Mitchell G. Spring
Oct 9, 2024; 44:e0602242024-e0602242024
BehavioralSystemsCognitive

Serotonin modulates diverse phenotypes and functions including depressive, aggressive, impulsive, and feeding behaviors, all of which have reward-related components. To date, research has focused on understanding these effects by measuring and manipulating dorsal raphe serotonin neurons and using single-receptor approaches. These studies have led to a better understanding of the heterogeneity of serotonin actions on behavior; however, they leave open many questions about the timing and location of serotonin's actions modulating the neural circuits that drive these behaviors. Recent advances in genetically encoded fluorescent biosensors, including the GPCR activation-based sensor for serotonin (GRAB-5-HT), enable the measurement of serotonin release in mice on a timescale compatible with a single rewarding event without corelease confounds. Given substantial evidence from slice electrophysiology experiments showing that serotonin influences neural activity of the striatal circuitry, and the known role of the dorsal medial striatal (DMS) in reward-directed behavior, we focused on understanding the parameters and timing that govern serotonin release in the DMS in the context of reward consumption, external reward value, internal state, and cued reward. Overall, we found that serotonin release is associated with each of these and encodes reward anticipation, value, approach, and consumption in the DMS.

Milagra, Spanish for “miracle,” was hatched and raised in captivity by foster condor parents after her mother died of avian flu in April 2023

Created in London in the 1960s, the tracks are heading to auction as part of a larger collection of memorabilia connected to the famous American guitarist

SOLIDWORKS Edition for Windows Vista delivers enhanced user experience plus advanced search, preview, and content distribution

On this episode of the HomeKit Insider Podcast we talk about Apple's new betas, discuss the major Matter 1.4 release which adds new categories and other improvements, and more!

An Apple supplier may have been tapped to build an Apple-designed smart home camera and future health-focused AirPods, according to analyst Ming-Chi Kuo.

iOS 18.2 with access to ChatGPT integrations, Image Playground, and Genmoji could finally roll out to the general public on December 9 based on a notice recently posted by a UK carrier.

A state court ruled that Virginia must turn over growth data by school and classroom teacher, without redacting the teachers' names.

DOVER, DE – Governor John Carney on Friday released the following statement on Director Eugene Young Jr.’s decision to step down March 8, 2024, from his current role as the head of the Delaware State Housing Authority. Director Young has served as the agency’s leader since 2021.   “Eugene is a strong leader dedicated to public service. […]

The mock test papers series-I will commence from November 18, 2024 while that for series-II will begin from December 9, 2024.

Allu Arjun, the star of Pushpa 2, will join Nandamuri Balakrishna on the iconic Telugu talk show ‘Unstoppable with NBK’. In this episode, airing November 15 on Aha, Arjun speaks about his acting inspirations, memorable co-stars, and personal insights shared by his mother. The episode will also preview Pushpa 2 and his historic National Award win.

Prashanth Neel’s Bagheera, starring Sriimurali as a vigilante IPS officer, comes to Netflix for streaming this December. Known for its compelling storyline and powerful cast, including Prakash Raj and Rukmini Vasanth, Bagheera captivated cinema-goers and emerged as a Diwali hit. Netflix’s acquisition marks a significant step for Kannada cinema on the platform, with Bagheera joining other Hombale Films projects. The exact streaming date remains unconfirmed, but fans can expect the movie in early December.

A Very Royal Scandal, featuring Ruth Wilson and Michael Sheen, brings viewers into the world of the British royal family’s explosive 2019 interview that revealed new truths about Prince Andrew. Now available in India on SonyLIV, the series dives deep into royal drama. Directed by Julian Jarrold and produced by Amazon MGM Studios, it revisits key events and figures surrounding one of the monarchy’s most notable scandals.

Google released a new experimental artificial intelligence (AI) tool on Monday aimed at helping users learn about new topics. Dubbed Learn About, the tool is different from the Mountain View-based tech giant's usual AI offerings, such as Gemini or AI Overviews. The experimental tool shows the information in a visual and interactive style and picks the data from educational sources.

Disney+ Hotstar's new Tamil series Parachute, directed by Sridhar K, features actors Shaam, Kishore, and Kani Thiru, focusing on a warm family dynamic. The teaser, now available on Disney+ Hotstar’s social media, introduces two children exploring the world around them. Produced by Krishna's Tribal Horse Entertainment, the series has a skilled technical crew, with Om Narayan on cinematography and Richard Kevin editing. Set to air on Disney+ Hotstar, this show is aimed at viewers who enjoy heartfelt family narratives.

The OTT release of Amaran starring Sivakarthikeyan has been delayed by a week as its strong box office performance continues, surpassing ₹200 crore in two weeks. Originally scheduled for Netflix after 28 days, Amaran will now be available mid-December. The film, based on Major Mukund Varadarajan's life, is directed by Rajkumar Periasamy. With audiences in Tamil Nadu, Kerala, and Karnataka filling theatres, this delay represents a rare shift to maximise earnings before its digital debut.

Cross, the new Prime Video crime-thriller series, debuts on November 14, 2024. Featuring Aldis Hodge as Alex Cross, this adaptation goes deeper into the detectives life than previous film versions. With 8 episodes in season 1, the show promises intense action and emotional depth as Cross faces a series of personal and professional challenges. The series marks a reimagined take on James Pattersons iconic character, with all episodes dropping on the same day for binge-watchers.

The supernatural horror fantasy The Watchers will stream on JioCinema in India beginning November 14, 2024. Directed by Ishana Night Shyamalan, the film stars Dakota Fanning as Mina, a young artist trapped in an eerie Irish forest with nocturnal beasts pursuing her and three strangers. The Watchers has gained attention for its gripping story, chilling atmosphere and for being Ishana’s directorial debut. The film is adapted from A.M. Shine's 2021 novel and has already captivated horror fans worldwide.

The exclusive fan event will take place in Seoul on November 24

The trailer of Pushpa 2 will release on November 17

From highly-anticipated blockbusters to critically acclaimed indie darlings, our comprehensive guide has got you covered

Directed by Nikhil Advani, Kal Ho Naa Ho features Shah Rukh Khan as Aman Mathur, Saif Ali Khan as Rohit Patel and Preity Zinta as Naina Catherine Kapur

The cast also included Rani Mukerji, Manoj Bajpayee, Amitabh Bachchan, Hema Malini and Boman Irani.

Consumers continue to benefit from carrier expansion and insurer oversight The Delaware Department of Insurance (DOI) has published its annual performance and productivity data, indicating continued success in serving consumers throughout the state. “In the face of inflation, climate change, the pandemic, and other challenges, our priority remains the same: the residents of our great […]

Another banner year for consumer protection and insurer competition In 2023, the Delaware Department of Insurance’s 101 team members served Delaware residents and seniors, attracted new companies, oversaw expansions of coverage and enhanced competition, and contributed substantial funds to the state. Today’s data release details how each team contributed to Delaware’s strong insurance environment. “Each […]

The Delaware Public Archives is pleased to announce the digital release of “The Abram H. Draper Collection.” This unique collection consists of 34 pieces of correspondence including letters and poetry from Sergeant Abram H. Draper to his wife Anna M. Wiley Draper during the American Civil War. The content ranges from detailed descriptions of Draper’s […]

Today, the Delaware Public Service Commission (PSC) released The Final Report assessing the conduct and results of Delmarva Power’s electric Standard Offer Service (SOS) reverse auction process for the 2021-2022 procurement year; the PSC was assisted by its technical consultant, Siemens PTI. Delmarva Power successfully secured all of the outstanding needs for full-requirement service for […]

Report addresses firearm, claims of new evidence The Department of Justice’s Division of Civil Rights & Public Trust (DCRPT) released Tuesday a supplemental report regarding the September 23, 2015 police shooting of Jeremy McDole. After the DOJ was presented in June with claims of new evidence and concerns about the validity of firearms evidence cited […]

Recommendations include housing, trauma training, expanding recovery resources in the criminal justice system The Delaware Drug Overdose Fatality Review Commission (DOFRC) has released its second annual report to Governor John Carney and the General Assembly. The 18-page report, released Tuesday, details five policy recommendations based on its review of a sample of 130 overdose fatalities […]

Attorney General Kathy Jennings released Tuesday a legislative agenda outlining ten policy priorities that she will advocate to the 151st General Assembly in 2021. “I know what we’re capable of in 2021, because I know what we accomplished together in the last two years,” said Attorney General Jennings. “We’ve made real progress, from historic criminal […]

Attorney General Kathy Jennings announced Friday that the Department of Justice charged 130 gun offenders and secured more than 245 total years in prison sentences on 18 gun convictions in the month of February.  Since 2019, the DOJ has an 83% conviction rate in Superior Court gun cases. “My first priority is combatting violent crime—particularly gun […]

Attorney General Kathy Jennings announced Friday that the Department of Justice charged 102 gun offenders and secured 279.5 total years in prison sentences on 67 gun convictions in the month of March. “My first priority is combatting violent crime—particularly gun crimes,” said AG Jennings.  “Gun violence is a both a national crisis and a local one. In Delaware, […]

Recommendations include a whole-person approach to substance use disorder treatment and broadened non-opioid options for chronic pain treatment  The Delaware Drug Overdose Fatality Review Commission (DOFRC) has released its second annual report to Governor John Carney and the General Assembly, announced Attorney General Kathy Jennings. The report examines a sample of 108 cases from fatal overdoses that occurred […]

  For Immediate Release Thursday, May 28, 2020. Wilmington, DE The Delaware Department of Labor releases Fraud Prevention guidelines for employers and claimants to protect against identity theft and fraud involving unemployment benefits during the COVID-19 pandemic.   Over the past few weeks, several states have reported incidents of identity theft and payment fraud regarding […]

December 28, 2020 For Immediate Release Kenneth Briscoe Email: kenneth.Briscoe@Delaware.gov   Wilmington, DE (Dec. 28, 2020) – On December 27, 2020, the President signed the latest COVID-19 Relief bill, which extends certain federal unemployment benefits available under the CARES Act. The bill provides the extension of the Pandemic Unemployment Assistance program (PUA) and Pandemic Emergency […]

WILMINGTON, Del —The Office of Women’s Advancement & Advocacy, a Division of the Delaware Department of Human Resources, in partnership with the Delaware Departments of Labor and Education, released a new report titled- Delaware Women in the Construction Trades: A Path to Economic Security. The report examines the current state of women working in the […]

WILMINGTON, Delaware – The Delaware Department of Labor (DOL) has re-released Fraud Prevention guidelines for employers and claimants to protect against identity theft and fraud involving unemployment insurance benefits as incidence of new consumer scams increase across the country. In recent months, the U.S. Federal Trade Commission (FTC) has received multiple reports of scams where […]

Fourth annual report highlights State accomplishments WILMINGTON, Del. – Governor John Carney on Thursday released the fourth annual report of the Government Efficiency and Accountability Review (GEAR) Board. Governor Carney established GEAR by Executive Order in February of 2017 in order to identify ways for state government to operate more efficiently, improve the delivery of state services, and provide […]

Fifth annual report highlights State’s continuous improvement accomplishments WILMINGTON, Del. – Governor John Carney released the fifth annual report of the Government Efficiency and Accountability Review (GEAR) Board. Governor Carney established GEAR by Executive Order in February 2017 in order to identify ways for state government to operate more efficiently, improve the delivery of state services, […]

Seventh annual report highlights State’s continuous improvement accomplishments   WILMINGTON, Del. – Governor John Carney on Monday released the seventh annual report of the Government Efficiency and Accountability Review (GEAR) Board. Governor Carney established GEAR under Executive Order #4 in February 2017 to identify ways for State government to sustain its culture of continuous improvement […]

DOVER, DE (March 25, 2022) – The Division of Public Health (DPH) is providing an update on COVID-19 statistics in Delaware, as of Thursday, March 24, 2022. As a result of declining COVID-19 cases, DPH is changing the frequency of these data releases from weekly to monthly.  The next data release will be April 22.  […]

NEW CASTLE (May 5, 2022) – Department of Health and Social Services (DHSS) Secretary Molly Magarik presented the State’s second annual Benchmark Trend Report at today’s Delaware Health Care Commission (DHCC) meeting. This report displays trends in Delaware’s health care spending and quality, comparing new 2020 data against a set benchmark, as well as baseline […]

DOVER, Del. – State Auditor Kathy McGuiness announced today the upcoming release of fifteen examinations of Delaware’s Long-Term Care Facilities. “Today my office is releasing the ‘Examination of The Moorings at Lewes Nursing Home Long-Term Healthcare Facility’, but there will be many more in the coming weeks as part of this office’s regular review of […]

DOVER, DE (August 30, 2022) – The Division of Public Health (DPH) is releasing a 2020 State Unintentional Drug Overdose Reporting System (SUDORS) fact sheet on all drug overdose deaths that occurred in Delaware. This snapshot contains fatality data abstracted from the state’s Overdose Data to Action (OD2A) collaborative. DPH collects and analyzes unintentional drug overdose […]

DOVER, DE (Oct. 10, 2022) – Delaware’s cancer mortality, or death, rate has further declined, according to the latest cancer data from the Division of Public Health (DPH).  Between 2005 and 2019, mortality rates for cancer at all locations throughout the body, known as all-site cancer, decreased an average of 1.7% per year in both Delaware and […]

NEW CASTLE (April 6, 2023) – Department of Health and Social Services (DHSS) Secretary Molly Magarik presented the State’s third annual Benchmark Trend Report at today’s Delaware Health Care Commission (DHCC) meeting. This report displays trends in Delaware’s health care spending and quality, comparing new 2021 data against a set benchmark, as well as baseline […]

The Office of the Marijuana Commissioner (OMC) has released additional sections of the informal draft regulations for review. The sections of draft regulations released today include the sections related to tracking, product health standards, packaging and labeling requirements, and advertising. The Informal Comment Period on the OMC website omc.delaware.gov will close on March 29, 2024. […]

The Office of the Marijuana Commissioner (OMC) has released additional sections of the informal draft regulations for review. The sections of draft regulations released today include the sections related to testing, sampling, waste, disposal, appeals, variances, and fee schedules. The Informal Comment Period on the OMC website omc.delaware.gov will close on March 29, 2024. Once this informal […]

NEW CASTLE (May 7, 2024) – Per capita health care spending in Delaware increased 6.3% in 2022 to $9,657, outpacing a 3% growth rate benchmark, according to the State of Delaware’s fourth annual Benchmark Trend Report presented Thursday May 2 to the Delaware Health Care Commission (DHCC) by Department of Health and Social Services (DHSS) […]