success Many Family Medicine Successful Interventions and Clinical Reviews for Common Illnesses By www.jabfm.org Published On :: 2020-03-16T09:31:37-07:00 Family physician researchers continue to provide assistance to improve family medicine care. Commentaries on social determinants of health lead off this issue. Next, we have several papers on successful interventions by clinicians and/or patients to improve diabetes control, and then other provide information on other practice interventions that make a difference in overall care. Drug advertising continues to mislead. There is costly and nonproductive overuse of specific types of care. Herein is also a Scoping Review of possible indices for determining timely initiation of advance care planning. The issue’s clinical reviews on use of transgender care, cervical myelopathy, and inhaled steroids for chronic obstructive pulmonary disease are pertinent, thorough, and timely. Full Article
success High-resolution carbon isotope stratigraphy of the Lower and Middle Ordovician succession of the Yangtze Platform, China: implications for global correlation By jgs.lyellcollection.org Published On :: 2020-05-04T02:10:48-07:00 The Lower and Middle Ordovician of the Yangtze Platform, China, is characterized by a sedimentary succession dominated by carbonate rocks. Three sections spanning the Nantsinkuan/Lunshan, Fenhsiang, Hunghuayuan, and Dawan/Zitai formations, corresponding to the Tremadocian–Dapingian in age, have been sampled for high-resolution 13C chemostratigraphy (542 samples in total). Our new 13C data reveal five tie-points with the potential for global correlation: (1) a positive 13C excursion in the lower Nantsinkuan Formation within the Tremadocian Rossodus manitouensis Zone; (2) an excursion with two peaks roughly within the late Tremadocian Paltodus ‘deltifer’ Zone; (3) a positive 13C shift in the lower Hunghuayuan Formation, within the early Floian Serratognathus diversus Zone; (4) a gradual positive 13C shift in the late Floian, ranging from the uppermost S. diversus Zone to the basal Oepikodus evae Zone; (5) a minor negative shift in the lower Dawan/Zitai Formation, within the early Dapingian Baltoniodus triangularis Zone. These excursions are herein used for correlation of the Yangtze Platform strata with successions from South China, North China, the Argentine Precordillera, North America and Baltica. From a palaeogeographical perspective the Gudongkou, Xiangshuidong and Daling sections represent depositional environments along an inner to outer ramp profile. 13C data from these sections show successively heavier (higher) 13C values with increasing depositional depth. This is interpreted as due to remineralization of organic carbon within the carbonate rocks. Supplementary material: Carbon and oxygen isotope data are available at: https://doi.org/10.6084/m9.figshare.c.4767080 Full Article
success The never ending success story of tranexamic acid in acquired bleeding By www.haematologica.org Published On :: 2020-05-01T00:05:41-07:00 Tranexamic acid (TXA) is an anti-fibrinolytic agent that acts by inhibiting plasminogen activation and fibrinolysis. Although its first clinical use dates back more than 50 years, this hemostatic agent is still the object of intense clinical and developmental research. In particular, renewed interest in TXA has arisen following evidence that it has a beneficial effect in reducing blood loss in a variety of medical and surgical conditions at increased risk of bleeding. Given this characteristic, TXA is currently considered a mainstay of Patient Blood Management programs aimed at reducing patients’ exposure to allogeneic blood transfusion. Importantly, recent large randomized controlled trials have consistently documented that the use of TXA confers a survival advantage in a number of globally critical clinical conditions associated with acute bleeding, including traumatic injury and post-partum hemorrhage, without increasing the thromboembolic risk. Full Article
success Ecological and Ontogenetic Components of Larval Lake Sturgeon Gut Microbiota Assembly, Successional Dynamics, and Ecological Evaluation of Neutral Community Processes [Microbial Ecology] By aem.asm.org Published On :: 2020-05-05T08:00:35-07:00 Gastrointestinal (GI) or gut microbiotas play essential roles in host development and physiology. These roles are influenced partly by the microbial community composition. During early developmental stages, the ecological processes underlying the assembly and successional changes in host GI community composition are influenced by numerous factors, including dispersal from the surrounding environment, age-dependent changes in the gut environment, and changes in dietary regimes. However, the relative importance of these factors to the gut microbiota is not well understood. We examined the effects of environmental (diet and water sources) and host early ontogenetic development on the diversity of and the compositional changes in the gut microbiota of a primitive teleost fish, the lake sturgeon (Acipenser fulvescens), based on massively parallel sequencing of the 16S rRNA gene. Fish larvae were raised in environments that differed in water source (stream versus filtered groundwater) and diet (supplemented versus nonsupplemented Artemia fish). We quantified the gut microbial community structure at three stages (prefeeding and 1 and 2 weeks after exogenous feeding began). The diversity declined and the community composition differed significantly among stages; however, only modest differences associated with dietary or water source treatments were documented. Many taxa present in the gut were over- or underrepresented relative to neutral expectations in each sampling period. The findings indicate dynamic relationships between the gut microbiota composition and host gastrointestinal physiology, with comparatively smaller influences being associated with the rearing environments. Neutral models of community assembly could not be rejected, but selectivity associated with microbe-host GI tract interactions through early ontogenetic stages was evident. The results have implications for sturgeon conservation and aquaculture production specifically and applications of microbe-based management in teleost fish generally. IMPORTANCE We quantified the effects of environment (diet and water sources) and host early ontogenetic development on the diversity of and compositional changes in gut microbial communities based on massively parallel sequencing of the 16S rRNA genes from the GI tracts of larval lake sturgeon (Acipenser fulvescens). The gut microbial community diversity declined and the community composition differed significantly among ontogenetic stages; however, only modest differences associated with dietary or water source treatments were documented. Selectivity associated with microbe-host GI tract interactions through early ontogenetic stages was evident. The results have implications for lake sturgeon and early larval ecology and survival in their natural habitat and for conservation and aquaculture production specifically, as well as applications of microbe-based management in teleost fish generally. Full Article
success Microbiome Predicts Blood-Cell Transplant Success [News in Brief] By cancerdiscovery.aacrjournals.org Published On :: 2020-05-01T00:05:26-07:00 A large international study found that the composition of the intestinal microbiome can predict clinical outcomes in patients undergoing allogenic hematopoietic-cell transplant (HCT) for blood cancers. The findings may help assess patients' transplantation-related mortality risk and aid in developing interventions to prevent or mitigate microbiome changes that affect HCT outcomes. Full Article
success Top Legal Tips for Successfully Investing in Vietnam By batdongsan.com.vn Published On :: 09:14 06/01/2015 With a population of about 90 million people, and one of the fastest growing economies in the world, Vietnam is proving to be an attractive place for foreign investors to do business. With a stable political environment and great economic potential, Vietnam is taking firm steps towards industrialization and modernization. Full Article
success World’s largest ever firework successfully explodes over Colorado By www.newscientist.com Published On :: Tue, 11 Feb 2020 12:43:58 +0000 Weighing around 1270 kilograms, the largest ever firework travelled at more than 480 kilometres and exploded over Steamboat Springs in Colorado Full Article
success All the power, no accountability. That's Trump's COVID success. By www.nbcnews.com Published On :: Thu, 07 May 2020 20:16:00 GMT Analysis: As the president declares victory over the coronavirus amid a rising death toll, his clear focus on extricating himself from responsibility becomes clearer. Full Article
success Basketball helped power Jets' Fant to football success By feeds.foxnews.com Published On :: Fri, 08 May 2020 13:03:47 GMT George Fant spent most of his college days at Western Kentucky shooting basketballs and grabbing rebounds as a physical power forward with big-time hoop dreams. Full Article 22538439-5d95-5f5d-86a4-f1489013254f fox-news/sports/nfl fox-news/sports/nfl/new-york-jets fnc fnc/sports article Associated Press
success War veteran, 99, applauded out of hospital after being successfully treated for Covid-19 By www.standard.co.uk Published On :: 2020-04-11T11:26:00Z Follow our live coronavirus updates HERE Coronavirus: the symptoms Full Article
success 'Success' as Covid-19 patient numbers in London fall by nearly 1,000 in week By www.standard.co.uk Published On :: 2020-04-20T10:16:00Z The sharp fall in the number of London patients in hospital with coronavirus has been hailed as a "success". Full Article
success Very high chance of successful coronavirus vaccine, says London trial lead By www.standard.co.uk Published On :: 2020-04-22T09:00:00Z Teams at Imperial and Oxford appeal to Londoners to join Covid-19 fight Full Article
success Success of lockdown may hamper vaccine trials, scientist says By www.standard.co.uk Published On :: 2020-04-24T12:45:12Z The success of the Government's shutdown measures to curb the spread of Covid-19 may hamper the process of gathering data to develop a vaccine, a scientist leading clinical trials has said. Full Article
success Lockdown messaging 'slightly too successful' with Britons scared to leave home once lifted, expert says By www.standard.co.uk Published On :: 2020-05-01T08:17:00Z Data shows Britons are fearful of relaxing social restrictions as Prime Minister Boris Johnson readies to publish 'road map' for easing lockdown Full Article
success Commercial space flights a step closer after successful Virgin Galactic spaceship trial in New Mexico By www.standard.co.uk Published On :: 2020-05-01T19:41:44Z Commercial space trips are a step closer to becoming reality after Virgin Galactic's spaceship took a glide and landed safely in the New Mexico desert. Full Article
success Yahoo News/YouGov poll: Most Americans deny Trump virus response is a 'success' — nearly half say Obama would be doing better By news.yahoo.com Published On :: Thu, 07 May 2020 09:43:16 -0400 The unfavorable comparison between the current president and his predecessor is one of the clearest signs to date of an emerging dynamic that will define the remainder of Trump’s term and the presidential election. Full Article
success HTC separates successful VR sales from struggling smartphone side By arstechnica.com Published On :: Thu, 30 Jun 2016 15:10:14 +0000 Spin-off subsidiary subsequently shan't subsidize sickly smartphone setup. Full Article Gaming & Culture business HTC steamvr vive
success Liverpool success and football stoppage may convince Jurgen Klopp to delay retirement, says Guillem Balague By www.standard.co.uk Published On :: 2020-05-01T19:35:00Z Liverpool's success combined with the current enforced break from football may have convinced Jurgen Klopp to prolong any future retirement plans, according to football journalist Guillem Balague. Full Article
success How a dating site aids liver transplant success By www.heraldsun.com.au Published On :: Wed, 11 Jan 2017 12:00:00 GMT THE same process used by an international matchmaking site to pair lonely hearts may hold the key to improving the outcomes of liver transplants. Full Article
success Victorian suppression of COVID-19's spread 'more successful than maybe we could have even imagined' By www.abc.net.au Published On :: Mon, 20 Apr 2020 09:28:16 +1000 Chief Health Officer Brett Sutton reveals theoretical modelling which suggests 36,000 people could have been killed by coronavirus in Victoria if no physical-distancing measures were put in place. Full Article COVID-19 Diseases and Disorders Health Education Schools Industry Business Economics and Finance Hospitality Government and Politics Federal Government Politics and Government State of Emergency States and Territories Respiratory Diseases
success Concerns over who gets access if a successful coronavirus vaccine is discovered By www.abc.net.au Published On :: Thu, 23 Apr 2020 04:57:42 +1000 As numerous laboratories race to develop a coronavirus vaccine, the Coalition for Epidemic Preparedness Innovation warns that it can't just be available to people in wealthy countries. Full Article Chemicals and Pharmaceuticals Health COVID-19 Epidemics and Pandemics Medical Research Vaccines and Immunity
success 7 Successful Companies With Unique Concepts That Ratan Tata Has Invested In By www.mensxp.com Published On :: Fri, 08 May 2020 13:34:52 +0530 Full Article Features
success 5 Indian Businessmen Who Believed & Invested In Start-Ups Which Turned Into Successful Businesses By www.mensxp.com Published On :: Fri, 08 May 2020 19:41:07 +0530 Full Article Features
success Bio Roundup: Acquisitive Alexion, CRISPR on COVID, C. diff Success & More By xconomy.com Published On :: Fri, 08 May 2020 14:33:23 +0000 Alexion Pharmaceuticals CEO Ludwig Hantson has made no secret that he wants to diversify his company’s drug portfolio and he has shown willingness to open the corporate checkbook to accomplish that goal. Last October, Alexion (NASDAQ: ALXN) struck a $930 million deal to acquire Achillion Pharmaceuticals, a biotech whose lead drug complements the Boston company’s […] Full Article Boston blog main Boston top stories Boulder/Denver blog main Boulder/Denver top stories Detroit blog main Detroit top stories Europe blog main Europe top stories Indiana blog main Indiana top stories National National blog main National top stories New York blog main New York top stories Raleigh-Durham blog main Raleigh-Durham top stories San Diego blog main San Diego top stories San Francisco blog main San Francisco top stories Seattle blog main Seattle top stories Texas blog main Texas top stories Wisconsin blog main Wisconsin top stories AbbVie Achillion Pharmaceuticals Akcea Therapeutics Alexion Pharmaceuticals Alnylam Pharmaceuticals andexanet alfa Antibe Therapeutics Apotex Arrowhead Pharmaceuticals AstraZeneca Avrobio Axcella Health. Newron Pharmaceuticals basal cell carcinoma BioMarin Pharmaceutical BioNtech Biotech blastic plasmacytoid dendritic cell neoplasm Bristol-myers Squibb Bruce Given cancer Cardiff Oncology Carla Poulson Celgene Cell Therapy cemiplimab Censa Pharmaceuticals Chemotherapy chlorambucil Chronic Lymphocytic Leukemia Clarametyx Biosciences Clostridium difficile COVID-19 CRISPR dapagliflozin Diagnostics DiNAQOR dry eye disease epilepsy Federal Trade Commission Ferring Pharmaceuticals FogPharma Fragile X Syndrome Gemini Therapeutics Gene Therapy Gilead Sciences Grail Incyte Innate Immune System investing Joseph Stauffer Kala Pharmaceuticals Kezar Life Sciences Kura Oncology Life Sciences lisocaptagene maraleucel Ludwig Hantson Magenta Therapeutics Marc Uknis Mark Erlander Menarini Group Microbiome microbiome drugs Myonexus Therapeutics Neurological Diseases Noreen Roth Henig Novartis Obinutuzumab Ovid Therapeutics Pfizer Portola Pharmaceuticals pravastatin Praxis Precision Medicines PTC Therapeutics rare disease drugs rebiotix Regeneron Pharmaceuticals remdesirvir Rett syndrome Sanofi Sarepta Therapeutics sarizotan Sherlock Biosciences startups Stemline Therapeutics systolic heart failure TG Therapeutics Tony Gibney TrovaGene U.S. Department of Justice ublituximab umbralisib Ventus Therapeutics Vir Biotechnology
success ACRO members talk UK competitiveness and enabling post-Brexit success By www.acrohealth.org Published On :: Thu, 19 Jul 2018 03:14:35 +0000 What happens to clinical research when the UK leaves the EU’s common market and regulatory structure? When public perceptions seem locked onto... Full Article News Brexit UK
success AstraZeneca success should prompt review of takeover rules | Nils Pratley By www.theguardian.com Published On :: 2020-04-29T18:31:26Z Firm’s recent success could have been very different had it been bought out by Pfizer in 2014It’s perhaps not surprising that the worth of healthcare companies should emerge during a global pandemic, but we should offer thanks for the UK’s big pharma twins – AstraZeneca and GlaxoSmithKline.The former, with its share price at all-time high, is now jostling with Shell and Unilever for the title of biggest company in the FTSE 100 index. Successful research bets, especially on cancer drugs, have transformed Astra. Continue reading... Full Article Pharmaceuticals industry AstraZeneca GlaxoSmithKline Business Barclays Next
success Mallinckrodt’s INOmax successful in trial of neonates with pulmonary hypertension By www.thepharmaletter.com Published On :: Mon, 04 May 2020 17:20:00 +0100 UK-based Mallinckrodt Pharmaceuticals has ended a trial of INOmax (nitric oxide) gas early due to positive… Full Article Drug Trial/Inomax/Mallinckrodt/Nitric Oxide/Pharmaceutical/Research/Respiratory and Pulmonary/UK
success New OCDETF Strike Force Site Unveiled, Successes of Phoenix Operation Highlighted By www.justice.gov Published On :: Wed, 30 Sep 2009 22:59:34 EDT Deputy Attorney General David W. Ogden, along with federal and local officials today officially unveiled the new Organized Crime Drug Enforcement Task Force (OCDETF) Strike Force site in Phoenix. Full Article OPA Press Releases
success Justice Department Announces Success in Battle Against Firearms Trafficking and Recovery Act Funds to Build on Project Gunrunner By www.justice.gov Published On :: Thu, 1 Oct 2009 18:48:03 EDT Deputy Attorney General David W. Ogden and Bureau of Alcohol, Tobacco, Firearms and Explosives (ATF) Acting Director Kenneth E. Melson today announced the results of ATF’s Gun Runner Impact Team (GRIT) initiative, a 120-day deployment of ATF resources to the Houston Field Division to disrupt illegal firearms trafficking by Mexican drug cartels Full Article OPA Press Releases
success Justice Department Announces Successful Resolution of Case Regarding Delaware State Prisons By www.justice.gov Published On :: Mon, 31 Dec 2012 14:07:08 EST The Justice Department announced that the state of Delaware has fully complied with the parties’ amended memorandum of agreement (MOA) which was reached after an investigation of three Delaware state prisons. The MOA, which includes reforms in mental health care, medical care and suicide prevention, was entered into after an investigation of the conditions at the James T. Vaughn Correctional Center, the Howard R. Young Correctional Institution and the Sussex Correctional Institution. Full Article OPA Press Releases
success Justice Department Announces the Successful Resolution of Its Agreement with the Orange County, Fla., Sheriff’s Office By www.justice.gov Published On :: Tue, 2 Apr 2013 15:17:39 EDT The United States announced today that the Orange County, Fla., Sheriff’s Office (OCSO) has successfully implemented an agreement on the use of electronic control weapons, commonly referred to as Tasers. Full Article OPA Press Releases
success Attorney General Holder Announces H. Marshall Jarrett to Retire from Executive Office for U.S. Attorneys; Monty Wilkinson Named as Successor By www.justice.gov Published On :: Fri, 28 Mar 2014 09:51:39 EDT Attorney General Eric Holder today announced the retirement of H. Marshall Jarrett, Director for the Executive Office for U.S. Attorneys (EOUSA) as well as the appointment of Monty Wilkinson as the new Director for EOUSA. Full Article OPA Press Releases
success Remarks by Associate Attorney General Tony West at My Brother's Keeper Summer Success Workshop By www.justice.gov Published On :: Fri, 18 Jul 2014 15:01:17 EDT "My Brother's Keeper is about letting young people take responsibility for themselves and realizing success on their own terms. Those of us in positions of leadership -- we need to do our part to make sure you have a fair shot at your dreams; that you're not being held back by bias and discrimination; that the justice system designed to protect your rights is treating you fairly. That's our job." Full Article Speech
success Justice Department Announces Successful Resolution of Consent Judgment Involving Detroit Police Department By www.justice.gov Published On :: Thu, 28 Aug 2014 13:34:14 EDT The Justice Department today announced the U.S. District Court for the Eastern District of Michigan’s termination of the consent judgment relating to the Detroit Police Department’s (DPD) use of force and arrest and witness detention practices. The Justice Department and the city of Detroit jointly sought the termination of the consent judgment and approval of a Transition Agreement maintaining federal oversight of the DPD for an additional 18 months. The transition agreement starts a new chapter of reform and accountability for the DPD as it works in collaboration with the Justice Department to better ensure constitutional policing, promote community confidence, and improve public safety in the city of Detroit. The Justice Department’s Civil Rights Division and the U.S. Attorney’s Office for the Eastern District of Michigan have worked cooperatively throughout the duration of this matter Full Article OPA Press Releases
success Recipe For Managing Data Disclosure Successfully With Academic Partners: A Public Gene Therapy Company Perspective By feedproxy.google.com Published On :: Tue, 24 Mar 2020 11:17:45 +0000 This blog post was written by Deanna Petersen, CBO of AVROBIO, as part of the From The Trenches feature of LifeSciVC. When AVROBIO went public in June 2018, I found myself on the steep end of an unexpected but interesting The post Recipe For Managing Data Disclosure Successfully With Academic Partners: A Public Gene Therapy Company Perspective appeared first on LifeSciVC. Full Article Business Development From The Trenches academic partners clinical trials gene therapy
success InstantGMP, Inc. Debuts Game-Plan for Success By feedproxy.google.com Published On :: Wed, 07 Feb 2018 21:39:00 GMT InstantGMP, Inc. released a much-anticipated enhancement to the Equipment Logs feature. Full Article
success Successfully Choosing and Maintaining a Contract Manufacturing Partnership By feedproxy.google.com Published On :: Tue, 13 Feb 2018 15:59:00 GMT In this INSIDER Q&A, experts in contract manufacturing discuss aspects a brand owner should evaluate, what should be outlined in an agreement and what ongoing QA checks to conduct during the partnership. Full Article
success FDA Site Inspections: 5 Tips for Success By polarisconsultants.blogspot.com Published On :: Tue, 02 Aug 2016 13:52:00 +0000 Anx·i·ety (noun)The state of uneasiness caused by apprehension of possible misfortune.Yep. That’s the word that comes to mind whenever anyone mentions FDA inspections.But anxiety often stems from a lack of control, and in a regulatory inspection, you have more control than you might think. There are many steps you can take -- before, during, and even after an inspection is over -- that can give you a fair degree of control over the outcome. Here, Polaris auditors Lauren Kelley and Michele Commins share some of those steps with you.Pre-inspection PreparationFor-cause inspections may be unannounced, but routine FDA inspections of submission data are scheduled in advance*. That means most inspections are not pop quizzes; they’re final exams. Remember how happy you were when a teacher gave you access to a prior year’s exam to study from? You knew the type of questions that would be asked. You knew how to prepare.So this is the first tip we’d like to share. FDA has, indeed, given you a copy of their exam in advance, in the form of its Compliance Program Guidance Manual, CPGM 7348.811. This is the document all FDA field investigators use to conduct inspections at clinical sites. It outlines in great detail what documents investigators will review, what dates they’re going to verify, what processes they’ll evaluate, what data they’ll collect, and what records they’re going to compare. Despite its rather uninspired title, this is your copy of the final exam. You know cramming is a risky strategy, so the earlier you get familiar with the CPGM the better. Inspection readiness is a state of preparedness more than it is a laundry list of activities; it takes some time to get there.When the Inspector’s in the HouseAccording to the CPGM, one of the first pieces of information the FDA investigator will obtain is a list of all of the studies performed by the clinical investigator, including protocol number, sponsor, and study dates. So even though FDA has scheduled its inspection with you, and has told you what study the investigator is coming to inspect, any study is fair game. An FDA investigator can look at any document she wants, or talk to any staff member he chooses, whether related to the “assigned” study or not.Most of your preparation will have been study-specific; questions about other studies will catch your staff off-guard, and a review of records for other studies may find them less than inspection-ready. So here’s our second tip. Avoid anything that might pique the investigator’s curiosity about a study that is not the original subject of the inspection. Make sure the room you reserve as your investigator’s “home base” is free of any documents, reports, notes, phone lists, and post-its. Make sure you tidy up offices, workspaces, and facilities site-wide, and keep extraneous chatter in check. After the VisitIf your FDA inspection resulted in zero observations, then stop reading, thank your awesome staff members, and go celebrate. If, however, you did receive a Form FDA 483, it’s probably not the end of the world, but you do have some work to do. Our third tip is this: remember that the sponsor/CRO is your ally here. They have as much invested in FDA’s assessment of your study data as you do, and they have the regulatory, QA, even legal resources that you might not. You’re not required to formally respond to 483s, but if you do, you’re likely to receive a more favorable Establishment Inspection Report (EIR) in the end. Let your sponsor/CRO help you with your response.Tips Do Not a Plan MakeTips are helpful, but you’ll need more than that to ensure a successful FDA site inspection. You need an inspection readiness plan -- a plan that you document and keep current. All site staff members need to train on the inspection procedures and the individual roles they will play. (Fourth tip: don’t forget to train your temporary employees; an office temp working at the receptionist desk could be the first person your FDA investigator speaks with.)A Last ThoughtInspections are stress-inducing events, and nervous people make mistakes. Investigators know this, and expertly exercise the “pregnant pause,” knowing how difficult it is for people to withstand an excruciating silence without volunteering unsolicited information. So one last tip: conduct a mock inspection before the FDA comes to visit. It will stress test your procedures and identify improvements you need to implement. A thorough mock inspection will give staff members an opportunity to rehearse their roles and interview techniques so they can execute your plan and speak to the FDA investigator with confidence._______________________________* For-cause inspections are also known as Investigator-oriented, and routine inspections are also known as study-oriented. A version of this article originally appeared in InSite, the Journal of the Society for Clinical Research Sites Full Article clinical trials Compliance FDA inspections inspection readiness mock inspection study sites
success Executable cancer models: successes and challenges By feeds.nature.com Published On :: 2020-04-27 Full Article
success John Park on the Key Player in North Korea's Leadership Succession By feedproxy.google.com Published On :: Apr 23, 2020 Apr 23, 2020Uncertainty of Kim Jong-un's health has many wondering what the future holds for North Korea. Full Article
success John Park on the Key Player in North Korea's Leadership Succession By feedproxy.google.com Published On :: Apr 23, 2020 Apr 23, 2020Uncertainty of Kim Jong-un's health has many wondering what the future holds for North Korea. Full Article
success John Park on the Key Player in North Korea's Leadership Succession By feedproxy.google.com Published On :: Apr 23, 2020 Apr 23, 2020Uncertainty of Kim Jong-un's health has many wondering what the future holds for North Korea. Full Article
success Building on the Success of the Earned Income Tax Credit By webfeeds.brookings.edu Published On :: Thu, 19 Jun 2014 00:00:00 -0400 The Earned Income Tax Credit (EITC) provides a refundable tax credit to lower-income working families. In 2011, the EITC reached 27.9 million tax filers at a total cost of $62.9 billion. Almost 20 percent of tax filers receive the EITC, and the average credit amount is $2,254 (IRS 2013). After expansions to the EITC in the late 1980s through the late 1990s—under Democrat and Republican administrations—the EITC now occupies a central place in the U.S. safety net. Based on the Census Bureau’s 2012 Supplemental Poverty Measure (SPM), the EITC keeps 6.5 million people, including 3.3 million children, out of poverty (Center on Budget and Policy Priorities [CBPP] 2014a). No other tax or transfer program prevents more children from living a life of poverty, and only Social Security keeps more people above poverty. Since the EITC is only eligible to tax filers who work, the credit’s impact on poverty takes place through encouraging employment by ensuring greater pay after taxes. The empirical research shows that the tax credit translates into sizable and robust increases in employment (Eissa and Liebman 1996; Meyer and Rosenbaum 2000, 2001). Thus, the credit reduces poverty through two channels: the actual credit, and increases in family earnings. This dual feature gives the EITC a unique place in the U.S. safety net; in contrast, many other programs redistribute income while, at least to some degree, discouraging work. Importantly, transferring income while encouraging work makes the EITC an efficient and cost-effective policy for increasing the after-tax income of low-earning Americans. Yet a program of this size and impact could be more equitable in its reach. Under the current design of the EITC, childless earners and families with only one child, for instance, receive disproportionately lower refunds. In 2014, families with two children (three or more children) are eligible for a maximum credit of $5,460 ($6,143) compared to $3,305 for families with one child. Married couples, despite their larger family sizes, receive only modestly more-generous EITC benefits compared to single filers. Childless earners benefit little from the EITC, and have a maximum credit of only $496—less than 10 percent of the two-child credit. Prominent proposals seek to mitigate these inequalities. President Obama’s fiscal year 2015 budget includes an expansion of the childless EITC, a concept outlined by John Karl Scholz in 2007 in a proposal for The Hamilton Project. Notably, MDRC is currently evaluating Paycheck Plus, a pilot program for an expanded EITC for workers without dependent children, for the New York City Center for Economic Opportunity (MDRC 2014). The recent Hamilton Project proposal for a secondary-earner tax credit addresses the so-called EITC penalty for married couples (Kearney and Turner 2013). And the more generous EITC credit for three or more children was recently enacted as part of the American Recovery and Reinvestment Act of 2009, and is currently scheduled to sunset in 2017. Considering this broad set of EITC reforms, and recognizing the demonstrated effectiveness of the program as an antipoverty program with numerous benefits, this policy memo proposes an expansion for the largest group of EITC recipients: families with one child. In particular, I propose to expand the one-child schedule to be on par with the two-child schedule, in equivalence scale-adjusted terms. An equivalence scale captures the cost of living for a household of a given size (and demographic composition) relative to the cost of living for a reference household of a single adult, and is a standard component in defining poverty thresholds. The proposal expands the maximum credit for one-child families to $4,641, from $3,305 under current law, an increase of about 40 percent. The expansion will lead to a roughly $1,000 increase in after-tax income for taxpayers in the bottom 40 percent of the income distribution receiving the higher credit. As this paper outlines, the expansion is justified on equity and efficiency grounds. This expansion is anchored in the equity principle in that the generosity of the credit should be proportional to the needs of families of differing sizes; I use the equivalence scale implicit in the poverty thresholds of the Census SPM as a guide for household needs. This proposal is also supported by efficiency principles given the EITC’s demonstrated success at raising labor supply among single mothers. The target population for the proposal is low-income working families with children. Implementing this proposal requires legislative action by the federal government; it is important to note that altering the EITC schedule requires a simple amendment to the tax code, and not a massive overhaul of our nation’s tax system. The revenue cost of the proposal derives from additional federal costs of the EITC, less the additional payroll and ordinary federal income taxes. The private benefits include increases in after-tax income and reductions in poverty. The proposal would also generate social benefits through the spillover effects that the increase in income plays in improving health and children’s cognitive skills (Dahl and Lochner 2012; Evans and Garthwaite 2014; Hoynes, Miller, and Simon forthcoming). Downloads Building on the Success of the Earned Income Tax Credit - Full Text Authors Hilary Hoynes Publication: The Hamilton Project Image Source: Bluestocking Full Article
success John Park on the Key Player in North Korea's Leadership Succession By feedproxy.google.com Published On :: Apr 23, 2020 Apr 23, 2020Uncertainty of Kim Jong-un's health has many wondering what the future holds for North Korea. Full Article
success Was 2015 a PR success for the new Global Goals? By webfeeds.brookings.edu Published On :: Fri, 10 Jun 2016 09:33:00 -0400 The year 2015 was a big one for global development policy debates, marking the end of the Millennium Development Goals (MDGs) and the launch of the new Sustainable Development Goals (SDGs), also known as the “Global Goals.” But how much did major media pay attention? Last September, Christine Zhang and I published a working paper that examined mentions of the MDGs across major English-language press and academic outlets from 2000 through 2014. We blogged highlights from the original paper here. More recently, we updated some of the results to account for last year’s major MDG-SDG debates and events. Figure 1 adds 2015 newspaper data on the MDGs and also includes SDG mentions over the entire time period. Figure 1: MDG and SDG mentions across 12 major newspapers, 2000-2015 Note: The 12 newspapers included are the Los Angeles Times (USA), The New York Times (USA), USA Today, and The Washington Post (USA), the Financial Times (UK), The Guardian (UK), The Independent (UK), The Daily Telegraph (UK), The Economist (UK), The Globe and Mail (Canada), the South China Morning Post (Hong Kong SAR), and The Sydney Morning Herald (Australia). Source: LexisNexis, authors’ calculations. Here are three key takeaways from the new graph: First, by measure of article counts, 2015 was the second most prominent year for media coverage of the interlinked MDG-SDG agendas. But it only saw 62 percent as much coverage as the MDGs received in 2005, the year of the U.N. Millennium Project’s final report (January), the Gleneagles G-8 summit (July), and the U.N. World Summit (September). Second, global summits have consistently helped to ramp up media attention and debate. The years 2005, 2008, 2010, and 2015 all stand out as the top years for references—the same years in which the U.N. convened major summits linked to the MDGs and, in 2015, the SDGs. But U.N. summits do not guarantee attention. Notably, the 2012 Rio+20 summit that initially called for the SDGs did not cause a big splash in the media outlets examined. Third, recent years saw a discernible transition from MDG references to SDG references. By 2015, fully 41 percent of the relevant articles referenced only the SDGs, 30 percent mentioned both the SDGs and the MDGs, while only 29 percent mentioned the MDGs alone. To be clear, these results do not provide a complete assessment of MDG-SDG media references in recent years, especially because social media and other new digital technologies now account for such a large share of public debate. (Note that the graph also excludes developing country newspapers, some of which we examined in the original working paper and similarly updated with 2015 results, but those do not make much difference to the overall story.) Thus one should not consider Figure 1 a definitive analysis of whether SDG advocates were successful in their public outreach campaigns last year. From a research perspective, the simple new-ness of “new media” renders long-term comparisons difficult. Restricting the data sample to print media offers one way to benchmark apples-to-apples coverage across the period of interest back to 2000. That said, a seasoned media observer once suggested to me that traditional news outlets are inherently less connected to the bottom-up nature of emerging SDG conversations, and hence less likely to cover the SDGs accurately than new media channels in which user-generated content helps to drive the conversation. It’s an interesting hypothesis worth testing. At a minimum, 2015 was a significant year for public conversations about the MDGs and SDGs, even if it might not have matched the peak year of 2005. An interesting line of research could seek to explain why. In any case, for analysts of the new SDGs, more sophisticated forms of global media benchmarking will undoubtedly be in order through to the new deadline of 2030. Authors John McArthur Full Article
success Success from the UN climate summit will hinge on new ways to build national action By webfeeds.brookings.edu Published On :: Tue, 17 Sep 2019 16:36:21 +0000 Next week’s U.N. Climate Action Summit in New York, and the roughly yearlong process it will kick off, presents the world with a challenge. On the one hand, the science of climate change is clear and it points to a need for a substantially enhanced global response—and quickly. Over the next year, as part of… Full Article
success Seattle Uniquely Placed to Compete on Global Stage, but Success is Not Inevitable By webfeeds.brookings.edu Published On :: Mon, 12 May 2014 15:21:00 -0400 In an increasingly international and interconnected economy, Seattle was global before global was cool. The region’s competitive global assets include internationally competitive firms, strategically important ports and one of the nation’s largest foreign-born populations. Still, today’s unique economic moment demands an extra measure of purposeful global engagement. As cities and metropolitan areas begin to emerge from the Great Recession, leaders are realizing the need to restructure the economy — to move from one based on debt and consumption to one powered by production and innovation. At the same time, most economic growth over the next decade will occur outside of America’s borders. As of 2009, the combined economies of Brazil, India and China eclipsed that of the United States and now account for more than one-fifth of the global economy. By 2018, their share is expected to surpass one-quarter. The developing world, with a rapidly rising middle class, represents a huge market opportunity for American firms. China and India alone are expected to increase their urban populations by more than 500 million over the next 20 years, which naturally leads to a rise in their consumer classes. By 2050, Chinese and Indian consumers will account for more than half of all middle-class consumption worldwide, up from just 2 percent in 2000. These growing metropolises will also require massive investments in infrastructure and face huge challenges as they expand, challenges that U.S. firms have the expertise to solve — in transportation and mobility, in sustainability and clean energy, in information technology and software. America’s metropolitan areas are uniquely positioned to take advantage of this dual challenge through increased trade and investment. The top 100 metro areas not only produce three-quarters of our gross domestic product, they also concentrate our most innovative firms, our research institutions and universities, and the majority of our skilled workers. So how does the central Puget Sound region stack up? Recently, I came to Seattle as part of the Global Cities Initiative, a joint project of the Brookings Institution and JPMorgan Chase. This initiative aims to catalyze a shift in economic development priorities and practices that would result in more globally connected metropolitan areas and more sustainable economic growth. The metro area has a strong platform for trade: firms such as Boeing, Microsoft, and Amazon; world-class research assets including the University of Washington and the Fred Hutchinson Cancer Research Center; and a strong legacy of globally oriented leadership, with a wide coalition, including public, private and civic leaders, actively promoting a regional strategy for global engagement. The data bear this out: While Seattle is the 15th largest metro area in the United States, it has the sixth highest export total, sending more than $47 billion in goods and services abroad in 2012. These exports are overwhelmingly driven by globally competitive clusters in aerospace and information technology. Partly due to this industry specialty, Seattle’s economy is also highly innovative and uniquely oriented toward science, technology, engineering and math: More than one-quarter of jobs in the metro are in STEM occupations, the fourth highest share of any metropolitan area in the country. Still, in such a competitive and dynamic global economy, no metro area can afford complacency. In order to maintain its position in the global economy, Seattle needs to get serious about global engagement. First, focus on global trade and investment. Continue the collaborative efforts of your public, private and civic leaders to focus economic development strategies on growth abroad. In Seattle earlier this month, regional leaders committed to expanding these efforts, joining the Global Cities Initiative’s Exchange, through which the metro area will develop a strategy to increase foreign direct investment in key industries. Second, invest in what matters. To compete globally, metro areas must be strong at home. In Seattle, this means shoring up your workforce-development pipeline so that local residents have a path to good jobs in advanced industries. It also calls for a regional approach to financing and delivering transportation solutions that not only reduce congestion at home, but also improve your connections abroad. Finally, metropolitan leaders must look beyond their own borders, identify their trading partners, and build relationships to increase both trade and investment. For example, as part of the Global Cities Initiative, Chicago and Mexico City entered into a first-of-its-kind economic partnership that builds on the extensive economic, social, cultural linkages between the two metros to make both more prosperous. There are promising efforts under way in the region, as the King County Aerospace Alliance has started collaborating with Aéro Montréal so that the two aerospace clusters can be more competitive. Simply put, in today’s economic landscape, every city is a global city. The success of regional economies hinges on their engagement throughout the global economy. Seattle has an enviable hand to play; but success is not inevitable. This opinion piece originally appeared in the Seattle Times. Authors Bruce Katz Full Article
success The Road Map to post-secondary success in Greater Seattle By webfeeds.brookings.edu Published On :: Wed, 24 Feb 2016 13:45:00 -0500 Think of Seattle’s workforce and you may imagine overworked tech employees at Amazon, Microsoft software developers, or Boeing engineers. But the region’s workforce’s story is more complicated. Alongside the highly skilled workers driving the region’s strong growth since the Great Recession is an increasingly diverse youth population in South Seattle and its surrounding South King County suburbs often disconnected from the region’s trademark innovation economy. As a result, the region faces a skills challenge as only one-quarter of the roughly one-half of King County adults who hold a bachelor’s degree are Washington natives. This limits both individual opportunity and long-term regional competitiveness: 67 percent of jobs in the state will demand postsecondary education within two years, according to an estimate from Georgetown University, but only 28 percent of students in South Seattle and the South King County suburbs receive a postsecondary credential by their mid-20s. These challenges aren’t unique. Many regions are grappling with rising diversity’s impact on the labor force, and thinking about how educational programs and outreach need to adapt to reach diverse populations in an era of constrained resources and growing suburban poverty. But Greater Seattle has an advantage over many communities: a committed group of cross-sector leaders working together as part of the Road Map Project and its ambitious goal “to double the number of students in South King County and South Seattle who are on track to graduate from college or earn a career credential by 2020 and to close racial/ethnic opportunity gaps.” In the six years since it started, Road Map has tackled the region’s educational disparities in many ways: connecting students to scholarships, boosting parental involvement, and attracting a $40 million federal Race to the Top grant for the region’s school districts. Its approach follows the collective impact model, which emphasizes setting shared goals and coordinating resources and activities to magnify the impact beyond that of isolated interventions. With four years left to meet its goal, Road Map released a report last month analyzing student success at the area’s community and technical colleges. This unique effort—marrying data from Road Map-area high schools with area community and technical colleges—produced a finely-grained view of 2011 high school graduates’ progress toward completion, tracking key criteria such as attaining college-readiness in math and completing 30 or more credits in the first year of college. Community and technical colleges are critical institutions in the region—nearly one-third of 2011 Road Map-area high school graduates were direct enrollees—but the report found that only slightly more than one-third of those students successfully completed a degree or transferred to a four-year institution within three years. And outcomes for blacks, Latinos, and, in many cases, Native Americans, consistently trail those of whites and Asians. In response, the Road Map report recommends a series of strategies aimed at attacking the problem from multiple directions, including working with high schools to boost college readiness, helping institutions improve their ability to deliver on student completion, adopting new culturally responsive strategies, and pushing for increased funding for both the institutions and student scholarships. Filling these gaps and meeting the 2020 goal will be difficult. A different Road Map Project report highlights an improving high school graduation rate, but lagging enrollment of graduates directly into college. Nevertheless, the region’s collaborative approach of working across institutions and jurisdictions continues to hold great promise. As more regions confront similar demographic challenges and seek new solutions for boosting skills and opportunity, Greater Seattle offers a compelling case study in how to move beyond one-off collaborations and initiatives to achieve real systems change. Authors Rachel BarkerAlan Berube Image Source: © JASON REDMOND / Reuters Full Article
success Building on the Success of the Earned Income Tax Credit By webfeeds.brookings.edu Published On :: Thu, 19 Jun 2014 00:00:00 -0400 The Earned Income Tax Credit (EITC) provides a refundable tax credit to lower-income working families. In 2011, the EITC reached 27.9 million tax filers at a total cost of $62.9 billion. Almost 20 percent of tax filers receive the EITC, and the average credit amount is $2,254 (IRS 2013). After expansions to the EITC in the late 1980s through the late 1990s—under Democrat and Republican administrations—the EITC now occupies a central place in the U.S. safety net. Based on the Census Bureau’s 2012 Supplemental Poverty Measure (SPM), the EITC keeps 6.5 million people, including 3.3 million children, out of poverty (Center on Budget and Policy Priorities [CBPP] 2014a). No other tax or transfer program prevents more children from living a life of poverty, and only Social Security keeps more people above poverty. Since the EITC is only eligible to tax filers who work, the credit’s impact on poverty takes place through encouraging employment by ensuring greater pay after taxes. The empirical research shows that the tax credit translates into sizable and robust increases in employment (Eissa and Liebman 1996; Meyer and Rosenbaum 2000, 2001). Thus, the credit reduces poverty through two channels: the actual credit, and increases in family earnings. This dual feature gives the EITC a unique place in the U.S. safety net; in contrast, many other programs redistribute income while, at least to some degree, discouraging work. Importantly, transferring income while encouraging work makes the EITC an efficient and cost-effective policy for increasing the after-tax income of low-earning Americans. Yet a program of this size and impact could be more equitable in its reach. Under the current design of the EITC, childless earners and families with only one child, for instance, receive disproportionately lower refunds. In 2014, families with two children (three or more children) are eligible for a maximum credit of $5,460 ($6,143) compared to $3,305 for families with one child. Married couples, despite their larger family sizes, receive only modestly more-generous EITC benefits compared to single filers. Childless earners benefit little from the EITC, and have a maximum credit of only $496—less than 10 percent of the two-child credit. Prominent proposals seek to mitigate these inequalities. President Obama’s fiscal year 2015 budget includes an expansion of the childless EITC, a concept outlined by John Karl Scholz in 2007 in a proposal for The Hamilton Project. Notably, MDRC is currently evaluating Paycheck Plus, a pilot program for an expanded EITC for workers without dependent children, for the New York City Center for Economic Opportunity (MDRC 2014). The recent Hamilton Project proposal for a secondary-earner tax credit addresses the so-called EITC penalty for married couples (Kearney and Turner 2013). And the more generous EITC credit for three or more children was recently enacted as part of the American Recovery and Reinvestment Act of 2009, and is currently scheduled to sunset in 2017. Considering this broad set of EITC reforms, and recognizing the demonstrated effectiveness of the program as an antipoverty program with numerous benefits, this policy memo proposes an expansion for the largest group of EITC recipients: families with one child. In particular, I propose to expand the one-child schedule to be on par with the two-child schedule, in equivalence scale-adjusted terms. An equivalence scale captures the cost of living for a household of a given size (and demographic composition) relative to the cost of living for a reference household of a single adult, and is a standard component in defining poverty thresholds. The proposal expands the maximum credit for one-child families to $4,641, from $3,305 under current law, an increase of about 40 percent. The expansion will lead to a roughly $1,000 increase in after-tax income for taxpayers in the bottom 40 percent of the income distribution receiving the higher credit. As this paper outlines, the expansion is justified on equity and efficiency grounds. This expansion is anchored in the equity principle in that the generosity of the credit should be proportional to the needs of families of differing sizes; I use the equivalence scale implicit in the poverty thresholds of the Census SPM as a guide for household needs. This proposal is also supported by efficiency principles given the EITC’s demonstrated success at raising labor supply among single mothers. The target population for the proposal is low-income working families with children. Implementing this proposal requires legislative action by the federal government; it is important to note that altering the EITC schedule requires a simple amendment to the tax code, and not a massive overhaul of our nation’s tax system. The revenue cost of the proposal derives from additional federal costs of the EITC, less the additional payroll and ordinary federal income taxes. The private benefits include increases in after-tax income and reductions in poverty. The proposal would also generate social benefits through the spillover effects that the increase in income plays in improving health and children’s cognitive skills (Dahl and Lochner 2012; Evans and Garthwaite 2014; Hoynes, Miller, and Simon forthcoming). Downloads Building on the Success of the Earned Income Tax Credit - Full Text Authors Hilary Hoynes Publication: The Hamilton Project Image Source: Bluestocking Full Article
success Organizing for Success: A Call to Action for the Kansas City Region By webfeeds.brookings.edu Published On :: Tue, 01 Aug 2006 00:00:00 -0400 Though possessing much economic strength, the Kansas City region faces stark barriers to its long term competitiveness, including a limited capacity for innovation, unfocused growth, and wide racial disparities. This paper—in conjunction with two companion papers delving into the region's economic assets and its life sciences economy—examines how Kansas City can overcome these challenges. Downloads Download full reportDownload assessment by Robert Weissbourd and Alen Amirkhanian Authors Jennifer S. Vey Full Article