WEEK two of the lockdown and I don't know about you, but I’m feeling a bit playful, so how about instead of a boring old wine column, we take a look at a drink that can be fun for all the family?

One of the country's most-loved couples returned to Channel 4 this week with Richard & Judy: Keep Reading And Carry On. The presenters talk to Georgia Humphreys about marriage, their love of books, and filming in lockdown.

Expert says labels, books, and writing centers all help with skill development

Source: www.reuters.com - Saturday, May 09, 2020
Little Richard, the self-proclaimed "architect of rock 'n' roll" who built his ground-breaking sound with a boiling blend of boogie-woogie, rhythm and blues and gospel, died on Saturday at the age of 87, Rolling Stone magazine reported.

For a moment, Wall Street seemed to be inching away from Saudi Arabia. Now, it’s already inching back.

Resistance to amoxicillin-clavulanate, a widely used beta-lactam/beta-lactamase inhibitor combination antibiotic, is rising globally, yet susceptibility testing remains challenging. To test whether whole-genome sequencing (WGS) could provide a more reliable assessment of susceptibility than traditional methods, we predicted resistance from WGS for 976 E. coli bloodstream infection isolates from Oxfordshire, UK, comparing against phenotypes from the BD Phoenix (calibrated against EUCAST guidelines). 339/976 (35%) isolates were amoxicillin-clavulanate resistant. Predictions based solely on beta-lactamase presence/absence performed poorly (sensitivity 23% (78/339)) but improved when genetic features associated with penicillinase hyper-production (e.g. promoter mutations, copy number estimates) were considered (sensitivity 82% (277/339); p<0.0001). Most discrepancies occurred in isolates with peri-breakpoint MICs. We investigated two potential causes; the phenotypic reference and the binary resistant/susceptible classification. We performed reference standard, replicated phenotyping in a random stratified subsample of 261/976 (27%) isolates using agar dilution, following both EUCAST and CLSI guidelines, which use different clavulanate concentrations. As well as disagreeing with each other, neither agar dilution phenotype aligned perfectly with genetic features. A random-effects model investigating associations between genetic features and MICs showed that some genetic features had small, variable and additive effects, resulting in variable resistance classification. Using model fixed-effects to predict MICs for the non-agar dilution isolates, predicted MICs were in essential agreement (±1 doubling dilution) with observed (BD Phoenix) MICs for 691/715 (97%) isolates. This suggests amoxicillin-clavulanate resistance in E. coli is quantitative, rather than qualitative, explaining the poorly reproducible binary (resistant/susceptible) phenotypes and suboptimal concordance between different phenotypic methods and with WGS-based predictions.

The off-label use of third generation cephalosporin (3GC) during in ovo vaccination or vaccination of newly hatched chicks, was a common practice worldwide. CMY-2-producing Escherichia coli have been disseminated among broiler production. The objectives of this study were to determine the epidemiological linkage of bla_CMY-2-positive plasmids among broilers both within and outside Japan because grandparent stock and parent stock were imported in Japan. We examined the whole genome sequences of 132 3GC-resistant E. coli isolates collected from healthy broilers during 2002-2014. The predominant 3GC-resistance gene was bla_CMY-2, which was detected in the plasmids of 87 (65.9%) isolates. The main plasmid replicon types were IncI1-I (n=21; 24.1%), IncI (n=12; 13.8%), IncB/O/K/Z (n=28; 32.2%), and IncC (n=22; 25.3%). Those plasmids were subjected to gene clustering and network analyses and plasmid multi-locus sequence typing (pMLST). The chromosomal DNA of isolates was subjected to MLST and single nucleotide variant (SNV)-based phylogenetic analysis.

MLST and SNV-based phylogenetic analysis revealed high diversity of E. coli isolates. ST429 harboring bla_CMY-2-positive IncB/O/K/Z was closely related to isolates from broiler in Germany harboring bla_CMY-2-positive IncB/O/K/Z. pST55-IncI and pST12-IncI1-I and pST3-IncC were prevalent in western Japan. pST12-IncI1-I and pST3-IncC were closely related to those detected in E. coli isolates from chicken in American continent, whereas 26 IncB/O/K/Z were related to those in Europe. These data will be useful to reveal the whole picture of transmission of CMY-2-producing bacteria in and out of Japan.

New research has found that inequality in SA has increased, with wealth becoming ever more concentrated among the rich.

Rock and roll legend Little Richard has died aged 87.

To honor a favorite professor and help students with the expenses associated with internships and study abroad, 1979 Penn State alumna Maryann Hunter created a fund in political science.

Little Richard, the self-proclaimed “architect of rock ‘n’ roll,” has died

Super-rich visitors to Cape Town over the holiday season have once again been willing to dig deep into their pockets for luxury rental accommodation.

After two unprofitable forays into augmented reality hardware, Snap is doubling down on its social camera eyewear with the $380 Spectacles 3 glasses featuring more 3D capabilities.

Brothers Keith and Richard Carlisle, who have been farming near Greenwood since the 1960s, were jointly honored for their service and contributions Thursday evening, presented with the Secretary's Award for Distinguished Service to Delaware Agriculture.

Like Maharashtra and Telangana, Odisha has also been forced to cut expenditure and defer some others, including salary payments to manage the finances at the current juncture.

Among other measures, the report suggests that inheritance tax, which was abolished in 1985, should be brought back as this would reduce concentration of wealth, widen tax base and enhance revenue.

The facelift infuses life into the Mahindra TUV300 and makes it a more feature-rich SUV than what it was before. We have listed out the pros and cons of this SUV in the video.

One of the founding fathers of rock’n’roll, songwriter and singer Little Richard, has died at the grand old age of 87. He inspired generations of musicians with his energy and drive to experiment with new genres.
Read Full Article at RT.com

Little Richard, the self-proclaimed 'architect of rock ‘n’ roll' whose piercing wail, pounding piano and towering pompadour irrevocably altered popular music while introducing black R&B to white America, has died Saturday. He was 87

Maran was ranked 43rd on the pan-India IIFL Wealth Hurun India Rich List 2019, released in September.

Saudi Arabia’s $320 billion sovereign wealth fund is exploring a potential investment in Reliance Industries Ltd.’s digital unit.

Dharampal Lakra of the Aam Aadmi Party (AAP) is the richest candidate in Delhi. He has declared wealth of close to Rs 300 crore.

Winds are from the West at 11.5 gusting to 19.6 MPH (10 gusting to 17 KT). The pressure is 1008.2 mb and the humidity is 52%. The wind chill is 28. Last Updated on May 9 2020, 11:53 am EDT.

visit News18 Urdu for latest news, breaking news, news headlines and updates from Trichur on politics, sports, entertainment, cricket, crime and more.

The UN Sustainable Development Goals aim to end global poverty, but poorer countries are struggling to hit them. More help from richer countries is crucial, writes Mazdak Rafaty.

Alphabet Inc.’s Google said it would invest 1 billion euros ($1.1 billion) to expand its data center infrastructure in the Netherlands.

Alphabet Inc.’s Google said it would invest 1 billion euros ($1.1 billion) to expand its data center infrastructure in the Netherlands.

An observer of Sir Richard Branson over say 20 years might have remarked how much older he looked as the keynote speaker at the BIO convention this week in San Diego. He struggled for words at times and was visibly tired by the end of his hour on stage; but he had lost nothing of his charm, nor had he varied in his iconoclastic approach to building great enterprises or his views on technology in the face of climate change.

Alphabet Inc.’s Google said it would invest 1 billion euros ($1.1 billion) to expand its data center infrastructure in the Netherlands.

The Supreme Court has ruled on what has been acknowledged as an issue of critical importance to the application of national planning policy, namely the proper interpretation of paragraph 49 of the National Planning Policy Framework (NPPF). This requ...

The Supreme Court’s decision in Zurich Insurance PLC UK Branch v International Energy Group Limited provides some clarity to the position of Clubs who face long-tail work related illness claims where multiple employers or insurers were involve...

Little Richard, the self-proclaimed "architect of rock 'n' roll" whose piercing wail, pounding piano and towering pompadour irrevocably altered popular music while introducing black R&B to white America, died Saturday. He was 87.

Little Richard, whose outrageous showmanship and lightning-fast rhythms intoxicated crowds in the 1950s with hits like “Tutti Frutti” and “Long Tall Sally,” has died. He was 87 years old. Citing the rock ‘n’ roll pioneer’s son, Rolling Stone magazine said Saturday the cause of death was unknown. With a distinctive voice that ranged from robust
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The post Little Richard: Founding father of rock dies at 87 appeared first on Vanguard News.

One of rock 'n' roll's founding fathers, he joined the likes of Chuck Berry and Fats Domino in bringing what was once called 'race music' into the mainstream

NASHVILLE, Tenn. (AP) — Little Richard, the self-proclaimed “architect of rock ‘n’ roll” whose piercing wail, pounding piano and towering pompadour irrevocably altered popular music while introducing black R&B to white America, has died Saturday. He was 87....

Little Richard, who helped shape the future of rock and roll in the 1950s and 1960s, died Saturday at age 87. Rolling Stone confirmed the news of his death and reported the cause of death was unknown. Born Richard Wayne Penniman in Macon, Georgia, Little Richard was known for a series of hits that included “Tutti Frutti,” “Long Tall Sally,” “Rip It Up,” “Lucille” and “Good Golly Miss Molly.” Little Richard’s contributions to the musical world were covered by a series of greats that...

Little Richard, the flamboyant, piano-pounding showman who injected sheer abandon into rock ’n’ roll in its early days, only to abandon the music again and again because it conflicted with his religious yearnings, died Saturday. He was 87. Pastor Bill Minson, a close friend of the singer, confirmed his death to the Associated Press. Minson said he also spoke to Little Richard’s son and brother. Minson added that the family is not releasing the cause of death. In hits such as “Tutti-Frutti,” “Long Tall Sally” and “Good Golly, Miss Molly,” the singer pushed the limits of tempo and vocal intensity, creating frantic explosions of sonic confetti. His records entered a pure, primal realm that...

Little Richard, the self-proclaimed "architect of rock 'n'...

NASHVILLE (AP) — Little Richard, the self-proclaimed “architect of rock ‘n’ roll” whose piercing wail, pounding piano and towering pompadour irrevocably altered popular music while introducing black R&B to white America, has died Saturday. He was 87. Pastor Bill Minson, a close friend of Little Richard’s, told The Associated Press that Little Richard died Saturday morning. Minson said he also spoke to Little Richard’s son and brother. Minson added that the family is not releasing the cause of death. Born Richard Penniman, Little Richard was one of rock ‘n’ roll’s founding fathers who helped shatter the color line on the music charts, joining Chuck Berry and Fats Domino in...

Little Richard, a founding father of Rock 'n' Roll, has died at the age of 87.

Richard influenced legions of performers whose fame would eventually outstrip his own.

Little Richard, whose outrageous showmanship and lightning-fast rhythms intoxicated crowds in the 1950s with hits like “Tutti Frutti” and “Long Tall Sally,” has died. He was 87.Citing the rock ‘n’ roll pioneer’s son, Rolling Stone magazine said on Saturday the cause of death was unknown.With a distinctive voice that ranged from robust belting to howling falsetto, Richard transfixed audiences and became an inspiration for artists including The Beatles as he transformed the blues into the…

As Asia’s rich contemplate where to place their nest eggs, most have overwhelmingly chosen Singapore over rival international financial centre Hong Kong so far this year, according to the region’s largest wealth manager.High-net-worth individuals have mainly instructed their private bankers at UBS to place new money in Singapore rather than Hong Kong, said Edmund Koh, the Swiss bank’s president in the Asia-Pacific region. Last year, the region’s high-net-worth individuals opened more new…