Megan Schutt has no time for the same-sex-marriage haters and her bold online personality is ensuring she is grabbing her chance on the national stage ahead of another ground-breaking WBBL campaign.

When Kalgoorlie's Super Pit gold mine started 30 years ago, there was not a single female employee. Today, the workforce is 30 per cent women, nearly double the mining industry average.

Youth unemployment has soared as a result of the coronavirus, prompting some young people to start their own businesses to try and claw their way back into the workforce.

Investors are calling for entrepreneurial skills to be taught in schools to help prepare children for the future 'gig-based' economy.

Mandatory drug and alcohol testing for elected representatives could soon be a reality for a second Tasmanian council, but the proposal is proving to be divisive with one councillor labelling it "highly invasive".

As bushfire conditions ease around Tasmania this weekend, the firefighter's union wants laws to back volunteers leaving work in an emergency as the bushfire season extends to as long as six months.

Balancing the scales of justice is an onerous responsibility for legal professionals when the freedom, futures, families, and finances of their clients are on the line.

A threat to close the Yallourn coal-fired power station earlier than planned has some asking whether Australia should look to Germany as a model for transition.

The national anthem has been rewritten and performed for the first time in Alice Springs by a group that says it should be more inclusive of all Australians.

The newly sworn-in Water Minister David Littleproud is to order ACCC inquiry into water trading in southern basin.

Murderer Michael Cardamone, who tortured and callously killed Victorian woman Karen Chetcuti-Verbunt in 2016, has his life jail term upheld by appeal judges who say the "dreadful punishment" is fit for "a dreadful crime".

A drenching is on its way for Queensland, with parts of the state set to receive their best rainfall in months today and on Saturday, with the potential for severe thunderstorms and damaging hail in some areas.

A Gosford judge describes Troy Johnson, a father of three who stalked and sexually assaulted a 12-year-old girl as she walked to school, as "hideous" and "depraved" before jailing him for almost 30 years.

The Murray-Darling Basin Authority will be investigated over its release of satellite images appearing to show dams filling with water, which David Littleproud labelled "premature" and "incorrect".

Grant personally responded to a video of the boy recreating his character Phoenix Buchanan's musical number from the film.

(United States First Circuit) - In a dispute arising out of a merger agreement in which one party agreed to indemnify the other against a purely hypothetical tax loss, involving the issue of whether the prepayments and credits, and resulting tax refunds, affect the tax indemnification obligation of the sellers, the District Court's judgment in favor of sellers is vacated and remanded for further proceedings where; 1) the indemnification provision is ambiguous as to how the tax refunds affect the indemnification obligation of the sellers; and 2) the parties' arguments about the purpose and negotiating history of the provision cannot be resolved without the aid of a fact-finder.

Stock Broker-turned-entrepreneur Alan Chan Sets Sights On Investing In Not Just Kpop, But The "Asian Pop" Entertainment Business

EMI UNIVERSAL MUSIC GROUP ASCAP CURROPTION

But the sudden spike in demand has led to material shortages andcost increases.

Independent Record Labels Now Represent 38.4% Of Global Recorded Music Market Share In 2016 With Global Revenues In Excess Of $6bn

The U.S. unemployment rate hit 14.7% in April, the highest rate since the Great Depression, as 20.5 million jobs vanished in the worst monthly loss on record. The figures are stark evidence of the damage the coronavirus has done to a now-shattered economy.

Nicki Micheaux learned about how to deal with depression.

“This first issue is all about presence and gratitude.”

Elizabeth Warren discusses access to capital for minorities.

The baker named the dessert company after her grandparents.

„Angguruk–Wamena–Angguruk!“ křičí do vysílačky mladík z kmene Jaliů v odletové hale pralesního letiště ve vesničce Angguruk, v srdci Západní Papuy, indonéské části Nové Guiney. Pravda, termín odletová hala je pro malou boudu s váhou, na níž se v Česku váží brambory, se stolem, židlí a jedinou vysílačkou poněkud nadnesený, ale tady, mezi Papuánci, není asi nic normální.

The PHP development team announces the immediate availability of PHP 7.2.30. This is a security release.All PHP 7.2 users are encouraged to upgrade to this version.For source downloads of PHP 7.2.30 please visit our downloads page, Windows source and binaries can be found on windows.php.net/download/. The list of changes is recorded in the ChangeLog.

The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide. Although gene-environment interactions have been implicated in the etiology of several disorders, the impact of paternal and/or maternal metabolic syndrome on the clinical phenotypes of offspring and the underlying genetic and epigenetic contributors of NAFLD have not been fully explored. To this end, we used the liver-specific insulin receptor knockout (LIRKO) mouse, a unique nondietary model manifesting 3 hallmarks that confer high risk for the development of NAFLD: hyperglycemia, insulin resistance, and dyslipidemia. We report that parental metabolic syndrome epigenetically reprograms members of the TGF-β family, including neuronal regeneration–related protein (NREP) and growth differentiation factor 15 (GDF15). NREP and GDF15 modulate the expression of several genes involved in the regulation of hepatic lipid metabolism. In particular, NREP downregulation increases the protein abundance of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) and ATP-citrate lyase (ACLY) in a TGF-β receptor/PI3K/protein kinase B–dependent manner, to regulate hepatic acetyl-CoA and cholesterol synthesis. Reduced hepatic expression of NREP in patients with NAFLD and substantial correlations between low serum NREP levels and the presence of steatosis and nonalcoholic steatohepatitis highlight the clinical translational relevance of our findings in the context of recent preclinical trials implicating ACLY in NAFLD progression.

Lamin A is a component of the inner nuclear membrane that, together with epigenetic factors, organizes the genome in higher order structures required for transcriptional control. Mutations in the lamin A/C gene cause several diseases belonging to the class of laminopathies, including muscular dystrophies. Nevertheless, molecular mechanisms involved in the pathogenesis of lamin A–dependent dystrophies are still largely unknown. The polycomb group (PcG) of proteins are epigenetic repressors and lamin A interactors, primarily involved in the maintenance of cell identity. Using a murine model of Emery-Dreifuss muscular dystrophy (EDMD), we show here that lamin A loss deregulated PcG positioning in muscle satellite stem cells, leading to derepression of non–muscle-specific genes and p16INK4a, a senescence driver encoded in the Cdkn2a locus. This aberrant transcriptional program caused impairment in self-renewal, loss of cell identity, and premature exhaustion of the quiescent satellite cell pool. Genetic ablation of the Cdkn2a locus restored muscle stem cell properties in lamin A/C–null dystrophic mice. Our findings establish a direct link between lamin A and PcG epigenetic silencing and indicate that lamin A–dependent muscular dystrophy can be ascribed to intrinsic epigenetic dysfunctions of muscle stem cells.

L’entité sécurité d’IBM (NYSE : IBM) a publié aujourd'hui son rapport X-Force Threat Intelligence Index 2020, qui souligne la façon dont les techniques des cybercriminels ont évolué après des décennies d'accès à des dizaines de milliards de données d'entreprises et de particuliers et à des centaines de milliers de failles logicielles. Selon le rapport, 60% des entrées initiales observées dans les réseaux des victimes ont exploité soit des données d’identification volées précédemment, soit des vulnérabilités logicielles connues, ce qui a permis aux attaquants de moins recourir à la ruse pour y accéder.

Des avancées technologiques qui permettent d'accroître encore le leadership du mainframe et en font le système incontournable pour traiter les données critiques des entreprises

IBM, rejoint par plus de 100 partenaires commerciaux, lance le réseau IBM Digital Marketing dans le cloud et aide les directeurs marketing (CMO) et leurs équipes à intégrer plus rapidement et plus facilement de nouveaux services marketing, afin de mesurer et d’améliorer leur efficacité en temps réel.

IBM annonce de nouveaux services IT basés sur le Cloud pour aider ses clients à intégrer de façon rapide, facile et sécurisée les Macs au sein de leurs entreprises et dans leurs applications.

aufeminin.com a choisi la solution de Bouygues Telecom Entreprises pour sa simplicité d’utilisation et sa sécurité

Česká národní banka čeká propad české ekonomiky o 8 procent. Na předkrizovou úroveň se nedostane ani v příštím roce. Restart bude záviset i na tom, jak rychle lidé začnou utrácet. Napovědí příští měsíce, kdy se víc lidí bude hlásit na úřady práce.

U.S. Unemployment Reaches 14.7 Percent – Chart from Great Depression Shows Risks Ahead

By Pam Martens and Russ Martens: May 8, 2020 ~   The data is out this morning and it’s not pretty. Nonfarm payrolls collapsed by 20.5 million jobs in April and the unemployment rate rose to 14.7 percent. The United States is now seeing the worst unemployment rates since the Great Depression. We prepared the above chart from data available at the Federal Reserve Economic Data (FRED) archives at the Federal Reserve Bank of St. Louis. Following the stock market crash of October 29, 1929, it was not until August 1931 that the unemployment rate reached 15.01 percent. We’re now at 14.7 percent unemployment from a rate of 3.5 percent just two months ago in February. Consider using the chart above to figure out just how much cash on hand you need to maintain.

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Podřízení na něj spoléhají v časech dobrých i zlých. A když přijdou opravdové těžkosti, záleží často jen na jeho schopnostech, jak moc se podnik otřese, nebo zda padne úplně.

Firmy i finanční trhy mají za sebou první letošní kvartál. Bilance obou není z důvodu preventivních vládních opatření proti šíření nákazy covid-19 nikterak růžová. To potvrzuje i Partners index podílových akciových fondů.

Nová zákon „Lex voucher“ stanovil pravidla pro vypořádání cestovních kanceláří s klienty. Na problematické situace, které mohou být s koupeným zájezdem spojeny, jsme se zeptali advokáta Ondřeje Vokála.

The growls from the caged hyena reverberate through the room as Mohamed Sheikh Yakub slumps silently in a chair nearby, hoping the animal will frighten away the evil spirits he says have troubled him since his divorce.

In an effort to find a balance between protecting the significant investment in our cellular devices and protecting the planet, LifeProof has developed a phone case that sources materials diverted from the ocean and simultaneously supports organizations directly involved in providing safe water, protecting ocean life and maintaining river habitat. [...]

Just ran into this gem at a Facebook group for entrepreneurs and employment opportunities.

Client: Hello! My business partner and I are seeking a couple of talented writers for a new online magazine we are creating. This would be an unpaid intern position, but you can work remotely and this would also be a great opportunity to gain some exposure and writing experience. Message me if you’re interested for details.

The comment section was breathtaking. I made some popcorn and refreshed it all night.

In an interview, 17-year-old American pop star Billie Eilish discusses the stress of fame, a time she feared was a never-ending black hole and the best coping mechanism.