Nearly 17 million children lack high-speed internet at home that's considered crucial to their ability to participate in remote learning during the pandemic, according to a new study.

These shots from the Smithsonian Magazine Photo Contest show why it’s one of the most-visited nations on earth

Slight miscommunication between OM workers in Israel leads to an unplanned chance to share the Gospel with a railway attendant.

The coronavirus closures are shaping a disruptive end to a tumultuous academic career for the Class of 2020.

Rebekka explains to her friend, Ana how she can be one with Jesus too. Ana and her father come to know the living God and experience His care...

The Kwena Square will cost R210 million. It will have 23 stores, a drive-thru RocoMamas and 407 parking bays.

Aloo chana jhol is a popular Bihari breakfast dish featuring boiled potatoes and chana simmered in a flavourful gravy.

5510 all in one printer manual

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If the idea of exercise is more attractive than the reality, you aren't alone. But there are ways to train your motivation and develop better habits

Title: SIBO (Small Intestinal Bacterial Overgrowth)
Category: Diseases and Conditions
Created: 10/28/2005 12:00:00 AM
Last Editorial Review: 8/8/2022 12:00:00 AM

In this study, the nonclinical pharmacokinetics of OLX702A-075-16, an RNA interference therapeutic currently in development, were investigated. OLX702A-075-16 is a novel N-acetylgalactosamine conjugated asymmetric small-interfering RNA (GalNAc-asiRNA) used for the treatment of an undisclosed liver disease. Its unique 16/21-mer asymmetric structure reduces nonspecific off-target effects without compromising efficacy. We investigated the plasma concentration, tissue distribution, metabolism, and renal excretion of OLX702A-075-16 following a subcutaneous administration in mice and rats. For bioanalysis, high-performance liquid chromatography with fluorescence detection was used. The results showed rapid clearance from plasma (0.5 to 1.5 hours of half-life) and predominant distribution to the liver and/or kidney. Less than 1% of the liver concentration of OLX702A-075-16 was detected in the other tissues. Metabolite profiling using liquid chromatography coupled with high-resolution mass spectrometry revealed that the intact duplex OLX702A-075-16 was the major compound in plasma. The GalNAc moiety was predominantly metabolized from the sense strand in the liver, with the unconjugated sense strand of OLX702A-075-16 accounting for more than 95% of the total exposure in the rat liver. Meanwhile, the antisense strand was metabolized by the sequential loss of nucleotides from the 3'-terminus by exonuclease, with the rat liver samples yielding the most diverse truncated forms of metabolites. Urinary excretion over 96 hours was less than 1% of the administered dose in rats. High plasma protein binding of OLX702A-075-16 likely inhibited its clearance through renal filtration.

Liam Payne, a former member of the boy band One Direction, was found dead in a hotel courtyard in Buenos Aires, Argentina on Wednesday evening, according to CNN and La Nacion, both of which cited local police.

The singer died after an apparent fall from the balcony of his third-floor hotel room. Argentinian authorities told Good Morning America that Payne had been staying at the hotel CasaSur in the upscale neighborhood of Palermo.

He was 31.

Read more at The Daily Beast.

It’s tempting to frame Straftat as a throwback to an older, better time for the multiplayer FPS, when the lingo was coded in frags and gibs and sucking it down, when satisfaction was drawn entirely from performance rather than some convoluted, artificial system of progression. Not only would this be inaccurate, but it would also do a disservice to what Straftat truly is, namely a wild overcorrection in response to the direction of modern multiplayer gunfests, one that careens straight through retro stations to arrive somewhere new and exciting.

Read more

Wonder Brands Inc. is recalling various brands of bread and buns because of pieces of metal in the products. According to the Canadian Food Inspection Agency (CFIA), the recalled products were distributed in Newfoundland and Labrador, Ontario and Quebec, Canada. The brands listed in the recall include Country Harvest, D’Italiano,... Continue Reading

Ryubi Miyase, Rinka Kumada star in film directed by Liar x Liar's Saiji Yakumo

Folks dedicated to the world of NFTs have access to loads of analytics and browsing tools, but none of them really work together. At least, that’s how new startup Curio sees things. Curio taps into several different sources of data to provide a powerful analytics tool for both browsing and tracking the value of NFTs. […]

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The Orioles have gone nearly the entire month of June allowing at least one home run in every game.

For years, Android phone makers like Xiaomi and OnePlus have been known to borrow design elements from Apple's iOS. Now, it seems Google itself might be dipping its toes into those waters. A New Look for Incoming Calls An APK teardown

Manchester : Manchester University Press, [2019]

Har Din Har Ghar Ayurveda announced as the theme for the year

Whether it’s PMC, DHFL, CKP or Franklin Templeton, it’s a story of ordinary middle-class folk losing their life savings

Emphasising the importance of expanding access to high-burden regions, the report calls for strategic initiatives to enable the production and distribution of life-saving antibiotics and antifungals

Heavy rain and high-velocity winds with a maximum sustained speed of 90-100 kmph lash coastal town of Bapatla, villages; three killed in rain-related accidents; power supply affected in many areas; cyclone moving towards north, say officials

For the second year in a row, Malappuram District could not field a team in the Kerala State senior basketball championship which begins here on Tuesday.

Materials have a major say in construction, as their manufacture has to be environment-friendly, making them energy-efficient, says green homes builder Chandrashekar Hariharan. By Ranjani Govind

What can De Montey Colony’s residents do to tackle the issue of mounting waste?

Recently, the dairy industry has experienced a decrease of ₹5 per liter in the milk price, causing concern among the predominantly women farmers involved in the sector. 

Once rated as one of the top batters of this generation, Virat Kohli's stock has fallen quite rapidly in Tests in recent years.

Nifty fell 64.1 points

The BSE Sensex went down by 240.75 points to 81,579.37 in early trade. The NSE Nifty declined 62.7 points to 24,994.65

Equity markets open strong but later decline; HDFC Bank gains, Kotak Mahindra Bank falls, global markets mixed

The 30-share Sensex declined 73.48 points or 0.09% to settle at 81,151.27

The BSE Sensex plummeted 662.87 points or 0.83% to settle at 79,402.29. The NSE Nifty tanked 218.60 points or 0.90% to 24,180.80

Equity indices fall due to foreign fund outflows and muted earnings, with Sensex and Nifty declining in early trade

The BSE Sensex declined 326.58 points to 78,455.66 in early trade

Market analysts said unabated foreign fund outflows and mixed global cues further dented investor sentiments

The stock market indices fall due to foreign fund outflows and weak blue-chip stocks; RBI to unveil monetary policy next month

The data shows that launches have been decelerating over the past four quarters while sales have been falling over the last three quarters

The acquisition of the mall would require a different structure to be set in place since it does not have a single owner or promoter

N.S. Ramanuja Tatacharya talks about his masterpieces in the language