As of Nov. 12, Apple’s 2024 MacBook Air with the new M3 chip is $200 off at Amazon, priced at $899.

As of Nov. 12, Apple’s latest Series 10 46mm smartwatch is now $50 off at Amazon, priced at $379.

Save 34% on an Apple AirTag at Walmart.

Apple AirPods 3 normally retail for $169. As of Nov. 12, they're on sale for $94 at Walmart.

Apple now lets you share location of lost items with third parties via Find My accessories and AirTags.

Is it a controversial design choice or a completely acceptable location for the new Mac mini power button?

The best Amazon deals on Nov. 12 include four Apple AirTags, Google Pixel 9, 40-inch Amazon Fire TV, and Google Pixel Watch 3.

One prominent Apple prognosticator says the company is working on a smart home camera for launch in 2026.

With the recent macOS Sequoia launch, Apple released some Apple Intelligence features. Here's what you can try out now.

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When the first woman in space, Valentina Tereshkova, orbited the Earth in 1963, there were only three active Earth observation satellites. Today, the number is 114 times greater. With more and better satellites, the impacts of advances in the space sector are particularly evident in agriculture, where space data improves insights into the individual components […]

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A contentious meeting of physicists highlighted concerns, failures and possible fixes for a crisis in condensed matter physics

Title: Don't Forget to Apply Sunscreen Before & After Water Fun
Category: Health News
Created: 8/27/2021 12:00:00 AM
Last Editorial Review: 8/27/2021 12:00:00 AM

High-throughput sequencing (HTS) technologies have been instrumental in investigating biological questions at the bulk and single-cell levels. Comparative analysis of two HTS data sets often relies on testing the statistical significance for the difference of two negative binomial distributions (DOTNB). Although negative binomial distributions are well studied, the theoretical results for DOTNB remain largely unexplored. Here, we derive basic analytical results for DOTNB and examine its asymptotic properties. As a state-of-the-art application of DOTNB, we introduce DEGage, a computational method for detecting differentially expressed genes (DEGs) in scRNA-seq data. DEGage calculates the mean of the sample-wise differences of gene expression levels as the test statistic and determines significant differential expression by computing the P-value with DOTNB. Extensive validation using simulated and real scRNA-seq data sets demonstrates that DEGage outperforms five popular DEG analysis tools: DEGseq2, DEsingle, edgeR, Monocle3, and scDD. DEGage is robust against high dropout levels and exhibits superior sensitivity when applied to balanced and imbalanced data sets, even with small sample sizes. We utilize DEGage to analyze prostate cancer scRNA-seq data sets and identify marker genes for 17 cell types. Furthermore, we apply DEGage to scRNA-seq data sets of mouse neurons with and without fear memory and reveal eight potential memory-related genes overlooked in previous analyses. The theoretical results and supporting software for DOTNB can be widely applied to comparative analyses of dispersed count data in HTS and broad research questions.

This review explores the concept of synergy in pharmacology, emphasizing its importance in optimizing treatment outcomes through the combination of drugs with different mechanisms of action. Synergy, defined as an effect greater than the expected additive effect elicited by individual agents according to specific predictive models, offers a promising approach to enhance therapeutic efficacy while minimizing adverse events. The historical evolution of synergy research, from ancient civilizations to modern pharmacology, highlights the ongoing quest to understand and harness synergistic interactions. Key concepts, such as concentration-response curves, additive effects, and predictive models, are discussed in detail, emphasizing the need for accurate assessment methods throughout translational drug development. Although various mathematical models exist for synergy analysis, selecting the appropriate model and software tools remains a challenge, necessitating careful consideration of experimental design and data interpretation. Furthermore, this review addresses practical considerations in synergy assessment, including preclinical and clinical approaches, mechanism of action, and statistical analysis. Optimizing synergy requires attention to concentration/dose ratios, target site localization, and timing of drug administration, ensuring that the benefits of combination therapy detected bench-side are translatable into clinical practice. Overall, the review advocates for a systematic approach to synergy assessment, incorporating robust statistical analysis, effective and simplified predictive models, and collaborative efforts across pivotal sectors, such as academic institutions, pharmaceutical companies, and regulatory agencies. By overcoming critical challenges and maximizing therapeutic potential, effective synergy assessment in drug development holds promise for advancing patient care.

It will likely release in 2026 and feature Apple Intelligence, according to a reliable analyst.

Chris suffers from "The Curse of the Steam Deck." Kelley can't pickpocket, so she mugs people at night. And Ryan likes practical grave robbers. Curl up in your clothmap quilt and enjoy our cozy '60s demon world.

The post RPG Cast – Episode 681: “Ganon Is Afraid of Homemade Apple Pie” appeared first on RPGamer.

Apple recently announced its new lineup of Macs and rolled out Apple Intelligence, its latest artificial intelligence-powered feature for its products.

If rumours are true and this one should be, I started it, we have a special edition of the Weekend show where we talk about the evolution of the role of the CIO with two incredible CIOs as the CIO Association of Canada turns 20. Don’t miss it.  MUSIC UP Can HP make you love […]

Apple Music gives a whole new meaning to the phrase the hits just keep on coming.  It’s not the opposing candidates, it’s public AI systems that are spreading election disinformation, and LockBit, the cybercriminal gang may be back from the dead and saying so long to the ChatGPT plugins, which went from innovation to legacy […]

Highly efficient SoCs offer up to 10 CPU cores, 32 GPU cores, 64GB of 400GB/s RAM.

Apple is making Siri smarter as part of updates that also promise improvements to Maps, Music and Photos.

M4 and M4 Pro get core count bumps; M4 Max relies on architectural improvements.

Will Apple keep one of the few single-fee alternatives to Photoshop available?

First Mac mini redesign in almost 15 years highlights how good the insides are.

I've spent a week with Apple Intelligence—here are the takeaways.

Work on Asahi's Vulkan GPU driver and various translation layers is paying off.

The film will be a comedy, not a serious historical drama.

The game will take "full advantage of Apple silicon," CD Projekt Red says.

Dozens of previously hard-to-access games can now be synced via Virtual Machine.