Ce jour, nous avons donc le droit à quelques potentielles nouvelles informations sur les futurs APU d'AMD, codename MEDUSA. Des APU que l'on pourrait retrouver dans les PS6 de SONY ainsi que dans la prochaine Xbox de Microsoft. Et MEDUSA devrait donc s'offrir les services d'une architecture ZEN 6, accompagné d'un iGPU en RDNA5, donc avec un puce NAVI 5x. Cet APU proposerait aussi un lien interconnect 2.5D afin de maximiser les échanges entre les différents composants présents sur le substrat. […]

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AMD's Zen 5 processors have been out a few months, and you know what that means for journalists like us -- it's time to start looking to the future. The successor to the Zen 5 architecture will naturally be Zen 6, and while AMD has confirmed that detail, the company said nothing else about its next-generation CPU architecture. We know from

ONE year since dubbing Kingsgrove the “new Alexandria”, one business has had to move out of the largely industrial suburb to make way for the new M5 tunnels.

Apple is likely to launch a refreshed Apple Vision Pro headset before a cheaper version of the product arrives, according to a new report.

Apple is believed to be working on "several ideas" for its overall Apple Vision product line and its future intentions. Currently, it is expected that an updated Apple Vision Pro will be the first, ahead of a rumored cheaper "Apple Vision" headset.

The next Apple Vision Pro would likely sport an M5 processor and other internal changes, but would otherwise be very similar to the existing model. It's expected to arrive in late 2025, reports Bloomberg, or the spring of 2026.


Rumor Score: ???? Possible


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Read the in depth Review of Canon EOS M50 MarkII Digital Cameras. Know detailed info about Canon EOS M50 MarkII configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of Samsung Galaxy M53 5G Mobile Phones. Know detailed info about Samsung Galaxy M53 5G configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of POCO M5 Mobile Phones. Know detailed info about POCO M5 configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of Sony WH-1000XM5 Audio Video. Know detailed info about Sony WH-1000XM5 configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of Audio Technica ATH-M50xBT2 Audio Video. Know detailed info about Audio Technica ATH-M50xBT2 configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

There is already a bunch of early Black Friday deals to check out, but if you're on the lookout for a great set of wireless headphones for yourself or a loved one, here's one that's absolutely worth your attention. Sony's WH-1000XM5 headphones have dropped to $298. That's a $102 discount.

This isn't quite the lowest price we've seen for the over-ear XM5s. They dropped to $280 at one point earlier this year. However, the headphones haven't gone back down to that point since, and this is still a great deal.

The XM5s are our pick for the best wireless headphones overall. We've long been recommending Sony's 1000X line and this is the best iteration to date. They earned a score of 95 in our review.

The redesigned headphones are much more comfortable to wear for extended periods than previous models. Sony has improved the active noise cancellation (ANC) feature as well, thanks to the addition of a new chip and four more microphones. We feel that the company's current flagship headphones do a better job of blocking out high frequencies and background noise (and even human voices) than the XM4s.

The XM5s can switch between noise modes depending on your location or activity, and they can pause audio automatically when you start speaking. They deliver better call quality than rival models and, in general, you'll get clear, crisp sound, including punchy bass. You won't need to charge the XM5s too often either, as they have a 30-hour battery life.

Check out all of the latest Black Friday and Cyber Monday deals here.

This article originally appeared on Engadget at https://www.engadget.com/deals/sonys-wh-1000xm5-headphones-are-100-off-in-this-black-friday-deal-192016343.html?src=rss

The 17-year-old was being transported to custody when she left the vehicle and was hit by a car.

A classy compact companion for all your music needs

Dependable battery life and a decent display enough to clinch the deal?

Gurman noted that the new model will likely look similar to the original Apple Vision Pro headset, and that most changes would include the upgrade in processing capabilities

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Have you dreamed of a simple yet feature-rich portable camera? Something that’s a step up from compact cameras but still small enough to carry around in your day bag? A camera that will deliver the image quality of an entry-level DSLR without the bulk? Oh, and still be affordable? The Canon m50 mirrorless camera just might be your dream come Continue Reading

The post Why Buy? Canon m50: A Real Review appeared first on Photodoto.

Accumulating evidence suggests that brown adipose tissue (BAT) is a potential therapeutic target for managing obesity and related diseases. PGAM family member 5, mitochondrial serine/threonine protein phosphatase (PGAM5), is a protein phosphatase that resides in the mitochondria and regulates many biological processes, including cell death, mitophagy, and immune responses. Because BAT is a mitochondria-rich tissue, we have hypothesized that PGAM5 has a physiological function in BAT. We previously reported that PGAM5-knockout (KO) mice are resistant to severe metabolic stress. Importantly, lipid accumulation is suppressed in PGAM5-KO BAT, even under unstressed conditions, raising the possibility that PGAM5 deficiency stimulates lipid consumption. However, the mechanism underlying this observation is undetermined. Here, using an array of biochemical approaches, including quantitative RT-PCR, immunoblotting, and oxygen consumption assays, we show that PGAM5 negatively regulates energy expenditure in brown adipocytes. We found that PGAM5-KO brown adipocytes have an enhanced oxygen consumption rate and increased expression of uncoupling protein 1 (UCP1), a protein that increases energy consumption in the mitochondria. Mechanistically, we found that PGAM5 phosphatase activity and intramembrane cleavage are required for suppression of UCP1 activity. Furthermore, utilizing a genome-wide siRNA screen in HeLa cells to search for regulators of PGAM5 cleavage, we identified a set of candidate genes, including phosphatidylserine decarboxylase (PISD), which catalyzes the formation of phosphatidylethanolamine at the mitochondrial membrane. Taken together, these results indicate that PGAM5 suppresses mitochondrial energy expenditure by down-regulating UCP1 expression in brown adipocytes and that its phosphatase activity and intramembrane cleavage are required for UCP1 suppression.

Accumulating evidence suggests that brown adipose tissue (BAT) is a potential therapeutic target for managing obesity and related diseases. PGAM family member 5, mitochondrial serine/threonine protein phosphatase (PGAM5), is a protein phosphatase that resides in the mitochondria and regulates many biological processes, including cell death, mitophagy, and immune responses. Because BAT is a mitochondria-rich tissue, we have hypothesized that PGAM5 has a physiological function in BAT. We previously reported that PGAM5-knockout (KO) mice are resistant to severe metabolic stress. Importantly, lipid accumulation is suppressed in PGAM5-KO BAT, even under unstressed conditions, raising the possibility that PGAM5 deficiency stimulates lipid consumption. However, the mechanism underlying this observation is undetermined. Here, using an array of biochemical approaches, including quantitative RT-PCR, immunoblotting, and oxygen consumption assays, we show that PGAM5 negatively regulates energy expenditure in brown adipocytes. We found that PGAM5-KO brown adipocytes have an enhanced oxygen consumption rate and increased expression of uncoupling protein 1 (UCP1), a protein that increases energy consumption in the mitochondria. Mechanistically, we found that PGAM5 phosphatase activity and intramembrane cleavage are required for suppression of UCP1 activity. Furthermore, utilizing a genome-wide siRNA screen in HeLa cells to search for regulators of PGAM5 cleavage, we identified a set of candidate genes, including phosphatidylserine decarboxylase (PISD), which catalyzes the formation of phosphatidylethanolamine at the mitochondrial membrane. Taken together, these results indicate that PGAM5 suppresses mitochondrial energy expenditure by down-regulating UCP1 expression in brown adipocytes and that its phosphatase activity and intramembrane cleavage are required for UCP1 suppression.

When you run an SQL query using SAS/ACCESS Interface to ODBC under the following conditions, you might receive an error: You run SAS 9.4M5 (TS1M5) or SAS 9.4M6 (TS1M6)  i

Accumulating evidence suggests that brown adipose tissue (BAT) is a potential therapeutic target for managing obesity and related diseases. PGAM family member 5, mitochondrial serine/threonine protein phosphatase (PGAM5), is a protein phosphatase that resides in the mitochondria and regulates many biological processes, including cell death, mitophagy, and immune responses. Because BAT is a mitochondria-rich tissue, we have hypothesized that PGAM5 has a physiological function in BAT. We previously reported that PGAM5-knockout (KO) mice are resistant to severe metabolic stress. Importantly, lipid accumulation is suppressed in PGAM5-KO BAT, even under unstressed conditions, raising the possibility that PGAM5 deficiency stimulates lipid consumption. However, the mechanism underlying this observation is undetermined. Here, using an array of biochemical approaches, including quantitative RT-PCR, immunoblotting, and oxygen consumption assays, we show that PGAM5 negatively regulates energy expenditure in brown adipocytes. We found that PGAM5-KO brown adipocytes have an enhanced oxygen consumption rate and increased expression of uncoupling protein 1 (UCP1), a protein that increases energy consumption in the mitochondria. Mechanistically, we found that PGAM5 phosphatase activity and intramembrane cleavage are required for suppression of UCP1 activity. Furthermore, utilizing a genome-wide siRNA screen in HeLa cells to search for regulators of PGAM5 cleavage, we identified a set of candidate genes, including phosphatidylserine decarboxylase (PISD), which catalyzes the formation of phosphatidylethanolamine at the mitochondrial membrane. Taken together, these results indicate that PGAM5 suppresses mitochondrial energy expenditure by down-regulating UCP1 expression in brown adipocytes and that its phosphatase activity and intramembrane cleavage are required for UCP1 suppression.

The Olympus OM-D E-M5 Mark III is an appealing camera for photographers already invested in Micro Four Thirds gear, but it isn't as innovative as previous entries in the series.

With 2018's M4 Forecasting Competition behind us (although analysis, interpretation, and debate continue), the new M5 Competition starts March 2. Running through June 30, M5 is utilizing actual data provided by Walmart. It will be implemented using Kaggle's Platform, with $100,000 in prize money. Forecasting practitioners are encouraged to participate, [...]

The post Get ready for M5 with launch of the Makridakis Open Forecasting Centre appeared first on The Business Forecasting Deal.

BMW has been spotted testing what appears to be a new performance flagship for the M5 range. Word on the street is that the car, which will likely be dubbed an M5 CS, is powered by a newly developed V-8. Porsche looks to be readying a Cayenne GTS Coupe to help bridge the performance gap between the S and Turbo. The new variant should debut next...

Tôi muốn xây căn nhà cấp 4 gồm 1 phòng khách, 2 phòng ngủ, phòng ăn + bếp, wc.

Category	Other Scheme - Other ETFs
NAV	90.4639
Repurchase Price
Sale Price
Date	08-May-2020

Dominic Evans, 21, of Devon has admitted to causing the death of his fiance Rayleigh Gill, 22, due to careless driving as they drove back from Gatwick airport after a family holiday to Egypt.

The man was seen peddling alongside two lanes of peak hour traffic in the busy M5 tunnel in Sydney on Thursday afternoon.

The rider had been travelling along Sydney's M5 tunnel which has a maximum speed of 80km/h on Monday when he noticed the device sitting on the car's bonnet beside him.

गैजेट डेस्क. चीनी स्मार्टफोन कंपनी हुवावे ने भारतीय बाजार में मीडियापैड M5 लाइट टैबलेट लॉन्च किया है। ये टैबलेट एम-पेन लाइट स्टायलस के साथ आता है। वहीं, इसमें 4GB रैम के साथ 64GB का स्टोरेज दिया है। इसकी कीमत 22,990 रुपए है। टैबलेट की बिक्री 6 मार्च से ऑनलाइन और ऑफलाइन दोनों स्टोर्स पर होगी।

हुवावे मीडियापैड M5 लाइट का स्पेसिफिकेशन

इसमें 10.1-इंच का फुल HD IPS मल्टी-टच डिस्प्ले दिया है। इसका रेजोल्यूशन 1920x1200 पिक्सल है। डिस्प्ले को बेहतर बनाने के लिए इसमें क्लेरीवीयू 5.0 टेक्नोलॉजी का इस्तेमाल किया गया है। ये टैबलेट एंड्रॉयड 8.0 ओरियो बेस्ड EMUI 8.0 ऑपरेटिंग सिस्टम पर रन करता है। इसमें किरीन 659 प्रोसेसर और ग्राफिक्स के लिए माली T830 जीपीयू दिया है।

इसका सबसे खास फीचर एम-पेन लाइट स्टायलस है। यानी टैबलेट पर किसी कॉपी की तरह राइटिंग की जा सकती है। इसमें हर्मन कार्डन के चार स्पीकर दिए हैं। इसमें 7,500mAh की बैटरी दी है। इसके साथ 18 वॉट का चार्जर आता है। कंपनी का दावा है कि ये 2.9 घंटे में फुल चार्ज हो जाती है। सिंगल चार्ज के बाद इस पर 13 घंटे तक लगातार वीडियो देख सकते हैं।

टैबलेट में Wi-Fi 802.11, LTE, ब्लूटूथ v4.2 के साथ दूसरे कनेक्टिविटी ऑप्शन भी मिलते हैं। इसका डायमेंशन 234.4x162.2x7.7mm और वजन 475 ग्राम है।

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