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As the year draws to a close, the holiday season is upon us once again. Although we still have two months until Christmas, studies have shown decorating early is actually good for your mood. The vibrant colors and twinkling lights simply trigger the release feel-good dopamine, which in turn, boosts happiness and energy. I must admit, Christmas decor makes me grin like a kid with ice-cream, until I look at the price tag of tinsel and garlands and baubles. Yikes! […]

The post Deck Your Halls for Less: 14 Christmas Decor Ideas Using IKEA Finds appeared first on IKEA Hackers.

The post Soulful Christmas Tree Decorations appeared first on English Russia.

Princeton's 'extremely supportive' environment for new ideas laid the foundation for an aha moment about a toggle switch in the fruit fly brain. Do humans have one, too? 

I learned to create decorative painted papers from Paulus Berensohn, Albie Smith, Lynne Perrella, Anne Bagby, and others by taking wonderful workshops from them in the 1990s, and soon adapted their techniques to making books with beadwork inserted into the covers, like the one below. I use my painted papers on the book covers and for signature covers, which look great with this type of binding.

But after moving to the island where I've lived for 20 years now, I gradually got into quilting and textile arts, kept the beadwork going, and cut way back on painting. Until now!

Inspired, cajoled, and arm-twisted by one of the Textile Guild members, who wants to learn how to paint papers and make books like mine, I agreed to teach a workshop (2 days of painting and 2 days of bookmaking) for the guild members. Of course, since I hadn't painted for many years, I first had to get back into practice. Yay! What fun I've been having, painting in my shed (thankfully heated). The paper below is my favorite of about 20 painted in the last two weeks. The size is 18 x 24 inches. (Please click to see the details!)

And below are two more to go with it.  The paper above will be used for a book cover, even though it will be hard for me to cut it up. The two papers below will be cut (horizontally) into thirds, and used as signature covers. For those unfamiliar with bookmaking, a signature is a section of papers within a book. Each of the six signatures in my book will be covered with this decorative paper.


It's a fun, playful, and experimental process to paint like this, easier for me than it would be to paint figuratively (landscape, still life, or people). With this type of painting, I just mix matte medium with a color or two of acrylic paint, and apply it by rolling, stamping, stenciling in layers. I keep adding layers until I like it, at which point it's a finished paper. There is always at least part of each paper that pleases me enough to use it for bookmaking and paper arts.

These are the basic supplies and tools I use to paint the papers:

1.) Although acrylic paints and this method can be used to paint on almost any surface or paper, I usually paint on 80-90# drawing paper to make decorative papers.

2.) I prefer using a roller to apply background colors or glazes, rather than a brush. My favorite, purchased online from Dick Blick Art Supplies, is a 2.2"  dense foam roller.

3.) Assorted stamps and stencils. I carve a lot of my own stamps, as you will see below, but sometimes also use commercial stamps. Note that commercial rubber stamps with fine detail for stamping with inks do not work well with acrylics, as the paint clogs the fine lines, ruining the stamp.

4.) Assorted materials, such as a notched adhesive-spreader, coarse sea-sponge, webbed food packaging materials, and bubble wrap are useful to print, texture, and stencil.

5.) Acrylic paints. I use heavy-body paint (rather than fluid acrylics) of student-grade or better quality.

6.) Matte medium and glazing medium (slow drying) are added to extend the paint.

I know, maybe you're thinking I should do a video tutorial. OK. You set it up, and I'll do it. In the meantime, I'd rather be painting...  Here are three more recently painted papers for your viewing pleasure (I hope).



The one directly above is my attempt to emulate batik fabric from India. I had a bedspread back in the hippy 60s with a burgundy design on a mustard yellow background, the memory of which was the inspiration for this paper. I carved all of the stamps used to make it.

I love to carve my own stamps, and sometimes cut my own stencils as well. Let's take a look at that process. It's quite easy really, requiring only a block of Speedy-Carve (or other high-density rubber carving block), and a Speed-Ball Carving tool. Designs can be free cut, drawn right on the carving block, or transferred from a tracing. Here's a fairly decent tutorial on the stamp carving process.

Designs? Well, everywhere I look I see possibilities for carving more stamps! Recently, visiting a fabric store with my quilting buddies, I spied a fat quarter of batik fabric with a luscious design. Here is the fabric:

And here is the stamp I carved from a tracing I made of the central flower. The stamp is the same size as on the fabric, about 3" in diameter.

I also cut a stencil, which you can see below. A friend had a commercial stencil of these three leaves, which I really liked. After borrowing her stencil to use on one of my papers, I traced the painted image, and cut out my own stencil. The tool in this image is a Speed-Ball cutter, which I use to carve the rubber to make stamps.

You've already seen (way above) the whole sheet of paper I painted using just this stamp and stencil, but here's a detail. If you click to enlarge, you can see more about how I paint in layers, first the background colors, next the leaves, then a different color over-stencil on the leaves, and last the flowers.

If you like to play with paint, you might want to give it a try! Here are just a few more of my recently painted papers to tempt you...





I'll be teaching a 2-day bookmaking workshop in mid-May using papers like these to create three different books. There may still be a spot or two available in the class. If you are interested, you can contact me for more information.

You may want to visit my website to see more about my handmade books and painted papers. And there are several earlier posts here on Beadlust with pictures of books made with painted decorative papers and beading by my students, as well as other related topics. Here are a few of them:

1. Wedding book
2. Lisa's book (from a workshop I taught in Wisconsin); her fabulous website is here.
3. Susan's book (from a workshop I taught in Wisconsin)
4. painting papers for making Christmas cards
5. Using symbols in our art and symbols in acrylic painting  
6. Using these techniques to paint with dyes on fabric and more fabric paint/dye examples

Susan Anderson took my bookmaking/painting/beading workshop twice at the Coupeville Art Center. These are the papers for her first book, and if you click to enlarge, you can also see her finished book.

And, to close this post, here is a photo of some of the handmade books I've created over the years... most of them utilize decorative painted papers and bead embroidery.

Thanks for sticking with me to the end of this long post :)!

Patterns of lines and dots associated with specific animal species in cave art may point to an early writing system.

Spanish football writer Guillem Balague talks to former Barcelona and Spain midfielder Andres Iniesta about his plans after retiring.

Review: Decolonization and its discontents The World Today mhiggins.drupal 1 August 2022

Jenna Marshall on a lively if flawed argument to find a way forward in a debate that has descended ‘into acrimony’.

Against Decolonization: Taking African Agency Seriously
Olufemi Taiwo, Hurst, £14.99

Decolonization was once heralded as a moment of potential and possibility for the formerly imperial world to chart a new way forward no longer tied to the apparatus of empire.

It marked a period of transition to nation states – and an expansion of a rights-based international community that would dispense with the morally bankrupt regime of racism, dispossession and subjugation that characterized colonialism.  
 

The descent of the decolonization debate

Half a century later, the debate surrounding decolonization has descended into acrimony. Some factions cast the issue of decolonization as a sustained attack on British and western culture writ large; other disparate voices coalesce around related social justice issues such as inequality, climate change and education. 

Decolonization has become ubiquitous in the public domain – and its ubiquity is the problem. In Against Decolonization, Olufemi Taiwo renounces a concept he conceives as having been emptied of serious study and analytical purchase; one incapable of addressing the complexities of modern global politics and more importantly, Africa’s place in it. 

Although the book attacks the inexhaustible ways in which the ‘trope of decolonization’ has been deployed, Taiwo is less bothered by the purported failures of scholars he deems ‘decolonizers’ and focuses his attention instead on the political landscape of African countries, past and present. 

Central to the book’s argument are two distinct scholarly strands on decolonization. The first, legal focus, centres on the political and economic forces of state-building. The second essays an ‘ideology’ of decolonization that rests on ‘forcing an ex-colony to forswear on pain of being forever under the yoke of colonization any and every cultural, political, intellectual, social and linguistic artefact, idea, process, institution and practice that retains even the slightest whiff of the colonial past’. 

Whether one should characterize the latter as simply a field of study or a potential set of policy arrangements remains unclear – yet what is certain is that it is too nebulous, too elastic, too open-ended to offer any substantive model or mechanism to understand postcolonial Africa. 
 

Correcting Eurocentric narcissism

 The decolonization research agenda in Africa came to prominence during the Cold War period of national liberation struggles.

The intellectual project that followed centred on dismantling Eurocentrism as colonial subjugation through its promotion of the West as the crucible of legitimate and scientific knowledge. Since then, scholars have argued that decolonization itself has become compromised by its enduringly Eurocentric gaze at the expense of the agency of African thinkers, creatives and statesmen and women. 

Taiwo seeks to correct this narcissism – and the omissions left in its wake – by introducing lesser-known Africans and pan-African scholars and cultural figures. These voices, he hopes, will illuminate issues often ignored by ‘decolonizers’ and spark a ‘renewed interest in an appreciation of the many different ways in which African thinkers have responded to the colonial experience’.
 

The decolonization of language

Taiwo challenges the decolonization of language as an oversold promise.

Romanticizing an imagined, pristine African pre-colonial past, he says, ultimately leads to nativism and atavism. As a case in point, Taiwo highlights bureaucratic instances of ‘language policy planning’ to deploy African languages in places such as Niger, Mali, Cameroon, Senegal and Nigeria that were hindered by multilingualism, education and high rates of illiteracy.

The author goes on to confront the abstract language of decolonization, which, he says, allows western scholars to unproblematically engage with the concept without any serious consideration of their own complicity in upholding systems of exclusion. It entrenches their own institutional power within the academy, amplifies their perspectives at the expense of others, and limits the possibilities for understanding the problems of world politics with deleterious effects on policy.

It is a serious claim, but there are issues to be addressed: Taiwo assumes there is coherence among scholars of decolonization, which is not the case. 

When Taiwo approaches how to foster political systems that cater to the needs of their citizens he dismantles the binary of ‘West as modern’ v ‘Africa as traditional’. Chieftaincies as traditional African governance, he points out, were the product of colonial anthropology, not Africans themselves. From the Fanti Confederation of 1871 to the Egba United Government in what is now Nigeria, Taiwo demonstrates that there has been a sustained tradition towards demands for democratic values. 

As he concedes an intellectual neglect of African philosophers that underlies the design and operations of Africa’s political institutions, Taiwo’s initial dismissal of the significance of cultural decolonization deserves another look. How should political and economic drives toward self-determination be advanced in the absence of knowledge shaped and mediated through African lived experiences?

In this respect, the tale of two decolonizations – the legal alongside the ideological – suggest an unhelpful, if not false, binary.
 

The problem of reconciling modernity and colonialism

What resonates throughout the book is the idea that Europe cannot profess to hold an exclusive intellectual claim to modernity. Its universal aspirations are open to all of humanity, allowing those who have historically been marginalized to be worldmakers. 

The idea that modernity and colonialism are irreconcilable is problematic. For instance, Taiwo argues that the curtailment of capitalism in Africa by restricting the growth of the middle classes while limiting competition between African capitalists and the metropole is the consequence of colonialism.

Yet the celebrated cultural anthropologist Sidney Mintz established an understanding that the matter for debate is not whether non-westerners were part of the modern system, but how and to what degree they were included and able to actualise its ideals. 

The emerging capitalist world economy needed non-western lands and labour, and so they were conscripted to this end. Recent abolitionist and black radical scholarship has built on this argument to maintain that capitalism not only requires inequality for it to function but that race – as a mechanism for producing ‘difference’ – enshrines it.

Acknowledging the unacknowledged

In the end, Taiwo communicates a palpable frustration at the state of academic discourses on contemporary Africa under the guise of emancipatory and radical scholarship. He offers an alternative approach whereby African students might rid themselves of a faddism that is ‘at best unsatisfactory’ and at worst produces ‘confusion, obscurantism, if not outright distortion and falsification’.

Yet out of this irritation, Taiwo’s greatest contribution in Against Decolonization might be to urge an acknowledgement of how and to what degree decolonization has become subdued and its political possibilities curtailed. He ultimately urges us to reconsider the purpose of the decolonization academic movement as an ethics to abide by rather than a social theory of the postcolonial world. 

This requires those ‘decolonizers’ on whose careers the term is built to adopt greater intellectual humility – to resist the posture of the anarchist radical scholar armed for the ‘good fight’. Instead, they should apply a scholarly curiosity to genuinely engage with those already on the battlefield, so to speak; those ‘doing the work’ in practice, but who have been unacknowledged until now.

Reflections at 100: Empire and decolonization Audio MVieira 1 November 2022

How did leading academics and policymakers think about and impact imperialism and decolonization from the 1920s to 1970s?

This episode of Reflections at 100, marking the centenary of International Affairs, looks at how empire and decolonization have been discussed in the journal.

Isabel and Krisztina speak to Meera Sabaratnam about how thinkers and policymakers from the 1920s to 1970s understood both empire and then decolonization. Meera highlights four tensions present within the discussions, and how these may impact the international order today.

Inderjeet Parmar delves deeper into the influence of Chatham House at the time and situates these discussions in the broader think-tank and global context.

Reflections at 100 is a mini-series accompanying the journal’s centenary Archive Collections. The collections bring together articles from our archive which speak to the past, present, and future of current affairs issues. In each podcast episode we speak to editors and contributors to the collection and explore what the research tells us about policymaking today. 

Explore the Archive Collection, free to access until mid-November 2022, including Meera’s introduction: 100 years of empire and decolonization.

International Affairs was started at Chatham House in 1922 to communicate research to members who could not attend in person. Over the past 100 years it has transformed into a journal that publishes academically rigorous and policy relevant research. It is published for Chatham House by Oxford University Press. Read the latest issue here. 

The U.S. Food and Drug Administration has determined commonly used oral phenylephrine is "not effective" and has proposed its removal from over-the-counter nasal decongestants.

The U.S. Food and Drug Administration has determined commonly used oral phenylephrine is "not effective" and has proposed its removal from over-the-counter nasal decongestants.

Gijs Joost Brouwer
Nov 4, 2009; 29:13992-14003
BehavioralSystemsCognitive

In demanding listening situations, a listener's motivational state may affect their cognitive investment. Here, we aim to delineate how domain-specific sensory processing, domain-general neural alpha power, and pupil size as a proxy for cognitive investment encode influences of motivational state under demanding listening. Participants (male and female) performed an auditory gap-detection task while the pupil size and the magnetoencephalogram were simultaneously recorded. Task demand and a listener's motivational state were orthogonally manipulated through changes in gap duration and monetary-reward prospect, respectively. Whereas task difficulty impaired performance, reward prospect enhanced it. The pupil size reliably indicated the modulatory impact of an individual's motivational state. At the neural level, the motivational state did not affect auditory sensory processing directly but impacted attentional postprocessing of an auditory event as reflected in the late evoked-response field and alpha-power change. Both pregap pupil dilation and higher parietal alpha power predicted better performance at the single-trial level. The current data support a framework wherein the motivational state acts as an attentional top–down neural means of postprocessing the auditory input in challenging listening situations.

The CIA burglar who went rogue: http://j.mp/UpJtCJ Using the Enigma and the Sigaba, world powers encrypted their messages in hopes of catching their opponents by surprise.

The 4,000-year-old burial chamber featured hieroglyphs referring to the woman, known as Idi, as the "lady of the house"

Jeff Monague has worked to incorporate Indigenous elements into Base Borden's Remembrance Day ceremonies — an acknowledgement he never had as a soldier.

See how to use CVOL to navigate volatile markets with its unique methodology and comprehensive suite of metrics.

Virtual reality goggles with a choice of soothing environments or guided meditations, a color-changing bubble wall, a prayer area, Zen garden and massage chair: These are all options provided by Penn State Wilkes-Barre’s Counseling Services to help students relax and stay calm.

Enhance your website's visibility in search engine results and attract more organic visitors by integrating digital public relations into your overall marketing strategy.

Based on the theme, “Lighting the Way,” decorations feature lanterns, lightships, lighthouses, starlight and luminarias.

Noted Kannada actor and director Guruprasad was found dead in his Bengaluru apartment today, the police said.

A man recently took to Reddit, seeking help identifying an unknown Devanagari text he found at a flea market in Germany.

Hello,

A mybe silly question came to my mind: When routing sense lines, is it better to hav them as close as possible to DUT or afer the decoupling capacitors ?

Force in red, sense in purple.

Best way is 1 or 2 ?

Thanks in advance and Merry Christmas to everybody !

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

Decolonizing the Arctic Council Decolonizing the Arctic Council

ferrard Tue, 11/08/2022 - 09:16

Massively parallel reporter assays (MPRAs) are powerful tools for quantifying the impacts of sequence variation on gene expression. Reading out molecular phenotypes with sequencing enables interrogating the impact of sequence variation beyond genome scale. Machine learning models integrate and codify information learned from MPRAs and enable generalization by predicting sequences outside the training data set. Models can provide a quantitative understanding of cis-regulatory codes controlling gene expression, enable variant stratification, and guide the design of synthetic regulatory elements for applications from synthetic biology to mRNA and gene therapy. This review focuses on cis-regulatory MPRAs, particularly those that interrogate cotranscriptional and post-transcriptional processes: alternative splicing, cleavage and polyadenylation, translation, and mRNA decay.

Extract

In cystic fibrosis (CF), Pseudomonas aeruginosa acquisition represents a turning point in disease progression. The presence of chronic P. aeruginosa infection is associated with worsening lung function and increased risk of earlier death, whereas treatment substantially improves lung function and survival [1, 2]. Efforts to diagnose and eradicate early P. aeruginosa provide lasting benefits for children with CF [3, 4]. However, the timing of infection varies considerably between individuals with CF, treatment centres [5, 6], and different birth cohorts of people with the disease [7, 8].

Comprehensive maps of neuronal connectivity provide a foundation for understanding the structure of neural circuits. In a circuit, neurons are diverse in morphology, electrophysiology, gene expression, activity, and other neuronal properties. Thus, constructing a comprehensive connectivity map requires associating various properties of neurons, including their connectivity, at cellular resolution. A commonly used approach is to use the gene expression profiles as an anchor to which all other neuronal properties are associated. Recent advances in genomics and anatomical techniques dramatically improved the ability to determine and associate the long-range projections of neurons with their gene expression profiles. These studies revealed unprecedented details of the gene–projection relationship, but also highlighted conceptual challenges in understanding this relationship. In this article, I delve into the findings and the challenges revealed by recent studies using state-of-the-art neuroanatomical and transcriptomic techniques. Building upon these insights, I propose an approach that focuses on understanding the gene–projection relationship through basic features in gene expression profiles and projections, respectively, that associate with underlying cellular processes. I then discuss how the developmental trajectories of projections and gene expression profiles create additional challenges and necessitate interrogating the gene–projection relationship across time. Finally, I explore complementary strategies that, together, can provide a comprehensive view of the gene–projection relationship.

Signal decoders are vital components in radio broadcasting. Without them, the transmission and reception of clear audio or data would be impossible. They take what is essentially noise and turn it into coherent, useful information. Having worked with radio broadcasting systems for some time, I’ve seen firsthand how essential decoders are to maintaining communication networks. […]

The post How Signal Decoders Are Used in Radio Broadcasting appeared first on Chart Attack.

Last year, FDA advisers unanimously voted that oral phenylephrine is ineffective.

As humans leave space junk behind, there may come a time when human bodies would need to decompose in space. Learn how this happens and why it's a slow process.

By Aimee Raleigh, Principal at Atlas Venture, as part of the From The Trenches feature of LifeSciVC Ever wondered what goes into diligencing a new idea, program, company, or platform? While each diligence is unique and every investor will have

The post Deconstructing the Diligence Process: An Approach to Vetting New Product Theses appeared first on LifeSciVC.

The FDA has proposed removing oral phenylephrine from its guidelines for over-the-counter drugs due to inefficacy as a decongestant. Use of this ingredient in cold and allergy medicines grew after a federal law required that pseudoephedrine-containing products be kept behind pharmacy counters.

The post FDA Takes Step Toward Removal of Ineffective Decongestants From the Market appeared first on MedCity News.

Lucy Letby is a British nurse who was arrested on suspicion of murdering eight babies and attempting to murder ten others while working at the Countess of Chester Hospital in England.

You may be familiar with the gut microbiome's impact on overall health. Surprisingly, a similar principle applies to the semen microbiome, which may significantly

In premature newborns with very low medlinkbirth weight/medlink, immature neurons' salt and water transporters can lead to brain tissue shrinking in response to oxygen deprivation (!--ref1--).

Home lighting decoration becoming a part of modern living environment has drawn increasing attention. Home lighting can render a good home environment and outstanding design features for our lives to create a warm ambience. It is easy when...

A bachelor pad is a home specifically for single men that are designed in a fashion that caters to their needs. The concept of a bachelor pad is prominent in urban areas where people migrate for work. Typically, a

Adding greenery to your home is the most economical and creative way to spruce up your home. Beautiful plants or greenery via design elements help add a lovely green sheen to any corner or space. From ho-hum to beautiful, you can

If you always wanted to replicate the plush-looking living room look featured in home decor magazines and simply brushed off the idea thinking it will cost the earth, then it's time you change this decor perspective for good. For a start,

A foyer area equals the 'impression card' for your home. Simply because that's the first thing everyone notices before entering your home. So it is extremely crucial that you present the foyer zone in such a way that it gives a

You may not have heard of Ottomans, but they can add oomph to your decor in numerous ways. This functional piece of furniture is extremely versatile and can be placed anywhere in your home. If you are bored of adding