En Caracol Radio estuvo Cielo Rusinque, superintendente de Industria y Comercio, explicando las medidas de la entidad.

Natalia Tinjacá, directora técnica de Transmilenio, habló sobre cómo afectó la movilidad de Transmilenio en bloqueo de vendedores ambulantes 

Juan Carlos Hernández, alcalde La Calera, se pronunció sobre los cambios que tendrá la calzada norte de la calle 84 y en qué horarios se establecería la medida

La Coordinadora Vecinal del Baix Besòs ha emitido un comunicado para apremiar a las administraciones públicas a aportar una solución definitiva al barraquismo con presencia en los márgenes del río Besòs desde hace años. via Pocket

Generative AI could also provide more opportunities for players to go off-script and create their own stories if designers can craft environments that feel more alive and can react to players’ choices in real-time.

Compre, the Bermuda-domiciled international legacy group, today announces the acquisition of two portfolios of European casualty and motor liabilities from separate undisclosed international insurance groups. A spokesperson said, “All necessary approvals have been granted by Bermudian and European regulators, allowing Compre’s class 3B Bermudian reinsurer Pallas Reinsurance Company Ltd. to reinsure approximately €200m of reserves […]

Google представила несколько нововведений для браузера Chrome на iPhone и iPad. В частности, функция Google Lens теперь позволяет одновременно искать по изображению и тексту.

Когда Apple впервые рассказала про интеграцию ChatGPT в наши айфоны, мне особенно запомнился тот факт, что нейросетью можно будет пользоваться абсолютно бесплатно. То есть выглядело это так, что владельцы техники Apple получают в своё распоряжение можный ИИ, за который все остальные пользователи платят по 20 долларов в месяц. Такой шаг был не совсем похож на...

Apple выпустила iOS 18.2 beta 3 для авторизованных разработчиков. Номер сборки — 22C5131e. Компания сообщила лишь про исправления ошибок и повышение стабильности. О другом не сообщается. Если что-то станет известно, мы обновим статью. Что нового: • вернулся старый видеоплеер в приложение Фото • начиная с iPadOS 18.2 beta 3, панель навигации в приложении TV теперь...

В iOS 18.2 beta 3 вернулся классический видеоплеер. Теперь видео открываются сразу на весь экран, как это было в предыдущих версиях системы. Новое приложение Фото в iOS 18 многих бесило, потому что по умолчанию открывало видео в уменьшенном размере с белой рамкой по боками. Чтобы развернуть его на весь экран, приходилось ещё раз нажимать на...

В коде третьей бета-версии iOS 18.2 найдены новые иконки приложений Климат и Медиа для CarPlay нового поколения. Впервые эти иконки появились в iOS 17.4, а сейчас компания немного изменила их дизайн. Apple утверждает на своём сайте, что первые автомобили с новым CarPlay появятся в 2024 году, но до сих пор ни один автопроизводитель не выпустил...

Apple выпустит iOS 18.2 с новыми функциями Apple Intelligence 9 декабря, сообщает MacRumors. Дата выпуска обновления основана на информации от британского оператора EE. Он сообщил своим клиентам, что с 9 декабря перестанет работать услуга, позволяющая пользователям совершать Wi-Fi звонки на iPad и Mac, когда их iPhone находится не рядом. В iOS 18.2 beta 2 обновились...

Google today announced several new features for the Chrome browser that's available on the iPhone and the iPad, with the new additions aimed at providing users with more intuitive ways for finding information and completing tasks.


Google Lens now supports searching with images and text at the same time, rather than search being limited to just an image. Users can add words to a visual query to refine results and conduct more complex searches.

Google Drive and Google Photos users can now save content from the web directly to those services from Chrome, freeing up on-device storage space. To save a file to Google Drive from Chrome, tap on the Google Drive option. Saving an image to ‌Photos‌ from Chrome can be done by long pressing on the image and then selecting the Save in Google ‌Photos‌ option.

For U.S. users, Chrome on iOS is gaining Shopping Insights, which are designed to better surface deals. If Chrome has Shopping Insights for a product that a user is searching for, there will be a "Good Deal Now" notification in the address bar. The feature requires signing into Chrome and toggling on "Make Searches and Browsing Better."

When viewing a map of an address in Chrome, users will soon be able to tap an underlined address and see a more detailed mini-map of the location directly in the browser without having to swap over to Google Maps. Google says that it is experimenting with this feature and will roll it out globally over the coming months.

This article, "Chrome for iOS Gets Google Lens Update, Shopping Insights and More" first appeared on MacRumors.com

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Apple today seeded the second public betas of upcoming iOS 18.2, iPadOS 18.2, and macOS Sequoia 15.2 updates, allowing the public to continue testing new features ahead of when the software launches. The public betas come a day after Apple provided developers with new betas.


Public beta testers can download the updates from the Settings app on each device after opting into the beta through Apple's public beta testing website. Note that Apple has also released public betas for watchOS 11.2, tvOS 18.2, and the latest HomePod software.

iOS 18.2, iPadOS 18.2, and ‌macOS Sequoia‌ introduce the next Apple Intelligence features, including the first image generation capabilities.

The update adds Image Playground, a new app for creating images based on text descriptions. You can enter anything you want, though Apple will suggest costumes, locations, items, and more to add to an image. There are options to create characters that resemble your friends and family, and you can choose a photo for ‌Image Playground‌ to use as inspiration to create a related image. Elements added to ‌Image Playground‌ creations are previewed, and there is a preview history so you can undo a change and go back to a prior version.

While ‌Image Playground‌ is a standalone app, it is also integrated into Messages, Notes, Freeform, and more. ‌Image Playground‌ does not make photorealistic images and is instead limited to animation or illustration styles.

The update also adds Genmoji, which are customizable emoji characters that you can create based on descriptions and phrases. Like ‌Image Playground‌ creations, you can base them on your friends and family, with the data pulled from the People album in Photos. You can also make characters using basic elements, and you'll get multiple ‌Genmoji‌ suggestions to choose from. You can create ‌Genmoji‌ using the emoji keyboard.

‌Genmoji‌ are limited to iOS 18.2 and iPadOS 18.2 right now, and will be coming to ‌macOS Sequoia‌ later.

Siri in iOS 18.2, iPadOS 18.2, and ‌macOS Sequoia‌ 15.2 has ChatGPT integration. If ‌Siri‌ is unable to provide an answer to a question, ‌Siri‌ will hand the request over to ChatGPT, though ‌Siri‌ will need user permission first. ChatGPT will answer the question and relay the information back through ‌Siri‌.

ChatGPT can be used to create content from scratch, including text and images. No account is required to use ChatGPT integration, and Apple and OpenAI do not store requests.

If you have an iPhone 16, there's a Visual Intelligence feature in iOS 18.2 that provides information about what's around you. Open up the camera and point it at a restaurant to get reviews, or point it at an item to search Google for it.

Some other Visual Intelligence capabilities include reading text out loud, detecting phone numbers and addresses to add them to Contacts, copying text, and summarizing text.

Apple added Writing Tools in iOS 18.1, but in iOS 18.2, you can more freely describe the tone or content change that you want to make, such as adding more action words, or turning an email into a poem.

‌Apple Intelligence‌ now supports localized English in Australia, Canada, New Zealand, South Africa, Ireland, and the UK in addition to U.S. English.

Wait List

If you've already been testing ‌Apple Intelligence‌ and are opted in, you will have access to Writing Tools, ChatGPT integration, and Visual Intelligence automatically.

There is a secondary waiting list for early access to use ‌Genmoji‌, ‌Image Playground‌, and Image Wand. You can sign up to get access in ‌Image Playground‌ or in the areas where you access ‌Genmoji‌ or Image Wand.

When you request access, you are added to a wait list for all three capabilities and you'll get a notification when the features are available for you to use. Apple will roll out access over time.

Availability and Compatibility

The public betas are available on all devices, but the ‌Apple Intelligence‌ features require a device capable of ‌Apple Intelligence‌.

Apple is still working on refining the new ‌Apple Intelligence‌ tools, and the company warns that ‌Genmoji‌, Image Wand, and ‌Image Playground‌ can sometimes give you results you weren't expecting. Apple is collecting feedback on these experiences and will refine them over time.

Release Date

Apple is expected to release the iOS 18.2, iPadOS 18.2, ‌macOS Sequoia‌ 15.2, watchOS 11.2, tvOS 18.2, and visionOS 2.2 updates in early December.
This article, "Apple Seeds Second Public Betas of iOS 18.2, iPadOS 18.2 and macOS Sequoia 15.2 With New Apple Intelligence Features" first appeared on MacRumors.com

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Apple previously confirmed that iOS 18.2 will be released in December, and now a potential release date within the month has surfaced.


We believe that Apple is likely planning to release iOS 18.2 on Monday, December 9, based on a recent notice that British carrier EE provided to its customers. In the notice, EE said it will be discontinuing an iPhone feature known as "Wi-Fi calling on other supported iCloud-connected devices" on December 9. The feature enables users to make Wi-Fi calls on devices like the iPad and Mac, even when their iPhone is not nearby.

The second developer beta of iOS 18.2 last week came bundled with a new EE carrier settings version numbered 60.5.2, up from 59.5.1 on the first iOS 18.2 beta and iOS 18.1. The new carrier settings version removed the "Add Wi-Fi Calling For Other Devices" toggle from the Wi-Fi Calling section in the Settings app on iPhones used by EE customers, in line with the carrier announcing that it will stop offering the feature next month.

Most carrier setting updates are bundled with iOS updates, aside from ones with bug fixes, so EE has likely indirectly revealed that iOS 18.2 will be released on December 9. We are not absolutely certain about this date, but it is a very likely possibility.

iOS 18.2 being released on December 9 would not be very surprising. Apple already said the update was coming next month, many iOS updates are released on Mondays, and the second half of the month is pretty much ruled out due to the holiday season. Nevertheless, you can now mark your calendars a little more precisely.

iOS 18.2 includes additional Apple Intelligence features for iPhone 15 Pro models and all iPhone 16 models, including Genmoji, Image Playground, ChatGPT integration for Siri, and more. On all compatible iPhones, the update also adds a new Defaults section in the Settings app, an item location sharing feature in the Find My app, and more.

(Thanks, Harvey!)

This article, "Apple Likely Planning to Release iOS 18.2 on December 9" first appeared on MacRumors.com

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Twofold the enjoyment with twice as many Brazilians on Tim Tales! Bottom hottie Igor Lucios is ecstatic over Deminho‘s enormously thick dick; he simply enjoys worshiping that large cock. It’s perfectly curved and really thick. And it feels like nirvana within his avaricious culo. Don’t Brazilians just know when they should crank up the temperature?... View Article

The post Tim Tales: Deminho and Igor Lucios appeared first on QueerClick.

New on NextDoorStudios, an ASGMax site: Colt Spence would do anything to just relax today. He’s been beyond stressed out from work and his wife won’t stop calling him incessantly just to check in and see how he’s doing. Finally thinking he has some alone time, he ends up getting a surprise visitor when Andrew... View Article

The post ASGMax | NextDoorStudios: Andrew Delta and Colt Spence – “No Time to Relax” appeared first on QueerClick.

Juniors and seniors in the Program in Visual Arts and Practice of Art Track in the Department of Art & Archaeology open their studios to the community. No tickets required; drop-in from 5:30-7 PM.

The app allows anyone, regardless of experience or skill, to generate cg animation.

The project is from Mattel Films, Shadowmachine, Jennifer Lopez’s Nuyorican Productions, and actor-producer Anthony Ramos.

The Vienna Dioscurides is an early 6th-century copy of De Materia Medica, a manuscript first created by the ancient Greek physician and pharmacologist Dioscurides. A precursor to all modern pharmacopeias, it remained in practical use until about 1600. The Vienna Dioscurides contains more than 400 pictures of animals and plants and is the earliest known manuscript to use a solid gold background. It is also the oldest surviving illustrated treatise on what type of animal?

Apple has released iOS 17.7.1 and iPadOS 17.7.1 for iPhone and iPad users who are not running iOS 18, which was just updated to includes support for Apple Intelligence with iOS 18.1 and iPadOS 18.1. The software updates include important security fixes, making them important updates to install if you’re still running the prior major ... Read More

The second beta versions of iOS 18.2, MacOS Sequoia 15.2, and iPadOS 18.2 are now available for users participating in the beta testing programs for Apple system software. The new betas continue to focus on additional Apple Intelligence features, expanding beyond the writing tools, smart replies, and summary features what was initially introduced in iOS ... Read More

The third betas of iOS 18.2, iPadOS 18.2, and MacOS Sequoia 15.2, are available for beta testers of Apple system software. The latest betas continue to emphasize on new Apple Intelligence features, including ChatGPT integration, Genmoji custom Emoji creation, Image Playground for AI image generation, and more. These new AI features are in addition to ... Read More

The iOS 18 update is a fun one with some intriguing new features, mostly for visual tweaks like adding dark mode icons and color hues, and of course there’s Apple Intelligence AI features if your iPhone is new enough to support those features. One of the other major changes in iOS 18 and iPadOS 18 ... Read More

Originally posted on Oct 28, 2022 It was an honor to be interviewed by the beautiful and patriotic Sandy Rios about my book and my journey writing it on her show, “Sandy Rios In the Morning.” https://afr.net/podcasts/sandy-rios-in-the-morning/2022/october/cynthia-farahat-discusses-her-new-book-the-secret-apparatus-the-muslim-brotherhood-s-industry-of-death/

Epoxide hydrolases (EHs) have been characterized and engineered as biocatalysts that convert epoxides to valuable chiral vicinal diol precursors of drugs and bioactive compounds. Nonetheless, the regioselectivity control of the epoxide ring opening by EHs remains challenging. Alp1U is an α/β-fold EH that exhibits poor regioselectivity in the epoxide hydrolysis of fluostatin C (compound 1) and produces a pair of stereoisomers. Herein, we established the absolute configuration of the two stereoisomeric products and determined the crystal structure of Alp1U. A Trp-186/Trp-187/Tyr-247 oxirane oxygen hole was identified in Alp1U that replaced the canonical Tyr/Tyr pair in α/β-EHs. Mutation of residues in the atypical oxirane oxygen hole of Alp1U improved the regioselectivity for epoxide hydrolysis on 1. The single site Y247F mutation led to highly regioselective (98%) attack at C-3 of 1, whereas the double mutation W187F/Y247F resulted in regioselective (94%) nucleophilic attack at C-2. Furthermore, single-crystal X-ray structures of the two regioselective Alp1U variants in complex with 1 were determined. These findings allowed insights into the reaction details of Alp1U and provided a new approach for engineering regioselective epoxide hydrolases.

Business Briefing: US election geopolitical and economic risk scenarios 10 October 2024 — 11:45AM TO 1:00PM Anonymous (not verified) 23 September 2024 Chatham House

Please join us for this critical discussion of the US Election related global business risks.

The outcome of the US presidential election will have significant, intersecting implications for global as well as American business. At stake will be the degree of continuity and stability on both the domestic and international fronts, with a Harris presidency pursuing policies building broadly on the Biden Administration and a second Trump Administration departing sharply from them—with both shaped and limited by control of Congress.

An already volatile geopolitical environment and global economy may become even more unpredictable in the face of potential American political instability and uncertain leadership in the international community.

Please join us for this critical session to discuss:

• How might trade policy differ between a Harris and Trump presidency? Will national security pressures, especially over China, lead to greater policy commonalities than expected?

• What might differing approaches to decarbonization and the energy transition mean for the future of policy toward EVs, critical mineral supply chains, and ‘green’ industrial subsidy?

• How might each Administration approach fiscal policy? Will either push for a tightening to the current loose policy—and what may be implications for US debt and the dollar?

• What economic effects can we expect in the case of a disputed election result or non-peaceful transfer of power—and will Corporate America be compelled to make public statements?

Despite its major importance in human health, the metabolic potential of the human gut microbiota is still poorly understood. We have recently shown that biosynthesis of Ruminococcin C (RumC), a novel ribosomally synthesized and posttranslationally modified peptide (RiPP) produced by the commensal bacterium Ruminococcus gnavus, requires two radical SAM enzymes (RumMC1 and RumMC2) catalyzing the formation of four Cα-thioether bridges. These bridges, which are essential for RumC's antibiotic properties against human pathogens such as Clostridium perfringens, define two hairpin domains giving this sactipeptide (sulfur-to-α-carbon thioether–containing peptide) an unusual architecture among natural products. We report here the biochemical and spectroscopic characterizations of RumMC2. EPR spectroscopy and mutagenesis data support that RumMC2 is a member of the large family of SPASM domain radical SAM enzymes characterized by the presence of three [4Fe-4S] clusters. We also demonstrate that this enzyme initiates its reaction by Cα H-atom abstraction and is able to catalyze the formation of nonnatural thioether bonds in engineered peptide substrates. Unexpectedly, our data support the formation of a ketoimine rather than an α,β-dehydro-amino acid intermediate during Cα-thioether bridge LC–MS/MS fragmentation. Finally, we explored the roles of the leader peptide and of the RiPP precursor peptide recognition element, present in myriad RiPP-modifying enzymes. Collectively, our data support a more complex role for the peptide recognition element and the core peptide for the installation of posttranslational modifications in RiPPs than previously anticipated and suggest a possible reaction intermediate for thioether bond formation.

Chi-Liang Eric Yen
Nov 1, 2008; 49:2283-2301
Thematic Reviews

Sir David Attenborough and the BBC Studios Natural History Unit awarded Chatham House Prize 2019 for ocean advocacy News Release sysadmin 18 November 2019

The 2019 Chatham House Prize is awarded to Sir David Attenborough and Julian Hector, head of BBC Studios Natural History Unit, for the galvanizing impact of the Blue Planet II series on tackling ocean plastic pollution.

Rhodopsin is a canonical class A photosensitive G protein–coupled receptor (GPCR), yet relatively few pharmaceutical agents targeting this visual receptor have been identified, in part due to the unique characteristics of its light-sensitive, covalently bound retinal ligands. Rhodopsin becomes activated when light isomerizes 11-cis-retinal into an agonist, all-trans-retinal (ATR), which enables the receptor to activate its G protein. We have previously demonstrated that, despite being covalently bound, ATR can display properties of equilibrium binding, yet how this is accomplished is unknown. Here, we describe a new approach for both identifying compounds that can activate and attenuate rhodopsin and testing the hypothesis that opsin binds retinal in equilibrium. Our method uses opsin-based fluorescent sensors, which directly report the formation of active receptor conformations by detecting the binding of G protein or arrestin fragments that have been fused onto the receptor's C terminus. We show that these biosensors can be used to monitor equilibrium binding of the agonist, ATR, as well as the noncovalent binding of β-ionone, an antagonist for G protein activation. Finally, we use these novel biosensors to observe ATR release from an activated, unlabeled receptor and its subsequent transfer to the sensor in real time. Taken together, these data support the retinal equilibrium binding hypothesis. The approach we describe should prove directly translatable to other GPCRs, providing a new tool for ligand discovery and mutant characterization.

Kailun Fang
Nov 30, 2020; 0:RA120.002081v1-mcp.RA120.002081
Research

The extracellular matrix encompasses a reservoir of bioactive macromolecules that modulates a cornucopia of biological functions. A prominent body of work posits matrix constituents as master regulators of autophagy and angiogenesis and provides molecular insight into how these two processes are coordinated. Here, we review current understanding of the molecular mechanisms underlying hyaluronan and HAS2 regulation and the role of soluble proteoglycan in affecting autophagy and angiogenesis. Specifically, we assess the role of proteoglycan-evoked autophagy in regulating angiogenesis via the HAS2-hyaluronan axis and ATG9A, a novel HAS2 binding partner. We discuss extracellular hyaluronan biology and the post-transcriptional and post-translational modifications that regulate its main synthesizer, HAS2. We highlight the emerging group of proteoglycans that utilize outside-in signaling to modulate autophagy and angiogenesis in cancer microenvironments and thoroughly review the most up-to-date understanding of endorepellin signaling in vascular endothelia, providing insight into the temporal complexities involved.

Douglas A. Andres
Dec 1, 2020; 61:1537-1537
Images in Lipid Research

This manuscript has been withdrawn by the Author.

The backbone of all sphingolipids (SLs) is a sphingoid long-chain base (LCB) to which a fatty acid is N-acylated. Considerable variability exists in the chain length and degree of saturation of both of these hydrophobic chains, and recent work has implicated ceramides with different LCBs and N-acyl chains in distinct biological processes; moreover, they may play different roles in disease states and possibly even act as prognostic markers. We now demonstrate that the half-life, or turnover rate, of ceramides containing diverse N-acyl chains is different. By means of a pulse-labeling protocol using stable-isotope, deuterated free fatty acids, and following their incorporation into ceramide and downstream SLs, we show that very-long-chain (VLC) ceramides containing C24:0 or C24:1 fatty acids turn over much more rapidly than long-chain (LC) ceramides containing C16:0 or C18:0 fatty acids due to the more rapid metabolism of the former into VLC sphingomyelin and VLC hexosylceramide. In contrast, d16:1 and d18:1 ceramides show similar rates of turnover, indicating that the length of the sphingoid LCB does not influence the flux of ceramides through the biosynthetic pathway. Together, these data demonstrate that the N-acyl chain length of SLs may not only affect membrane biophysical properties but also influence the rate of metabolism of SLs so as to regulate their levels and perhaps their biological functions.

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers and known for its extensive genetic heterogeneity, high therapeutic resistance, and strong variation in intrinsic radiosensitivity. To understand the molecular mechanisms underlying radioresistance, we screened the phenotypic response of 38 PDAC cell lines to ionizing radiation. Subsequent phosphoproteomic analysis of two representative sensitive and resistant lines led to the reproducible identification of 7,800 proteins and 13,000 phosphorylation sites (p-sites). Approximately 700 p-sites on 400 proteins showed abundance changes after radiation in all cell lines regardless of their phenotypic sensitivity. Apart from recapitulating known radiation response phosphorylation markers such as on proteins involved in DNA damage repair, the analysis uncovered many novel members of a radiation-responsive signaling network that was apparent only at the level of protein phosphorylation. These regulated p-sites were enriched in potential ATM substrates and in vitro kinase assays corroborated 10 of these. Comparing the proteomes and phosphoproteomes of radiosensitive and -resistant cells pointed to additional tractable radioresistance mechanisms involving apoptotic proteins. For instance, elevated NADPH quinine oxidoreductase 1 (NQO1) expression in radioresistant cells may aid in clearing harmful reactive oxygen species. Resistant cells also showed elevated phosphorylation levels of proteins involved in cytoskeleton organization including actin dynamics and focal adhesion kinase (FAK) activity and one resistant cell line showed a strong migration phenotype. Pharmacological inhibition of the kinases FAK by Defactinib and of CHEK1 by Rabusertib showed a statistically significant sensitization to radiation in radioresistant PDAC cells. Together, the presented data map a comprehensive molecular network of radiation-induced signaling, improves the understanding of radioresistance and provides avenues for developing radiotherapeutic strategies.

The molecular mechanism associated with mammalian meiosis has yet to be fully explored, and one of the main reasons for this lack of exploration is that some meiosis-essential genes are still unknown. The profiling of gene expression during spermatogenesis has been performed in previous studies, yet few studies have aimed to find new functional genes. Since there is a huge gap between the number of genes that are able to be quantified and the number of genes that can be characterized by phenotype screening in one assay, an efficient method to rank quantified genes according to phenotypic relevance is of great importance. We proposed to rank genes by the probability of their function in mammalian meiosis based on global protein abundance using machine learning. Here, nine types of germ cells focusing on continual substages of meiosis prophase I were isolated, and the corresponding proteomes were quantified by high-resolution mass spectrometry. By combining meiotic labels annotated from the MGI mouse knockout database and the spermatogenesis proteomics dataset, a supervised machine learning package, FuncProFinder, was developed to rank meiosis-essential candidates. Of the candidates whose functions were unannotated, four of ten genes with the top prediction scores, Zcwpw1, Tesmin, 1700102P08Rik and Kctd19, were validated as meiosis-essential genes by knockout mouse models. Therefore,  mammalian meiosis-essential genes could be efficiently predicted based on the protein abundance dataset, which provides a paradigm for other functional gene mining from a related abundance dataset.

South Africa's Land Reform Quandary: Scenarios and Policy 10 July 2018 — 10:00AM TO 11:00AM Anonymous (not verified) 13 June 2018 Chatham House, London

Slow delivery on expectations of land redistribution in South Africa has once again put the issue at the forefront of political debate in the country. A parliamentary public consultation process will consider whether constitutional change is required to accelerate expropriation without compensation. Policymakers face dual - often opposing - pressures due to investors’ fears of negative economic impacts as well as citizens’ frustrations over persistent inequality and hardship. State land and tribal trust land remain contentious issues for rural economic development, but with two thirds of the population now living in urban areas policy responses must be as cognizant of the country’s future as it is of its past.

At this meeting, Terence Corrigan, project manager at the South African Institute of Race Relations, will discuss the current debates on expropriation and present the institute’s latest research on future scenarios of land reform in South Africa.

Attendance at this event is by invitation only.

The National Institute for Health and Care Excellence (NICE) has recommended that all women with suspected endometriosis be offered an early transvaginal ultrasound scan, even if the pelvic or abdominal examination is normal.In its updated guideline1 on the diagnosis and management of endometriosis, NICE recommends specialist ultrasound as an alternative to magnetic resonance imaging for investigating suspected cases of the condition in secondary care.The updated guideline follows recent reports from both the National Confidential Enquiry into Patient Outcome and Death2 and Endometriosis UK which highlighted problems with delayed diagnoses, partly owing to a lack of awareness among healthcare professionals of the condition and how it presents. Such delays can result in prolonged suffering, ill health, and risks to fertility, the reports warned.Other new and updated recommendations include asking women with suspected endometriosis if any first degree relatives have a history of the condition, and considering neurodiversity when taking into account...

Jennifer L. Zamanian
May 2, 2012; 32:6391-6410
Neurobiology of Disease

by Qu Dongyu, Director-General of the Food and Agriculture Organization of the United Nations (FAO).

Durante un viaje misionero de un mes, Eduardo aprendió a escuchar y reconocer la voz de Dios, tanto personalmente como ministrando a otros.

With elections looming in Japan and the U.S., what impact will these events have on global equity markets? We explore an effective hedging approach.

Transform your iPhone 16 into a digital art studio with iOS 18.2's Image Playground, the latest tool for creating custom visuals with a few taps.

With the release of iOS 18.2, Apple's Image Playground app offers users an accessible way to create custom digital images, sparking creative possibilities for iPhone owners. Part of Apple's expanding Apple Intelligence suite, Image Playground debuted in developer betas in late 2024.

With each update, Apple has strived to make Image Playground more responsive and intuitive, aiming to provide a smoother user experience as the feature matures. In the second developer beta of iOS 18.2, notable improvements are already evident, particularly in rendering speed and the alignment between user prompts and generated images.


Continue Reading on AppleInsider | Discuss on our Forums

A hidden feature in iOS 18.1 will automatically reboot a locked iPhone when it is asleep but hasn't been unlocked for a while, presumably as a security measure.

The third developer beta of iOS 18.2 is now available for all compatible iPhone models, as Apple Intelligence testing continues. Here's everything you need to know about the update.

On Monday, Apple released iOS 18.2 developer beta 3, with build number 22C5131e, up from the previous 22C5125e. While the update is compatible with devices as old as the iPhone XS and iPhone XR, the software includes a variety of Apple Intelligence features that only work on iPhone 15 Pro, iPhone 15 Pro Max, and the iPhone 16 range.

The iOS 18.2 update introduces support for Image Playground, Genmoji, Visual Intelligence, and ChatGPT integration via Siri. There's also a new FindMy feature that helps users locate lost luggage or AirTags.


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