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Tesla CEO Elon Musk said Saturday the company will file a lawsuit against Alameda County and threatened to move its headquarters and future programs to Texas or Nevada immediately, escalating a fight between the company and health officials over whether its factory in Fremont can reopen. Tesla had planned to bring back about 30% of […]

“Breathing would be delightful,” the director of products told me in our kickoff. His startup was growing fast. It had a bunch of new funding, the pressure was on to ship, and the team was underwater. I was there to help and take the pressure off so they could breathe. “Let’s begin to think strategically […]

The post Successful Scaling: How to Grow Without Tumbling Back Down appeared first on ReadWrite.

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Here are the latest developments in the coronavirus crisis.

velocityconf: New #velocityconf CA program preview is up: http://t.co/rKjf91RXdD @ariyahidayat on End-to-End JS Quality Analysis.

Can you tell who’s who? No, nor can we.

South Africa's net death rate has decreased amid the Covid-19 pandemic over the past five weeks, despite the 186 deaths thus far, Health Minister Zweli Mkhize says.

As a digital company, your business is not bound by conventional borders and has the freedom and opportunity to reach customers anywhere in the world. And just as you look outward for new markets, customers are also looking beyond their physical borders for their goods and services. As a study by KPMG shows, online buyers […]

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The Amateur Traveler talks to Richard Miller of the SparkleTack podcast (about San Francisco history) about San Francisco. Richard guides us in a driving/walking tour from west to east. We start at lands end and end up near fisherman's wharf while talking about the sites and history of many of the places in between. This is a great companion episode with the 2 part soundseeing walking tour of San Francisco.

The Amateur Traveler talks to Carole Terwilliger Meyers the author of Weekend Adventures in San Francisco and Northern California. Carole comes on the show to talk about California’s traditional wine country of Napa and Sonoma Valleys. This episode focuses primarily on the Napa Valley and the many wineries that can be found there. We explore recreated castles, wine tasting , tours as well as other none wine related sites like mud baths, petrified forests, and the CIA (The Culinary Institute). We talk about restaurants and hotels, picnics and the wine train. Whether you are a connoisseur, a foodie or just a tourist, the Napa Valley has much to offer.

The Amateur Traveler talks to Sam Oppenheim who makes a rare 4th appearance on the show to talk about Bali in Indonesia. Sam started his exploration of Bali in Ubud which is the cultural capital of the area. He met two of the people mentioned in the popular book Eat, Pray, Love: Wayan and Ketut Liyer. In Ubud he attended some of the traditional Balinese dances (Legong, Barong and Kecak). Sam explored the Hindu temples and the resort area of Kuta Beach with its famous nightlife, dove a ship wreck and explored the island by motorcycle. Sam’s does regret was not getting down to Nusa Dua on the southern tip with its wonderful sunsets or out to Komodo.

The Amateur Traveler talks to Dan Stromberg about his recent trip to Mali. Mali is a destination so remote that Dan says “I couldn’t imagine myself being here when I was there”. Dan started in the capital city of Bamako, before heading out to Bandiagara and Dogon country. The highlight of the visit was a trek along the Bandiagara Escarpment which is a UNESCO World Heritage site. Dan and his girlfriend, along with a guide, walked and hiked along the cliffs and then stayed in the local villages of the Dogon people at the base of this 200 km long sandstone cliff.

The Amateur Traveler talks to Andy Dye about his adopted hometown of Melbourne Australia. Andy grew up in England but fell in love with Melbourne. Sure the weather was better but Andy also discovered a city with street art, vibrant cafes, culture and sport. Melbourne is the home of Australian Rules Foolball which was apparently invented by people who thought that rugby was too tame. Andy talks about wandering around the Central Business District (CBD) and discovering out of the way cafes. Melbourne has museums (like the Melbourne Museum, the Australia Center for the Moving Image), galleries (like the National Gallery of Victoria) and an aquarium. Melbourne is a multi-cultural city and no places show it off better than the Queen Victoria Market or Sydney Road Brunswick. He also talks about side trips such as going to see the penguins at Phillip Island.

The Amateur Traveler talks to Eric Schwartzman (author, educator and podcaster) about his hometown of Los Angeles. Over a two part series of episodes Eric will give us sample itineraries for 4 days in the Los Angeles area. Be forewarned that no theme parks will be involved in Eric's tour but instead an insider's look at LA. So pack up your swim suit, a sport coat and nice shoes and get in your car to explore LA. Along the way Eric points out the cafes, coffee shops, restaurants, hotels and movie locations that he thinks you should know about.

Day 1: Eric starts us at the beach at Santa Monica. We visit the Santa Monica Pier, the rides and the aquarium and then head to Venice with its pier, canals, and famous muscle beach.

Day 2: We follow Eric to Beverly Hills and Westwood. We look over the valley from the Getty Center above the valley. We visit Century City which is now the home for high rises but one was where John Wayne shot westerns. We go shopping on world famous Rodeo Drive.

The Amateur Traveler talks to Eric Schwartzman (author, educator and podcaster) about his hometown of Los Angeles. In this second part of a two part series of episodes Eric will give us the last two days of his sample itineraries for 4 days in the Los Angeles area. In this insider’s look at LA Eric points out the cafes, coffee shops, restaurants, hotels and movie locations that he thinks you should know about.

Day 3: Hollywood – Sunset Strip, Grauman’s Chinese Theater, Roosevelt, L.A.’s best chili dog, Academy Awards theater, Sunset Grill, Hollywood Cemetary and more.

Day 4: Downtown – Chinatown for dim sum, Olvera St. for Mole, Union Station for breathtaking Mission Architecture, Santee Alley and Los Angeles St. for discount children’s formal wear, Disney Hall for magnificent modern architecture and Our Lady of Angels Catholic Church.

The Amateur Traveler talks to Alix (of Alix and Jace’s Amazing Adventure) about her hometown of Sydney Australia. Alix has many ideas about fun things to do in Sydney so you don’t just end up with the rest of the tourists on Darling Harbor. After you have climbed the Harbor Bridge and visited the Sydney Opera House she recommends a beach walk by word famous Bondi Beach, a chance to sleep with the animals of the Taronga Zoo and the out of the way Manly Beach. She tells us what’s the best day of the year to see Sydney (although also the most expensive). Alix also gives us a dizzying list of Sydney restaurants to try.

The Amateur Traveler talks to Bethany of the Nevada Tourism Bureau about Lake Tahoe. Lake Tahoe is a high elevation alpine lake on the border of California and Nevada. It is surrounded by 18 ski areas so it is a popular winter destination. In the winter it is also a great place for back country hiking, cross country skiing, snowshoeing, and snowmobiling. In the Summer, Tahoe is a popular area for hiking, fishing and outdoor activities. But, there is another side to Tahoe which is the casinos, restaurants, and entertainment of Nevada's South Tahoe.

The Amateur Traveler talks to Dave Kerwin about his recent trip to Northern Queensland. Dave recommends 2 main stops on your trip: the Atherton Tablelands, Daintree National Park and the Great Barrier Reef.

The Amateur Traveler talks to Carrie from cruisebuzz.net about a popular vacation spot just off the coast of California, Catalina Island. 

Hear about travel to Perth, Australia as the Amateur Traveler talks to Carmen from double-barrelledtravel.com. Carmen grew up in Perth and lived for 21 years in this city on Australia’s Western shore. Perth is a beautiful city located where a river his the white sand beaches. 

Hear about travel to South Australia as the Amateur Traveler alks to Dave and Deb from ThePlanetD.com about their recent trip down under.

Hear about travel to Lassen National Park in northern California as the Amateur Traveler talks to Dick Jordan about this spectacular if less visited destination. Lassen is in northeastern California. It is just as easy to get to from San Francisco as Yosemite National Park but with fewer tourists and one more volcano. The park centers around the dormant volcano Mt. Lassen and features other geothermal active areas.

Hear about travel to Tasmania in Australia as the Amateur Traveler talks to Robert Reid, the Offbeat Observer for National Geographic Traveler, about his recent trip to Van Diemen’s Land.

Hear about travel to Northern Australia (Northwest Territories) as the Amateur Traveler talks to Sam Guerra from EscapeFromTheBay.blogspot.com. The "Top End" is "one of the more exotic parts of Australia for sure and it's definitely the closest place you can go to get an authentic feel for aboriginal culture which in my opinion is something that makes Australia unique. There is a lot of natural beauty and a lot of wildlife up there. It is nearly untouched."

Hear about travel to Canberra, Australia as the Amateur Traveler talks to Tenele Conway from www.hungryplanetblog.com about Australia's capital city and the Australian Capital Territory.

Hear about travel to Santa Barbara, California as the Amateur Traveler talks to Heather Simon from wellplannedtravel.net about the "American Riviera".

Hear about travel to San Diego as the Amateur Traveler talks to Mike from MikesRoadTrip.com about this beautiful city in Southern California.

Hear about travel to Sydney, Australia as the Amateur Traveler talks to Roma Small from RoamingRequired.com about her hometown. 

Hear about travel to California's premier wine region of Napa and Sonoma as the Amateur Traveler talks again to free lance journalist Jill Robinson about this area with more than just wine... but a lot of that

Hear about travel to Western Australia as the Amateur Traveler talks to Erica Carrico from ericacarrico.com about her trip to the wild and surprising Pilbara region.

Hear about travel to San Francisco, California as the Amateur Traveler talks to Jill Robinson and Kimberley Levato authors of 100 Things to Do in San Francisco Before You Die.

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Hear about travel to the Island of Bali in Indonesia as the Amateur Traveler talks to David Brodie from TravelIn10.com about a recent family trip to this popular tropical destination.

Hear about the best of California's state parks as the Amateur Traveler talks to Jeff Ohlfs who has been to all the parks in the state park system.

An evangelical church network in California will ignore Democratic Gov. Gavin Newsom’s executive prohibitions this month, opening sanctuary doors for communal worship despite the ongoing coronavirus pandemic. According to Fox News, California Church United, representing roughly 3,000 churches and 2.5 million congregants statewide, announced Thursday that it will return to conducting in-person services by Pentecost…

The post Huge Group of California Churches Announces Plan To Defy Governor Newsom’s Order appeared first on The Western Journal.

“Outbreaks have sparked riots and propelled public-health innovations, prefigured revolutions and redrawn maps.” – The New Yorker, April 2020 “Nothing will be the same.”  That’s the overwhelming takeaway I’ve heard from dozens of conversations I’ve had with C-suite leaders, physicians, policy experts and media professionals these past few weeks.  When it comes to the business … Continue reading "An Open Letter To American Corporations: It’s Good Business (and Smart Marketing) To Support Quality Journalism"

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The post REPORT: US issues new visa restrictions for country’s journalists appeared first on Dennis Michael Lynch.

The DML News App offers the best in news reporting.

The post REPORT: US slams new restrictions on journalists from this country appeared first on Dennis Michael Lynch.

The following article, BREAKING: MI Lawmakers File Lawsuit Challenging Governor’s “Improper” and “Invalid” Emergency Orders: “We’ve attempted to partner with our governor, but she’s rejected”, was first published on 100PercentFedUp.com.

In addition to crushing Michigan's economy, the governor's reckless, one-size-fits-all executive orders are harming an untold number of Michigan citizens.

Continue reading: BREAKING: MI Lawmakers File Lawsuit Challenging Governor’s “Improper” and “Invalid” Emergency Orders: “We’ve attempted to partner with our governor, but she’s rejected” ...

The following article, Attorney for Jailed Dallas Salon Owner Shelley Luther Slams Obama Loyalist Judge as a “Tiny Tyrant”, was first published on 100PercentFedUp.com.

Warren Norred, attorney for Shelley Luther, joined Tucker Carlson to discuss the decision by an Obama loyalist Texas judge to jail his client for reopening her salon during the COVID-19 pandemic. Norred said the judge has exposed himself for the “tiny tyrant” that he is. The judge jailed Luther and even fined her $7,000. Texas […]

Continue reading: Attorney for Jailed Dallas Salon Owner Shelley Luther Slams Obama Loyalist Judge as a “Tiny Tyrant” ...

The following article, Video: Salon Owner Shelley Luther Released from Jail After Obama-Loyalist Judge Sentenced Her to 7 Days, was first published on 100PercentFedUp.com.

Salon A La Mode owner Shelley Luther was just released from jail today. The Texas Supreme Court and Texas Governor Greg Abbott both called for her release today (see below). When Luther left jail she was greeted by supporters who yelled “Shelley’s Free!” She thanked all of the new friends she’s made during this difficult […]

Continue reading: Video: Salon Owner Shelley Luther Released from Jail After Obama-Loyalist Judge Sentenced Her to 7 Days ...

The transcription factor forkhead box P3 (FOXP3) is a biomarker for regulatory T cells and can also be expressed in cancer cells, but its function in cancer appears to be divergent. The role of hepatocyte-expressed FOXP3 in hepatocellular carcinoma (HCC) is unknown. Here, we collected tumor samples and clinical information from 115 HCC patients and used five human cancer cell lines. We examined FOXP3 mRNA sequences for mutations, used a luciferase assay to assess promoter activities of FOXP3's target genes, and employed mouse tumor models to confirm in vitro results. We detected mutations in the FKH domain of FOXP3 mRNAs in 33% of the HCC tumor tissues, but in none of the adjacent nontumor tissues. None of the mutations occurred at high frequency, indicating that they occurred randomly. Notably, the mutations were not detected in the corresponding regions of FOXP3 genomic DNA, and many of them resulted in amino acid substitutions in the FKH region, altering FOXP3's subcellular localization. FOXP3 delocalization from the nucleus to the cytoplasm caused loss of transcriptional regulation of its target genes, inactivated its tumor-inhibitory capability, and changed cellular responses to histone deacetylase (HDAC) inhibitors. More complex FKH mutations appeared to be associated with worse prognosis in HCC patients. We conclude that mutations in the FKH domain of FOXP3 mRNA frequently occur in HCC and that these mutations are caused by errors in transcription and are not derived from genomic DNA mutations. Our results suggest that transcriptional mutagenesis of FOXP3 plays a role in HCC.

Invitation Only Research Event

Event participants

Ali Farhan Hamid, Governor of Anbar Province
Chair: Dr Renad Mansour, Senior Research Fellow, Middle East and North Africa Programme, Chatham House

Research Event

Event participants