The coronavirus crisis has sent U.S. unemployment surging to 14.7 percent, a level last seen when the country was in the throes of the Depression ...

President Donald Trump says he resuscitated Barack Obama’s gasping economy and proceeded to build it to its strongest in generations. Now as record job losses mount across the country, the decline will bear his name in history as well.And those losses come just six months before the election.Presidents of both parties take credit for the economy when it’s roaring and are usually blamed when it fails, regardless of the circumstances of the downturn. An unemployment rate for April of 14.7 per…

Bhumi Pednekar believes female representation in cinema is extremely important to her

ISLAMABAD: The COVID-19 pandemic has created immediate challenges for institutions that serve affected communities, a study says.It was prepared by six academics associated with prestigious...

[[ This is a content summary only. Visit my website for full links, other content, and more! ]]

ISLAMABAD: The COVID-19 pandemic has created immediate challenges for institutions that serve affected communities, a study says.It was prepared by six academics associated with prestigious...

[[ This is a content summary only. Visit my website for full links, other content, and more! ]]

ISLAMABAD: The COVID-19 pandemic has created immediate challenges for institutions that serve affected communities, a study says.It was prepared by six academics associated with prestigious...

[[ This is a content summary only. Visit my website for full links, other content, and more! ]]

ISLAMABAD: The US unemployment rate hit 14.7 percent in April, the highest rate since the Great Depression, as 20.5 million jobs vanished in the worst monthly loss on record. The figures are stark evidence of the damage the coronavirus has done to a now-shattered economy.The losses, reported by...

There is a growing perception among the people of Karachi that they are being intentionally deprived of their fundamental rights by both the Pakistan Tehreek-e-Insaf -led federal government and the Pakistan Peoples Party -led Sindh government.Pak Sarzameen Party Chairman Syed Mustafa Kamal said...

Microchip Releases Version 2.1 of TimeProvider 4100 Timing Grandmaster

The program aimed to increase the role of women entrepreneurs in economic development and address constraints they and micro, small, and medium-sized enterprises (MSMEs) faced. The program had two components—a policy-based loan (PBL) and a financial intermediation loan (FIL) — each at $20.0 million. The program was supported by a technical assistance (TA) capacity building component of $0.6 million.

ADB's Women Entrepreneurs Finance Initiative (We-Fi) has been instrumental in empowering and creating opportunities for women-led small and medium entrepreneurs in Sri Lanka. Nelum's story is one of the testaments to this.

Section 58. Data EEPROM

AT25010B/AT25020B/AT25040B SPI Automotive Temperature Serial EEPROM Data Sheet

Approved project 53097-002 in Papua New Guinea.

Game theory helps calculate the probabilities of an outcome in adversarial situations, and we use several games as models – but now there’s one that can cover many situations

The latest figures from the Labor Department released on Friday showed the U.S. economy losing 20.5 million jobs in April, the steepest plunge in payrolls since the Great Depression. Colette Luke has more.

So what if Rudolph can’t really fly? He and the herd have some truly amazing evolutionary adaptations that could inspire new treatments for human diseases

The latest figures from the Labor Department released on Friday showed the U.S. economy losing 20.5 million jobs in April, the steepest plunge in payrolls since the Great Depression. Colette Luke has more.

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ABSTRACT

Mobile elements—plasmids and phages—are important components of microbial function and evolution via traits that they encode and their capacity to shuttle genetic material between species. We here report the unusually rich array of mobile elements within the genome of Arsenophonus nasoniae, the son-killer symbiont of the parasitic wasp Nasonia vitripennis. This microbe’s genome has the highest prophage complement reported to date, with over 50 genomic regions that represent either intact or degraded phage material. Moreover, the genome is predicted to include 17 extrachromosomal genetic elements, which carry many genes predicted to be important at the microbe-host interface, derived from a diverse assemblage of insect-associated gammaproteobacteria. In our system, this diversity was previously masked by repetitive mobile elements that broke the assembly derived from short reads. These findings suggest that other complex bacterial genomes will be revealed in the era of long-read sequencing.

IMPORTANCE The biology of many bacteria is critically dependent on genes carried on plasmid and phage mobile elements. These elements shuttle between microbial species, thus providing an important source of biological innovation across taxa. It has recently been recognized that mobile elements are also important in symbiotic bacteria, which form long-lasting interactions with their host. In this study, we report a bacterial symbiont genome that carries a highly complex array of these elements. Arsenophonus nasoniae is the son-killer microbe of the parasitic wasp Nasonia vitripennis and exists with the wasp throughout its life cycle. We completed its genome with the aid of recently developed long-read technology. This assembly contained over 50 chromosomal regions of phage origin and 17 extrachromosomal elements within the genome, encoding many important traits at the host-microbe interface. Thus, the biology of this symbiont is enabled by a complex array of mobile elements.

The corrinoid B₁₂ is synthesized only by prokaryotes yet is widely required by eukaryotes as an enzyme cofactor. Microalgae have evolved B₁₂ dependence on multiple occasions, and we previously demonstrated that experimental evolution of the non–B₁₂-requiring alga Chlamydomonas reinhardtii in media supplemented with B₁₂ generated a B₁₂-dependent mutant (hereafter metE7). This clone provides a unique opportunity to study the physiology of a nascent B₁₂ auxotroph. Our analyses demonstrate that B₁₂ deprivation of metE7 disrupts C1 metabolism, causes an accumulation of starch and triacylglycerides, and leads to a decrease in photosynthetic pigments, proteins, and free amino acids. B₁₂ deprivation also caused a substantial increase in reactive oxygen species, which preceded rapid cell death. Survival could be improved without compromising growth by simultaneously depriving the cells of nitrogen, suggesting a type of cross protection. Significantly, we found further improvements in survival under B₁₂ limitation and an increase in B₁₂ use efficiency after metE7 underwent a further period of experimental evolution, this time in coculture with a B₁₂-producing bacterium. Therefore, although an early B₁₂-dependent alga would likely be poorly adapted to coping with B₁₂ deprivation, association with B₁₂-producers can ensure long-term survival whilst also providing a suitable environment for evolving mechanisms to tolerate B₁₂ limitation better.

Pediatricians are encouraged to address male adolescent sexual and reproductive health on a regular basis, including taking a sexual history, discussing healthy sexuality, performing an appropriate physical examination, providing patient-centered and age-appropriate anticipatory guidance, and administering appropriate vaccinations. These services can be provided to male adolescent patients in a confidential and culturally appropriate manner, can promote healthy sexual relationships and responsibility, can and involve parents in age-appropriate discussions about sexual health.

OBJECTIVES:

To determine if in utero selective serotonin reuptake inhibitor (SSRI) or selective serotonin norepinephrine inhibitor (SNRI) exposure is associated with developmental vulnerability in kindergarten among children whose mothers were diagnosed with prenatal mood or anxiety disorder.

The Hippo pathway is an evolutionarily conserved signaling network that regulates organ size, cell fate, and tumorigenesis. In the context of organ size control, the pathway incorporates a large variety of cellular cues, such as cell polarity and adhesion, into an integrated transcriptional response. The central Hippo signaling effector is the transcriptional coactivator Yorkie, which controls gene expression in partnership with different transcription factors, most notably Scalloped. When it is not activated by Yorkie, Scalloped can act as a repressor of transcription, at least in part due to its interaction with the corepressor protein Tgi. The mechanism by which Tgi represses transcription is incompletely understood, and therefore we sought to identify proteins that potentially operate together with Tgi. Using an affinity purification and mass-spectrometry approach we identified Pits and CtBP as Tgi-interacting proteins, both of which have been linked to transcriptional repression. Both Pits and CtBP were required for Tgi to suppress the growth of the Drosophila melanogaster eye and CtBP loss suppressed the undergrowth of yorkie mutant eye tissue. Furthermore, as reported previously for Tgi, overexpression of Pits repressed transcription of Hippo pathway target genes. These findings suggest that Tgi might operate together with Pits and CtBP to repress transcription of genes that normally promote tissue growth. The human orthologs of Tgi, CtBP, and Pits (VGLL4, CTBP2, and IRF2BP2) have previously been shown to physically and functionally interact to control transcription, implying that the mechanism by which these proteins control transcriptional repression is conserved throughout evolution.