ava

Available for Preorder: The 2024-25 Economic Report on Pharmaceutical Wholesalers and Specialty Distributors

On October 8, 2024, Drug Channels Institute will release our 2024-25 Economic Report on Pharmaceutical Wholesalers and Specialty Distributors. This report—our fifteenth edition—remains the most comprehensive, fact-based tool for understanding and analyzing the large and growing U.S. pharmaceutical distribution industry.

9 chapters, 350+ pages, 178 exhibits, 750+ endnotes: There is nothing else available that comes close to this valuable resource.

We are providing you with the opportunity to preorder this thoroughly updated, revised, and expanded 2024-25 edition at special discounted prices. This means that you can be among the first to access our new report. Those who preorder will receive a download link before October 8.
You can pay online with all major credit cards (Visa, MasterCard, American Express, and Discover) or via PayPal. Click here to contact us if you would like to pay by corporate check or ACH.

Special preorder and launch pricing discounts will be valid through October 23, 2024.

Read on for more details.
Read more »
       




ava

NOW AVAILABLE: 2024–25 Economic Report on Pharmaceutical Wholesalers and Specialty Distributors

I am pleased to announce Drug Channels Institute's new 2024–25 Economic Report on Pharmaceutical Wholesalers and Specialty Distributors, available for purchase and immediate download.
We’re offering special discounted pricing if you order before October 23, 2024.

2024–25 Economic Report on Pharmaceutical Wholesalers and Specialty Distributors—our 15th edition--remains the most comprehensive, fact-based tool for understanding and analyzing the large and growing U.S. pharmaceutical distribution industry. This 2024-25 edition includes substantial new material—outlined on page vii of the report overview.

9 chapters, 380+ pages, 178 exhibits, more than 750 endnotes: There is nothing else available that comes close to this valuable resource.

You can pay online with all major credit cards (Visa, MasterCard, American Express, and Discover) or via PayPal. Click here to contact us if you would like to pay by corporate check or ACH.

Email Paula Fein (paula@drugchannels.net) if you’d like to bundle your report purchase with access to DCI’s video webinars.

If you preordered the report, you should have already received an email with download instructions last week. Please contact us if you did not receive your email.

Read on for some additional details.
Read more »
       




ava

MHRA to consult on making two progestogen-only contraceptives available without a prescription

Consultations on the reclassification of two progestogen-only contraceptive pills from prescription-only to pharmacy medicines have been launched.




ava

Can FDA's New Transparency Survive Avandia?

PDUFA V commitments signal a strong commitment to tolerance of open debate in the face of uncertainty.

I can admit to a rather powerful lack of enthusiasm when reading about interpersonal squabbles. It’s even worse in the scientific world: when I read about debates getting mired in personal attacks I tend to simply stop reading and move on to something else.

However, the really interesting part of this week’s meeting of an FDA joint Advisory Committee to discuss the controversial diabetes drug Avandia – at least in the sense of likely long-term impact – is not the scientific question under discussion, but the surfacing and handling of the raging interpersonal battle going on right now inside the Division of Cardiovascular and Renal Products. So I'll have to swallow my distaste and follow along with the drama.

Two words that make us mistrust Duke:
 Anil Potti Christian Laettner

Not that the scientific question at hand – does Avandia pose significant heart risks? – isn't interesting. It is. But if there’s one thing that everyone seems to agree on, it’s that we don’t have good data on the topic. Despite the re-adjudication of RECORD, no one trusts its design (and, ironically, the one trial with a design to rigorously answer the question was halted after intense pressure, despite an AdComm recommendation that it continue).  And no one seems particularly enthused about changing the current status of Avandia: in all likelihood it will continue to be permitted to be marketed under heavy restrictions. Rather than changing the future of diabetes, I suspect the committee will be content to let us slog along the same mucky trail.

The really interesting question, that will potentially impact CDER for years to come, is how it can function with frothing, open dissent among its staffers. As has been widely reported, FDA reviewer Tom Marciniak has written a rather wild and vitriolic assessment of the RECORD trial, excoriating most everyone involved. In a particularly stunning passage, Marciniak appears to claim that the entire output of anyone working at Duke University cannot be trusted because of the fraud committed by Duke cancer researcher Anil Potti:
I would have thought that the two words “Anil Potti” are sufficient for convincing anyone that Duke University is a poor choice for a contractor whose task it is to confirm the integrity of scientific research. 
(One wonders how far Marciniak is willing to take his guilt-by-association theme. Are the words “Cheng Yi Liang” sufficient to convince us that all FDA employees, including Marciniak, are poor choices for deciding matter relating to publicly-traded companies? Should I not comment on government activities because I’m a resident of Illinois (my two words: “Rod Blagojevich”)?)

Rather than censoring or reprimanding Marciniak, his supervisors have taken the extraordinary step of letting him publicly air his criticisms, and then they have in turn publicly criticized his methods and approach.

I have been unable to think of a similar situation at any regulatory agency. The tolerance for dissent being displayed by FDA is, I believe, completely unprecedented.

And that’s the cliffhanger for me: can the FDA’s commitment to transparency extend so far as to accommodate public disagreements about its own approval decisions? Can it do so even when the disagreements take an extremely nasty and inappropriate tone?

  • Rather than considering that open debate is a good thing, will journalists jump on the drama and portray agency leadership as weak and indecisive?
  • Will the usual suspects in Congress be able to exploit this disagreement for their own political gain? How many House subcommittees will be summoning Janet Woodcock in the coming weeks?

I think what Bob Temple and Norman Stockbridge are doing is a tremendous experiment in open government. If they can pull it off, it could force other agencies to radically rethink how they go about crafting and implementing regulations. However, I also worry that it is politically simply not a viable approach, and that the agency will ultimately be seriously hurt by attacks from the media and legislators.

Where is this coming from?

As part of its recent PDUFA V commitment, the FDA put out a fascinating draft document, Structured Approach to Benefit-Risk Assessment in Drug Regulatory Decision-Making. It didn't get a lot of attention when first published back in February (few FDA documents do). However, it lays out a rather bold vision for how the FDA can acknowledge the existence of uncertainty in its evaluation of new drugs. Its proposed structure even envisions an open and honest accounting of divergent interpretations of data:
When they're frothing at the mouth, even Atticus
doesn't let them publish a review
A framework for benefit-risk decision-making that summarizes the relevant facts, uncertainties, and key areas of judgment, and clearly explains how these factors influence a regulatory decision, can greatly inform and clarify the regulatory discussion. Such a framework can provide transparency regarding the basis of conflicting recommendations made by different parties using the same information.
(Emphasis mine.)

Of course, the structured framework here is designed to reflect rational disagreement. Marciniak’s scattershot insults are in many ways a terrible first case for trying out a new level of transparency.

The draft framework notes that safety issues, like Avandia, are some of the major areas of uncertainty in the regulatory process. Contrast this vision of coolly and systematically addressing uncertainties with the sad reality of Marciniak’s attack:
In contrast to the prospective and highly planned studies of effectiveness, safety findings emerge from a wide range of sources, including spontaneous adverse event reports, epidemiology studies, meta-analyses of controlled trials, or in some cases from randomized, controlled trials. However, even controlled trials, where the evidence of an effect is generally most persuasive, can sometimes provide contradictory and inconsistent findings on safety as the analyses are in many cases not planned and often reflect multiple testing. A systematic approach that specifies the sources of evidence, the strength of each piece of evidence, and draws conclusions that explain how the uncertainty weighed on the decision, can lead to more explicit communication of regulatory decisions. We anticipate that this work will continue beyond FY 2013.
I hope that work will continue beyond 2013. Thoughtful, open discussions of real uncertainties are one of the most worthwhile goals FDA can aspire to, even if it means having to learn how to do so without letting the Marciniaks of the world scuttle the whole endeavor.

[Update June 6: Further bolstering the idea that the AdCom is just as much about FDA's ability to transparently manage differences of expert opinion in the face of uncertain data, CDER Director Janet Woodcock posted this note on the FDA's blog. She's pretty explicit about the bigger picture:
There have been, and continue to be, differences of opinion and scientific disputes, which is not uncommon within the agency, stemming from varied conclusions about the existing data, not only with Avandia, but with other FDA-regulated products. 
At FDA, we actively encourage and welcome robust scientific debate on the complex matters we deal with — as such a transparent approach ensures the scientific input we need, enriches the discussions, and enhances our decision-making.
I agree, and hope she can pull it off.]




ava

A US Ambassador Working for Cuba? Charges Against Former Diplomat Victor Manuel Rocha Spotlight Havana's Importance in the World of Spying

Calder Walton writes that if proved, Victor Manuel Rocha's espionage would place him among the longest-serving spies in modern times. Allowing him to operate as a spy in the senior echelons of the U.S. government for so long would represent a staggering U.S. security failure.




ava

In Praise of Madhu Dandavate, The Telegraph

The Indian socialist tradition is now moribund, but there was a time when it had a profound and mostly salutary influence on politics and society. Yet few people now know of its past vigour and dynamism. The Congress, the Communists, the regional parties, the Ambedkarites, and (especially in recent years) the Jana Sangh and the [...]




ava

Navigating China’s Opportunistic Approach to Overseas Naval Base Acquisition

This report, by Maxwell Simon (MPP '23) and Jayaram Ravi (MPP '23), explores the drivers of setback and success that China has encountered in the process of developing dual-use and military-dedicated naval installations abroad. It looks at cases where China has considered or actively pursued military-dedicated installations to characterize Beijing’s general approach to overseas naval base acquisition.




ava

The Clayton Built� "Patriot" Home Available to Homeowners - The Patriot

The Patriot offers modern amenities along with brand-name appliances. For each unit sold, Clayton will donate $100 to Hope for the Warriors�.






ava

Once Again Havana Hosts the Major Annual Event of the World's Finest Tobacco, the Habano - XVIII Habanos Festival

XVIII Habanos Festival: Once Again Havana Hosts the Major Annual Event of the World's Finest Tobacco, the Habano






ava

Jedi Performers Engage in Epic Lightsaber Challenge at the Top of the World's Tallest Building - Dubai's Burj Khalifa - as Star Wars: The Force Awakens Becomes Available for Digital Download - Two Jedi performers ascend the world�

Two Jedi performers ascend the world�s tallest building




ava

Study: Small Business Owners Are Not Taking Full Advantage of Available Resources - Kala Gibson Video

Kala Gibson, Head of Business Banking at Fifth Third Bank, discusses the importance of small businesses to our economy and communities







ava

PeriCoach�, New FDA-Approved Pelvic Floor Training System For Women, Now Available - Christine Lewicky-Gaupp, MD

Dr. Lewicky-Gaupp knows what a significant problem UI can be for millions of women � many of whom suffer in silence. Here she explains why the PeriCoach System is an important new treatment option.





ava

A Book Is a Story — But Which Story Is It?: The Craft of THE CHANGELING, by Victor LaValle

Before I start talking about Victor LaValle's beautiful book, a point of housekeeping: Now that an eon has passed, I've finally updated my praise and awards page for Jane, Unlimited. I have a bad habit of never getting around to this task until it's time to start clearing things out for the new book. The nice thing about it is that I get to revisit a book that's dear to me, years after I've stopped thinking about it. Jane is a book that divides readers for sure. I want to thank everyone who got that book and took it into your hearts and brains. If you don't know about Jane, Unlimited, here's a quick intro: An orphan named Jane arrives at an island mansion owned by a friend, then quickly starts to get the sense that strange things are afoot there. At a certain point, when Jane needs to make a decision, the book breaks off into five different decisions she could make — and each decision takes her into an adventure in a different genre. There's a mystery story, a spy story, a horror story, a sci-fi story, and a fantasy. They're all connected and interwoven; and yes, the multiverse exists :). It's a weird book and I'm very, very proud of it! If you're curious, I'll point you to the NYTBR review, which is concise and generous and does a good job expressing its flavor.

***

So. Today I want to talk about the craft of using existing, well-known stories to fortify your own story — thus building ready-made narrative magic into your story's foundations.

Reimagining a classic story is, of course, an age-old tradition. There was a time when I read all the King Arthur retellings I could find, though this list shows me that I missed a great many. Some of my all-time favorite books come from this tradition: Tam Lin by Pamela Dean, a retelling of the old Scottish ballad that takes place in a fictional college in Minnesota in the 1970s; Deerskin by Robin McKinley, which I held close to my heart while I was writing Fire and which is based on the Charles Perrault fairy tale Donkeyskin; Ash by Malinda Lo, a lesbian retelling of Cinderella. Every writer who goes down this path has their own take on whatever story they're reimagining, disrupting the familiar in their own unique way so that we can get some objective distance and consider the story again in a new light. One of the best things about stories is the way they all change and grow in meaning and significance with every new story that joins the pantheon.

Victor LaValle's The Changeling is a modern-day, New York City-based retelling of the old changeling folktale. In the classic version of that tale, fairies steal a human baby and replace it with something else, usually a (creepy) fairy child. In LaValle's retelling, the focus is the emotional journey of the baby's father, Apollo Kagwa, whose wife Emma Valentine starts acting odd after their baby is born. Horror ensues. In the wake of the horror, Apollo must figure out what the heck just happened, and how to move on.

LaValle's take on the changeling story is unique in plenty of ways. For example, the way race and gender factor into the power dynamics. The choice to center the point of view around a father. The extreme horrificness of the violence that occurs. The story's broad-ranging modern-day New York City settings, from a fancy Manhattan restaurant to Apollo's home in Washington Heights to an abandoned island in the East River to upscale suburbs and a forest in Queens. These are the sorts of alterations commonly made by writers retelling old stories: time, location, culture, tone. When we know we're reading a retelling, we expect changes in these categories.

But LaValle does something else too: he infuses this book with many, many stories that aren't the official story he's retelling. The Changeling is a book positively swimming in story. And one of this book's charms is that as a consequence, Apollo spends a lot of the book making mistakes about what story he's in. LaValle uses stories to illuminate, but also to mislead. I think it makes for a really unique approach to characterization.

It also steers Apollo through a character transformation that I find exquisitely touching, for reasons I'll try to explain without spoiling the plot too much.

Apollo Kagwa's father, who disappears before his fourth birthday, is a white man from Syracuse. His mother, Lillian Kagwa, is a Black woman, an immigrant from Uganda, who raises him and who recognizes early on that her son lives and breathes stories. Lillian can't find enough books to satisfy young Apollo. He also has a mind for business. When Lillian discovers that Apollo has been selling his books after reading them, she helps him establish a used bookselling business. In due course, he grows up to be a rare bookseller.

Unquestionably, this is the story of a man who knows all about stories. As a rare bookseller who spends his time digging through rude and racist people's basements looking for valuable treasures, Apollo deals in stories. He seeks stories out, recognizes their value, owns them, sells them. He also builds stories around himself as protection and comfort, often repeating to himself, in moments of anxiety or fear, the mantra, I am the god, Apollo. I am the god, Apollo. And he uses stories to comfort and ground himself — particularly Maurice Sendak's picture book Outside Over There, a changeling tale that Apollo believes his missing father lovingly left for him.

So. Apollo knows stories. And yet, as I said above, as this story plays out, LaValle gives us evidence that Apollo is often wrong about what story he's in. He admires the wrong people in his life as heroes (for example, his father). He misses the incredibly powerful sorcerers right in front of his eyes: his wife Emma; Emma's sister, Kim; Emma's friend, Nichelle; his mother, Lillian. As he moves through the world, he imagines he sees fairy tale traps where there are none, and he misses the huge, important fairy tale turning points, the moments that really matter. The clues are right in front of his face. Sometimes the women in his life even announce them aloud to him, and he still disregards them. Like all of us, the story Apollo tells himself about his own life is flawed and distorted by his own wishes, heartbreaks, assumptions, and biases. Among those biases, by my reading, is the tiniest edge of unconscious condescension to women. Or maybe even that's going too far; maybe it's simply that Apollo fails to see and appreciate the women around him fully. He's a good man. But he doesn't quite get it.

And yet, Apollo's story is one of transformation. Over the course of this book, through a great deal of trial and tribulation, Apollo learns to see what story he's in, who the heroes are, and who has the power to create a safe world for him and his family. And who are these heroes? Ultimately, women. What Apollo learns is that he's in a story in which he needs to see and respect the intelligence, insight, and power of women. Black women, specifically. By my reading, this is a tale of a well-meaning, vulnerable, flawed man learning feminism.

Maybe you can see why I love it?

And I also love how it's done. I love the way this book swirls with stories, and the way both the reader and Apollo are moving along on different paths through the stories, trying to understand which of the stories matter to Apollo's story, and how.

It makes me think in a fresh, new way about how to weave other stories into one's story, whether one's story is a retelling, or just a story with narrative influences. There's no end to the creative approaches to this — but if you're imbuing your own story with other stories, I do think it's a good idea to choose a deliberate approach. There's a danger in trying to use other stories in your story as a shortcut for creating mood and meaning. The author who throws lots of existing stories into a book might create the impression of depth, but you want to make sure it's not just an impression. You don't want to use other stories to obscure an empty hole or a weak foundation in your own story, or make it seem like your story has meaning it doesn't have. I say this as a writer who's familiar with that moment when, after trying to shoehorn a known story into something I'm writing, I realize I'm being lazy. I'm trying to make someone else's work do my work. Or maybe I realize that I simply don't know enough about my own story yet, and I'm using those other stories to obscure that fact from myself.

If you're alluding to another story in your story, there needs to be a reason. Ask yourself, what structural function are these references performing? What manner of tool are they? What do they accomplish? Why have I chosen the stories I've chosen?

There doesn't need to be a profound or complicated answer, but there needs to be an answer. For example, in Rebecca Stead's When You Reach Me, Miranda's favorite book is A Wrinkle in Time, for what turn out to be some pretty straightforward textual reasons. In the space of that book, it ends up being a perfect allusion. In the review of Jane, Unlimited I linked to above, the reviewer notes that it turns out there's a reason Jane wears Doctor Who pajamas. Though I wouldn't call Jane my most straightforward book, there are some pretty straightforward reasons I dressed her in those pajamas! You can have simple or complicated reasons for referring to other stories in your story. It can be a reason that's quiet, subtle, and small. It doesn't have to be groundbreaking. But you have to link those stories to yours in meaningful ways, and you also have to make sure that your own story is the biggest and most relevant story in the book. If you find yourself trying to create depth in an insubstantial story by borrowing someone else's story, then I recommend spending some time focusing on the hard work of your own story.

And if, in the process, you find yourself jettisoning some of the references to that other story, or even abandoning that other story altogether? That's fine too. One of my current works in progress started out as something of a Peter Pan retelling. It's now come so far from that point that the only remaining allusion is a couple of names — that I'm probably going to change, because the book doesn't need them anymore. That book needed to grow the way it did. J. M. Barrie's book was my path in; my story needed to start with his, then diverge. Another example: Earlier in this post, when I explained that Jane, Unlimited is about an orphan named Jane who comes to a mysterious house, maybe you thought of Jane Eyre. In early drafts of that book, I kept trying to work in versions of actual scenes from Jane Eyre. For example, I tried hard to find a place for a scene paralleling the one where Jane almost gets run over by Mr. Rochester in the dark. Eventually, I let all that go. At a certain point, the needs of my story became a lot more important than strengthening allusions to Jane Eyre (or Rebecca, or Winnie the Pooh, or any of the other texts that Jane, Unlimited references). I found a balance with all the allusions — or I hope I did, the reader is free to disagree! — and tried hard to focus on my story, my versions, my point. I think Jane still swims with those other stories, hopefully in ways that create depth, and part of getting to that point was letting some of it go. Often it doesn't take much to invoke a story that's part of our cultural consciousness.

To demonstrate that often it doesn't take much, let's return to The Changeling. I want to show an example of what I've explained about how this book uses stories to elucidate Apollo's failure to recognize his own story. I'll focus on one scene that I think encapsulates the skill with which LaValle layers story over story over story — to tell Apollo's story about misreading his own story. It's also wonderfully written, so that'll be fun to talk about too :).

The scene I'm going to look at takes place over the course of Chapters 11 and 12. The setting is a fancy New York restaurant that evokes a fairy tale aura. If you want to read along, you'll find this scene on pages 41 through 51 in the 2017 Spiegel & Grau hardcover edition. Point of view shifts in this book, but these two chapters are told from Apollo's point of view.

First, some context: in the scene after this scene, Emma Valentine gives birth to their child. (That's an incredible scene too! It happens in a stopped A train on its way to Washington Heights!) This means that the scene I'm about to talk about is Apollo's last chance to understand his own story before everything changes. As I think you know by now, he fails. He barrels into  parenthood still unable to see what's in front of his eyes, and the consequences are catastrophic.

But first, he has dinner at a restaurant! Or rather, he doesn't have dinner, because the items on the menu are terrifyingly expensive, so he just fills up on bread — but we'll get to that.

Let's start with the opening of Chapter 11. We're on Duane Street, a fancy street in lower Manhattan. Apollo has just been digging through the old, abandoned books of some rude people in Queens. Now he's meeting Emma and Emma's friend Nichelle for dinner at Bouley, which is a real New York restaurant. Or rather, it used to be; it closed in 2017, the year this book was published.

Here's how the chapter starts: "Entering Bouley Restaurant felt like stepping inside a gingerbread house. .... when he opened the door and stepped into the foyer, he found himself surrounded by apples. Shelves had been built into the wall, running as high as the ceiling; rows of fresh red apples and their scent enveloped him. The door to Duane Street shut behind him, and Apollo felt as if he'd stumbled into a small cottage off an overgrown path in a dark wood" (41).

(By the way, if this room sounds too playful, magical, or wonderful to be true — here's an article that includes a photo of Bouley's apple entrance: "What's David Bouley Going to Do With all Those Apples When He Closes His Flagship Restaurant?")

So. With these opening lines, LaValle accomplishes two things: (1) he fixes a real-life restaurant firmly in the world of fairy tale. And (2) he signals to us what story Apollo thinks he's in. Because we all know that when Hansel and Gretel step into a cottage off an overgrown path in a dark wood with walls made of gingerbread, cake, and candies, things do not go well for them.

I don't want to take any of the fairy tale references in this book too literally or drag them out too far. Though LaValle can be pretty explicit sometimes about what he's referencing, his touch remains light, and I don't want to beat it to death. But as I said before, Apollo doesn't eat anything but bread during this dinner. He tells himself it's because he's afraid of the bill, but we also know that on some unconscious level, he thinks he's inside the story of Hansel and Gretel. And if you're inside that story, you know damn well that it's not safe to eat the food! Of course, as it turns out, Apollo could eat anything he wants safely, because Nichelle is paying for the dinner. Apollo's wrong: his story isn't Hansel and Gretel.

This is a pretty straightforward example of how this skilled writer uses a conscious and deliberate reference to a widely-known story that then shows us that Apollo is a little bit lost inside all the stories of his life. Also, as settings go, this description of the foyer of Bouley is evocative and beautiful. The sentences of this book are eminently readable. It's something I noticed again and again: despite a fair amount of description, my eyes never glazed over and I never struggled to picture what was being described to me. LaValle doesn't use flowery language or waste words. He tells you what it looks like and he tells you how Apollo experiences it. And he attaches it to story spaces we already know, spaces that are part of our cultural language of stories, so it feels familiar and right. For me, at this point in the book, it was enjoyable to be a little bit lost with Apollo, because the language was so lush and the setting so fairy-tale familiar; because I myself, sitting outside the story, could go eat something if I got hungry, without worrying about evil witches; and also because I had some grounding that Apollo doesn't have. Apollo doesn't know that his own book is called The Changeling. He's just trying to survive each new story, whatever it turns out to be, as he steps into it.

LaValle does a good job creating sympathy in the reader for Apollo's mistakes and confusions. Consider Apollo's experience as he moves further into Bouley: "The dining room's vaulted ceilings had been laid with eighteen-karat gold leaf sheets, and on top of that a twelve-karat white gold varnish, so the ceiling seemed as supple as suede. The floors were Burgundy stone, overlaid by Persian rugs. If the foyer felt like a woodland cottage and the waiting area a haunted parlor, the dining room became an ancient castle's great hall.….Apollo felt as if he was trekking through realms rather than rooms. If there had been men in full armor posted as sentries, it wouldn't have surprised him. And in fact, when the maître d' reached the right table, there was a queen waiting there. Emma Valentine, too pregnant to stand" (42).

This is one of the dangers of being a story man: If your entire life is steeped in story, you're going to see those stories everywhere. Surely that makes it confusing to isolate which story is yours?

On the other hand, Apollo totally notices that Emma is a queen — but then he dismisses it. This is another danger of a life steeped in story: you make associations and assume that they're metaphors. Emma isn't like a queen. She is a queen — or if not a queen, some other category of extremely powerful and important woman. Maybe one of Apollo's problems is that he's so steeped in story that he can't get hold of what's real? Or maybe he believes in magic within the context of a story, but he doesn't believe in magic in real life? Or maybe he lives too much inside stories, and needs to wake up and live his real life?

This is what good layering does. It leaves the reader with lots of fascinating and fun questions!

By the way, Emma has her favorite stories too — and LaValle's choices for her illuminate her character to anyone who's paying attention. The most important movie from Emma's childhood, which she watched repeatedly in her hometown library in Virginia, is a Brazilian movie called Quilombo, "the only movie in the entire library that had black people on the cover. Of course I wanted to watch it!" (28). It's a movie about the slave uprisings in Brazil, and it "shows tons of Portuguese people getting killed by those slaves" (28). At dinner, Nichelle brings it up: "This girl tried to get me to watch a movie about a slave uprising when I was busy trying to figure out how to marry that boy out of New Edition" (47). While Apollo is worrying about eating the food, LaValle reminds us that Emma is engaged in matters of disruption to major power structures. Ding ding ding! Pay attention, Apollo!

But Apollo is too hungry and anxious to pay attention. The dinner progresses as dinners do. Apollo, not knowing that Nichelle is buying, becomes more and more horrified as Nichelle and Emma order delicacy after delicacy. Nichelle gets roaring drunk. Emma, who rarely sleeps anymore, is drifting, half-asleep in her seat. "Apollo, meanwhile, had ingested nothing but tapwater and the restaurant bread. While the bread tasted magnificent, it wasn't enough. By dessert, Apollo and Emma had low batteries, but Nichelle seemed wired to a generator" (46).

Near the end of the dinner, Emma leaves the table to find the bathroom. She's thirty-eight weeks pregnant and "That flan wants to come back up," she says quietly (47). When she leaves, Nichelle, like any good soothsayer in any good folktale, takes the opportunity to try to tell Apollo what matters.

First, she tells Apollo that "There's a nude photo of your wife in an art gallery in Amsterdam." Then she explains that before Emma married Apollo, Emma went to Brazil, where "she had a few adventures" (48). In particular, "Emma met this Dutch photographer down there in Brazil" (49).

Nichelle goes on to explain that one day while the photographer was taking photos in an abandoned factory, he needed to pee, so he left Emma alone with the equipment. And she decided to take a picture of herself, setting up the shot with a timer. "She makes the shot in front of a wall that's been half torn down so you can see she's standing inside a man-made building that's gone to the dogs, but over her right shoulder you can see the forest that surrounds this factory. Two worlds at once. Crumbling civilization and an explosion of the natural world. / "Emma walks into the shot, and just before the shutter clicks, she pulls off her dress and takes that photo nude!"

What's the photo like? How does Emma look? "Wiry and fierce, naked and unashamed. She's looking into that camera lens like she can see you, whoever you are, wherever you are. She looks like a fucking sorceress, Apollo. It was one of the most beautiful things I've ever seen" (50).

So, here's Nichelle, telling Apollo what he's glancingly considered before in a fond, condescending sort of way: Emma is a sorceress. Nichelle is saying this to Apollo in simple, straightforward words: Emma is a sorceress, with a great capacity for adventure.

What is Apollo doing during this conversation?

He's sitting there thinking to himself, "Dutch photographer? / Dutch fucking photographer?" (49)

And when he finally speaks, what does he say?

"'And the Dutch guy?' Apollo asked. 'What was his name?'" (59)

This moment is, of course, the stuff of everyday real life and the stuff of fairy tales. Jealousy and possessiveness, leading to a character's blunder or misbehavior. In fairy tales, we see jealousy as an archetype — like the queen who decides to destroy the young woman who's usurped her position as the fairest of them all. In Apollo's life, it comes across as fairly typical and annoying sexism.

Nichelle's response to this question contains everything. Everything this book is about; everything that leads to catastrophe, and ultimately to Apollo's growth and transformation: "Nichelle watched him quietly for seconds. She narrowed her eyes when she spoke. 'I'm trying to tell you something important, and you are focused on bullshit'" (50).

For just a moment, Apollo gets it. He falls "back into his chair as if Nichelle had kicked him" (51). He tells her he's ready, he's finally listening.

And then the maître d' appears, sprinting across the restaurant, shouting for Apollo, because the baby is coming. Which means that everything is about to change, and it's too late.

Apollo's failures in this scene are familiar and understandable, even when they're annoying. He's hungry, distracted, and worried about his wife who's probably vomiting flan in the bathroom. Also, Nichelle is completely, obnoxiously drunk, so why should Apollo recognize the power or truth of her words? Maybe I should clarify that at this point in the book, I didn't appreciate that Emma was a legit sorceress either. We haven't learned the stakes yet, and we don't know how much we're going to be needing a sorceress later. But more to the point, most of this book is from Apollo's point of view, and right now Apollo is hungry, distracted, and worried. There are more important things to worry about, or so he thinks. And I care about him. Even though as the reader, I'm better positioned than he is to recognize his mistakes, I'm right there with him.

This all comes down to LaValle's skilled balancing of story and character. So much comes across in this one scene, and there are so many other equally rich scenes. If you like to sit in that place where spinning stories come together, you should read this book.

I'll close my study of The Changeling by adding this: I know enough from my own experience as a writer to suspect that while LaValle was writing this book, he wasn't always certain what story he was writing either. As we write, our story keeps surprising us, interrupting us, frustrating us and sending us off in the wrong direction. But not only did he find his own story (and Apollo's too), but he did a beautiful job weaving all the other stories in.

If you're writing something that alludes to other stories, I hope you'll find LaValle's use of classic stories exciting, rather than intimidating. When you ask yourself, Why this story?, it's an opportunity to figure out how far along you are in establishing your own story. If you don't have an answer yet, maybe you need to be focusing less on the classic story and more on your own story. If you have a few answers, but you're completely overwhelmed and not sure how many references you should make or where anything is going — take a moment to congratulate yourself, because that sounds to me like progress. When you're in the middle of writing something, there's always a sense of overwhelm and confusion about how well you're balancing things. You have a few potential answers? Great! Soldier on, and after a while, check in again. What's your story now?

And that's that. I hope you've enjoyed my post about the balance of story in Victor LaValle's The Changeling!

Reading like a writer.






ava

Assessee can avail ITC only on tax paid on services for leasing/ renting/ hiring of motor vehicles for women's safety

The AAR, Tamil Nadu in the case of M/s. CMA CGM Global Business Services (India) (P.) Ltd., In Re [Order No. 15/ARA/2024 dated July 15, 2024] ruled that an Assessee is eligible to avail input services in respect of leasing/ renting/ hiring of motor vehicles of motor vehicles to provide transportatio




ava

Nothing OS 3.0 Open Beta 2 Now Available for Phone (2a): Here's How to Install It

The latest update to Nothing's operating system is now available for users with the Phone (2a), as the company rolls out the second open beta for Nothing OS 3.0. While this version is currently exclusive to the Phone (2a), users of




ava

New stickers & shirts now available!

I have submitted the manufacturing order for my new set of pins! They are at the factory now — I should be receiving my stock in the month of August sometime. Here are the final designs. Pre-orders are still open! This project has been really fun! I enjoyed the challenge of designing a bunch of new stuff (which I haven’t done in a while), and it’s been really interesting seeing which designs have hit and which are are little less popular. I can already tell that a few of these are going to be one print run only. So, this ... Read more



  • Blog
  • blog: product announcements

ava

'He was a nightmare': Employee's savage review after quitting exposes entitled boss, leads to their termination

When you're applying for jobs, you're probably checking out every online review you can find to dodge any potential red flags. After all, who wants to go through multiple interviews only to discover that the company's run by an entitled boss who thinks coworkers should act like "family"? Hard pass. Sites that let employees rate companies are a goldmine for honest feedback—sometimes with details that make you grateful for the warning.

Well, after one employee spent six grueling months working under a new VP, they tried to clue in the higher-ups about just how awful the new boss was. When the owner didn't take their concerns seriously, they took things a step further, leaving a brutally honest review that laid everything bare. The best part is it worked. The entitled boss eventually got the boot, and the company's culture finally went back to normal. Unfortunately, the original employee who exposed the mess had already quit—but at least they left with a story of sweet, well-deserved karma.




ava

Dr. Nupur Srivastava's Pathway Integrating Energy Healing and Neuroplasticity

Highlights: Dr. Srivastava combines energy healing with neuroplasticity to promote holistic health Neuroplastici




ava

Transforming Healthcare: Improving Doctor and Nurse Availability in India

Highlights: 82% rise in medical colleges from 2014 to 2023 112% increase in MBBS seats and 127% in PG seats




ava

Diabetes and Tooth Loss Aggravate Cognitive Decline in Older Adults

Diabetes is a known risk factor for cognitive decline and dementia. The hallmark features of diabetes such as high blood sugar, insulin resistance, inflammation,





ava

MedAvante Opens Moscow Office and Successfully Completes First Centralized Ratings Assessment

MedAvante Opens Moscow Office and Successfully Completes First Centralized Ratings Assessment




ava

Zembrace Symtouch Anti-Migraine Injection of Dr. Reddy's Now Available in the US

Food and Drug Administration (FDA) approves the anti-migraine injection of an Indian-based pharmaceutical company for treating patients in the United States.




ava

What is the budget for Prabhas and Hanu Raghavapudi's film?

After Salaar and Kalki, fans of Prabhas are eagerly waiting for his upcoming film The Raaja Saab which is slated for release in the month of April 2025. Meanwhile, the actor is shooting for Hanu Raghavapudi directorial produced by Mythri Movie Makers.




ava

PM Modi in Maha rally dares MVA leaders to make Cong praise Savarkar, Bal Thackeray's ideology

Prime Minister Narendra Modi on Friday dared the Maha Vikas Aghadi (MVA) leaders to make Congress leaders, especially Yuvraj (referring to Leader of Opposition in Lok Sabha Rahul Gandhi,) praise Veer Savarkar's sacrifice and his contribution in the country's freedom struggle.




ava

After selling his last AI startup to Meta, Beyond Presence’s founder nabs $3.1M to build lifelike avatars

Computer vision applications are getting a huge boost from advances in smartphones combined with AI that helps fill in the gaps of what everyday devices cannot see. Using these tools, a startup out of Munich called Beyond Presence believes it holds the keys to what is coming next: Hyper-realistic avatars that look and sound exactly […]

© 2024 TechCrunch. All rights reserved. For personal use only.




ava

Samsung unveils Galaxy Buds 3 Pro and Buds 3, available for preorder now and shipping July 24

While Samsung has maintained its own familiar design with the standard Galaxy Buds 3, the Pro are experiencing a sort of Apple identity crisis.

© 2024 TechCrunch. All rights reserved. For personal use only.




ava

Atlassian’s Rovo AI is now generally available

Atlassian first showed off Rovo six months ago. Rovo is what the company calls its “AI teammate” that combines smarter search and chat-based AI tools with agents that can help users automate some of their workflows in tools like Jira and Confluence. At its Team ’24 Europe event in Barcelona, the company has now announced […]

© 2024 TechCrunch. All rights reserved. For personal use only.




ava

Avadhesh Yadav @ Awadhesh Yadav vs The State Of Bihar on 11 November, 2024

Heard learned counsel for the petitioner and learned APP for the State.

2. Petitioner is apprehending his arrest in connection with Bihpur P.S. Case No.47 of 2024, registered for the offence punishable u/s 147, 148, 149, 447, 385, 387, 307, 504, 506 of IPC and 27 of Arms Act.

3. Allegedly, petitioner along with some known and unknown co-accused persons came to the informant's house and started abusing for demand of extortion. It is further alleged that the petitioner along with one another co-accused started firing with the intention to create fear.




ava

Nandini Chakravarty vs State Of West Bengal on 12 November, 2024

1. Heard Mr. Supriyo Dutta, representing the Applicant is present in person.

2. This Original Application has been registered on the basis of a letter petition submitted in the office of the Tribunal through email dated 18.07.2024 alleging that industrial factories and workshops around the village of the Applicant at Purbannapara located at Makardah Mouza under Domjur Block, District, Howrah has been causing severe environmental problems to the lives of the local people due to obnoxious gaseous effluents.

3. It is also alleged that the Saraswati Canal has been blocked due to it being used for dumping of waste water and other industrial waste material3 by several industries present in the area that continue unregulated dumping of the industrial wastes also resulting in deterioration of the environment in the locale.




ava

Bhagavan Ram D Patel vs State Of Kerala on 8 November, 2024

Dated this the 08th day of November, 2024 The application is filed under Section 483 of the Bharatiya Nagarik Suraksha Sanhita, 2023, by the 8 th accused in Crime No.1360/2024 of the Cherthala Police Station, Alappuzha, which is registered against the accused persons for allegedly committing the offences punishable under Sections 406, 419, 420, 468, 471, 506 read with Section 34 of the Indian Penal Code, 1860 and Section 66D of the Information Technology Act. The petitioner was remanded to judicial custody on 09.09.2024.

2. The crux of the prosecution case is that: the accused, in furtherance of their common intention, had during the period from September 2023 to 13.05.2024 induced the defacto complainant to make investments in their companies named 'INVESCO CAPITAL' and 'GOLDMANS SACHS'. Accordingly the defacto 2024:KER:83459 complainant invested Rs.7,65,00,000/- by transferring the amount from his and his wife's joint account believing that he would receive Rs.39,72,85,929/-. However, the accused did not pay any profit or return the capital. Thus, the accused have committed the above offences.




ava

Deepak S. Kavadiya vs Addl. Divisional Commissioner Konkan ... on 12 November, 2024

1. Revision Application is allowed.

2. The order of Competent Authority Konkan Division in case No.178 of 2023 dated 06.08.2024 is set aside.

3. The Parties be informed accordingly.

24) Thus, the Revisional Authority has relied upon Section 55 of the MRC Act for accepting the contention of the licensee that in absence of registration of the licence agreement, her version of ___Page No.19 of 33___ 12 November 2024 Megha 908_wp_14856_2024_fc.docx licence being granted for commercial use would prevail. Section 55 of the Act provides for providing for compulsory registration of tenancy agreement and consequences of non-registration. Section 55 provides as under:




ava

Smt R Leelavathi vs State Of Karnataka on 12 November, 2024

IN RE: B.K.NAGARAJAPPA

6. The petitioner Sri B.K.Nagarajappa had served the Corporation between 05.04.2021 to 30.06.2022 as General Manager. Previous approval has been granted for the purpose of investigation as regards the following:

NC: 2024:KHC:45706 PÀæ.¸ÀA ¥Éưøï oÁuÉ C¥ÀgÁzsÀ ¸ÀASÉå 1 PÀ®§ÄVð f¯Éè, PÁ¼ÀV ªÉÆ.¸ÀA.79/2022 gÀ PÀ®A ¥Éưøï oÁuÉ 406, 409, 420, gÉ/« 34 L¦¹ 2 ¨ÉAUÀ¼ÀÆgÀÄ £ÀUÀgÀ ¹zÁÝ¥ÀÄgÀ ªÉÆ.¸ÀA.56/2023, PÀ®A ¥Éưøï oÁuÉ 406, 420 ¸ÀºÀ 149 L¦¹ 3 ¨ÉAUÀ¼ÀÆgÀÄ UÁæªÀiÁAvÀgÀ f¯Éè ªÉÆ.¸ÀA.07/2023, PÀ®A-




ava

Gurudeva Brahmanand Trust Committee vs Sankappa S/O Ningappa Banavannavar on 5 November, 2024

(PER: THE HON'BLE MR. JUSTICE C.M. POONACHA) The present writ petition is filed by the plaintiff challenging the order dated 16.07.2024 passed in M.A.No.7/2023 by the Court of the Senior Civil Judge and JMFC, Kalaghatagi1.

2. The relevant facts leading to the present writ petition are that the plaintiff instituted a suit in O.S.No.11/2023 before the Civil Judge and JMFC, Kalghatagi2 wherein the respondents herein arrayed as defendants. The reliefs sought for in the suit are extracted herein for ready reference.

"14. Prayer: That, the most respectfully and graciously prayed that, this hon'ble Court be please to pass decree in favour of plaintiff as under:-




ava

Pavan H.M. Manohar @ Pavan @ Pavan ... vs The State Of Karnataka By on 5 November, 2024

The petitioner - accused is before this Court calling in question proceedings in Spl.C.No.1338/2024 registered for offences punishable under Sections 417, 420 and 313 of the Indian Penal Code, 1860 (the 'IPC' for short).

-3-

NC: 2024:KHC:44321

2. Heard Sri. Hemanth Kumar K., learned counsel appearing for the petitioner, Sri. R. Rangaswamy, learned HCGP appearing for respondent No.1 and Sri. K.A. Prathap, learned counsel appearing for respondent No.2.

3. Facts adumbrated are as follows:

The second respondent is the complainant, registers a complaint on 28.03.2024 for the afore quoted offences. The crux of the complaint is that the complainant and the petitioner get acquainted to each other in the year 2021, while they were working together. The narration in the complaint that the friendship blossomed into relationship and the relationship was physical as well. Further allegation in the complaint is that the petitioner had physical relationship with the complainant on the pretext of marriage or on the promise of marriage. The promise having been broken is what leads the complainant to register a complaint with the jurisdictional police for the aforesaid offences. The police after investigation filed a charge sheet and the matter is presently pending as a special case in 1338/2024 for the afore quoted offences.




ava

Jokes: Java के 4 वर्जन पूछे जाने पर संता ने दिया ऐसा जवाब, इंटरव्यू लेने वाले हो गए बेहोश, पढ़ें मजेदार जोक्स

JOKES: स्वास्थ्य के लिहाज से हंसना बेहद जरूरी होता है। हंसने से लोग स्वस्थ रहते हैं। भाग दौड़ भरी जिंदगी के चलते लोगों का हंसना अब गायब ही हो रहा है। आपके लिए कई गुदगुदाने और मजेदार जोक्स लेकर




ava

Border Gavaskar Trophy: রোহিত শর্মার বদলে রাতারাতি অস্ট্রেলিয়ায় ভারতের অধিনায়ক বিরাট কোহলি!

Border Gavaskar Trophy Sparks Internet Storm: রোহিত শর্মার বদলে রাতারাতি ভারতের অধিনায়ক বিরাট কোহলি! এক পোস্টারেই ঝড় নেটপাড়ায়...  




ava

Border-Gavaskar Trophy: অজি দৈনিকে হিন্দি-পঞ্জাবিতে বোল্ড হেডলাইন! পাতা জুড়ে বুক চিতিয়ে বাইশ গজের রাজা...

Virat Kohli Fever: বিরাট কোহলির জ্বরে কাঁপছে অস্ট্রেলিয়া... চমকে দিল স্থানীয় খবরের কাগজ!  




ava

Former Cricketer Sanjay Manjrekar's Big Advice For Team India For Border-Gavaskar Trophy 2024

With presitigious Border-Gavaskar Trophy tournament round the corner, Former Indian cricketer Sanjay Manjrekar shared some important and useful advices for Team India. Rohit Sharma and men, who recently faced a humiliating test series defeat vs New Zealand, are currently underconfidence and




ava

Gautam Gambhir Press Conference: India Head Coach Comments On Rohit Sharma's Availability, Virat Kohli's Form

During a recent press conference, Gautam Gambhir, head coach of the Indian cricket team, discussed the team's future and performance. He downplayed the idea of a transition period for Indian cricket, focusing instead on upcoming series. Gambhir mentioned Jasprit Bumrah might




ava

Border-Gavaskar Trophy: Jasprit Bumrah To Captain India In 1st Test, If...

The Indian men's cricket team is gearing up for the first Test of the 2024-25 Border-Gavaskar Trophy against Australia. This match will be held at Optus Stadium in Perth, starting on November 22. There is a possibility that Jasprit Bumrah might




ava

iPhone 16 Series Repair Parts Now Available at Self-Service Repair Store—but Is It Available in India?

Apple has begun selling repair parts for the iPhone 16 and 16 Pro models through its self-service repair store. Customers can find components and tools to fix or replace various parts, including the display, battery, rear camera system, TrueDepth camera for