The Delaware State Housing Authority (DSHA), in partnership with The Money School and the Delaware Federation of Housing Counselors, held its annual Homebuyer Fair on Saturday, April 5, 2014, at the Chase Center on the Riverfront in Wilmington, Delaware. The Fair – geared toward providing prospective homebuyers with the opportunity to learn about the steps in purchasing a home – was a great success for the fourth year in a row.

OM Chile’s Children’s Ministry knows the power of God’s Word and the support of encouraging adults can change children’s lives.

The Delaware Department of Justice’s Family Division announced that a new targeting of child support absconders has resulted in location of individuals who collectively owe more than $1 million in child support payments in order for them to begin paying support to their families. Led by Deputy Attorney General Phyllis Scully, Special Investigator William McGillan, […]

The two funds are designed to spur job growth in Delaware Community and business leaders came together today to celebrate the success of a small business initiative which began in Wilmington a few years ago and to announce a complimentary effort that will support small businesses and job growth throughout Delaware. Facilitated by West End […]

Governor Jack Markell, DNREC Secretary Collin O’Mara and Delaware Department of Agriculture Secretary Ed Kee joined Delmarva Wellnet Foundation-EDEN Delmarva members to celebrate the success of the foundation’s food recycling project REPLENISH.

Delaware’s wildland fire crew is returning to the First State after successfully battling wildfires in Colorado and Wyoming. The Delaware Forest Service dispatched the firefighters to Colorado on July 25. Their first assignment was assisting Colorado’s Bureau of Land Management on the 492-acre Milk Fire near Craig, Colorado. Next, they were sent by the Rocky Mountain Geographic Area Coordination Center to the 1,287-acre Tokewanna Fire near Mountain View, Wyoming. Finally, on August 4, they were dispatched to the 12,276-acre Whit Fire, located east of Yellowstone National Park near Cody, Wyoming.

Delaware's wildfire crew returns to the First State this week after wrapping up a successful two-week assignment fighting blazes in northern Idaho's Panhandle National Forests.  The crew is scheduled to be back at Blackbird State Forest on Thursday, August 23, at approximately 6:15 p.m. The Delaware Forest Service dispatched the team of 20 wildland firefighters to Montana on August 4 and the crew was immediately sent to northern Idaho to fight the Copper Mountain Fire, situated on the Canadian border. This past week, the crew battled the Cougar Fire, a 5,880-acre blaze burning in steep rugged terrain located approximately 5 miles east of Hope, Idaho.

Agency: DTCC Closing Date: 6/2/2020

Seaford Police Department Phone: (302) 629-6644 Address: 300 Virginia Avenue, Seaford, DE 19973 Fax: (302) 629-0672 EMERGENCY 911   Seaford Police Department Non-traditional Distracted Driving Operation a Success   08/01/2019   In June and July of 2019, the Seaford Police Department, in conjunction with the Delaware Office of Highway Safety, conducted ‘Operation Cool Down,’ a […]

“We didn’t see any association between getting this medicine and the chance of dying or being intubated,” lead researcher Dr. Neil Schluger told Reuters in a telephone interview.

Jagdishan and Bharucha are the internal candidates and have been serving the bank for many years each, while Garg is working with American bank Citi at present.

Indian luxury train, the Indian Maharaja, has bagged the award for the Best Asian Luxury Train for the third year in a row. The train was felicitated at World Travel Awards 2012, quoted by Wall Street Journal as “the travel industry’s equivalent to the Oscars”. The awards are...

Termed "a successful failure", the spacecraft which had three astronauts- James Lovell Jr, Fred Haise Jr, and John Swigert Jr- on board managed to return to the Earth despite facing an explosion like situation after a blast in its oxygen tank.

The spacecraft entered the return orbit at 12:21 pm after which its return capsule separated with its service capsule at 1:33 pm.

Banknet Group will publish stories of achievers, entrepreneurs from BFSI, IT

FIU's Margherita Bianchin and Federica Frasca opted to stay in South Florida rather than return to Italy, where the coronavirus struck ahead of the United States.

Hello Spectre Users, Simulating S-parameters in a time domain (transient, periodic steady state) simulator has been and continues to be a challenge for many analog and RF designers. I'm often asked: What is required in order to achieve accurate...(read more)

Hi All, If you were unable to attend IMS 2017 in June 2017, the IMS MicroApp “7 Habits of Highly Successful S-Parameters” is on our Cadence website. On Cadence Online Support , the in-depth AppNote is here: 20466646 . Best regards, Tawna...(read more)

ST Microelectronics reported their success with IEEE 1801 / UPF low-power simulation using Incisive Enterprise Simulator at CDNLive India in November 2013. We were able to meet with Mohit Jain just after his presentation and recorded this video that explains the key points in his paper.

With eight years of experience and pioneering technology in native low-power simulation, Mohit was able to apply Incisive Enterprise Simulator to a low-power demonstrator in preparation for use with a production set-top box chip.  Mohit was impressed with the ease in which he was able to reuse his existing IEEE 1801 / UPF code successfully, including the power format files and the macro models coded in his Liberty files. Mohit also discusses how he used the power-aware Cadence SimVision debugger.

The Cadence low-power verification solution for IEEE 1801 / UPF also incorporates the patent-pending Power Supply Network visualization in the SimVision debugger.  You can learn more about that in the Incisive low-power verification Rapid Adoption Kit for IEEE 1801 / UPF here in Cadence Online Support.

Just another happy Cadence low-power verification user!

Regards,

 Adam "The Jouler" Sherer 

Freescale was a successful Incisive® simulation CPF low-power user when they decided to step up their game. In November 2013, at CDNLive India, they presented a paper explaining how they improved their ability to find power-related bugs using a more sophisticated verification flow.  We were able to catch up with Abhinav Nawal just after his presentation to capture this video explaining the key points in his paper.

Abhinav had already established a low-power simulation process using directed tests for a design with power intent captured in CPF. While that is a sound approach, it tends to focus on the states associated with each power control module and at least some of the critical power mode changes.  Since the full system can potentially exercise unforeseen combinations of power states, the directed test approach may be insufficient. Abhinav built a more complete low-power verification approach rooted in a low-power verification plan captured in Cadence® Incisive Enterprise Manager.  He still used Incisive Enterprise Simulator and the SimVision debugger to execute and debug his design, but he also added Incisive Metric Center to analyze coverage from his low-power tests and connect that data back to the low-power verification plan.  As a result, he was able to find many critical system-level corner case issues, which, left undetected, would have been catastrophic for his SoC.  In the paper, Abhinav presents some of the key problems this approach was able to find.

You can achieve results similar to Abhinav. Incisive Enterprise Simulator can generate a low-power verification plan from the power format, power-aware assertions, and it can collect power-aware knowledge.  To get started, you can use the Incisive Low-Power Simulation Rapid Adoption Kit (RAK) for CPF available on Cadence Online Support.

Just another happy Cadence low-power verification user!

Regards,

Adam "The Jouler" Sherer  

PARIS, France – September 10th, 2019 – Dassault Systèmes, the 3DEXPERIENCE Company, world leader in 3D design software, 3D Digital Mock Up and Product Lifecycle Management (PLM) solutions, today announces that it has successfully priced its inaugural senior unsecured Eurobonds in four tranches for a total of €3.65 billion. This bond issue has the following maturities: 3 years and 5 years, which carry zero coupons and 7-year and 10-year tranches priced at 0.19% and 0.44% respectively. The...

Dr Samir Hamrouni, CEO of the World Free Zones Organization, outlines the attributes that are essential to flourishing free zones.

Embodied by its huge historic port and diverse population, Antwerp has long embraced globalisation. Renewed impetus from stakeholders across Belgium’s second most populous city is ensuring ample opportunities for foreign investors.

The U.K. could be producing electricity from a geothermal plant for the first time early next decade after drilling at a site in southwest England showed it could become a viable part of the renewable energy mix.

People in Germany are more pessimistic than the rest of Europe regarding their country’s progress on its energy transition, or engergiewende.

Korean biopharma company, PharmAbcine, is commencing full-scale clinical trials of a brain cancer treatment in the United States, following pioneering early phase trials in Australia.

People in Germany are more pessimistic than the rest of Europe regarding their country’s progress on its energy transition, or engergiewende.

A partnership between Austrade and Hort Innovation Australia is supporting horticulture growers and exporters to build reputation and market share in China.

An Australian water treatment company is winning business in China amid the COVID-19 outbreak.

People in Germany are more pessimistic than the rest of Europe regarding their country’s progress on its energy transition, or engergiewende.

An Australian water treatment company is winning business in China amid the COVID-19 outbreak.

Ramoyle Developments Limited v Scottish Borders Council [2019] CSOH 1 A local authority entered a contract to sell an area of land for regeneration.  Either party to the contract was entitled to withdraw from the sale if the purchasers failed t...

Central government funding has long been focused on social infrastructure such as schools and housing - with massive programmes of investment such as Building Schools for the Future. Infrastructure such as roads and bridges has not typically been fu...

Iceland has the coronavirus pandemic better under control than most other countries. In an interview, Prime Minister Katrín Jakobsdóttir explains the next important steps for her country.

In R (on the application of Diocese of Menevia and others) v Swansea City and County Council1 (“the Council”), the Administrative Court was required to consider whether a change in policy made by the Council in respect of school transpor...

R (on the application of Tesco Stores Limited) v Forest of Dean District Council and (1) JD Norman Lydney Limited (2) Asda Stores Limited (3) Windmill Limited (4) MMC Land & Regeneration Limited1 The Court of Appeal, upholding a decision of the ...

(MENAFN - Trend News Agency) BAKU, Azerbaijan, May 9 Trend: The May edition of the influential Russian magazine "Natsionalnaya Oborona" (National Defe... ......

Rovers boss Tony Mowbray admits he would like to be successful for the Owners, who have expressed their care and concern for club staff throughout the current crisis. The manager has remained in regular contact with the Owners since the season was suspended in mid-March due to the Coronavirus outbreak. He...

Paraguayan President Mario Abdo Benítez has said the spread of coronavirus in Brazil threatens his...

Sanderson Limited v Simtom Food Products Limited [2019] EWHC 442 (TCC) Summary Whatever the sector, IT transformation can deliver superior services, development of dynamic business models, increased customer satisfaction, returns and cost savings. ...

North Korea’s Kim Jong-un has sent a “verbal message” to Chinese leader Xi Jinping, state media KCNA reported on Friday, after weeks of speculation about his health.The news agency did not explain what it meant by a “verbal message,” and it was not clear if Kim and Xi had spoken directly.The message was “in connection with the fact that China is registering success in preventing the Covid-19 infection”, according to KCNA, with Kim extending his “warm greetings” to Xi.Rumours about Kim’s health…

Professor Samuel Yeung-shan Wong says he loves Canada, and wants it to learn from Hong Kong’s successes in the battle with Covid-19.Wong, director of the Chinese University of Hong Kong’s school of public health, earned his medical degree at the University of Toronto in the 1990s and did his residency in Halifax, Nova Scotia.When he chats with his Canadian cousins they tell him that “they aren’t going out”, he said. Hong Kong, meanwhile, has avoided a Canadian-style lockdown, and on Friday…

Despite variations across countries on policy mix and timing, a pragmatic focus on sustained growth, poverty reduction, and inclusiveness characterize Asia’s economic rise 

Samsung chief Lee Jae-yong apologized on Wednesday for a massive fiddle that allowed him to take over leadership of the publicly traded conglomerate from his ailing father.Without offering to surrender his own position, Lee promised to end the hereditary transfer of leadership at some point in the f...

Title: Fitness Key to Long-Term Weight Loss Success
Category: Health News
Created: 3/31/2020 12:00:00 AM
Last Editorial Review: 4/1/2020 12:00:00 AM

Title: Vitamin D May Affect Lung Transplant Success
Category: Health News
Created: 4/27/2012 6:06:00 PM
Last Editorial Review: 4/30/2012 12:00:00 AM

ABSTRACT

One of the primary functions of the mucosal barrier, found lining epithelial cells, is to serve as a first-line of defense against microbial pathogens. The major structural components of mucus are heavily glycosylated proteins called mucins. Mucins are key components of the innate immune system as they aid in the clearance of pathogens and can decrease pathogen virulence. It has also been recently reported that individual mucins and derived glycans can attenuate the virulence of the human pathogen Pseudomonas aeruginosa. Here, we show data indicating that mucins not only play a role in host defense but that they can also be subverted by P. aeruginosa to cause disease. We found that the mucin MUL-1 and mucin-derived monosaccharides N-acetyl-galactosamine and N-acetylglucosamine are required for P. aeruginosa killing of Caenorhabditis elegans. We also found that the defective adhesion of P. aeruginosa to human lung alveolar epithelial cells, deficient in the mucin MUC1, can be reversed by the addition of individual monosaccharides. The monosaccharides identified in this study are found in a wide range of organisms where they act as host factors required for bacterial pathogenesis. While mucins in C. elegans lack sialic acid caps, which makes their monosaccharides readily available, they are capped in other species. Pathogens such as P. aeruginosa that lack sialidases may rely on enzymes from other bacteria to utilize mucin-derived monosaccharides.

IMPORTANCE One of the first lines of defense present at mucosal epithelial tissues is mucus, which is a highly viscous material formed by mucin glycoproteins. Mucins serve various functions, but importantly they aid in the clearance of pathogens and debris from epithelial barriers and serve as innate immune factors. In this study, we describe a requirement of host monosaccharides, likely derived from host mucins, for the ability of Pseudomonas aeruginosa to colonize the intestine and ultimately cause death in Caenorhabditis elegans. We also demonstrate that monosaccharides alter the ability of bacteria to bind to both Caenorhabditis elegans intestinal cells and human lung alveolar epithelial cells, suggesting that there are conserved mechanisms underlying host-pathogen interactions in a range of organisms. By gaining a better understanding of pathogen-mucin interactions, we can develop better approaches to protect against pathogen infection.

Purpose:

To identify specific actions and characteristics of health care providers (HCPs) in the United States and Canada that influenced patients with type 2 diabetes who were initially reluctant to begin insulin.