If you are a traveler with an open mind towards avant-garde hospitality with innovative approaches and pushing boundaries of ideas and creativity, you are in for an adventure.
Photographer Zion Ozeri, whose parents immigrated to Israel from Yemen, documents the last generation of a bygone era in The Jews of Yemen – The Last Generation.
Ibiza, a stunning island in the Mediterranean Sea, is globally renowned for its electric nightlife and vibrant party scene. This picturesque island has become the epitome of summer party destinations. It attracts visitors from all corners of the world with its beautiful beaches, mesmerizing sunsets, and, most notably, its unparalleled nightlife. Clubs in Ibiza are not just venues; they are the beating heart of the island’s culture as they showcase world-class DJs, groundbreaking music, and unforgettable experiences to define the essence of a perfect summer getaway. The purpose of this article is to guide you through the exhilarating nightlife of Ibiza. Whether you’re a seasoned club-goer or a first-time visitor, this comprehensive guide to the top 10 must-visit nightclubs will ensure you hit the hottest spots and make the most of your nights in Ibiza. From iconic institutions to cutting-edge clubs, we’ve curated a list that captures the diversity and vibrancy of Ibiza’s nightlife. These places promise unforgettable nights filled with music, dance, and celebration. Why Ibiza? Ibiza stands as a beacon for nightlife enthusiasts from around the globe. It’s celebrated for its unmatched party scene and vibrant atmosphere. But what exactly catapults this Balearic Island into the spotlight as a world-renowned destination for nightlife? Diverse Music Scene: Ibiza’s music landscape is as varied as it is electrifying. From techno and house to EDM and indie rock, the island offers something for every taste, hosted across an array of clubs and venues. Vibrant Atmosphere: There’s an infectious energy that permeates Ibiza’s nightlife. Whether you’re dancing under the stars at an outdoor beach club or losing yourself in the immersive environment of an underground venue, the atmosphere is always charged with excitement. Stunning Venues: Ibiza’s nightclubs are more than just places to dance; they’re architectural wonders and sensory experiences. From clubs with breathtaking views of the Mediterranean to venues that push the boundaries of interior design, Ibiza offers stunning settings that elevate the party experience to new heights. Criteria for Selection When it comes to pinpointing the top 10 nightclubs in Ibiza, our selection is driven by a carefully considered set of criteria. We aim to showcase venues that not only dominate the nightlife scene but also offer unique experiences that leave a lasting impression. The following factors play a crucial role in our selection: Music Genres: A club’s musical offerings are pivotal. We look for diversity and quality, favoring venues that host world-renowned DJs to suit a wide range of musical tastes. Atmosphere: The vibe of a nightclub is its soul. We seek out places that offer more than just a dance floor. In fact, we prioritize those who create an immersive experience through their energy, design, and crowd. Reputation: A club’s reputation is built on years of delivering exceptional nights out. We consider the esteem in which venues are held by both locals and international visitors, as well as their recognition within the global nightlife community. Overall Experience: Finally, we factor in the overall experience, including the quality of sound and lighting systems, the presence of unique features (like outdoor terraces or poolside dance floors), and the level of service provided. A club that offers an unforgettable night out, from entry to exit, makes our list. Club 1: Amnesia Ibiza Location San Rafael, Ibiza Music Genres Techno House EDM Atmosphere Amnesia Ibiza stands out for its high-energy ambiance which makes it a sanctuary for dance music enthusiasts. The club’s iconic terrace offers an immersive experience that draws partygoers into a world of euphoric beats and rhythms. Notable Features Famous Foam Parties: These unique and wildly entertaining parties are a signature Amnesia experience. State-of-the-Art Sound System: Delivers crystal-clear audio that enhances the musical journey. Spectacular Light Shows: Visually stunning displays complement the sonic experience, creating unforgettable moments. Highlights Legends of the electronic music scene, such as Carl Cox and Marco Carola, are regulars here, guaranteeing an unmatched lineup of performances. Club 2: Pacha Ibiza Location Ibiza Town, Ibiza Music Genres House Techno EDM Atmosphere Pacha Ibiza exudes a glamorous and chic vibe and offers a luxurious nightclub experience. Its atmosphere attracts a stylish crowd to dance the night away in one of the island’s most iconic settings. Notable Features Iconic Cherry Logo: A symbol of the club’s heritage and prestige. VIP Sections: For those seeking a more exclusive experience, with stunning views of Ibiza Town. Elegant Decor: Pacha’s interior design combines style with comfort, creating a uniquely sophisticated environment. Highlights Hosting world-renowned DJs like David Guetta and Martin Solveig, Pacha remains at the forefront of Ibiza’s nightlife scene. Club 3: DC-10 Location Sant Josep de sa Talaia, Ibiza Music Genres Techno House Atmosphere DC-10 is celebrated for its raw and underground atmosphere. This club offers an intimate setting where the focus is squarely on the music and the communal experience of dance. Notable Features Open-Air Terrace: Provides a unique outdoor clubbing experience. Industrial Vibe: The club’s minimalist, warehouse-style setup enhances its gritty, authentic feel. Immersive Experiences: DC-10’s events are designed to create a deep connection between the DJs and the crowd. Highlights Home to the legendary Circoloco parties, DC-10 attracts top DJs such as Seth Troxler and The Martinez Brothers to ensure an unparalleled lineup and vibe. Club 4: Ushuaïa Ibiza Beach Club Location Playa d’en Bossa, Ibiza Music Genres EDM House Atmosphere Ushuaïa Ibiza Beach Club is the epitome of an extravagant outdoor party experience. With its poolside setting, it invites guests to dance under the sun and stars in one of the most breathtaking venues on the island. Notable Features Massive Stage: Hosts some of the biggest names in the music industry. Stunning Visuals: Offers a sensory feast with its impressive light shows and stage productions. Celebrity Appearances: A hotspot for celebrities, adding to the club’s allure. Highlights Iconic pool parties featuring world-class performances by artists like Calvin Harris and Avicii are the heart of Ushuaïa’s appeal. Club 5: Hï Ibiza Location Playa d’en Bossa, Ibiza Music Genres Techno House EDM Atmosphere Hï Ibiza offers a sophisticated and futuristic nightclub experience. Its immersive atmosphere is crafted through cutting-edge sound and stunning visuals that make every night a journey into the future of nightlife. Notable Features Cutting-Edge Sound System: Delivers unparalleled audio quality. Immersive Production: Engages all senses for a complete clubbing experience. Stunning Visuals: The club’s design and lighting create a mesmerizing environment. Highlights Glitterbox parties at Hï Ibiza shine with disco and house music vibes, featuring top DJs and a vibrant, inclusive atmosphere. Club 6: Privilege Ibiza Location San Rafael, Ibiza Music Genres House Techno EDM Atmosphere Privilege Ibiza is recognized for its massive scale and extravagant atmosphere. Holding the Guinness World Record for the world’s largest club, it offers an immersive experience with panoramic views of Ibiza. Notable Features World’s Largest Club: A title that adds to its legendary status. Panoramic Views: The club’s location and design provide breathtaking views of the island. Highlights Resistance parties at Privilege are a highlight, featuring top techno and house DJs like Adam Beyer and Charlotte de Witte to create unforgettable nights. Club 7: Eden Ibiza Location San Antonio, Ibiza Music Genres House Techno EDM Atmosphere Eden Ibiza strikes a perfect balance between lively and intimate as it creates an energetic atmosphere for music lovers to enjoy themselves up close with the performers. Notable Features Renovated Venue: A recent makeover has injected new life into Eden, enhancing its appeal. Impressive LED Screens: Add to the visual experience, complementing the beats with captivating displays. Intimate Dance Floor: Despite its size, Eden maintains an intimate feel, making every night more personal. Highlights Toolroom parties at Eden are a standout, with house music legends like Mark Knight behind the decks. Club 8: Heart Ibiza Location Ibiza Town, Ibiza Music Genres Eclectic Avant-garde Live performances Atmosphere Heart Ibiza offers an artistic and immersive experience with a blend of music, art, and gastronomy into a unique nightlife adventure to tantalize all senses. Notable Features Fusion of Music, Art, and Gastronomy: A unique concept that stands out in Ibiza’s nightlife. Stunning Interior Design: Adds to the immersive experience with its beauty and creativity. Highlights Heart Factory events are particularly notable for their live performances and DJ sets by international artists, making each night a unique journey. Club 9: Ibiza Rocks Hotel Location San Antonio, Ibiza Music Genres Indie Rock EDM Atmosphere Ibiza Rocks Hotel is known for its lively and vibrant environment, where the poolside setting adds a refreshing twist to the traditional nightclub experience. Notable Features Outdoor Stage: Offers a unique venue for live music under the Ibiza sun and stars. Pool Parties: Bring an energetic and fun atmosphere, perfect for daytime reveling. Live Music Events: Unlike many other clubs focusing solely on DJs, Ibiza Rocks hosts live bands and performances. Highlights The Ibiza Rocks Pool Party series is a summer highlight, featuring an eclectic mix of live performances by indie bands and DJs. It offers something different from the typical club scene. Club 10: Octan Ibiza Location Playa d’en Bossa, Ibiza Music Genres Techno House Atmosphere Octan Ibiza brings a raw and underground vibe to the forefront of Ibiza’s nightlife. Its intimate setting allows for an immersive clubbing experience that’s both intense and personal. Notable Features Intimate Dance Floors: Designed to create a close connection between the DJs and the crowd. Immersive Experiences: Focused on delivering cutting-edge underground parties. Legacy: Carrying the torch from the famed Sankeys Ibiza, Octan continues to push the boundaries of the electronic music scene. Highlights The club is a haven for enthusiasts of techno and house music, and it hosts cutting-edge underground parties with leading DJs in the genre. Frequently Asked Questions (FAQ) What is the legal drinking age in Ibiza? The legal drinking age in Ibiza is 18 years old. Is there a dress code for Ibiza nightclubs? Dress codes can vary. While some clubs are more relaxed, others might require a more upscale attire. It’s best to check the specific club’s policy before going. How much does it cost to enter Ibiza nightclubs? Entrance fees can range widely from club to club and depending on the event or DJ playing. Prices can vary from €20 to over €50. VIP services and tables will cost significantly more. Are there any age restrictions for entry into nightclubs? Yes, most nightclubs in Ibiza have an age restriction of 18 years and above. Is it necessary to book tickets in advance for Ibiza nightclubs? It’s highly recommended to book tickets in advance, especially for popular events, to ensure entry and often at a lower price. What are the typical opening hours for Ibiza nightclubs? Nightclubs usually open around midnight and can go on till dawn, with peak hours from 1 AM to 4 AM. Are there any safety tips for clubbing in Ibiza? Stay hydrated, especially if dancing for long periods. Keep an eye on your belongings. Never accept drinks from strangers. Stick with your friends and plan how to get back to your accommodation safely. Conclusion We’ve explored the top 10 must-visit nightclubs in Ibiza, and each offers its unique vibe. From the extravagant and glamorous to the raw and underground, Ibiza’s nightlife is unparalleled. Its diverse music scenes and world-renowned DJs provide an unforgettable experience for every partygoer. Whether you’re drawn to the legendary foam parties of Amnesia, the sophisticated atmosphere of Hï Ibiza, or the intimate underground vibes of Octan, the island caters to all. We encourage you to dive into the vibrant energy of Ibiza’s nightlife scene and experience the magic of these iconic clubs firsthand.
The post Top 10 Must-Visit Ibiza Nightclubs: Your Ultimate Guide to the Island’s Hottest Spots appeared first on Geeky Traveller.
A selection of some of the most striking sports photographs taken around the world over the past seven days.
More than 1,000 images of the national park are being made available for use free of charge.
James Barnor, who has photographed the likes of Muhammad Ali, is being honoured in Accra.
A nature reserve's photography club is holding its annual display at the end of August.
Stunning shots of gannets, goldfinch and grouse on show as the Bird Photographer of the Year award winners are announced
A picture of a fox cub has won a prestigious European Wildlife Photographer of the Year award.
For 15 years, David Gilliver has been a pioneer in the technique of painting with light.
A new study traces the farming heritage of Wales and shows there's more to the common sheep pen than meets the eye.
An appeal is made for people to come forward who went to a party the night before the shooting.
Joe Biden’s stupid, corrupt regime can’t even get a simple Veterans Day message right. As the nation came together to celebrate those who served out country, Biden’s Department of Defense pushed out a social media message telling Americans “Veterans Day, honoring all who served.” While, that is a perfectly fine message, the DoD added a […]
The post Biden’s Nitwit Dept. of Defense Uses Photo of Chinese Jet in Veterans Day Message appeared first on The Lid.
I’m not sure why, but Brazil seems to be somewhat overlooked by photographers. It doesn’t quite add up for those who have extensively traveled the country. It’s such a beautiful nation. Hopefully, this guide to the best places in Brazil for photography will encourage a few photographers to give this wonderfully diverse country a chance. In this guide, I’ll delve into some of the top spots to capture stunning photos in Brazil, while also addressing some of the logistical challenges […]
The post The Best Places in Brazil for Photography appeared first on Brendan van Son Photography.
The genres of photography are so often mischaracterized. But, most of these genres are at least pretty obvious. In street photography, you’re photographing the street life. In landscape photography, you’re photographing the landscapes. And of course in wildlife photography you’re photographing the, well, you get the idea. So what is travel photography? What makes travel photography so interesting is that it isn’t a subject that you’re photographing: it’s an activity. But also, it is a subject…? Wait… let me explain. […]
The post What is Travel Photography? appeared first on Brendan van Son Photography.
I’ve been toying at the idea of recording a podcast about my thoughts on AI photography for a while now. For a while, I’ve put it off because I really don’t know if I want to add any more volume to a subject that’s already been talked about and debated for a while. But, it seems like AI photography, or even just AI photography tools aren’t going anywhere. So, here are my thoughts, questions, and my own personal ethics when […]
The post Is AI Photography Here to Stay? Ethics, Goals, and Questions. appeared first on Brendan van Son Photography.
The World Meteorological Organisation (WMO) has raised the alarm over climate change, reporting 2024 is the world's hottest year yet.
Time's arrow may not be as unidirectional as we were led to believe. According to Scientific American, a group of quantum physical researchers at the University of Toronto had observed evidence of what they're calling "negative time"—specifically, of photons exiting a material before they ever entered it, to begin with. — Read the rest
The post Physicists find evidence of "negative time" in photons appeared first on Boing Boing.
Nonphotochemical quenching (NPQ) is a mechanism of regulating light harvesting that protects the photosynthetic apparatus from photodamage by dissipating excess absorbed excitation energy as heat. In higher plants, the major light-harvesting antenna complex (LHCII) of photosystem (PS) II is directly involved in NPQ. The aggregation of LHCII is proposed to be involved in quenching. However, the lack of success in isolating native LHCII aggregates has limited the direct interrogation of this process. The isolation of LHCII in its native state from thylakoid membranes has been problematic because of the use of detergent, which tends to dissociate loosely bound proteins, and the abundance of pigment–protein complexes (e.g. PSI and PSII) embedded in the photosynthetic membrane, which hinders the preparation of aggregated LHCII. Here, we used a novel purification method employing detergent and amphipols to entrap LHCII in its natural states. To enrich the photosynthetic membrane with the major LHCII, we used Arabidopsis thaliana plants lacking the PSII minor antenna complexes (NoM), treated with lincomycin to inhibit the synthesis of PSI and PSII core proteins. Using sucrose density gradients, we succeeded in isolating the trimeric and aggregated forms of LHCII antenna. Violaxanthin- and zeaxanthin-enriched complexes were investigated in dark-adapted, NPQ, and dark recovery states. Zeaxanthin-enriched antenna complexes showed the greatest amount of aggregated LHCII. Notably, the amount of aggregated LHCII decreased upon relaxation of NPQ. Employing this novel preparative method, we obtained a direct evidence for the role of in vivo LHCII aggregation in NPQ.
Heterotrimeric G-proteins are signaling switches broadly divided into four families based on the sequence and functional similarity of their Gα subunits: Gs, Gi/o, Gq/11, and G12/13. Artificial mutations that activate Gα subunits of each of these families have long been known to induce oncogenic transformation in experimental systems. With the advent of next-generation sequencing, activating hotspot mutations in Gs, Gi/o, or Gq/11 proteins have also been identified in patient tumor samples. In contrast, patient tumor-associated G12/13 mutations characterized to date lead to inactivation rather than activation. By using bioinformatic pathway analysis and signaling assays, here we identified cancer-associated hotspot mutations in Arg-200 of Gα13 (encoded by GNA13) as potent activators of oncogenic signaling. First, we found that components of a G12/13-dependent signaling cascade that culminates in activation of the Hippo pathway effectors YAP and TAZ is frequently altered in bladder cancer. Up-regulation of this signaling cascade correlates with increased YAP/TAZ activation transcriptional signatures in this cancer type. Among the G12/13 pathway alterations were mutations in Arg-200 of Gα13, which we validated to promote YAP/TAZ-dependent (TEAD) and MRTF-A/B-dependent (SRE.L) transcriptional activity. We further showed that this mechanism relies on the same RhoGEF-RhoGTPase cascade components that are up-regulated in bladder cancers. Moreover, Gα13 Arg-200 mutants induced oncogenic transformation in vitro as determined by focus formation assays. In summary, our findings on Gα13 mutants establish that naturally occurring hotspot mutations in Gα subunits of any of the four families of heterotrimeric G-proteins are putative cancer drivers.
Dr. Rekha Thomas from the University of Washington discusses three-dimensional image reconstructions from two-dimensional photos. The mathematics of image reconstruction is both simpler and more abstract than it seems. To reconstruct a 3D model based on photographic data, researchers and algorithms must solve a set of polynomial equations. Some solutions to these equations work mathematically, but correspond to an unrealistic scenario — for instance, a camera that took a photo backwards. Additional constraints help ensure this doesn't happen. Researchers are now investigating the mathematical structures underlying image reconstruction, and stumbling over unexpected links with geometry and algebra.
dannyhennesy posted a photo:
On the Capital planet the rebellious droids had followed maily the Bat-Bot, but as time progressed his circuits had gone all mushy at 780 years or so without maintenance…
Several splinter groups all with their local bot leaders emerged such as the Che-bot, the traffic-light-robot and the Butt-bot, but none of these collected enough sentient circuits to call themselves a popular (or Animata) mass movement!
That was until a cyborg came along, one known as Jones, a long time prisoner and terrorist, his easy solutions to every problem rang well in the masses' auditory circuits!!!
His slogans and simple rhetoric were simple enough for the simple traffic-light to comprehend and cheer!
His language was full of hate towards the organics and especially the humans who were the most common races among the ruling class of the federation!!!
Despite being a “Fleshie” himself his message collected the angry enslaved
bot community by only weeks all rebellious robots except for a few fringe loonies had forgotten the old leaders…
One morning at Jones gave the signal…
All over the capital planet hordes and swarms of any form of mechanical sentient beings attacked first the police stations, then the Company boards running the planet and the federation as well as their starfleet…
Many died, especially the low level police and army! Many mechanicals died too, but their ranks were soon filled by Mutant fleshie allies of the lower levels who hated the Federation feudal society and upper classes as much as their technological allies…
The Federation state apparatus and ruling class, most of their fleet army fled when they knew the game was up, they activated the emergency escape plan and whole city blocks with important factories, administrational units, valuable assets and so on separated from the capital by hidden rocket engines and homed in their course to Mars…
On Mars the federation regrouped and formed their new society…
On the Capital planet, the robots proclaimed the first Techno-republic of the advanced inorganic civilization, the low level fleshies left behind, became slaves and their mutant allies got to rule their own minute chiefdoms as protectorates under the Techno-republic…
Jones was now the undisputed ruler of the capital planet, but the victory was a pyrros one since, all important buildings, all of value was now one Mars!
But as Jones put it:
Our proud race the Techno-species didn’t need the Fleshies administration, their infrastructure, their spaceships…
We shall start from scratch, with a new administration, a new order, every droid shall work at 4x speed than they did during human oppression since now we are free and the fleshies shall work twice as hard than the Techno-Race, until we have breed enough new fleshies so they can do all work!
Our future is bright and shiny like glistering shiny metal!
The snapshot seen here is from the first police station attacked in sector 45-34v-ss-g the first one to fall according to official techno-history!
———————————————/
Designers note:
I am sad to say that this is the last episode in this years-spanning space series… At least for a while, I will still post LEGO hobby stuff here but without a storyline, perhaps small designs and builds… and occasionally a story when I feel like it!!!
I would like to thank all who had been in this journey of our heros, but it has taken far to much time and effort and since the state of the world is as it is, I am spiraling down in another depression, I must stop it before I reach the abyss, so I have remove some stress out of my equation… I ended it in a cliffhanger so I can easily restart it when my mental health improves… I hope that won’t be forever???
I would love if someone used my characters or ideas, please send me a link if you do, I would love to read it or look at it!!!
But there will be more Lego, just in different format without long stories, I need to focus more on my art and to be honest that is the only time the mental pain eases, when I create!!!
Peace and Noise!
MushroomBrain a FOL
Lawford Hatcher
Proc. Amer. Math. Soc. 152 (), 5191-5205.
Abstract, references and article information
The St Catherine South police are probing the fatal shooting of a fisherman in Old Harbour Bay in the parish on Sunday.
Highly engineered phytases, which sequentially hydrolyze the hexakisphosphate ester of inositol known as phytic acid, are routinely added to the feeds of monogastric animals to improve phosphate bioavailability. New phytases are sought as starting points to further optimize the rate and extent of dephosphorylation of phytate in the animal digestive tract. Multiple inositol polyphosphate phosphatases (MINPPs) are clade 2 histidine phosphatases (HP2P) able to carry out the stepwise hydrolysis of phytate. MINPPs are not restricted by a strong positional specificity making them attractive targets for development as feed enzymes. Here, we describe the characterization of a MINPP from the Gram-positive bacterium Bifidobacterium longum (BlMINPP). BlMINPP has a typical HP2P-fold but, unusually, possesses a large α-domain polypeptide insertion relative to other MINPPs. This insertion, termed the U-loop, spans the active site and contributes to substrate specificity pockets underpopulated in other HP2Ps. Mutagenesis of U-loop residues reveals its contribution to enzyme kinetics and thermostability. Moreover, four crystal structures of the protein along the catalytic cycle capture, for the first time in an HP2P, a large ligand-driven α-domain motion essential to allow substrate access to the active site. This motion recruits residues both downstream of a molecular hinge and on the U-loop to participate in specificity subsites, and mutagenesis identified a mobile lysine residue as a key determinant of positional specificity of the enzyme. Taken together, these data provide important new insights to the factors determining stability, substrate recognition, and the structural mechanism of hydrolysis in this industrially important group of enzymes.
The SAS 9.4M4 (TS1M4) Hot Fix D7G004 for ODS Templates installs national language support (NLS) content regardless of whether the languages were installed during the initial deployment. Having sparse
Photoreceptors have high energy-demands and a high density of mitochondria that produce adenosine triphosphate (ATP) through oxidative phosphorylation (OXPHOS) of fuel substrates. Although glucose is the major fuel for central nervous system (CNS) brain neurons, in photoreceptors (also CNS), most glucose is not metabolized through OXPHOS but is instead metabolized into lactate by aerobic glycolysis. The major fuel sources for photoreceptor mitochondria remained unclear for almost six decades. Similar to other tissues (like heart and skeletal muscle) with high metabolic rates, photoreceptors were recently found to metabolize fatty acids (palmitate) through OXPHOS. Disruption of lipid entry into photoreceptors leads to extracellular lipid accumulation, suppressed glucose transporter expression, and a duel lipid/glucose fuel shortage. Modulation of lipid metabolism helps restore photoreceptor function. However, further elucidation of the types of lipids used as retinal energy sources, the metabolic interaction with other fuel pathways, as well as the crosstalk among retinal cells to provide energy to photoreceptors is not yet known. In this review, we will focus on the current understanding of photoreceptor energy demand and sources, and potential future investigations of photoreceptor metabolism.
The essential fatty acid DHA (22:6, omega-3 or n-3) is enriched in and required for the membrane biogenesis and function of photoreceptor cells (PRC), synapses, mitochondria, etc. of the CNS. PRC DHA becomes an acyl chain at the sn-2 of phosphatidylcholine (PC), amounting to more than 50% of the PRC outer segment phospholipids, where phototransduction takes place. Very long chain PUFAs (VLC-PUFAs,n-3, ≥ 28 carbons) are at the sn-1 of this PC molecular species and interact with rhodopsin. PRC shed their tips (DHA-rich membrane disks) daily, which in turn are phagocytized by the retinal pigment epithelium (RPE), where DHA is recycled back to PRC inner segments to be used for the biogenesis of new photoreceptor membranes. Here, we review the structures and stereochemistry of novel elovanoid (ELV)-N32 and ELV-N34 to be ELV-N32: (14Z,17Z,20R,21E,23E,25Z,27S,29Z)-20,27-dihydroxydo-triaconta-14,17,21,23,25,29-hexaenoic acid; ELV-N34: (16Z,19Z,22R,23E,25E,27Z,29S,31Z)-22,29-dihydroxytetra-triaconta-16,19,23,25,27,31-hexaenoic acid. ELVs are low-abundance, high-potency, protective mediators. Their bioactivity includes enhancing of anti-apoptotic and pro-survival protein expression with concomitant downregulation of pro-apoptotic proteins when RPE is confronted with uncompensated oxidative stress (UOS). ELVs also target PRC/RPE senescence gene programming, the senescence secretory phenotype in the interphotoreceptor matrix (IPM), as well as inflammaging (chronic, sterile, low-grade inflammation). An important lesson on neuroprotection is highlighted by the ELV mediators that target the terminally differentiated PRC and RPE, sustaining a beautifully synchronized renewal process. The role of ELVs in PRC and RPE viability and function uncovers insights on disease mechanisms and the development of therapeutics for age-related macular degeneration (AMD), Alzheimer’s disease (AD), and other pathologies.
After Ohtani's nearly unprecedented two-way success during his American League Rookie of the Year campaign last year, more clubs are looking into the possibility of having players who can both pitch and play a position. Walsh fits that bill, as he has been a power-hitting first baseman and outfielder in the Minors, but he's made 10 pitching appearances over the past three seasons as well. The Angels are experimenting with him doing both this spring and this upcoming season.
CAMBRIDGE, England, Oct. 15, 2024 — Nu Quantum has announced a proof-of-principle prototype that advances the development of modular, distributed quantum computers by enabling connections across different qubit modalities and […]
The post Nu Quantum Unveils Qubit-Photon Interface to Enable Distributed Quantum Computing Networks appeared first on HPCwire.
PITTSBURGH, Sept. 24, 2024 — Ansys and TSMC today announced a successful pilot with Microsoft that significantly speeds-up the simulation and analysis of silicon photonic components. Together, the companies achieved […]
The post TSMC Collaborates with Ansys and Microsoft to Accelerate Photonic Simulations appeared first on HPCwire.
SANTA CLARA, Calif., Oct. 22, 2024 — Celestial AI today announced the acquisition of silicon photonics intellectual property from Rockley Photonics, including worldwide issued and pending patents. The combination of Celestial […]
The post Celestial AI Acquires Rockley Photonics Patent Portfolio, Strengthening Photonic Fabric IP appeared first on HPCwire.
COLLEGE PARK, Md., Nov. 8, 2024 — IonQ, a leader in the quantum computing industry, has announced a partnership with NKT Photonics, a subsidiary of Hamamatsu Photonics, to procure next-generation laser […]
The post IonQ and NKT Photonics Collaborate on Next-Gen Laser Tech for Quantum Data Centers appeared first on HPCwire.
COLLEGE PARK, Md., Nov. 11, 2024 — IonQ, a leader in the quantum computing industry, has announced that it is developing photonic integrated circuits (PICs) and chip-scale ion trap technology for […]
The post IonQ Partners with imec to Advance Quantum Computers with Photonic Integrated Circuits appeared first on HPCwire.
Do you hate having your photo taken? Portrait photographer Teri Hofford is here to change your mind. She unpacks why you may think you look bad in photos — and how to boost your confidence for those moments captured on camera.
Dougherty County, a largely black school district in an region heavily affected by coronavirus, is no longer subject to desegregation orders first imposed in 1963.
The Indiana state teachers' union is pushing to protect student and staff safety during active-shooter trainings.
Many are whipsawed by shutdown recommendations aimed at stemming the coronavirus, and the logistical and financial consequences of those actions.