Several studies have shown that behavioral problems can be associated with defecation and voiding disorders, although few studies have looked directly at a link between a diagnosis of attention-deficit/hyperactivity disorder (ADHD) and constipation or fecal incontinence.

We identified an increased risk for both constipation and fecal incontinence in children with ADHD. In patients with concomitant ADHD and defecation disorders, more aggressive medical and behavioral treatment of the constipation or fecal incontinence may be warranted. (Read the full article)

Recent studies have shown that participating in the Supplemental Nutrition Assistance Program (SNAP) is associated with improved household food security. With the exception of 1 descriptive analysis, studies have not examined how SNAP affects children’s food security.

This article estimates the association between SNAP and children’s food security using the largest, most rigorous national study of food security to date. Given current proposals to reduce program size, this study underscores SNAP’s importance in affecting children’s well-being. (Read the full article)

In-person peer counseling to pregnant and new mothers has been shown to improve breastfeeding modestly in three US RCTs. But this level of support for WIC is unlikely to be scaled up nationally in the current fiscal environment.

We randomly assigned WIC clients to a telephone peer counseling program relative to standard WIC support for breastfeeding. Nonexclusive breastfeeding among Spanish-speakers increased at 1, 3, and 6 months, but the program had much less of an effect on English-speaking clients. (Read the full article)

Preparticipation physical evaluations (PPEs) are considered necessary for a high standard of care for US scholastic athletes. However, important questions remain regarding consistency of implementation and content of cardiovascular screening practices among states.

Our results show that PPE policies are variable among US states, and adoption of current PPE-4 best practices is slow, demonstrating the need for nationwide PPE standardization. (Read the full article)

Head Start, a federally funded preschool program for low-income US children, has been reported to have beneficial effects on developmental outcomes. The association of Head Start participation with changes in children’s BMI has not been examined.

Preschool-aged children with an unhealthy weight status who participated in Head Start had a significantly healthier BMI by kindergarten entry age than comparison children in a primary care health system (both those receiving and those not receiving Medicaid). (Read the full article)

Our list of the best iPad apps can transform your iPad, iPad mini, or iPad Pro into the ultimate tablet computer for work and play.

Apple is thought to be planning a merger of its app platforms, which means a developer can develop an app once and have it automatically run on iPhone, iPad, and Mac without any extra work. The initiative is called 'Marzipan.'

Afraid someone might be able to access your phone and get to your files and pictures? Add an extra layer of security with these apps.

Adobe's initial attempt to shoehorn the sprawling Photoshop image editor into the tablet form-factor makes an impressive and pleasing start, but it really is just a start.

If you already use an iPad to do work or make art, Apple's excellent iPadOS will improve the experience, though it still doesn't provide all functionality of a laptop.

Sometimes your iPhone just isn't big enough to enjoy the best of iOS gaming. Grab your iPad and take advantage of the expanded screen real estate with these games.

Men were also more likely to request a transfer to a school with a male principal.

Slacker Radio's iPad app has an eye-catching, intuitive interface, deep customization options, offline playback, on-demand streaming, and the usual Slacker bells and whistles which make it a must-have for music fans.

Malaria parasites invade and replicate within red blood cells (RBCs), extensively modifying their structure and gaining access to the extracellular environment by placing the plasmodial surface anion channel (PSAC) into the RBC membrane. Expression of members of the cytoadherence linked antigen gene 3 (clag3) family is required for PSAC activity, a process that is regulated epigenetically. PSAC is a well-established route of uptake for large, hydrophilic antimalarial compounds and parasites can acquire resistance by silencing clag3 gene expression, thereby reducing drug uptake. We found that exposure to sub-IC50 concentrations of the histone methyltransferase inhibitor chaetocin caused substantial changes in both clag3 gene expression and RBC permeability, reversing acquired resistance to the antimalarial compound blasticidin S that is transported through PSAC. Chaetocin treatment also altered progression of parasites through their replicative cycle, presumably by changing their ability to modify chromatin appropriately to enable DNA replication. These results indicate that targeting histone modifiers could represent a novel tool for reversing epigenetically acquired drug resistance in P. falciparum.

Since 2012, single low dose of primaquine (SLDPQ, 0.25mg/kg) has been recommended with artemisinin-based combination therapies, as first-line treatment of acute uncomplicated Plasmodium falciparum malaria, to interrupt its transmission, especially in low transmission settings of multidrug, including artemisinin, resistance. Policy makers in Cambodia have been reluctant to implement this recommendation due to primaquine safety concerns and lack of data on its efficacy.

In this randomized controlled trial, 109 Cambodians with acute uncomplicated P. falciparum malaria received dihydroartemisinin-piperaquine (DP) alone or combined with SLDPQ on the first treatment day. Transmission-blocking efficacy of SLDPQ was evaluated on Days 0, 1, 2, 3, 7, 14, 21, 28 and recrudescence by reverse transcriptase polymerase chain reaction (RT-PCR) (gametocyte prevalence) and membrane-feeding assays with Anopheles minimus mosquitoes (gametocyte infectivity). Without the influence of recrudescent infections, DP+SLDPQ reduced gametocyte carriage 3 fold compared to DP. Of 48 patients tested on Day 0, only three patients were infectious to mosquitoes (~6%). Post-treatment, three patients were infectious: on D14 (3.5%, 1/29), and on the first and seventh day of recrudescence (8.3%, 1/12 for each); this overall low infectivity precluded our ability to assess its transmission blocking efficacy.

Our study confirms effective gametocyte clearance of SLDPQ when combined with DP in multidrug resistant P. falciparum and the negative impact of recrudescent infections due to poor DP efficacy. Artesunate-mefloquine (ASMQ) has replaced DP and ASMQ-SLDPQ has been deployed to treat all P. falciparum symptomatic patients to further support the elimination of multidrug resistant P. falciparum in Cambodia.

Gepotidacin, a triazaacenaphthylene bacterial type II topoisomerase inhibitor, is in development for treatment of uncomplicated urinary tract infection (uUTI). This Phase 2a study in female participants with uUTI evaluated the pharmacokinetics (primary objective), safety, and exploratory efficacy of gepotidacin. Eligible participants (N = 22) were confined to the clinic at baseline, received oral gepotidacin 1,500 mg twice daily for 5 days (on-therapy; Days 1 to 5), and returned to the clinic for test-of-cure (Days 10 to 13) and follow-up (Day 28±3). Pharmacokinetic, safety, clinical, and microbiological assessments were performed. Maximum plasma concentrations were observed approximately 1.5 to 2 hours postdose. Steady state was attained by Day 3. Urinary exposure over the dosing interval increased from 3,742 μg.h/ml (Day 1) to 5,973 μg.h/ml (Day 4), with trough concentrations of 322 to 352 μg/ml from Day 3 onward. Gepotidacin had an acceptable safety-risk profile with no treatment-limiting adverse events and no clinically relevant safety trends. Clinical success was achieved in 19 (86%) and 18 (82%) of 22 participants at test-of-cure and follow-up, respectively. Eight participants had a qualifying baseline uropathogen (growth; ≥10⁵ CFU/ml). A therapeutic (combined clinical and microbiological [no growth; <10³ CFU/ml]) successful response was achieved in 6 (75%) and 5 (63%) of 8 participants at test-of-cure and follow-up, respectively. Plasma area under the free-drug concentration-time curve over 24 hours at steady state divided by the MIC (fAUC_0-24/MIC) and urine AUC_0-24/MIC ranged from 6.99 to 90.5 and 1,292 to 121,698, respectively. Further evaluation of gepotidacin in uUTI is warranted. (NCT03568942)

Dihydroartemisinin-piperaquine has shown excellent efficacy and tolerability in malaria treatment. However, concerns have been raised of potentially harmful cardiotoxic effects associated with piperaquine. The population pharmacokinetics and cardiac effects of piperaquine were evaluated in 1,000 patients, mostly children enrolled in a multicentre trial from 10 sites in Africa. A linear relationship described the QTc-prolonging effect of piperaquine, estimating a 5.90ms mean QTc-prolongation per 100ng/mL increase in piperaquine concentration. The effect of piperaquine on absolute QTc-interval estimated a mean maximum QTc-interval of 456ms (EC₅₀=209ng/mL). Simulations from the pharmacokinetic-pharmacodynamic models predicted 1.98-2.46% risk of having QTc-prolongation > 60ms in all treatment settings. Although piperaquine administration resulted in QTc-prolongation, no cardiovascular adverse events were found in these patients. Thus, the use of dihydroartemisinin-piperaquine should not be limited by this concern.

Earlier genetic and inhibitor studies have shown that epigenetic regulation of gene expression is critical for malaria parasite survival in multiple life stages and a promising target for new anti-malarials. We therefore evaluated the activity of 350 diverse epigenetic inhibitors against multiple stages of Plasmodium falciparum. We observed ≥90% inhibition at 10 μM for 28% of compounds against asexual blood stages and early gametocytes, of which a third retained ≥90% inhibition at 1 μM.

Two alumni and one community partner contribute clinical medicine and research experience during the pandemic

Is your favorite music missing on your iPhone or iPad? Maybe you inadvertently turned off syncing or accidentally deleted those tunes. All is not lost; here's how to recover your music.

The 1TB Samsung 860 EVO m.2 SSD is just $119 today, the 10.2-inch iPad is back in stock with a 15 percent discount, and you can save $250 on the 13-inch MacBook Pro.

A new guide from the National Center for Learning Disabilities and Understood.org offers advice on how school leaders can best serve students with disabilities and support special education teachers.

The need for materials, training, guidance from district administrators, and access to staff with expertise in serving students with disabilities is especially acute in schools that serve primarily black and Latino students, a new survey finds.

T. Michael O'Shea
Jul 1, 1999; 104:15-21
ARTICLES

New data from the National Center for Education Statistics find that principals at private schools tend to have more experience, 9.7 years on average leading schools versus 6.8 years for public school principals.

Today there are discounts on the Dell Insprion 15 5000 laptop, 12.9-inch iPad Pro, a few SSD and HDD storage devices, the second-generation AirPods, and more.

The Tennessee department of education is proposing unsually comprehensive legislation that will require all current and new K-3 teachers, and those who train them, to know evidence-based reading instruction.

School superintendents, principals, and school board members found a lot to like in a draft bill to renew the Elementary and Secondary Education Act.

Principals who also teach are a long tradition in a rural Maryland school system, where teachers and school leaders alike attest to the benefits. But some education leadership experts argue the double duty wouldn't work in all schools.

Seven universities are making major changes to how they train future principals, as part of $48.5 million Wallace Foundation initiative to redesign university-based principal-preparation programs, according to a new report from RAND.

Ultimately, the payment of municipal utilities and taxes is the responsibility of the property owner, explains an attorney.

This multicenter study analyzes the effects of pediatric inpatient asthma pathways on quality of care across varied hospital settings.

Program to include a re-enactment of the July 11, 1804 duel between Alexander Hamilton and political rival Aaron Burr which resulted in Hamilton’s passing on July 12, 1804.

Participants in Delaware's Women, Infants and Children (WIC) program can now use special coupons to purchase fresh fruits and vegetables at 11 Delaware farmers' markets under a pilot program beginning this week.

Agency: GSS Closing Date: 5/20/2020

Delaware will hold its 16th Drug Take-Back Day on Saturday, April 28, 2018, to help reduce the risk of prescription medications being diverted for misuse. Delawareans can discard their expired or unused medications at 24 locations statewide between 10 a.m. and 2 p.m.

WILMINGTON, Del. – In support of a movement to transform how health care is delivered and paid for in the state, Delaware was one of eight states chosen to participate in a National Governors Association initiative to harness data systems to inform health policymaking. Joining Arkansas, Colorado, Indiana, Iowa, Minnesota, Vermont and Washington, Delaware’s team […]

Sat., Oct. 26, 2019: Delaware residents can safely dispose of their unused or expired prescription medications at designated sites throughout the state as part of the 18th National Prescription Drug Take-Back Day.

Washington D.C. – Division of Public Health (DPH) Director Dr. Karyl Rattay participated in a Congressional briefing for members of the U.S. Senate and U.S. House of Representatives on Capitol Hill today, November 7, 2019, regarding maternal and infant health as part of a panel discussion hosted by March of Dimes. The briefing, “Making the […]

Covid-19 is a new virus, whose behaviour is yet to be unravelled. Mutations cannot be ruled out. It is no one-stroke flattening of the curve.

Attorney General Kathy Jennings today announced that Delaware has joined a bipartisan, multistate investigation of JUUL Labs. The 39-state coalition is investigating JUUL’s marketing and sales practices, including targeting of youth. The investigation also concerns claims regarding nicotine content, statements regarding the risks and safety of e-cigarettes, and the effectiveness of e-cigarettes as smoking cessation […]

Wilmington. Governor Carney changed upcoming School Board and Municipal Elections in his 6th update to the State of Emergency. The Governor ordered School Board elections scheduled for May 12th delayed until June 16th. He  also ordered municipal elections scheduled before May 15th cancelled and  rescheduled no earlier than May 15, 2020. The Governor further ordered […]

The Delaware Emergency Management Agency (DEMA) encourages people across the state to take part in the Great Shakeout Earthquake Drill

The therapy involves taking antibodies from the blood of a person who has recovered from COVID-19 and transfusing those antibodies into an active coronavirus patient to help kickstart the immune system.

Tony Ferguson and Justin Gaethje have both successfully made weight ahead of the UFC's first fight card in nearly two months on Saturday night, in what promises to be a fiercely violent affair between the two lightweight stars.
Read Full Article at RT.com

Darjeeling's Himalayan Mountaineering Institute (HMI) has unveiled a novel competition to encourage people to stay inside their homes.

With deep sorrow, it is to inform that on Saturday, May 2nd, 2020 at approximately 8:45 PM, Judicial Member, Lokpal of India, Justice Ajay Kumar Tripathi passed away at AIIMS, New Delhi. He was infected with Corona virus and was admitted to AIIMS on

We present the facts of Express Entry as an option for candidates who have credentials that are similar to the credentials of Meghan and Harry. Their qualifying for permanent residence in Canada is a matter of discussion. There is news about the potential…

1. Not anticipating worst situation in India: Harsh Vardhan on Covid-19 pandemic  Times of India
2. Health ministry says learn to live with coronavirus as India's COVID-19 count crosses 56,000  Livemint
3. Government Tweaks Rules For Testing As COVID-19 Cases Rise. Details Here  NDTV
4. People must learn to live with the virus, follow prevention guidelines: Govt  Moneycontrol
5. Coronavirus: Do not anticipate worst case situation like developed countries in India, says govt  Livemint
6. View Full coverage on Google News