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Discovery and optimisation of pyrazolo[1,5-a]pyrimidines as aryl hydrocarbon receptor antagonists

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, 15,3477-3484
DOI: 10.1039/D4MD00266K, Research Article
Raitis Bobrovs, Svetlana Terentjeva, Ninni Elise Olafsen, Zilvinas Dambrauskas, Antanas Gulbinas, Toivo Maimets, Indrek Teino, Aigars Jirgensons, Jason Matthews, Kristaps Jaudzems
The aryl hydrocarbon receptor (AHR) is a versatile ligand-dependent transcription factor involved in diverse biological processes, from metabolic adaptations to immune system regulation.
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Medicinal chemistry-based perspective on thiophene and its derivatives: Exploring the structural insights to discover plausible druggable leads

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00450G, Review Article
Shikha Thakur, Devendra Kumar, shivani jaiswal, Kapil Kumar Goel, Pramod Rawat, Vivek Srivastava, Sonia Dhiman, Hemant R Jadhav, Ashish Ranjan Dwivedi
Thiophene is a privileged pharmacophore in medicinal chemistry owing to its diversified biological attributes. The thiophene moiety has been ranked 4th in US FDA drug approval of small drug molecules,...
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Miniaturized click chemistry and direct screening facilitate the discovery of triazole piperazine SARS-CoV-2 Mpro inhibitors with improved metabolic stability

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00555D, Research Article
Shenghua Gao, Letian Song, Bing Ye, Mianling Yang, Junyi Li, Manyu Gu, Ann E. Tollefson, Karoly Toth, Peng Zhan, Xinyong Liu
The continuous mutational nature of SARS-CoV-2 and its inter-species' similarities emphasize the urgent need to design and develop more direct-acting antiviral agents against highly infectious variants.
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Discovery of N-substituted-2-oxoindolin benzoylhydrazines as c-MET/SMO modulators in EGFRi-resistant non-small cell lung cancer

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00553H, Research Article
Stefano Tomassi, Benito Natale, Michele Roggia, Luisa Amato, Caterina De Rosa, Carminia Maria Della Corte, Emma Baglini, Giorgio Amendola, Anna Messere, Salvatore Di Maro, Elisabetta Barresi, Federico Da Settimo, Maria Letizia Trincavelli, Fortunato Ciardiello, Sabrina Taliani, Floriana Morgillo, Sandro Cosconati
Non-small cell lung cancer (NSCLC), the leading cause of cancer-related mortality worldwide, poses a formidable challenge due to its heterogeneity and the emergence of resistance to targeted therapies.
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Will real estate recover in 2015?

By www.thehindu.com
Published On :: Fri, 16 Jan 2015 14:27:47 +0530

The top localities that have generated a lot of interest among buyers in Hyderabad are Uppal, Chandanagar, Gachibowli, Kondapur, Kukatpally, Manikonda and Miyapur


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 Kuruvai coverage rose by 40% above normal in last five years

By www.thehindu.com
Published On :: Tue, 21 May 2024 22:45:57 +0530

The normal coverage is about 3.24 lakh acres for the delta. However, going by the average for the last five years, the figure comes to 4.57 lakh acres — a nearly 40% rise.


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Shape memory and recovery mechanism in hard magnetic soft materials

By pubs.rsc.org
Published On ::

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM01165A, Paper
Rong Jia, Kai Tan, Qian Deng
Two parts are integrated to close a circle: shape memory and recovery of hard-magnetic soft materials (HMSMs).
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Discover the punch in power yoga

By www.thehindu.com
Published On :: Sat, 30 Apr 2016 16:32:53 +0530

We tried out Power Yoga and found there are many incorrect assumptions the mind makes about the body


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Editorial. Senior cover

By www.thehindubusinessline.com
Published On :: Tue, 17 Sep 2024 21:01:49 +0530

PM-JAY will need tweaks to deliver geriatric care


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Govt can waive off GST on health cover, step up focus on insurance penetration: FGII CEO Anup Rau

By www.thehindubusinessline.com
Published On :: Fri, 25 Oct 2024 18:21:31 +0530

Removing GST on health insurance would make it more affordable, driving higher penetration and reducing the government’s burden


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  • Money & Banking
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Turnaround : A Story of Recovery / directed by: Moira Simpson ; produced by: Jennifer Torrance, Moira Simpson, John Taylor, Kathleen Shannon ; production agency: National Film Board of Canada (Montreal)

By darius.uleth.ca
Published On ::

Montreal : National Film Board of Canada, 2017


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Man arrested and 20 stolen motorcycles worth ₹15 lakh recovered in Nandyal

By www.thehindu.com
Published On :: Mon, 11 Nov 2024 20:52:54 +0530


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Ageing Kohli, Rohit must rekindle youthful mindset to rediscover lost glory: Greg Chappell

By www.thehindu.com
Published On :: Fri, 08 Nov 2024 13:30:40 +0530

According to Chappell, the ageing Sharma and Kohli must summon the same drive and focus that once marked their prime years if India hopes to reclaim its form on foreign soil


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A journey of discovery

By www.thehindu.com
Published On :: Sun, 11 Oct 2015 17:00:13 +0530

How you can make the best use of a management education.


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Discover your true calling through psychometric tests

By www.thehindu.com
Published On :: Sun, 06 Dec 2015 17:00:46 +0530

It is a useful tool that offers career clarity and opens up new possibilities.


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Discover your true calling

By www.thehindu.com
Published On :: Sun, 17 Apr 2016 17:00:09 +0530

Psychometric test is a useful tool that offers career clarity and opens up new possibilities.


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Surface science studies of the coverage dependent adsorption of methyl acetate and methyl propanoate on graphite

By pubs.rsc.org
Published On ::

RSC Adv., 2024, 14,35373-35385
DOI: 10.1039/D4RA04466E, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Jack E. Fulker, Wendy A. Brown
The adsorption of methyl acetate and methyl propanoate has been studied on a graphite surface at 28 K. TPD data show that the desorption energy of both molecules is highly coverage dependent with repulsive interactions being seen at low coverages.
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Electromagnetic wave effects on Mn-doped superparamagnetic iron oxide nanofluids: applications in enhanced oil recovery

By pubs.rsc.org
Published On ::

RSC Adv., 2024, 14,35671-35678
DOI: 10.1039/D4RA04500A, Paper
Open Access
Mohamad Amin Bin Hamid, Beh Hoe Guan, Chan Kar Tim, Hassan Soleimani
This study reveals that both direct current (DC) and alternating current (AC) electromagnetic fields can effectively reduce the interfacial tension (IFT) of Mn-doped Fe3O4 nanofluids, with AC fields showing more predictable and pronounced effects.
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Computational discovery of two-dimensional tetragonal group IV–V monolayers

By pubs.rsc.org
Published On ::

RSC Adv., 2024, 14,36173-36180
DOI: 10.1039/D4RA06623E, Paper
Open Access
Qiubao Lin, Jungang Huang, Yimei Fang, Feng Zheng, Kaixuan Chen, Shunqing Wu, Zi-Zhong Zhu
Structural prediction of a stable tetragonal Td4 phase of 2D group IV–V monolayers.
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Scientists discover new antidote to cobra venom

By www.thehindu.com
Published On :: Thu, 18 Jul 2024 22:00:00 +0530

A commonly used blood thinner can be repurposed as an inexpensive antivenom treatment, a study published in Science Translational Medicine has said


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Dev Javia recovers to outwit Rethin Pranav

By www.thehindu.com
Published On :: Tue, 12 Nov 2024 20:06:21 +0530


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A review of carbon recovery in sewage treatment and analysis of product options for a typical water recycling plant

By pubs.rsc.org
Published On ::

Environ. Sci.: Water Res. Technol., 2024, Advance Article
DOI: 10.1039/D4EW00160E, Critical Review
Arash Mohseni, Linhua Fan, Li Gao, Joel Segal, Felicity Roddick
Reviewed existing and emerging technologies for carbon recovery from WWTPs, best options investigated as case study for typical conventional plant.
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A Logic-Based Resilience Metric for Water Resource Recovery Facilities

By pubs.rsc.org
Published On ::

Environ. Sci.: Water Res. Technol., 2024, Accepted Manuscript
DOI: 10.1039/D4EW00649F, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Anna Stefania Laino, Ben Wooding, Sadegh Soudjani, Russell James Davenport
This study develops quantifiable metrics to describe the resilience of Water Resource Recovery Facilities (WRRFs) to extreme and exceptional shock and stress events, such as those posed by long-term challenges...
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Sludge-derived novel Fe3O4–MgO@C composites for tetracycline abatement from wastewater using sustainable bio-electro-Fenton and nutrient recovery with co-precipitation: a waste-to-resource strategy

By pubs.rsc.org
Published On ::

Environ. Sci.: Water Res. Technol., 2024, Advance Article
DOI: 10.1039/D4EW00684D, Paper
Azhan Ahmad, Monali Priyadarshini, Shraddha Yadav, Makarand M. Ghangrekar, Rao Y. Surampalli
Developing efficient Fenton catalysts for the remediation of emerging pollutants is one of the challenges for researchers.
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Kerala seeks to expand public health insurance scheme to cover ‘missing middle’

By www.thehindu.com
Published On :: Fri, 08 Nov 2024 21:20:42 +0530

While this may move the State closer to the goal of universal health coverage, the expansion may hinge on additional funds to be generated by charging a premium to existing beneficiaries of the State scheme, which, at present, is in bad financial shape


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Will Budget offer cover for the common man?

By www.thehindubusinessline.com
Published On :: Sun, 04 Mar 2018 16:48:12 +0530

The Centre’s focus on affordable housing and healthcare is a welcome step


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Data-driven discovery of electrode materials for protonic ceramic cells

By pubs.rsc.org
Published On ::

Energy Environ. Sci., 2024, Advance Article
DOI: 10.1039/D4EE03762F, Paper
Open Access
Xueyu Hu, Yucun Zhou, Zheyu Luo, Haoyu Li, Nai Shi, Zhijun Liu, Weilin Zhang, Weining Wang, Yong Ding, Meilin Liu
A schematic representation of a four-stage data-driven material screening methodology, progressing from uncovering unexplored chemical spaces through high-throughput calculations to validating findings in protonic ceramic cells.
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Cover matters: Enhanced performance of multistage solar evaporator with tuned optical and thermal cover properties

By pubs.rsc.org
Published On ::

Energy Environ. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4EE02710H, Paper
Shiteng Li, Shang Liu, Qijun Yang, Shuai Deng, Meng Lin
To address global water scarcity and improve off-grid pure water production, this study focuses on enhancing the performance of inverted solar evaporators by optimizing the design of cover materials. By...
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XRDMatch: a semi-supervised learning framework to efficiently discover room temperature lithium superionic conductors

By pubs.rsc.org
Published On ::

Energy Environ. Sci., 2024, Advance Article
DOI: 10.1039/D4EE02970D, Paper
Zheng Wan, Zhenying Chen, Hao Chen, Yizhi Jiang, Jinhuan Zhang, Yidong Wang, Jindong Wang, Hao Sun, Zhongjie Zhu, Jinhui Zhu, Linyi Yang, Wei Ye, Shikun Zhang, Xing Xie, Yue Zhang, Xiaodong Zhuang, Xiao He, Jinrong Yang
We propose XRDMatch, a semi-supervised learning framework that integrates consistency regularization and pseudo-labeling. Using X-ray diffraction patterns as descriptors, it effectively addresses data scarcity by leveraging abundant unlabeled data.
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Ashok Leyland expands to Southeast Asia, expects domestic market recovery in H2

By www.thehindubusinessline.com
Published On :: Fri, 08 Nov 2024 20:25:25 +0530

EV Arm Switch Mobility set for EBITDA break-even this fiscal


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City is now under denser tree cover

By www.thehindu.com
Published On :: Fri, 18 Mar 2016 15:28:19 +0530

Bengaluru’s arboreal history records that trees were initially planted for spiritual reasons. They have followed the ornamental, archival and commercial trajectory since then


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New genus of jumping spiders ‘Tenkana’ discovered in south India

By www.thehindu.com
Published On :: Tue, 22 Oct 2024 21:08:07 +0530

Unlike related species that live in forests, Tenkana spiders prefer drier areas and ground habitats and have been found in Tamil Nadu, Puducherry, Karnataka, Telangana and Andhra Pradesh 


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Scientists uncover a magnetic misunderstanding about Uranus

By www.thehindu.com
Published On :: Tue, 12 Nov 2024 08:36:32 +0530

Much of what we know is based on Voyager 2’s flyby of Uranus in 1986, but now it seems the probe visited at a time of unusual conditions


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Money laundering laws will now cover cryptocurrency trade

By www.thehindu.com
Published On :: Wed, 08 Mar 2023 18:39:50 +0530

Indian cryptocurrency exchanges will have to report suspicious activity to the Financial Intelligence Unit India


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Water On The Moon: Surprising New Discovery Reveals The Moon Has More Water Than Expected!

By
Published On :: Tuesday, September 24, 2024, 13:03 +0530

New research reveals that the Moon contains far more water than previously thought, surprising scientists and reshaping future lunar exploration plans!


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Rupee recovers from all-time low level, opens 25 paise higher at 83.84 against US dollar

By www.thehindubusinessline.com
Published On :: Tue, 06 Aug 2024 10:22:59 +0530

Meanwhile, the dollar index gained 0.16 per cent to 102.85 points


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Currency outlook: Dollar index recovers

By www.thehindubusinessline.com
Published On :: Sat, 31 Aug 2024 19:03:00 +0530

Immediate resistance ahead has to be broken to gain more strength


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Reply To: [Solved] Full Page Backgrounds on iOS (background-size: cover)

By css-tricks.com
Published On :: Sun, 19 Jan 2020 15:51:01 +0000

Hi.
@brandonmcconnell
A few years ago now but any chance you could elucidate how to implement your solution on a WordPress site to someone in the self-taught hack category? e.g. where would you put that code: function.php, style.php etc?
Can’t believe this problem existed the first place!
Many thanks


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Discover your calling

By www.thehindu.com
Published On :: Sat, 19 Aug 2023 14:43:09 +0530

Uncertain about your career options? Low on self-confidence? This career counselling column may help


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Member of a robbery gang from Madhya Pradesh arrested, booty recovered

By www.thehindu.com
Published On :: Tue, 12 Nov 2024 23:20:26 +0530


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'I was trying to discover myself'

By www.rediff.com
Published On :: Mon, 18 Mar 2024 12:37:07 +0530

'In 2009, I was trying to discover myself as an actor, and that's when the journey started. I'm 41 years old and have been associated with this film for 16 years.'


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An overseas St. Andrews University Student of the 1950s discovers my Scotland.

By encore.st-andrews.ac.uk
Published On ::

[Australia] : Published by tckbrown@netspace.net.au, 2015.


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Do MSPs cover cost of production?

By www.thehindubusinessline.com
Published On :: Tue, 12 Nov 2024 21:09:11 +0530

Crop costs. They do not seem to factor in climate risk, input costs and factor costs adequately


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Take recovery from ‘avoidance transactions’ seriously, IBBI tells creditors. 

By www.thehindubusinessline.com
Published On :: Tue, 12 Nov 2024 22:07:48 +0530

Recovery for creditors could go up at least 10 per cent on such approach, says IBBI Chief Mital; Till Sep 2024, total clawback on avoidance transactions applications stood at ₹7,516 crore


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Optiemus enters into JV with Corning International to produce ‘Made in India’ mobile glass covers

By www.thehindubusinessline.com
Published On :: Fri, 01 Sep 2023 18:53:30 +0530

The 70:30 JV between Optiemus and Corning will help expand India’s electronics manufacturing ecosystem


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  • Mobiles & Tablets
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Samsung's third-quarter profit recovery slows as it struggles in AI chips

By www.thehindu.com
Published On :: Tue, 08 Oct 2024 09:44:23 +0530

Samsung has been the world's biggest memory chipmaker for three decades but it increasingly faces competition in both conventional and advanced chips


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Infinix’s first flip phone Zero Flip launched with 3.64 inch cover display and 50 MP selfie lens

By www.thehindu.com
Published On :: Thu, 17 Oct 2024 14:52:06 +0530

The Infinix Zero Flip cover and displays have a similar 120 Hz refresh rate


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Asus Zenbook S14 OLED Review | Impressive ultrabook covering all essentials

By www.thehindu.com
Published On :: Wed, 30 Oct 2024 08:00:00 +0530

Priced at ₹1,49,990, this laptop isn’t just about looks—it brings AI-driven performance, a stunning OLED display, and a range of productivity enhancements to the table


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Insurance Query: Coverage for adventure sports

By www.thehindubusinessline.com
Published On :: Fri, 24 May 2024 19:11:34 +0530

Ensure that your policy covers a broad range of activities, including mountaineering, skydiving and skiing, among others


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WazirX proposes launching decentralised exchange and recovery token as investors wait to access locked up crypto

By www.thehindu.com
Published On :: Thu, 07 Nov 2024 13:35:13 +0530

WazirX proposed launching a decentralised exchange as well as a recovery token for outstanding debt settlement, as users are unable to access their existing crypto


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