I am gratified to see the continuing adoption of Forecast Value Added by organizations worldwide. FVA is an easy to understand and easy to apply approach for identifying bad practices in your forecasting process. And I'm particularly gratified to see coverage of FVA in two new books, which the authors [...]

The post Vandeput's Data Science for Supply Chain Forecasting (book excerpt) appeared first on The Business Forecasting Deal.

What makes something easy (or difficult) to forecast? This question was answered by Prof. Rob Hyndman on the Forecasting Impact podcast (February 6, 2021), and it's worth a look at his response. Rob was recently named a Fellow of the International Institute of Forecasters, and is someone who is known [...]

The post Hyndman's 5 Conditions for Easy Forecasting appeared first on The Business Forecasting Deal.

M6 Financial Forecasting Competition The Makridakis Open Forecasting Center has announced the M6 Financial Forecasting Competition, to begin in February 2022. This will be a "live" competition running through February 2023, with a focus on forecasts of stock price (returns) and risk, and on investment decisions based on the forecasts. [...]

The post M6 Financial Forecasting Competition announced appeared first on The Business Forecasting Deal.

I've never been much of a fan of forecasting approaches to intermittent demand. In situations like intermittent demand (or other areas where we have little hope of reasonably accurate forecasts), my thinking is "why bother?" If we can't expect to solve the problem with forecasting, we need a different approach. [...]

The post Intermittent Demand Forecasting (new book by Boylan and Syntetos) appeared first on The Business Forecasting Deal.

[SAPS] - Polokwane based Hawks Serious Commercial Crime Investigation in collaboration with National Traffic Anti-corruption Unit arrested 11 suspects between the ages of 27 and 57 for alleged fraud at various Provinces during operation "SISFIKILE".

Have you ever encountered ERROR(SPMHNI-67) while importing logic? If yes, you might already know that you had to export libraries of the design and make sure that paths (devpath, padpath, and psmpath) include the location of exported files.  

Starting in SPB23.1, if you go to File > Import > Logic/Netlist and click on the Other tab, you will see an option, Reuse device files for existing components. 

After selecting this option, ERROR(SPMHNI-67) will no longer be there in the log file, because the tool will automatically extract device files and seamlessly use them for newly imported data. In other words, SPB_23.1 lets you reuse the device / component definitions already in the design without first having to dump libraries manually. An excellent improvement, don’t you think?  

Dear all,

I defined two design variables in ADE Assembler, say V1 and V2, that define the voltage 1 and voltage 2 of a "vpulse" voltage source in my schematic.

Then, I define V1 = 1.0, and V2 = 2.0, run a transient simulation, and everything is as expexcted. The source provides pulses between 1.0 V and 2.0 V.

Next, I set V1 = 1.0:0.5:1.5, thereby creating a parametric sweep with 1.0 V and 1.5 V for V1. I keep V2 at 2.0 V. Then the simulation fails, and all I get is "netl err" in my Output Expressions and an error message that the results directory does not exist and nothing can be plotted: This is reasonable, as the results directory is deleted on starting a new simulation, and as there is no simulation result, none of my output expressions can be plotted.

WARNING (OCN-6040): The specified directory does not exist, or the directory does not contain valid PSF results.
        Ensure that the path to the directory is correct and the directory has a logFile and PSF result files.
WARNING (ADE-1065): No simulation results are available.
ERROR (WIA-1175): Cannot plot waveform signals because no waveform data is available for plotting.
One of the possible reasons can be that 'Save' check box for these signals are not selected in the Outputs Setup pane. Ensure that these check boxes are selected before you run the simulation.

Normally, this kind of para,metric sweep is not a problem, I have done this many times before. There must be something special in THIS PARTICULAR test bench or simulator setup. The trouble is, I don't get any useful error messages.

Does anyone know what might be the problem here OR where to find useful information to investigate further (log files stored somewhere)? Thank you!

Regards,

Volker

P.S. Using Corners instead does not help either. Running it through all values by hand works, though.

When posting code to the forums, copy from a text editor such as notepad, not from word or Outlook. Be sure to click the HTML tab BEFORE you paste your text.

Click on the "html" mode tab on your "reply" dialog box. Then wrap your text with like this:

pasted text

NOTE: Do not put a space in the I have done that here so it will show up as text. Also, be sure to click the HTML tab BEFORE you paste your text. This is how it will look when coded correctly pasted text

I have been involved in the Virtuoso RF Solution for the last four years. Most of the customers I work with have a SiP package already in progress. They often ask "How do I get my SiP design into Virtuoso RF Solution?" I am excited about new functionality in the latest ICADVM20.1 ISR25 release. It is a new GUI under the Tools menu called Enablement. (read more)

Australian wine was showcased to retailers, distributors, sommeliers and media at key tasting events in Korea.

From today Australian and Indonesian businesses and workers will have even greater opportunities to boost their skills and expertise, with the signing of an expanded Memorandum of Understanding on the Indonesia-Australia Skills Development Exchange Pilot.

While the expansion of democracy is a key condition for peace, the Achilles’ heel of democracies is that their leaders are constrained by electoral calendars, forcing them to push for peace or delay, whereas autocracies can afford to play the long game to achieve the favorable outcomes they desire. Take, for example, the current wars […]

In Ephesians 3:16–19, Paul prays that believers would be “strengthened with power through His Spirit in the inner man” in order that they might understand the “love of Christ which surpasses knowledge.” In other words, it takes a lot of Spirit-supplied strength for us to catch even a glimpse of God’s love—and when we do, we’ve only scratched the surface.

Due to worsening political instability, escalating gang violence, and a lack of basic services, Haiti is in the midst of one of the most severe humanitarian crises in the world. According to a 2024 ACAPS report, gangs have seized 85 percent of the nation’s capital, Port-Au-Prince, resulting in over 700,000 displaced persons. Many of the […]

The Asian Development Bank is ramping up investment in technical and vocational education and training in Bhutan, which is helping to train thousands

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to write effective test cases in manual testing

Commercially available quantum technology could let stock traders coordinate decisions to buy or sell nearly instantaneously using a technique called “quantum telepathy”

These stunning photographs are all shortlisted for the Sony World Photography Awards 2024

Taylor Roades's images of a river in north-west Alaska that has turned orange because of global warming have won the New Scientist Editors Award at the Earth Photo competition

Title: What Can and Can't I Eat When Fasting?
Category: Health and Living
Created: 8/16/2022 12:00:00 AM
Last Editorial Review: 8/16/2022 12:00:00 AM

Title: What Happens to Metabolism in Fasting?
Category: Health and Living
Created: 8/26/2022 12:00:00 AM
Last Editorial Review: 8/26/2022 12:00:00 AM

Title: Preexisting Health Issues Add to Problems for Disaster Survivors
Category: Health News
Created: 8/26/2010 4:10:00 PM
Last Editorial Review: 8/27/2010 12:00:00 AM

Title: Scientists Get Closer to Long-Lasting Flu Vaccine
Category: Health News
Created: 8/24/2015 12:00:00 AM
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Title: Alex Trebek Back Hosting 'Jeopardy!' After Completing Chemotherapy
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Title: Posting All Those Selfies Online Could Backfire, Study Finds
Category: Health News
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Last Editorial Review: 8/30/2019 12:00:00 AM

Title: Changes to CDC's COVID-19 Testing Guidelines Trigger Concern
Category: Health News
Created: 8/26/2020 12:00:00 AM
Last Editorial Review: 8/27/2020 12:00:00 AM

Title: First Lady Jill Biden Leaves Isolation After Testing Negative for COVID Twice
Category: Health News
Created: 8/22/2022 12:00:00 AM
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Title: Fasting Diet Could Help Folks With Type 2 Diabetes
Category: Health News
Created: 7/26/2022 12:00:00 AM
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Title: HIV Testing Plummeted During Pandemic
Category: Health News
Created: 6/27/2022 12:00:00 AM
Last Editorial Review: 6/27/2022 12:00:00 AM

Mapping transcriptomic variations using either short- or long-read RNA sequencing is a staple of genomic research. Long reads are able to capture entire isoforms and overcome repetitive regions, whereas short reads still provide improved coverage and error rates. Yet, open questions remain, such as how to quantitatively compare the technologies, can we combine them, and what is the benefit of such a combined view? We tackle these questions by first creating a pipeline to assess matched long- and short-read data using a variety of transcriptome statistics. We find that across data sets, algorithms, and technologies, matched short-read data detects ~30% more splice junctions, such that ~10%–30% of the splice junctions included at ≥20% by short reads are missed by long reads. In contrast, long reads detect many more intron-retention events and can detect full isoforms, pointing to the benefit of combining the technologies. We introduce MAJIQ-L, an extension of the MAJIQ software, to enable a unified view of transcriptome variations from both technologies and demonstrate its benefits. Our software can be used to assess any future long-read technology or algorithm and can be combined with short-read data for improved transcriptome analysis.

Without compromising accuracy, point of care testing (POCT) provides immediate results at the time of in person patient consultation. The purpose of this study was to evaluate time until therapeutic intervention with POCT HbA1c versus venipuncture, where venipuncture was considered standard of care.

The primary outcome was time (hours) to implementation of a therapeutic intervention based on POCT HbA1c result, as compared with most recent venipuncture HbA1c before the study and its associated therapeutic intervention. A total of 94 POCT HbA1c tests were included in the primary analysis.

For the POCT HbA1c, the mean time to therapeutic intervention was 1.6 ± 3.14 hours. For the previous venipuncture HbA1c, the mean time to therapeutic intervention was 1376.66 ± 3356.6 hours (P < .001). Overall, this trial showed that POCT HbA1c results in a significantly faster time to therapeutic intervention than venipuncture in a primary care clinic that serves a rural population.

BACKGROUND:Practice on fasting prior to extubation in critically ill patients is variable. Efficacy of fasting in reducing gastric volume has not been well established. The primary objective of this study was to assess the effect of 4 h of fasting on prevalence of empty stomach using gastric ultrasonography in critically ill subjects who are fasted for extubation. The secondary objectives were to evaluate the change in gastric volumes during 4 h of fasting and to determine factors associated with empty stomach after fasting.METHODS:This was a single-center, prospective, observational study on adult ICU subjects who were enterally fed for at least 6 h continuously and mechanically ventilated. Gastric ultrasound was performed immediately prior to commencement of fasting, after 4 h of fasting, and after nasogastric (NG) aspiration after 4 h of fasting. An empty stomach was defined as a gastric volume ≤ 1.5 mL/kg.RESULTS:Forty subjects were recruited, and 38 (95%) had images suitable for analysis. The prevalence of empty stomach increased after 4 h of fasting (25 [65.8%] vs 31 [81.6%], P = .041) and after 4 h of fasting with NG aspiration (25 [65.8%] vs 34 [89.5%], P = .008). There was a significant difference in median (interquartile range) gastric volume per body weight between before fasting and 4 h after fasting (1.0 [0.5–1.8] mL/kg vs 0.4 [0.2–1.0] mL/kg, P < .001). No patient factors were associated with higher prevalence of empty stomach after 4 h of fasting.CONCLUSIONS:Most mechanically ventilated subjects had empty stomachs prior to fasting for extubation. Fasting for 4 h further increased the prevalence of empty stomach at extubation to > 80%.

BACKGROUND:Pulmonary function tests (PFTs) have historically used race-specific prediction equations. The recent American Thoracic Society guidelines recommend the use of a race-neutral approach in prediction equations. There are limited studies centering the opinions of practicing pulmonologists on the use of race in spirometry. Provider opinion will impact adoption of the new guideline. The aim of this study was to ascertain the beliefs of academic pulmonary and critical care providers regarding the use of race as a variable in spirometry prediction equations.METHODS:We report data from 151 open-ended responses from a voluntary, nationwide survey (distributed by the Association of Pulmonary Critical Care Medicine Program Directors) of academic pulmonary and critical care providers regarding the use of race in PFT prediction equations. Responses were coded using inductive and deductive methods, and a thematic content analysis was conducted.RESULTS:There was a balanced distribution of opinions among respondents supporting, opposing, or being unsure about the incorporation of race in spirometry prediction equations. Responses demonstrated a wide array of understanding related to the concept and definition of race and its relationship to physiology.CONCLUSIONS:There was no consensus among providers regarding the use of race in spirometry prediction equations. Concepts of race having biologic implications persist among pulmonary providers and will likely affect the uptake of the Global Lung Function Initiative per the American Thoracic Society guidelines.

The CYP3A7 enzyme accounts for ~50% of the total cytochrome P450 (P450) content in fetal and neonatal livers and is the predominant P450 involved in neonatal xenobiotic metabolism. Additionally, it is a key player in healthy birth outcomes through the oxidation of dehydroepiandrosterone (DHEA) and DHEA-sulfate. The amount of the other hepatic CYP3A isoforms, CYP3A4 and CYP3A5, expressed in neonates is low but highly variable, and therefore the activity of individual CYP3A isoforms is difficult to differentiate due to their functional similarities. Consequently, a better understanding of the contribution of CYP3A7 to drug metabolism is essential to identify the risk that drugs may pose to neonates and developing infants. To distinguish CYP3A7 activity from CYP3A4/5, we sought to further characterize the selectivity of the specific CYP3A inhibitors CYP3cide, clobetasol, and azamulin. We used three substrate probes, dibenzylfluorescein, luciferin-PPXE, and midazolam, to determine the IC₅₀ and metabolism-dependent inhibition (MDI) properties of the CYP3A inhibitors. Probe selection had a significant effect on the IC₅₀ values and P450 inactivation across all inhibitory compounds and enzymes. CYP3cide and azamulin were both identified as MDIs and were most specific for CYP3A4. Contrary to previous reports, we found that clobetasol propionate (CP) was not an MDI of CYP3A5 but was more selective for CYP3A5 over CYP3A4/7. We further investigated CYP3cide and CP’s ability to differentiate CYP3A7 activity in an equal mixture of recombinant CYP3A4, CYP3A5, and CYP3A7, and our results provide confidence of CYP3cide’s and CP’s ability to distinguish CYP3A7 activity in the presence of the other CYP3A isoforms.

ABSTRACTBackground: This analysis aimed to evaluate the effectiveness of eliciting sexual partners from HIV-positive clients using the elicitation box model (where an HIV-positive index can report sexual contacts on paper and insert in a box for a health care provider to contact at a later time) compared to the conventional model (in which a health care provider elicits sexual contacts directly from clients) in Akwa Ibom, Southern Nigeria.Methods: Between March 2021 and April 2022, data were collected from index testing registers at 4 health facilities with a high volume of HIV clients currently on treatment in 4 local government areas in Akwa Ibom State. Primary outcome analyzed was the elicitation ratio (number of partners elicited per HIV-index offered index testing services). Secondary outcomes were the index testing acceptance (index HIV-positive clients accepted index testing service), testing coverage (partners tested for HIV from a list of partners elicited from HIV-index accepted index testing services), testing yield (index partners identified HIV positive from index partners HIV-tested), and linkage rate (index partners identified HIV positive and linked to antiretroviral therapy).Results: Of the total 2,705 index clients offered index testing services, 91.9% accepted, with 2,043 and 439 indexes opting for conventional elicitation and elicitation box models, respectively. A total of 3,796 sexual contacts were elicited: 2,546 using the conventional model (elicitation ratio=1:1) and 1,250 using the elicitation box model (elicitation ratio=1:3). Testing coverage was significantly higher in the conventional compared to the elicitation box model (P<.001). However, there was no significant difference in the testing yield (P=.81) and linkage rate using the conventional compared to elicitation box models (P=.13).Conclusion: The implementation of the elicitation box model resulted in an increase in partner elicitation compared to the conventional model. Increasing the testing coverage by implementing the elicitation box model should be considered.

Robert Eggers' re-imagining of the legendary vampire has his fangs out for prey in a very unusual manner.

Family business Graham’s Family Dairy has secured a multinational listing

Sega are delisting several bundles of 'classic' games from digital stores, along with "select individual" games. On Steam specifically, this adds up to over 60 games in total, including several actual classics including the original Streets Of Rage trilogy, Crazy Taxi, and Jet Set Radio.

The games will be removed on December 6th but will remain playable to those who already own them.

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It was the 20-year anniversary of Halo 2 at the weekend, which saw the shooter's modern counterparts celebrating with classic multiplayer maps and long-lost levels. But also emerging from the dust of time are insights to the sequel's development back in 2004. Rolling Stone interviewed two key designers of the game and made a fun discovery. The Flood (the sickly pale alien infestation that briefly turns Halo into sci-fi horror) was partly inspired by a colourful and innocent children's book about a nice elephant.

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"Where’s my Neo-Volkite pistol, Warhammer 40,000: Space Marine 2?" was my perhaps slightly ungrateful reaction upon booting the action game up after the previous patch. "I didn’t even know what a Neo-Volkite pistol was until five minutes ago, but now this whole game is trash until I get one!." As promised in the roadmap, the last big update added a whole new Operations map, complete with a gargantuan new pseudo-boss in the form of a hierophant bio-titan. It did not, however, give me my beloved pistol. It’s fine. It’s in now, along with a few, less Neo-Volkite updates to other weapons.

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A Spot robot equipped with a blowtorch can locate weeds on farms and precisely heat them up to stop them growing, offering a possible alternative to herbicides

Google’s NotebookLM tool is billed as an AI-powered research assistant and can even turn your text history into a jovial fake podcast. But it could also tempt you into narcissism and nostalgia, says Jacob Aron