Archives, Room Use Only - TK5741.N47 1921

Archives, Room Use Only - TK5262.K54 1897

Archives, Room Use Only - TK5481.K33 1934

Archives, Room Use Only - Z43.C37 1923

I won’t lie to you: I might’ve pounded the table emphatically a few times while reading Mark Boulton’s latest entry:

We can now design effective adaptive layouts that respond to their environment. If these layouts are based on a system that defines its ratios from the content, then there is connectedness on two levels: connectedness to the device, and connectedness to the content.

Mark’s thinking about flexible, content-driven grids has me damned excited about his upcoming talk at AEA Boston, and you know I’ll be flinging fistfuls of lucre at my laptop screen whenever his new book’s available to preorder.

The web really feels fun again.

It doesn't pay to be rich and live in California these days.

His 1955 song Tutti Frutti helped the genre enter American life

Little Richards died on Saturday at the age of 87

In the title hydrated hybrid compound C14H14N2OS2·H2O, the planar imidazo[1,2-a]pyridine ring system is linked to the 1,3-di­thiol­ane moiety by an enone bridge. The atoms of the C—C bond in the 1,3-di­thiol­ane ring are disordered over two positions with occupancies of 0.579 (14) and 0.421 (14) and both disordered rings adopt a half-chair conformation. The oxygen atom of the enone bridge is involved in a weak intra­molecular C—H⋯O hydrogen bond, which generates an S(6) graph-set motif. In the crystal, the hybrid mol­ecules are associated in R22(14) dimeric units by weak C—H⋯O inter­actions. O—H⋯O hydrogen bonds link the water mol­ecules, forming infinite self-assembled chains along the b-axis direction to which the dimers are connected via O—H⋯N hydrogen bonding. Analysis of inter­molecular contacts using Hirshfeld surface analysis and contact enrichment ratio descriptors indicate that hydrogen bonds induced by water mol­ecules are the main driving force in the crystal packing formation.

Whole-mount (WM) platelet preparation followed by transmission electron microscopy (TEM) observation is the standard method currently used to assess dense granule (DG) deficiency (DGD). However, due to the electron-density-based contrast mechanism in TEM, other granules such as α-granules might cause false DG detection. Here, scanning transmission X-ray microscopy (STXM) was used to identify DGs and minimize false DG detection of human platelets. STXM image stacks of human platelets were collected at the calcium (Ca) L2,3 absorption edge and then converted to optical density maps. Ca distribution maps, obtained by subtracting the optical density maps at the pre-edge region from those at the post-edge region, were used to identify DGs based on the Ca richness. DGs were successfully detected using this STXM method without false detection, based on Ca maps for four human platelets. Spectral analysis of granules in human platelets confirmed that DGs contain a richer Ca content than other granules. The Ca distribution maps facilitated more effective DG identification than TEM which might falsely detect DGs. Correct identification of DGs would be important to assess the status of platelets and DG-related diseases. Therefore, this STXM method is proposed as a promising approach for better DG identification and diagnosis, as a complementary tool to the current WM TEM approach.

The crystallization of amidase, the ultimate enzyme in the Trp-dependent auxin-biosynthesis pathway, from Arabidopsis thaliana was attempted using protein samples with at least 95% purity. Cube-shaped crystals that were assumed to be amidase crystals that belonged to space group I4 (unit-cell parameters a = b = 128.6, c = 249.7 Å) were obtained and diffracted to 3.0 Å resolution. Molecular replacement using structures from the PDB containing the amidase signature fold as search models was unsuccessful in yielding a convincing solution. Using the Sequence-Independent Molecular replacement Based on Available Databases (SIMBAD) program, it was discovered that the structure corresponded to dihydrolipoamide succinyltransferase from Escherichia coli (PDB entry 1c4t), which is considered to be a common crystallization contaminant protein. The structure was refined to an Rwork of 23.0% and an Rfree of 27.2% at 3.0 Å resolution. The structure was compared with others of the same protein deposited in the PDB. This is the first report of the structure of dihydrolipo­amide succinyltransferase isolated without an expression tag and in this novel crystal form.

Bacterial cytokinesis is mediated by the Z-ring, which is formed by the prokaryotic tubulin homolog FtsZ. Recent data indicate that the Z-ring is composed of small patches of FtsZ protofilaments that travel around the bacterial cell by treadmilling. Treadmilling involves a switch from a relaxed (R) state, favored for monomers, to a tense (T) conformation, which is favored upon association into filaments. The R conformation has been observed in numerous monomeric FtsZ crystal structures and the T conformation in Staphylococcus aureus FtsZ crystallized as assembled filaments. However, while Escherichia coli has served as a main model system for the study of the Z-ring and the associated divisome, a structure has not yet been reported for E. coli FtsZ. To address this gap, structures were determined of the E. coli FtsZ mutant FtsZ(L178E) with GDP and GTP bound to 1.35 and 1.40 Å resolution, respectively. The E. coli FtsZ(L178E) structures both crystallized as straight filaments with subunits in the R conformation. These high-resolution structures can be employed to facilitate experimental cell-division studies and their interpretation in E. coli.

Over 170 molecules have been detected in space, from simple diatomic molecules like CO to complex organic molecules with over 70 atoms, such as fullerene. […]

The post Astronomers explore the rich chemistry surrounding an evolved star appeared first on Smithsonian Insider.

Galaxies are sometimes found in large clusters with many hundreds of members. Typically there is a giant elliptical galaxy near the center; most of these ellipticals are very bright emitters of radio radiation as a result of activity around supermassive black holes at their nuclei.

The post Enriching the Intracluster Medium appeared first on Smithsonian Insider.

Richard Wunderman is managing editor of the Bulletin of the Global Volcanism Network and a geologist in the Division of Mineral Sciences at the Smithsonian’s […]

The post Q&A: Smithsonian volcanologist Richard Wunderman answers questions about the Aug. 23, East Coast earthquake appeared first on Smithsonian Insider.

On Monday, Aug. 21, beginning shortly after 9 a.m. Pacific Time, the sky will darken across North America as the moon’s orbit carries it between […]

The post Enrich your solar eclipse experience with this new app! appeared first on Smithsonian Insider.

What’s an Asian small-clawed otter’s favorite enrichment toy? Anything it can get its paws on! This species’ dexterous, partially-webbed digits are adept at feeling for […]

The post Otterly engaging: Zoo enrichment appeared first on Smithsonian Insider.

 Inspired by Steampunk design, Richard Wilks talks about his larger than life 3-point mobile contraption. Through the merging of transportation and art, he created […]

The post Artist Richard Wilkes on “Evotrope” appeared first on Smithsonian Insider.

Good morning. I am Richard Bonnie, chair of the Committee on Developing a Strategy to Reduce and Prevent Underage Drinking.

Efforts to convert civilian research reactors from weapon-grade highly enriched uranium (HEU) to low enriched uranium (LEU) fuels are taking significantly longer than anticipated, says a congressionally mandated report from the National Academies of Sciences, Engineering, and Medicine.

Researchers in Berlin have demonstrated that urban wasteland areas can be used as suitable habitats for a range of grassland species. Using simple and cost-effective measures to sow grassland seed mixtures, they found that such areas flourished despite poor soil conditions and high levels of impact from people.

Researchers in Berlin have demonstrated that urban wasteland areas can be used as suitable habitats for a range of grassland species. Using simple and cost-effective measures to sow grassland seed mixtures, they found that such areas flourished despite poor soil conditions and high levels of impact from people.

Digital initiatives that began pre lockdown are giving the carmarker confidence that it will emerge stronger when the dust settles.

Results-based agri-environment measures are an alternative to management-based measures that, in certain circumstances, could be both more effective and more cost-efficient, since their payment depends on the provision of the desired conservation outcome. This study reviews the success of a scheme, introduced in Germany in 2000, to preserve biodiversity in species-rich grassland.

Farming fish together with seaweed and other species could help improve the sustainability of aquaculture and reduce pollution. A new study provides a tool for designing sustainable fish farming systems and calculates their potential to recycle waste. An example of a salmon farming system incorporating seaweed and sea urchins could reduce nitrogen releases to the environment by 45%.

Little Richard, one of the founding fathers of rock and roll, has died at the age of 87.

Richard Johnson believes that it is a tall order for any top-flight club, not just Watford, to hand homegrown players from the academy a chance to play in the Premier League due to what is at stake in financial and sporting terms.

In May 1999 Richard Johnson stitched his name indelibly into Watford folklore by helping the club end an 11-year top-flight exile courtesy of a 2-0 win over Bolton at Wembley in the play-off final.

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The agency CEO talks to PRWeek's Steve Barrett about the results of his firm's 2020 Trust Barometer.

Switch from hot oatmeal to cool chia pudding for a chilled, healthy breakfast on a sweltering summer day.

Mining the plentiful resources of the moon and near-Earth asteroids could alter the course of human history, adding trillions of dollars to the world economy an

Visiting Florida's Space Coast ahead of next week's primary, the GOP presidential candidate vows to build a permanent U.S. colony on the moon.

On 'Sarah's Summer House,' interior designer Sarah Richardson tackles a most formidable challenge: The eco-renovation of her off the grid summer cottage located

Newt Gingrich may be controversial, but he's also outspoken. (So at least you know where he stands.)

Transition to clean energy meant to provide a proof of concept to other island nations in the Caribbean.

We asked Carla Hall, Mayim Bialik, Andy Richter, Izabella Miko about their Earth Day plans.

Commercially made cat trees can cost hundreds of dollars, but you can save money and make your kitty happy with DIY feline furniture.

Billy Joel said "only the good die young." He was wrong. The poor and the middle class die younger, too.

For decades, Proenneke lived in a handmade cabin at Alaska's Twin Lakes; his writings and films have left a legacy.

Organic gardening brings benefits to both you and the plant

The former vice president has benefited from sustainable investments, Silicon Valley leadership and the sale of Current TV.

The Virgin Galactic founder envisions a near-future where space travel is as easy (and luxurious) as first-class air travel.

Even celebrities need a non-human best friend. Here are a few glimpses of pets with their famous humans.

Zurich's David Martin explains why he made the move from Allianz to Zurich and how brokers helped him take the leap.

She replaces Nick Amin who is set to move from his role as group chief operations and IT officer to supporting work on the firm’s strategic review in Asia.