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The antivirulent Staphylococcal sRNA SprC regulates CzrB efflux pump to adapt its response to zinc toxicity [ARTICLE]

Bacterial regulatory RNAs (sRNAs) are important players to control gene expression. In Staphylococcus aureus, SprC is an antivirulent trans-acting sRNA known to base-pair with the major autolysin atl mRNA, preventing its translation. Using MS2-affinity purification coupled with RNA sequencing, we looked for its sRNA-RNA interactome and identified 14 novel mRNA targets. In vitro biochemical investigations revealed that SprC binds two of them, czrB and deoD, and uses a single accessible region to regulate its targets, including Atl translation. Unlike Atl regulation, the characterization of the SprC-czrB interaction pinpointed a destabilization of the czrAB cotranscript, leading to a decrease of the mRNA level that impaired CzrB zinc efflux pump expression. On a physiological standpoint, we showed that SprC expression is detrimental to combat against zinc toxicity. In addition, phagocyctosis assays revealed a significant, but moderate, increase of czrB mRNA levels in a sprC-deleted mutant, indicating a functional link between SprC and czrB upon internalization in macrophages, and suggesting a role in resistance to both oxidative and zinc bursts. Altogether, our data uncover a novel pathway in which SprC is implicated, highlighting the multiple strategies used by S. aureus to balance virulence using an RNA regulator.




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Adapting the Social Norms Exploration Tool in the Democratic Republic of the Congo to Identify Social Norms for Behavior Change

ABSTRACTIn the Democratic Republic of the Congo (DRC), male engagement, social norms, and social networks mitigate family planning behavior. We discuss the adaptation of the Social Norms Exploration Tool (SNET), which identifies relevant social norms and community members upholding these norms, to inform the development of family planning interventions in the DRC. The SNET provides activity tools and templates to guide users through the following steps: (1) plan and prepare, (2) identify reference groups, (3) explore social norms, (4) analyze results, and (5) apply findings.The SNET approach resulted in discussion of social norms, particularly around birth spacing and gender norms framing the man as the decision-maker. However, despite applying a methodology specifically designed to identify social norms, other factors limiting use of contraceptive methods were identified in the process, including lack of education, rumors, and misconceptions. Adaptations were needed to include the full range of reference groups due to narrow phrasing of primary questions, and some of the participatory methods were overly complicated. Feedback from experienced data collectors suggested that the social norms framework is not intuitive, is difficult to apply correctly, and may require that data collectors have a stronger foundation in the relevant concepts to produce valid and actionable results.Although the SNET provides language for discussing normative factors and techniques to identify reference groups and social norms, modifications to the implementation process are recommended when adapting the tool for research.




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Validation of a Simplified Tissue-to-Reference Ratio Measurement Using SUVR to Assess Synaptic Density Alterations in Alzheimer Disease with [11C]UCB-J PET

Simplified methods of acquisition and quantification would facilitate the use of synaptic density imaging in multicenter and longitudinal studies of Alzheimer disease (AD). We validated a simplified tissue-to-reference ratio method using SUV ratios (SUVRs) for estimating synaptic density with [11C]UCB-J PET. Methods: Participants included 31 older adults with AD and 16 with normal cognition. The distribution volume ratio (DVR) using simplified reference tissue model 2 was compared with SUVR at short scan windows using a whole-cerebellum reference region. Results: Synaptic density was reduced in AD participants using DVR or SUVR. SUVR using later scan windows (60–90 or 70–90 min) was minimally biased, with the strongest correlation with DVR. Effect sizes using SUVR at these late time windows were minimally reduced compared with effect sizes with DVR. Conclusion: A simplified tissue-to-reference method may be useful for multicenter and longitudinal studies seeking to measure synaptic density in AD.




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Reimagining Biologically Adapted Somatostatin Receptor-Targeted Radionuclide Therapy: Perspectives Based on Personal Experience and Observations on Recent Trials




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U.S.-backed Syrian forces recapture Raqqa from Islamic State group

Fighters of Syrian Democratic Forces celebrate after Raqqa in Syria was liberated from Islamic State militants on Oct. 17. Photo by Erik De Castro/Reuters

U.S.-backed Syrian Democratic Forces announced Tuesday that they had captured the city of Raqqa from Islamic State militants.

“Everything is finished in Raqqa, our forces have taken full control of Raqqa,” SDF spokesman Talal Sello told AFP. A formal declaration would be announced after operations to clear any remaining sleeper cells and to remove landmines in the city were completed, Sello added.

The move is a major setback for the Islamic State which considered Raqqa the de-facto capital of its self-declared caliphate. It comes on the third anniversary of the global effort to defeat ISIS.

Raqqa was the first provincial capital to fall from government control in March 2013 after it was captured by a rebel army. The army included both Syrian opposition groups and more hard line  parties including al-Nusra and the Islamic State.

A civilian government  that was established in the city divided two months later, and less than a year later ISIS recaptured Raqqa and named the the capital of their caliphate.

About 900 civilians have been killed since the the start of the five-month operation, including 570 people in coalition air raids, according to the Syrian Network for Human Rights. The Britain-based Syrian Observatory for Human Rights put the civilian death toll at 1,130 people. American journalist James Foley was beheaded in the mountains south of the city.

SDF fighters pulled down the Islamic State’s black flag from the city’s National Hospital near the city’s stadium, according to a Reuters report.

Special presidential envoy for the Global Coalition to Defeat ISIS Brett McGurk said in August that the U.S. would attempt to perform a “stabilization” in Raqqa — including demining, removing rubble from major pathways to allow trucks and equipment through, and “basic electricity, sewage, water, the basic essentials to allow populations to come back to their home.”

It is not clear when the 300,000 civilians who have fled Raqqa since April during the operation will be able to return.

The post U.S.-backed Syrian forces recapture Raqqa from Islamic State group appeared first on PBS NewsHour.




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Two new books explore how UFOs captured the world’s imagination

Greg Eghigian's After the Flying Saucers Came and Luis Elizondo's Imminent both show how our fascination with UFOs goes beyond simple curiosity




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An AI can beat CAPTCHA tests 100 per cent of the time

CAPTCHA tests are supposed to distinguish humans from bots, but an AI system mastered the problem after training on thousands of images of road scenes




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Oceans could be used for carbon capture on a big scale

In this week's issue of our environment newsletter, we look at the carbon capture potential of the world's oceans and what effect beavers are having in the Arctic (spoiler: it's not good).




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Whale scientists capture the sights and sounds of a baby sperm whale birth for the first time

Scientists are using machine learning to decode and eventually translate how sperm whales communicate with Morse code-like clicks and pauses.



  • Radio/Quirks & Quarks

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Cement is everywhere. The industry is turning to carbon capture to curb emissions, and it's not alone

Cement is ubiquitous, but the process of making it emits carbon into the atmosphere. The industry says there's no easy way to avoid that, which is why it's turning to carbon capture and storage technology as a way to decarbonize.



  • News/Canada/Calgary

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Nova Scotia biologist adapting COVID-19 technology to detect oyster disease

A biologist at Cape Breton University is hoping a piece of technology used to keep people safe in the pandemic can help protect Nova Scotia's oysters against the effects of warming waters.



  • News/Canada/Nova Scotia

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New Oviraptorosaur Species Discovered in China

A new genus and species of early-diverging oviraptorosaurian dinosaur has been identified from two specimens found in Inner Mongolia, China.

The post New Oviraptorosaur Species Discovered in China appeared first on Sci.News: Breaking Science News.




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Delight in These 15 Photos That Capture the Exotic Undersea Lives of Jellyfish

Despite their often dangerous stings, these creatures create serene scenes as they float through the deep sea




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‘Captain America: Brave New World’ trailer: Anthony Mackie faces off against Harrison Ford’s hulking red president

Directed by Julius Onah, the upcoming film sees Ford as President Thaddeus “Thunderbolt” Ross, who offers Wilson an official role within the military, hoping to make Captain America a government ally




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Canada captain Alphonso Davies to miss CONCACAF Nations League quarterfinal against Suriname

Canada will be without captain Alphonso Davies for its upcoming CONCACAF Nations League quarterfinal against Suriname. Canada Soccer says the Bayern Munich star has withdrawn as a "precautionary measure due to physical fatigue."




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Out Now: ‘Punch Club 2: Fast Forward’, ‘Labyrinth: The Wizard’s Cat’, ‘TENSEI’, ‘Vampire: The Masquerade – Shadows of New York’, ‘Auto Pirates: Captains Cup’, ‘Jenny LeClue – Detectivu’ and More

Each and every day new mobile games are hitting the App Store, and so each week we put together a …




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A ‘Mystery Mollusc’ Has See-Through Skin and Wears a Hood to Capture Prey

Researchers describe a new nudibranch that is genetically drastically different from its closest relatives.




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The best laptop you can buy in 2024

Laptops are evolving fast, with some new models harnessing AI-powered features that adapt to your usage and improve performance in real time. These AI PCs can optimize battery life, manage power across tasks and even enhance webcam quality during video calls. While AI integration is still relatively new in laptops, it’s a feature to watch if you’re considering future-proofing your setup. Plus, it’s exciting to see how these AI-powered PCs might handle everything from productivity to entertainment, offering smart adjustments and enhancements that could make our digital lives a bit easier.

Out of the 11 notebooks we've tested and reviewed in the first half of 2024, we consider Apple's 13-inch MacBook Air M3 to be the best laptop for most people, and this is still the case in our November top picks. It's powerful enough to handle most tasks (even light video editing); it has a great screen and built-in speakers; and its battery could last around 20 hours (depending on what you're doing, of course). The MacBook Air M3 is also one of the lightest and thinnest systems we've reviewed, and it's dead silent, thanks to a fanless design. While Apple has debuted its new M4 chip in the recent iPad Pro, we may not see it in the MacBook Air until next year. For now, the MacBook Air M3 is still an excellent laptop to buy, particularly if you need a machine with good battery life.

Of course, not everyone wants a MacBook, and there are excellent Windows laptops and Chromebooks out there, too. Windows systems offer a range of configurations, from budget to high-end UHD screens with stunning IPS panels that boast high nits for vivid brightness. Chromebooks, on the other hand, tend to be more affordable and are great for users who mostly work online. Whether you need a powerhouse for creative work, a compact system for note-taking, or a laptop that can handle family movie night, there’s something for everyone in today’s laptop market.

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Engadget has been reviewing laptops for two decades, and while the definition of what a portable PC is has changed considerably since, our obsession with testing their limits and serving up informative buying advice remains the same. Be it a hybrid tablet like Microsoft's Surface machines, a rotating 2-in-1 convertible like HP's Spectre x360s or a plain old clamshell notebook, our review process follows similar beats. How does it look and feel? How fast is it? Whether it’s a Windows device powered by an Intel Core i5 or higher, a MacBook or a Chromebook, we aim to answer the most important question: Is it actually worth your hard-earned cash? We also pay close attention to webcam quality and display features, including IPS panels and nits of brightness, as they can make a big difference in daily use.

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You can expect to spend between $1,000 and $1,800 for a new laptop these days, depending on the configuration. If you're looking for more of a workhorse, that could cost you well over $2,000 for additional RAM, storage, as well as a beefier graphics card and CPU. But you can also find some affordable laptops under $1,000 if you're willing to overlook build quality (or buy a refurbished or previous generation machine, which we highly recommend). Systems with AMD chips tend to come in cheaper than their Intel counterparts, but the bulk of their cost will come down to other components like RAM and storage.

I’ve included our favorite affordable model in this best laptop buying guide, but we have a list of the best budget laptops that you can check out as well.

There's a good chance you've already committed to an operating system, but my advice is to be as flexible as possible. These days, most major software is compatible with both Macs and PCs. (Of course, it's another story if you've become dependent on an Apple-only app like Final Cut Pro.) Web-based apps, naturally, will work on any platform with an internet browser.

If you're an Apple-loyalist, there aren't many reasons to consider Windows laptops (unless you want a secondary gaming machine). But for Windows users, macOS is becoming more tempting every year. Apple's MacBooks, powered by its M-series Silicon chips, are among the fastest and most efficient laptops we've ever seen. They're incredibly well-built and have tremendous battery life to boot. MacOS itself is also an easy platform to learn, especially if you're used to iOS and iPadOS.

That brings up another point: iPhone users may want to consider Macs because of the seamless integration with Apple's other platforms. You can't respond to iMessage conversations easily or hop into FaceTime chats on Windows PCs, but doing so is simple on Macs. (Microsoft's Phone Link app lets you send iOS users individual texts, but not media or group chats.) Android users, meanwhile, may be better off with Windows, as Phone Link can make calls, synchronize all your texts and also access your phone's photos.

As for whether you’ll want a PC with a dedicated Copilot AI button on the keyboard, that depends on how often you see yourself using Microsoft’s generative tools. Given we’re only just seeing the first slate of AI PCs, it would be wiser to wait out the hype and see what improvements might come over time.

And what about ChromeOS? Chromebooks are a smart and (typically) inexpensive way to browse the web and hop on a few video chats, but they're not the best choice as your primary computer. There aren't many apps or games that work offline, and they also don't work with powerful software suites like Adobe's (you can use the stripped-down Adobe Express and Photoshop online tools, though).

Chromebooks are great secondary machines to use alongside a more powerful Mac or PC, and they're popular in schools because they're cheap and easy for IT workers to manage. And if all you need is web access, or a notebook for a kid, a Chromebook might be enough.

If, for some reason, you’re looking for a powerful ChromeOS system, there are also Chromebook Plus models to consider. These machines sport faster processors and more RAM than typical Google notebooks, and they can also tap into a few of the company’s online AI features, like AI image generation and photo processing.

These days, most laptops ship with a few USB-C ports, which can handle both charging and speedy data transfers. Apple's MacBooks also include a separate connection for MagSafe power, and you'll find custom power connections on some PCs like Microsoft's Surface. Older USB Type-A connections are less common now, but they still pop up in systems like HP's Spectre x360 14, as well as many models from ASUS.

If you're a fan of wired headphones, it's worth keeping a close eye on headphone jack availability. Many lightweight laptops, like Dell's XPS 13, don’t have the 3.5mm socket entirely. They usually include a USB-C to 3.5mm adapter, but that's a clunky solution, and it also takes up a USB port. Sure, most people use wireless earbuds and cans today, but it's still helpful to have a wired one around for when those devices run out of juice.

Most laptops in 2024 offer Wi-Fi 6 or 6E and Bluetooth 5.0 or later, which should mean faster and more stable connections if you have compatible routers and devices. While Wi-Fi 7 routers have started appearing, that spec hasn't made its way into laptops yet. As for cellular coverage, there are notebooks like the Surface Pro 9 and Samsung Galaxy Book models that offer integrated 5G. But from our testing, that feature may not be worth the cost of a separate data plan. Instead, you could tether to your smartphone or invest in a wireless hotspot that can keep multiple devices online.

So how portable do you want your laptop to be? That's the ultimate question you need to ask when choosing between various screen sizes. 13-inch machines have become a solid starting point for most shoppers — it's enough real estate for the majority of tasks like emailing and writing, and it also helps keep machines relatively light (typically between two to three pounds). Thanks to manufacturing advancements, these dainty machines sometimes even come with larger screens (the smaller MacBook Air actually has a 13.6-inch display).

If you have trouble seeing fine text, we’d recommend going for a display larger than 13 inches. ASUS’s Zephyrus G14 is a solid 14-inch option for gamers, and we’re also seeing more productivity-focused machines aim for that size, like the XPS 14 and MacBook Pro. While 14-inch notebooks are a bit heavier than 13-inch models, coming in between three to four pounds, their screens are noticeably roomier.

For artists, or anyone else who needs a large canvas, a 15-inch laptop may make the most sense. They typically weigh between 3.5 and 4.5 pounds, but that extra heft may be worth it to fit wider video editing timelines or Photoshop windows. And, as you'd expect, you'll also pay a bit more for a 15-inch notebook compared to smaller ones (the 15-inch MacBook Air starts at $1,299, while the smaller model goes for $999). PC makers are also replacing 15-inch systems with 16-inch versions, which will give you even more space to work.

You can still find laptops with 17-inch or 18-inch screens, but those are typically gaming systems or souped-up workstations. They're not meant for mere computing mortals.

A laptop's battery life depends on several factors: The power draw from the screen and other hardware, the optimizations used to avoid unnecessary power drain, and, of course, the size of the actual battery. One of our favorite systems, the Dell XPS 13, lasted 13 hours and 15 minutes in the PCMark 10 battery benchmark. In real-world testing, I was able to use it for a day and a half without needing a recharge. The MacBook Air 13-inch, meanwhile, lasted 20 hours in our benchmark and kept running for more than two work days of my typical workflow. In general, you should expect a modern laptop to last at least eight hours.

If battery life is your absolute priority, I'd strongly suggest looking at Macs over Windows PCs. Apple's M-series chips are essentially mobile hardware, with all of the power efficiency you'd expect from something originally designed for phones. Qualcomm’s upcoming Snapdragon chips could help Windows PCs compete with Apple’s astonishing battery life, but we’ve yet to see those in action. Chromebooks also typically get decent battery life (as long as you don’t overstuff them with power-draining tabs).

A laptop's refresh rate refers to the amount of times its screen is cycled every second. Modern displays like IPS LCDs and OLEDs support 60Hz refresh rates at a minimum, but we're seeing more devices offering 120Hz, 240Hz and beyond. The higher the number, the faster the screen is refreshed, which ultimately leads to a smoother experience while mousing around or scrolling through web pages. (If you want to get a sense of what a slow refresh rate looks like, just grab an e-reader like the Kindle and try to flip between book pages.)

While high refresh rates used to be reserved for gaming laptops, nowadays we're seeing more mainstream machines like the XPS 13 offer 120Hz (or variable rates that move between 60Hz and 120Hz). If there's one knock against the MacBook Air, it's that it's still stuck at 60Hz.

If you’re buying a new laptop, you’ll want to make sure it’s powered by the latest CPUs. For Windows PCs, that includes Intel’s Core Ultra chips for thin-and-light machines or the 14th-gen HX chips for beefier systems. The Core Ultra series have NPUs for handling AI tasks, while the HX hardware does not – they’re based on Intel’s previous chip architecture, and they’re more focused on delivering raw horsepower. Intel's older 13th-gen and 12th-gen laptop chips also don't have NPUs, so keep that in mind if you're looking at used systems.

You'll also see AMD's Ryzen 8000 and 9000 chips in plenty of new systems like the ASUS Zephyrus G14 and Razer Blade 14. Those CPUs mainly target gaming laptops and high performance systems, while you'll still find AMD’s older Ryzen 7000 chips in ultraportables. AMD's main advantage is that its chips also include Radeon graphics, which are far more capable than Intel's Arc hardware (though those are getting better).

Qualcomm’s new Snapdragon X Elite and X Plus are also an option in Copilot+ PCs (more on those below). Since they’re based on mobile chip designs, they’re likely also more power efficient than AMD and Intel’s hardware. In the past, we’ve avoided recommending Snapdragon chips because they led to a slow and frustrating Windows experience. But Microsoft claims it’s rebuilt Windows 11 around Snapdragon’s Arm-based architecture, which should lead to far faster performance and better app compatibility.

As for Apple's laptops, you'll be choosing between the M3, M3 Pro and M3 Ultra, each of which is progressively more powerful. Apple is also keeping its older M2 chip around for the $999 MacBook Air, which is still a solid performer for the price. Apple’s M4 chip made its debut in the recent iPad Pro, but it’s not in any laptops yet (and it likely won’t be until the end of 2024).

A GPU, or graphics processing unit, is the component that communicates directly with a laptop's display. Laptop CPUs all have some form of integrated GPU: Intel has either its standard graphics or beefier Arc hardware, while AMD's chips include fast Radeon mobile graphics. If you want to play demanding games at high speeds (measured in frames per second, or fps), or if you need some extra power for rendering video or 3D models, you can configure a laptop with a dedicated GPU like NVIDIA's RTX 40-series hardware or AMD's Radeon RX 7000. Just be sure to leave room in your budget if you want a powerful GPU, as they typically add $300 or more to the cost of a laptop.

Apple's M-series chips, meanwhile, have GPU cores that can perform as well as NVIDIA’s and AMD's lower-end dedicated GPUs. That's quite the accomplishment for systems like this (especially the MacBook Air and 14-inch MacBook Pro), and it's another reason we highly recommend Apple's notebooks.

Simply put, an AI PC is a computer equipped with a neural processing unit (NPU), which is designed to handle AI-related tasks. Much like how GPUs tackle heavy-duty gaming and rendering workloads, NPUs are designed to handle the complex math necessary for AI workloads. They’re also far more power efficient than CPUs or GPUs, which could lead to better battery performance in laptops. While many factors go into NPU performance, for the most part we measure their potential speed by TOPS (tera operations per second).

We were primed for AI PCs in 2024 based on the chips Intel and AMD announced late last year. Intel unveiled its "Core Ultra" CPUs in December, its first to include an NPU for AI work. AMD also announced its Ryzen 8040 AI mobile chips that month (and it couldn't help but say they were faster than Intel's new hardware). But in May, Microsoft announced its Copilot+ initiative, which is pushing major PC makers to deliver premium AI PCs with specifications including 16GB of RAM, 256GB SSDs and NPUs with at least 40 TOPS of AI performance.

Copilot+ is more than just a marketing term: Microsoft is also launching AI-powered features in Windows 11 that take advantage of powerful NPUs. That includes Recall, which can help you locate anything you’ve done on your PC (whenever it finally launches), as well as Cocreator in Paint, which can generate AI images based on text prompts and doodles.

If you buy an AI PC that isn’t Copilot+ certified, you’ll still be able to use some features like Windows Studio Effects, which can blur your background in video calls or keep you in frame. Developers like Adobe and Audacity are also building features into their apps that can take advantage of NPUs.

At the time of this post, Chromebook Plus notebooks can also access a few of Google’s online AI features, like image generation and photo processing.

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This Apple laptop is just a larger version of the 13-inch M3 MacBook Air. It's still quite portable at 3.3 pounds, and some will appreciating having just a tad more screen real estate all the time. Configuration options are the same as well; you can spec out the 15-inch Air with up to 24GB of RAM and 2TB of storage. But considering it starts off $200 more than the smaller model, it's primarily best for those who absolutely need a larger screen and are willing to pay for it.

Aside from its lovely OLED screen, the ASUS Zenbook 14 OLED doesn't stand out from the crowded laptop field in any way. It just looks dull and boring, especially compared to the strikingly beautiful ASUS Zephyrus G14, which also came out this year. While you can probably find the Zenbook 14 for a decent price, I'd recommend holding out for something with a bit more personality (and with a less wobbly screen hinge).

The Razer Blade has almost everything you'd want in a 14-inch gaming notebook, but it's far pricier than the Zephyrus G14 on this list, and it doesn’t even have an SD card reader. It would be a solid competitor once its price falls a bit, and it's certainly a great option if you just have to have a jet-black laptop.

Framework gave its modularity magic to the Laptop 16, delivering a gaming notebook where almost every single component is user replaceable. But you'll have to pay a pretty penny to snag it with upgraded hardware, and its optional Radeon 7700S GPU was surprisingly slow.

The Alienware m16 r2 has been revamped with a slimmer case, but it’s otherwise a fairly typical gaming laptop. It’s a solid option for Alienware fans, but you’ll find better hardware and deals elsewhere.

The Zenbook Duo is a fascinating dual-screened notebook, and according to my colleague Sam Rutherford it’s the first of its kind that’s worth buying. But its unique hardware isn’t really meant for mainstream consumers, and Windows 11 still doesn’t support multi-screen setups well enough to make full use of the Zenbook Duo’s ample canvas.

Dell’s XPS 16 is big and beautiful, but it’s far too expensive compared to the competition. Plus, it uses a capacitive row of function keys that you basically can’t see under bright light and has too few ports for a machine of this size.

See Also:

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It’s hard to come up with an average battery life for laptops, since that will ultimately depend on what you’re doing with them. An ultraportable like the MacBook Air that sips power can last around 20 hours in our battery benchmark, and around two full work days of real-world usage. But a gaming laptop may last only a few hours if you’re actively playing something while on battery. At this point, Macs are delivering far better battery life than PCs, thanks to Apple’s Silicon chips, but Microsoft claims Copilot+ systems with Qualcomm chips will also get over 20 hours of batter life.

The more RAM you have, the more things your computer can do simultaneously. For that reason, we recommend buying PCs and Macs with at least 16GB of RAM. That gives you enough memory to have several applications open at once, as well as web browsers filled with RAM-hogging tabs. Many PC games also require at least 16GB of RAM. While you could use a system with 8GB of RAM for basic tasks, you’ll quickly run into slowdowns and error messages as your apps stack up. Many laptops, especially ultraportables, don’t let you upgrade RAM, too – so you’ll have to buy an entirely new computer if you didn’t equip enough memory at the start.

If you’re a hardcore gamer, programmer or planning to render videos or 3D models, then you may want to go for 32GB of RAM or more. And if you just need a secondary laptop for lighter work – perhaps a no-frills system for writing – then you can probably get by with 8GB. Just be sure to keep those browser tabs in check.

There is no one-size-fits-all solution when it comes to laptop storage. You’ll typically find configurations between 256GB and 1TB SSDs (solid state drives) on most laptops, and I’d recommend most people get at least 512GB. That’ll be enough space for large apps, music and video files without stressing your system too much. If you’re a media hoarder, or want to play a ton of games, then it’s definitely worth getting a 1TB SSD.

If you’ll mainly be streaming your shows and music, and would rather invest in RAM or other hardware, then 256GB of storage would be serviceable. I’d recommend staying away from any machine with 128GB of storage though. Most of that will be taken up by the operating system, and you’ll likely run into issues cramming in large apps after a few months.

We recommend springing for extra built-in storage or investing in a portable SSD for backing up your most important files. It's also worth noting that Chromebooks tend to come with less built-in storage — 32GB, 64GB or 128GB — since ChromeOS encourages users to save their files in the cloud rather than on the device. In that case, 128GB is plenty.

You can expect to spend between $1,000 and $1,800 for a typical 13-inch laptop today. As I explained above, you'll pay more if you want to stuff in more RAM or better GPU hardware. But you can also find deals below $1,000 if you look for refurbished or older-generation models.

Simply put, macOS is the operating system in all of Apple's notebooks and desktops, while Windows powers the vast majority of PCs. You'll also find Chromebooks running Google's ChromeOS, but those are basically just web browsers running on top of Linux.

Debating the differences between Windows and Macs is something PC nerds have been doing since the '80s, so we won't be declaring a winner here. There are some small, negligible distinctions, like using a Command versus a Control key, how file explorers work and concerns about viruses and security. For the most part, those are minor issues or have become moot thanks to better built-in security.

But if you care more about playing the newest games, you'll want to have a Windows system. If you're more focused on creative apps, like Photoshop, Premiere and Final Cut Pro, then macOS may be a better fit (especially if you're running an iPhone).

There is no single "best" laptop brand, but judging from this guide alone, we're generally impressed by notebooks from Apple, Dell and ASUS. They all offer fast, reliable and sturdy machines. HP also makes some eye-catching devices if you want an option that’s the most aesthetic. Those four brands, along with Lenovo and Acer, dominate laptop sales worldwide. We'd avoid systems from any retail store brands, or companies that don't have a major presence in the US.

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Product

Tested configuration

Tested battery life

Rated battery life

Apple MacBook Air M3 (13-inch)

Apple M3, 16GB RAM, 512GB SSD

21 hours

Up to 18 hours

Dell XPS 13

Intel Core Ultra 7 155H CPU, 16GB RAM, 512GB SSD

13 hours

Up to 18 hours

ASUS ROG Zephyrus G14

AMD Ryzen 9 8945HS, 32GB RAM, 1TB SSD, NVIDIA GeForce RTX 4070

7.5 hours

10 hours

Lenovo IdeaPad Flex 5

13th-gen Intel Core i3, 8GB RAM, 128GB storage

6 hours

10 hours

HP Pavilion Aero

AMD Ryzen 5800U, 16GB RAM, 512GB SSD

Up to 9.75 hours

Up to 10.5 hours

Apple MacBook Pro M4 (14-inch)

Apple M4, 16GB RAM, 512GB SSD

34 hours

24 hours

HP Spectre x360 14

Intel Core Ultra 7 155H, 32GB RAM, 2TB SSD

5 hours

Up to 13 hours

Lenovo ThinkPad X1 Carbon Gen 1

Intel Core Ultra 7 165U, 32GB RAM, 512GB SSD

Up to 13 hours

"All day battery life"

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November 2024: Updated to include the M4-powered MacBook Pros.

August 2024: Updated to include the Lenovo ThinkPad X1 Carbon Gen 12.

June 2024: Updated with more information about current AI PCs, Microsoft’s Copilot+ initiative and the latest CPUs from Intel, AMD and Qualcomm. We’ve also added a FAQ query around RAM and updated the “Other laptops we’ve tested” section to include the Alienware m16 r2, Dell XPS 16 and ASUS Zenbook Duo.

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This article originally appeared on Engadget at https://www.engadget.com/computing/laptops/best-laptops-120008636.html?src=rss




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Bormioli Pharma partners with Chiesi to supplypackaging in Carbon Capture PET

Bormioli Pharma has announced a partnership with Chiesi, an international, research-focused biopharmaceutical company (Chiesi Group), to supply Carbon Capture PET bottles.




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Let African Communities Manage Their Climate Adaptation Plans

Outside groups often offer their solutions for climate adaptation in Africa. But the best people to manage the climate crisis are the people in those communities themselves. For climate adaptation to succeed in Africa, let communities and local leaders show the way




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Making the Case for Climate Adaptation: A Conversation with Richard Zeckhauser

Eminent Harvard economist Richard Zeckhauser presented arguments for additional climate adaptation measures in the latest episode of “Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program.” The podcast is produced by the Harvard Environmental Economics Program.





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How we built Google Meet’s adaptive audio feature

Here's how we built adaptive audio in Meet, which transforms multiple laptops in close proximity into a unified audio system so you can create ad-hoc meeting spaces IRL.




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Taishi Mori's Asoko de Hataraku Musubu-san Series to End in 2 Chapters

Manga about sales representative who likes condom researcher Musubu-san launched in 2017




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Manga Adaptation of Akinari Asakura's Rokunin no Usotsuki na Daigakusei Novel Ends

Keiga Ōsawa's Rokunin no Usotsuki no Daigakusei: Plus One manga launched in 2022




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Stage mom of 16-year-old divorces husband via email, CC's his entire family and friend group: '[He's] unable to adapt to any change'

There's divorce, and then there's burning every bridge you've ever built! This stage mom of a 16-year-old is sharing her story about what happened when she and her husband decided to call it quits via email, and it is a messy story. 

I suppose every divorce is messy in its own way. Some couples face cheating allegations, with one partner losing trust in their spouse. Others realize they're just not compatible anymore, and have different life goals. And of course, it's always more complicated when family is involved, whether that's having a bunch of kids or having parents who live at home (or both). 

It's not like you can totally keep the public out of the loop when you divorce your spouse. You'll have to pack up everything you own and move, sign legal documents, and face big life changes. Still, the way this stage mom went about it had people on the r/AITAH subreddit calling her out for her behavior. Check out the full story below and see if you side with her or her husband. 

Up next, read about these employees who got fired almost as soon as they started the job, like one dude who refused to wear safety gear, telling the supervisor "no" to his face! 




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Is this the final chapter of the Sue Gray saga?

The government has confirmed Sue Gray will not take up her post as the PM's envoy to the nations and regions.




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Young England face 'baptism of fire'

England's hockey squad is going "in at the deep end" at the Champions Trophy in Australia, says coach Jason Lee




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Sensory Adaptations Make Dental Visits Pleasant for Autistic Children

Autistic children exhibited significantly decreased sympathetic activity and increased relaxation in a sensory-adapted dental environment (SADE) during





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Ancient Eastern Arabians' Malaria Adaptation Unveiled

Residents of ancient Eastern Arabia seem to have acquired resistance to medlinkmalaria/medlink after the introduction of agriculture in the region approximately five thousand years ago.




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Buy Gorgeous Wedding Sarees to Capture the Tradition of Elegance and Beauty

Every girl has a desire to look her best on the day of her wedding. After all marriage is the most important day in any girl's life. The day when...




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Rural livelihoods in India, climate change adaptation for rural poor in India - NRMC

NRMC India was established in 2004 as a wholly owned subsidiary of DD International, the contracting agency for the UK Government’s Department of International Development (DFID), The European Community, The World...




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I feel privileged and honoured to captain Australia, says Inglis

After being named as Australia's captain for the third ODI and subsequent T20Is against Pakistan, wicketkeeper-batter Josh Inglis said he feels really privileged and honoured to be entrusted with the leadership job.




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KGF: Chapter 2 Posters

Here is the first look posters from Rocking Star Yash's KGF: Chapter 2.




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'Ageing gracefully': Kareena Kapoor goes bold in bikini; captures shirtless Saif Ali Khan in Maldives

Taking to her Instagram handle, Kareena shared photos and wrote, "Saturday selfies with one thrown in of the husband." In the photos, Kareena opted for no-makeup look as she flaunted her natural beauty. Saif Ali Khan looked handsome in neon colour pants.




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In a global first, NTPC plant starts converting captured CO2 into methanol

Government-owned power giant NTPC announced on Friday that in "a major groundbreaking achievement," it has been "successful in the synthesis of CO2 captured from flue gas with hydrogen produced from a PEM electrolyser, which was then converted into methanol at NTPC's Vindhyachal plant."




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'Your honesty makes me...': Parineeti Chopra pens filmy wish for husband Raghav Chadha; captures unseen moments

Parineeti used an audio that spoke about how two opposite people fall in love. She used pictures and videos, which went along with the video and also penned a heartfelt note for her husband.




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Just call back the Indian Captain!

Just call back the Indian Captain!It is national shame followed by ongoing IPL cheer leading scam enveloping national pride!


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Direct ocean capture may be the next frontier for carbon removal

Amsterdam-based Brineworks, a company specializing in seawater electrolysis technology, says its innovative method is expected to cost under $100 per ton of CO2 at scale.

© 2024 TechCrunch. All rights reserved. For personal use only.





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National Highway Authority Of India vs Rajesh Kaptyaksh on 12 November, 2024

IN THE HIGH COURT OF HIMACHAL PRADESH, SHIMLA Arbitration Appeal No.9 of 2024 along with Arbitration Appeal Nos.86 & 88 of 2024 Date of decision: 12.11.2024

1. Arbitration Appeal No.9 of 2024 National Highway Authority of India. ...Appellant.

Versus Rajesh Kaptyaksh. ...Respondent. 2. Arbitration Appeal No.86 of 2024 National Highway Authority of India. ...Appellant. Versus Narain Singh. ...Respondent. 3. Arbitration Appeal No.88 of 2024 National Highway Authority of India. ...Appellant. Versus Babu Ram. ...Respondent. Coram:




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North Korean Missile Captures Images of Earth From Space

North Korea released images of earth from space, which it claims were captured by a camera attached to the Hwasong-12 intermediate-range ballistic missile it launched Sunday. The weapon tested appears to be one of the country’s most powerful in years. Photo: KCNA/KNS/AFP




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Border-Gavaskar Trophy: Jasprit Bumrah To Captain India In 1st Test, If...

The Indian men's cricket team is gearing up for the first Test of the 2024-25 Border-Gavaskar Trophy against Australia. This match will be held at Optus Stadium in Perth, starting on November 22. There is a possibility that Jasprit Bumrah might




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Fan Asks Suryakumar Yadav 'Why India Is Not Travelling To Pakistan'? Here's What T20 Captain Said

The Board of Control for Cricket in India (BCCI) has decided against sending the Indian cricket team to Pakistan for the ICC Champions Trophy 2025. This decision has sparked a significant debate among fans and former cricketers. The BCCI cited 'security




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Maximise Battery Health for Smartphones and Laptops with These Effective Charging Tricks

In the digital age, battery health is crucial for tech enthusiasts. Devices like smartphones and laptops are indispensable, yet their batteries degrade over time. Understanding best practices for charging can extend battery life significantly. This article delves into advanced strategies to




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Apple Dominates AI PC Market as Mac Computers Capture 60% of AI PC Shipments in Q2 2024: Report

Global shipments of artificial intelligence (AI) PCs saw a significant rise in Q2 2024, as reported by market research firm Canalys. Over 8.8 million AI-capable computers were shipped, with Apple's Mac computers making up the majority. The adoption of these devices




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IND vs SA 3rd T20 Free Live Streaming: When, Where And How To Watch India vs South Africa Match Live Telecast On TV, Mobile Apps And Laptop?

India and South Africa will face off in the series-deciding 3rd T20I at Centurion on November 13. Scroll down to check complete live streaming details of the match. 




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Nafion coated nanopore electrode for improving electrochemical aptamer-based biosensing

Faraday Discuss., 2024, Advance Article
DOI: 10.1039/D4FD00144C, Paper
Open Access
Grayson F. Huldin, Junming Huang, Julius Reitemeier, Kaiyu X. Fu
Nafion blocks the aptamer's active sites from planar gold, while the aptamer retains its redox activity from nanoporous gold.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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