Mammalian circadian clocks are driven by transcription/translation feedback loops composed of positive transcriptional activators (BMAL1 and CLOCK) and negative repressors (CRYPTOCHROMEs (CRYs) and PERIODs (PERs)). CRYs, in complex with PERs, bind to the BMAL1/CLOCK complex and repress E-box–driven transcription of clock-associated genes. There are two individual CRYs, with CRY1 exhibiting higher affinity to the BMAL1/CLOCK complex than CRY2. It is known that this differential binding is regulated by a dynamic serine-rich loop adjacent to the secondary pocket of both CRYs, but the underlying features controlling loop dynamics are not known. Here we report that allosteric regulation of the serine-rich loop is mediated by Arg-293 of CRY1, identified as a rare CRY1 SNP in the Ensembl and 1000 Genomes databases. The p.Arg293His CRY1 variant caused a shortened circadian period in a Cry1−/−Cry2−/− double knockout mouse embryonic fibroblast cell line. Moreover, the variant displayed reduced repressor activity on BMAL1/CLOCK driven transcription, which is explained by reduced affinity to BMAL1/CLOCK in the absence of PER2 compared with CRY1. Molecular dynamics simulations revealed that the p.Arg293His CRY1 variant altered a communication pathway between Arg-293 and the serine loop by reducing its dynamicity. Collectively, this study provides direct evidence that allosterism in CRY1 is critical for the regulation of circadian rhythm.

After much anticipation, the National Institute of Standards and Technology (NIST) issued its first Post Quantum Cryptography (PQC) standards today. They are intended to defeat efforts by quantum computers powerful […]

The post NIST Issues Post Quantum Cryptography Standards and Calls for their Adoption appeared first on HPCwire.

The CIA burglar who went rogue: http://j.mp/UpJtCJ Using the Enigma and the Sigaba, world powers encrypted their messages in hopes of catching their opponents by surprise.

Quebec provincial police have confirmed that the body found in a Montreal nature park on Oct. 30 was that of kidnapping victim and cryptocurrency influencer Kevin Mirshahi.

North Korean hackers have disguised malware in seemingly harmless macOS apps using sophisticated code to bypass security checks and target unsuspecting users.

Bitcoin soared to a record high above $81 000 on Monday on expectations that cryptocurrencies will boom in a favourable regulatory environment following the election of Donald Trump as U.S. president and pro-crypto candidates to

The overall crypto market grew by 1.42 percent in the last 24 hours. Bitcoin was joined by Dogecoin, Cardano, Ripple, and Tron on the profit-making side of the crypto charts on Monday, November 11.

Bitget Wallet and Foresight Ventures have collaborated to invest $20 million (roughly Rs. 168 crore) in Telegram, aiming to accelerate the growth of its Mini Apps initiative, as announced on Monday, November 11.

Prosecutors said Bitcoin Fog processed more than $400 million in untraceable transactions, including $78 million involving known darknet markets. Defense lawyer Tor Ekeland called the verdict “disappointing” and said they will appeal.

Bitcoin created its third all-time high in the past week, surging past $89,900 (roughly Rs. 75.9 lakh) in the last 24 hours, amid an ongoing surge spurred by Donald Trump's victory in the recently concluded US Presidential elections.  Here's why investors are optimistic about US President-elect Donald Trump's return to the White House in January 2025.

The overall crypto market cap tumbled by 4.12 percent over the last day due to market fluctuations. Bitcoin and Ether both registered losses on Wednesday. Tether, Solana, and Tron also saw registered losses alongside BTC and ETH. Ripple and Tron saw losses. 

Crypto may not work long-term as a currency, thanks to volatility and fraud concern issues. But the blockchain technology on which it relies might be here to stay

Former US president Donald Trump's cryptocurrency platform had a faltering sales launch Tuesday, with only a fraction of its digital tokens that went on the market finding a buyer.

Police and electricity authorities have raided buildings in Chachoengsao and Surat Thani provinces, arrested suspects and seized cryptocurrency mining machines that stole tens of millions of baht worth of electricity.

Understanding the evolution of chromatin conformation among species is fundamental to elucidate the architecture and plasticity of genomes. Nonrandom interactions of linearly distant loci regulate gene function in species-specific patterns, affecting genome function, evolution, and, ultimately, speciation. Yet, data from nonmodel organisms are scarce. To capture the macroevolutionary diversity of vertebrate chromatin conformation, here we generate de novo genome assemblies for two cryptodiran (hidden-neck) turtles via Illumina sequencing, chromosome conformation capture, and RNA-seq: Apalone spinifera (ZZ/ZW, 2n = 66) and Staurotypus triporcatus (XX/XY, 2n = 54). We detected differences in the three-dimensional (3D) chromatin structure in turtles compared to other amniotes beyond the fusion/fission events detected in the linear genomes. Namely, whole-genome comparisons revealed distinct trends of chromosome rearrangements in turtles: (1) a low rate of genome reshuffling in Apalone (Trionychidae) whose karyotype is highly conserved when compared to chicken (likely ancestral for turtles), and (2) a moderate rate of fusions/fissions in Staurotypus (Kinosternidae) and Trachemys scripta (Emydidae). Furthermore, we identified a chromosome folding pattern that enables "centromere–telomere interactions" previously undetected in turtles. The combined turtle pattern of "centromere–telomere interactions" (discovered here) plus "centromere clustering" (previously reported in sauropsids) is novel for amniotes and it counters previous hypotheses about amniote 3D chromatin structure. We hypothesize that the divergent pattern found in turtles originated from an amniote ancestral state defined by a nuclear configuration with extensive associations among microchromosomes that were preserved upon the reshuffling of the linear genome.

Le corps ligoté en état de décomposition retrouvé le 30 octobre dans l’un des parcs les plus achalandés de Montréal est celui de Kevin Mirshahi.

May 24, 2024

Quantum computers are probably coming—and when they arrive, they will, most likely, be able to break our standard public-key cryptography algorithms.

As the dust settles on a post-election stock market rally, some firms have already gained.

Antônio Vinicius Gritzbach had recently agreed to hand over information about the Primeiro Comando da Capital group.

The US Senate has approved the inclusion of new provisions in the bipartisan infrastructure bill to require intermediaries involved in cryptocurrency trading to report details about transactions.

Threat type: Ransomware

Aliases: Trojan-Ransom.FileCrypter (IKARUS)

Platforms: Windows

Overall Risk Rating: Low

Damage Potential: Medium

Distribution Potential: Low

Reported Infection: Low

Information Exposure: Low

Overview:

This Ransomware arrives on a system as a file dropped by other malware or as a file downloaded unknowingly by users when visiting malicious sites.

It terminates itself if it detects it is being run in a virtual environment.

The U.S. Energy Information Administration (EIA) is initiating a provisional survey of electricity consumption information from identified cryptocurrency mining companies operating in the United States.

MobileCoin, the startup known for building Signal’s crypto payments feature, has appointed a new CEO as it works on expanding its encrypted money transfer service to global users in need of a more modern remittance solution. Sara Drakeley is taking the helm as MobileCoin’s new chief executive officer. Replacing her previous role as the firm’s […]

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This year’s Super Bowl drew advertisers willing to pay up to $7 million for a 30-second spot. WSJ advertising editor Suzanne Vranica and reporter Paul Vigna break down what to watch for from both new cryptocurrency brands and old regulars like Budweiser. Photo Illustration: Alexander Hotz/WSJ

Shiba Inu Coin’s recent surge, and subsequent fall in value, is part of a growing trend of meme coins that are rivaling some of the largest digital tokens in the world. WSJ retail investing reporter Caitlin McCabe explains why investors are pouring money into this meme based cryptocurrency. Photo: Amber Bragdon/Getty Images

Do terms like “nonfungible token,” “minting,” and “gas fees” sound like a foreign language to you? To better understand it -- and explain it -- WSJ’s Joanna Stern turned her son’s art into an NFT on the Ethereum blockchain. Photo illustration: Jacob Reynolds

The crypto firm added that elevated interest rates, inflationary pressures, and tightening liquidity have created a more “cautious macroeconomic environment”

Bitcoin was inching towards its March 2024 all-time-high price of $73,750.07, but those whose crypto assets are locked with the WazirX exchange after a cyberattack are anxious about missing out

Most transactions in the financial system take place behind closed doors. Not so the bitcoin network, which runs on blockchain technology – on which transactions can actually be visualised. But what's the real deal when it comes to crypto? Is its vision of decentralisation and data integrity all its cracked up to be? Cathy Mulligan is a visiting researcher at Imperial College's Centre for Cryptocurrency Research and Engineering, and she's breaking down the blockchain hype and leading the dialogue on how businesses should use this technology. ABOUT WIRED SMARTER Experts and business leaders from the worlds of Energy, Money and Retail gathered at Kings Place, London, for WIRED Smarter on October 9, 2018. Discover some of the fascinating insights from speakers here: http://wired.uk/V29vMg ABOUT WIRED EVENTS WIRED events shine a spotlight on the innovators, inventors and entrepreneurs who are changing our world for the better. Explore this channel for videos showing on-stage talks, behind-the-scenes action, exclusive interviews and performances from our roster of events. Join us as we uncover the most relevant, up-and-coming trends and meet the people building the future. ABOUT WIRED WIRED brings you the future as it happens - the people, the trends, the big ideas that will change our lives. An award-winning printed monthly and online publication. WIRED is an agenda-setting magazine offering brain food on a wide range of topics, from science, technology and business to pop-culture and politics. CONNECT WITH WIRED Web: http://po.st/WiredVideo Twitter: http://po.st/TwitterWired Facebook: http://po.st/FacebookWired Google+: http://po.st/GoogleWired Instagram: http://po.st/InstagramWired Magazine: http://po.st/MagazineWired Newsletter: http://po.st/NewslettersWired

On June 18, 2019, Facebook announced its virtual currency Libra. In Facebook’s vision, it should become a global currency for billions of people, especially those in developing countries who have no access to banks or financial services. In other words, Digital money which you can transfer to other people or simply use to buy stuff. But is it a true cryptocurrency and how will the world respond to a currency controlled by a group of mega-corporations? #facebook #libra #crypto

Ashley Tyson, spends her time aligning diverse teams, working on decentralized systems and supporting blockchain ecosystem initiatives like Ethereum Community Fund and ETHPrize. She is the Co-founder, Web3 Foundation and in this session from WIRED Smarter 2020, she shares a new way of thinking about the web exploring what a return to the original principles of the web looks like and how cryptocurrency can enable that. ABOUT WIRED SMARTER Curated by WIRED’s award-winning editorial team, WIRED Smarter gathers the disruptive minds across business, technology, retail, finance and politics to investigate how innovation, technological advances and world events are changing the way we interact with customers. CONNECT WITH WIRED Events: http://wired.uk/events Subscribe for Events Information: http://wired.uk/signup Web: http://bit.ly/VideoWired Twitter: http://bit.ly/TwitterWired Facebook: http://bit.ly/FacebookWired Instagram: http://bit.ly/InstagramWired Magazine: http://bit.ly/MagazineWired Newsletter: http://bit.ly/NewslettersWired

National Bureau of Economic Research

National Bureau of Economic Research

IEEE / Institute of Electrical and Electronics Engineers Incorporated

IEEE / Institute of Electrical and Electronics Engineers Incorporated

The cryptocurrency climbed as much as 4.3 per cent to an unprecedented $79,771 on Sunday

A report by Chainalysis says India leads the world on global adoption index for crypto this year

The largest token climbed as much as 6.1 per cent on Sunday and extended gains to hit an unprecedented $82,300 on November 11

As money continues to pour into crypto following Donald Trump’s election victory, bitcoin has climbed to yet another record high

Bitcoin lags behind bonds, stocks and gold, signaling a possible slowdown in the crypto market

The European Union is working on new rules and controls that crypto companies will have to comply with

Celsius hopes that Bitcoin mining will help it repair its damaged relationship with customers, whose funds were frozen

Indian cryptocurrency exchanges will have to report suspicious activity to the Financial Intelligence Unit India

M2 crypto exchange said there had been a “cybersecurity incident involving $13.7 million, which was swiftly responded to”