U.S. Sens. Ron Wyden, D-Ore., Jeff Merkley, D-Ore., Lisa Murkowski, R-Alaska, and Patty Murray, D-Wash., today announced funding will be awarded to build the United States’ first open-ocean, power grid-connected wave energy test facility at a site off the Oregon coast, according to a U.S. Senate press release.
 

The insurance industry has lots of exposure to climate change. But as Warren Buffet has explained, not so much for companies that do annual policy adjustments, like Berkshire Hathaway. Their exposure is limited because the trends are baked into the premiums. But there is an opportunity for reducing insurance risk due to climate change, and it comes from the insurance industry itself. The business model is to have car insurance salespeople provide leads to virtual electric car charging services. This has perfect demographics because electric vehicle owners are very receptive to solar electricity. Who wouldn’t want a clean transportation solution with local job creation that can’t be offshore?

The United States in 2019 will become the world’s largest market for grid-connected battery energy storage, as solar-plus-storage and peaking capacity requirements drive increased procurement, according to IHS Markit.

Presentation by Don Ball of Chemcut Corporation

Africa’s first grid-connected biogas plant will begin supplying power by March 1, according to Johnnie McMillan, managing director of Tropical Power Kenya Ltd.

As a general rule of data privacy protection in Hong Kong, personal data should be used only for the original purpose for which the data was collected, or a directly related purpose. One exception is where the data user obtains the consent from the ...

  Pursuant to Article 3:246 paragraph 1 of the Dutch Civil Code (DCC) pledgees have the power to enforce their right of pledge on receivables by claiming (direct) payment of the receivable. This power also includes the right to enforce rights o...

1. Introduction 1.1 The Charity Commission has recently released detailed guidance for charities on their connections to non-charities, highlighting that whilst such connections can bring benefits they can also present risks and challenges. Common s...

Enabling Cloud Connectivity to All MCUs and MPUs, Microchip Launches a Range of Embedded IoT Solutions for Rapid Prototyping

New Functional Safety Ready AVR® DA Microcontroller Family Enables Real-Time Control, Connectivity and HMI Applications

Due to the global COVID-19 pandemic, engineers and scientists are finding themselves suddenly working from home or other remote locations. We’d like to help you continue to use MATLAB and Simulink productively. We hope this brief collection of resources will help you access MATLAB, collaborate and connect with others, and... read more >>

MPLAB Connect Configurator V2.3.9

ADB’s Transport Sector Flood Recovery Project helped reinstate bridge approach roads, culverts, and stream crossings and rebuilt three elevated bridges, reestablishing a seamless east–west road link on Guadalcanal and within Honiara. All works incorporated climate- and disaster-proof design.

  Sericulture farms in India’s northeastern state of Assam, are suddenly witnessing a rush of female workers.

Approved project 50333-001 in Bangladesh.

East Asia is setting the pace for the recent trend in regional and interregional integration, which is associated with multilateral infrastructure connectivity initiatives.

Please join us for our Smart Cities & Connected Communities Think Tank Roundtable on Wednesday, May 19. Clint Vince, Chair of Dentons' US Energy practice and Co-chair of Dentons' Global Energy sector, will moderate this event along with a panel of industry leaders for a discussion on the future of cybersecurity concerns.

East Asia is setting the pace for the recent trend in regional and interregional integration, which is associated with multilateral infrastructure connectivity initiatives.

AN2784 - USB4712 Auto-FlexConnect Implementation Guidelines

HARMAN Professional Solutions and IBM (NYSE: IBM) Watson Internet of Things (IoT) today unveiled Voice-Enabled Cognitive Rooms. Using IBM's Watson artificial intelligence (AI) technology and HARMAN AKG microphones, JBL speakers and AMX AV control and ...

Today’s companies see the importance of design as more consumers demand elegance alongside flawless functionality and exceptional user experience. As a company that has created countless ingenious product designs in different markets all over the ...

Since Samsung’s acquisition of HARMAN less than two years ago, the two companies have worked closely to create and implement connective technologies that align with what consumers want today – and in the future. As technology grows ever more capable,...

At HARMAN, our Connected Car division designs, engineers and innovates every day to provide connected solutions for our most valued partners, and our compute model integration with Mercedes-Benz is no exception. Earlier this year, the luxury vehicle ...

HARMAN has a rich history of bringing legendary connected technologies to life. Our team has an unwavering commitment to create the best-performing products and innovations that deliver the most connected, personalized experiences for a broad range of...

Palo Alto, CA – Aha™ by HARMAN today announced that the new 2014 Mazda3 to be launched in Japan, the United States, and a number of additional North American and Asian Countries this fall will offer access to the Aha free service with the ability to select presets from more than 40,000* audio and information stations from Japan and other countries.

It’s the best of both worlds – matching the thrill of the open road on two wheels with the ultimate in convenience, connectivity and entertainment at your fingertips. HARMAN is pleased to work with Yamaha to help perfect this blend with the introduction...

NEW YORK AUTO SHOW – March 23, 2016 – HARMAN International Industries, Incorporated (NYSE:HAR), the premier connected technologies company for automotive, consumer and enterprise markets, will join leading global automakers at the 2016 New York Auto Show...

Cloud technology, big data and artificial intelligence are empowering automakers to create in-car experiences that rival the at-home experience for end users. Automakers themselves can leverage these technologies over time to consistently and ...

While the automotive industry is taking great strides to make a truly autonomous future a reality, there is still a long way to go before fully autonomous vehicles are on our roads. In the meantime, automakers and technology suppliers are developing...

In business and in life, measuring progress is a crucial step to staying on track and achieving your goals. After all, how can you determine how far you’ve come without looking back to where you began? As HARMAN continues to celebrate World Quality...

Ground-breaking aviation technology is on display at this week's Paris Airshow. Jim Drury went to take a look.

Title: AHA News: Hearing Loss and the Connection to Alzheimer's Disease, Dementia
Category: Health News
Created: 5/6/2020 12:00:00 AM
Last Editorial Review: 5/7/2020 12:00:00 AM

Title: Doctors Feel Less Connected to Obese Patients, Study Suggests
Category: Health News
Created: 4/26/2013 2:36:00 PM
Last Editorial Review: 4/29/2013 12:00:00 AM

Title: AHA News: The Often-Overlooked Connection Between Sleep Troubles and Stroke
Category: Health News
Created: 5/2/2019 12:00:00 AM
Last Editorial Review: 5/3/2019 12:00:00 AM

Lipid rafts are highly ordered regions of the plasma membrane that are enriched in cholesterol and sphingolipids and play important roles in many cells. In hematopoietic stem and progenitor cells (HSPCs), lipid rafts house receptors critical for normal hematopoiesis. Lipid rafts also can bind and sequester kinases that induce negative feedback pathways to limit proliferative cytokine receptor cycling back to the cell membrane. Modulation of lipid rafts occurs through an array of mechanisms, with optimal cholesterol efflux one of the major regulators. As such, cholesterol homeostasis also regulates hematopoiesis. Increased lipid raft content, which occurs in response to changes in cholesterol efflux in the membrane, can result in prolonged receptor occupancy in the cell membrane and enhanced signaling. In addition, certain diseases, like diabetes, may contribute to lipid raft formation and affect cholesterol retention in rafts. In this review, we explore the role of lipid raft-related mechanisms in hematopoiesis and CVD (specifically, atherosclerosis) and discuss how defective cholesterol efflux pathways in HSPCs contribute to expansion of lipid rafts, thereby promoting myelopoiesis and thrombopoiesis. We also discuss the utility of cholesterol acceptors in contributing to lipid raft regulation and disruption, and highlight the potential to manipulate these pathways for therapeutic gain in CVD as well as other disorders with aberrant hematopoiesis.

ABSTRACT

Protein homeostasis is critical for proliferation and viability of all organisms. For Candida albicans, protein homeostasis also modulates the transition between yeast and filamentous forms, which is critical for virulence. A key regulator of morphogenesis is the molecular chaperone Hsp90, which mediates proteostasis under physiological and stress conditions. Hsp90 regulates morphogenesis by repressing cyclic AMP-protein kinase A (cAMP-PKA) signaling, such that inhibition of Hsp90 causes filamentation in the absence of an inducing cue. We explored the effect of perturbation of another facet of protein homeostasis and discovered that morphogenesis is also regulated by the proteasome, a large 33-subunit protein complex consisting of a 20S catalytic core and two 19S regulatory particles, which controls degradation of intracellular proteins. We identified a conserved role of the proteasome in morphogenesis as pharmacological inhibition of the proteasome induced filamentation of C. albicans and the related species Candida dubliniensis, Candida tropicalis, Candida krusei, and Candida parapsilosis. For C. albicans, genetic depletion of any of 29 subunits of the 19S or 20S particle induced filamentation. Filaments induced by inhibition of either the proteasome or Hsp90 have shared structural characteristics, such as aberrant nuclear content, and shared genetic dependencies, such as intact cAMP-PKA signaling. Consistent with a functional connection between these facets of protein homeostasis that modulate morphogenesis, we observed that proteasome inhibition results in an accumulation of ubiquitinated proteins that overwhelm Hsp90 function, relieving Hsp90-mediated repression of morphogenesis. Together, our findings provide a mechanism whereby interconnected facets of proteostasis regulate C. albicans morphogenesis.

IMPORTANCE Fungi cause life-threatening infections and pose a serious threat to human health as there are very few effective antifungal drugs. Candida albicans is a major human fungal pathogen and cause of morbidity and mortality in immunocompromised individuals. A key trait that enables C. albicans virulence is its ability to transition between yeast and filamentous forms. Understanding the mechanisms regulating this virulence trait can facilitate the development of much-needed, novel therapeutic strategies. A key regulator of morphogenesis is the molecular chaperone Hsp90, which is crucial for proteostasis. Here, we expanded our understanding of how proteostasis regulates fungal morphogenesis and identified the proteasome as a repressor of filamentation in C. albicans and related species. Our work suggests that proteasome inhibition overwhelms Hsp90 function, thereby inducing morphogenesis. This work provides a foundation for understanding the role of the proteasome in fungal virulence and offers potential for targeting the proteasome to disarm fungal pathogens.

Finding common ground and building trust between local stakeholders could help prevent violent encounters between police and young black men, new research finds.

At the pinnacle of the 17th century scientific revolution, René Descartes, the father of modern philosophy, published his monumental Meditations on First Philosophy (1), in which he proposed a division between soul and body—mind and brain—with the former in charge of our thoughts and conscious decisions (res cogitans) and the...

Mutations in protein-coding genes are well established as the basis for human cancer, yet how alterations within noncoding genome, a substantial fraction of which contain cis-regulatory elements (CRE), contribute to cancer pathophysiology remains elusive. Here, we developed an integrative approach to systematically identify and characterize noncoding regulatory variants with functional consequences in human hematopoietic malignancies. Combining targeted resequencing of hematopoietic lineage–associated CREs and mutation discovery, we uncovered 1,836 recurrently mutated CREs containing leukemia-associated noncoding variants. By enhanced CRISPR/dCas9–based CRE perturbation screening and functional analyses, we identified 218 variant-associated oncogenic or tumor-suppressive CREs in human leukemia. Noncoding variants at KRAS and PER2 enhancers reside in proximity to nuclear receptor (NR) binding regions and modulate transcriptional activities in response to NR signaling in leukemia cells. NR binding sites frequently colocalize with noncoding variants across cancer types. Hence, recurrent noncoding variants connect enhancer dysregulation with nuclear receptor signaling in hematopoietic malignancies.

Three marketing experts share their unconventional means of capturing the attention of potential homeowners of today.

Tips and game suggestions for gaming first-timers and veterans alike