is fair to say that at this point, it would be nice to have some sort of comprehensive idea of how FDA views the risks associated with treating children with medications tested only on adults. Are they in general less efficacious? More? Is PK in children predictable from adult studies a reasonable percentage of the time, or does it need to be recharacterized with every drug?

Essentially, my point is that BPCA/PREA is a pretty crude tool: it is both too broad in setting what is basically a single standard for all new adult medications, and too vague as to what exactly that standard is.

In fact, a 2008 published review from FDA staffers and a 2012 Institute of Medicine report both show one clear trend: in a significant majority of cases, pediatric studies resulted in validating the adult medication in children, mostly with predictable dose and formulation adjustments (77 of 108 compounds (71%) in the FDA review, and 27 of 45 (60%) in the IOM review, had label changes that simply reflected that use of the drug was acceptable in younger patients).

So, it seems, most of the time, children are in fact not terribly unlike small adults.

But it’s also true that the percentages of studies that show lack of efficacy, or bring to light a new safety issue with the drug’s use in children, is well above zero. There is some extremely important information here.

To paraphrase John Wanamaker: we know that half our PREA studies are a waste of time; we just don’t know which half.

This would seem to me to be the highest regulatory priority – to be able to predict which new drugs will work as expected in children, and which may truly require further study. After a couple hundred compounds have gone through this process, we really ought to be better positioned to understand how certain pharmacological properties might increase or decrease the risks of drugs behaving differently than expected in children. Unfortunately, neither the FDA nor the IOM papers venture any hypotheses about this – both end up providing long lists of examples of certain points, but not providing any explanatory mechanisms that might enable us to engage in some predictive risk assessment.

While FDASIA did not advance PREA in terms of more rigorously defining the scope of pediatric requirements (or, better yet, requiring FDA to do so), it did address one lingering concern by requiring that FDA publish non-compliance letters for sponsors that do not meet their commitments. (PREA, like FDAAA, is a bit plagued by lingering suspicions that it’s widely ignored by industry.)

The first batch of letters and responses has been published, and it offers some early insights into the problems engendered by the nebulous nature of PREA and its implementation.

These examples, unfortunately, are still a bit opaque – we will need to wait on the FDA responses to the sponsors to see if some of the counter-claims are deemed credible. In addition, there are a few references to prior deferral requests, but the details of the request (and rationales for the subsequent FDA denials) do not appear to be publicly available. You can read FDA’s take on the new postings on their blog, or in the predictably excellent coverage from Alec Gaffney at RAPS.

Looking through the first 4 drugs publicly identified for noncompliance, the clear trend is that there is no trend. All these PREA requirements have been missed for dramatically different reasons.

Here’s a quick rundown of the drugs at issue – and, more interestingly, the sponsor responses:

1. Renvela - Genzyme (full response)

Genzyme appears to be laying responsibility for the delay firmly at FDA’s feet here, basically claiming that FDA continued to pile on new requirements over time:

Genzyme’s correspondence with the FDA regarding pediatric plans and design of this study began in 2006 and included a face to face meeting with FDA in May 2009. Genzyme submitted 8 revisions of the pediatric study design based on feedback from FDA including that received in 4 General Advice Letters. The Advice Letter dated February 17, 2011  contained further recommendations on the study design, yet still required the final clinical study report  by December 31, 2011.

This highlights one of PREA’s real problems: the requirements as specified in most drug approval letters are not specific enough to fully dictate the study protocol. Instead, there is a lot of back and forth between the sponsor and FDA, and it seems that FDA does not always fully account for their own contribution to delays in getting studies started.

2. Hectorol - Genzyme (full response)

In this one, Genzyme blames the FDA not for too much feedback, but for none at all:

On December 22, 2010, Genzyme submitted a revised pediatric development plan (Serial No. 212) which was intended to address FDA feedback and concerns that had been received to date. This submission included proposed protocol HECT05310. [...] At this time, Genzyme has not received feedback from the FDA on the protocol included in the December 22, 2010 submission.

If this is true, it appears extremely embarrassing for FDA. Have they really not provided feedback in over 2.5 years, and yet still sending noncompliance letters to the sponsor? It will be very interesting to see an FDA response to this.

3. Cleviprex – The Medicines Company (full response)

This is the only case where the pharma company appears to be clearly trying to game the system a bit. According to their response:

Recognizing that, due to circumstances beyond the company’s control, the pediatric assessment could not be completed by the due date, The Medicines Company notified FDA in September 2010, and sought an extension. At that time, it was FDA’s view that no extensions were available. Following the passage of FDASIA, which specifically authorizes deferral extensions, the company again sought a deferral extension in December 2012. 

So, after hearing that they had to move forward in 2010, the company promptly waited 2 years to ask for another extension. During that time, the letter seems to imply that they did not try to move the study forward at all, preferring to roll the dice and wait for changing laws to help them get out from under the obligation.

4. Twinject/Adrenaclick – Amedra (full response)

The details of this one are heavily redacted, but it may also be a bit of gamesmanship from the sponsor. After purchasing the injectors, Amedra asked for a deferral. When the deferral was denied, they simply asked for the requirements to be waived altogether. That seems backwards, but perhaps there's a good reason for that.

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Interview Jean Jouzel, Pr�sident du jury

Today, Gareth Hinds's beautiful graphic novel adaptation of Graceling hits stores. Join us for an event! Here's a link to all your options.