Published at LXer: MYiR Tech�s MYC-LD25X is a compact 39x37mm system-on-module built around the STMicro STM32MP25 dual-core Cortex-A35 SoC running at 1.5GHz with a Cortex-M33 core, and an NPU...

KUCHING: Sarawak police seized 10.4 kilograms (kg) of syabu estimated to be worth RM332,800 in a raid conducted at an apartment in Matang on Monday.

Sarawak Police Commissioner Datuk Mancha Ata said during the raid, a 57-year-old local man who tested positive for methamphetamine and amphetamine was also arrested.

“The total amount of drugs seized could be used by 52,000 addicts and a Kawasaki Z900 motorcycle estimated to be worth RM50,000 was also seized.

“Initial investigations by the police also found that the suspect had a record of past offences under Section 12(2) of the Dangerous Drugs Act 1952,“ he said in a statement here today.

Mancha said the suspect would be remanded for seven days from today until Nov 19 to assist in investigations under Section 39B of the Dangerous Drugs Act 1952.

Felix Prangenberg, Jordan Godwin and Jordan O´Kane escaped the english rain to film this nice video for Doomed Brand at the M32 DIY spot in Bristol. You can watch their new video right here!

Enjoy the video, your kunstform BMX Shop Team!



Video: Doomed Brand

Related links:

• all Products of Doomed Brand
• all signature parts of Felix Prangenberg
• kunstform YouTube Channel

Mettler Toledo's next-generation metal detection systems are designed to identify contaminants in a range of food manufacturing applications, with game-changing SENSE software extending intelligent control across the entire system.

U-Boot with GRUB support for BeagleBone and BeagleBone Black

U-Boot for BeagleBone Green (git version)

U-Boot with Extlinux support for BeagleBone and BeagleBone Black

An all purpose Java bytecode manipulation and analysis framework.

An all purpose Java bytecode manipulation and analysis framework.

An all purpose Java bytecode manipulation and analysis framework.

The M3 Touring is proof that fun and practicality are not mutually exclusive. #bmw #m3touring #familycar

Preclinical data have shown that ¹⁶¹Tb-labeled peptides targeting the somatostatin receptor are therapeutically more effective for peptide receptor radionuclide therapy than are their ¹⁷⁷Lu-labeled counterparts. To further substantiate this enhanced therapeutic effect, we performed cellular dosimetry to quantify the absorbed dose to the cell nucleus and compared dose–response curves to evaluate differences in relative biological effectiveness in vitro. Methods: CA20948 cell survival was assessed after treatment with [¹⁶¹Tb]Tb- and [¹⁷⁷Lu]Lu-DOTATATE (agonist) and with [¹⁶¹Tb]Tb- and [¹⁷⁷Lu]Lu-DOTA-LM3 (antagonist) via a clonogenic assay. Cell binding, internalization, and dissociation assays were performed up to 7 d to acquire time-integrated activity coefficients. Separate S values for each type of particle emission (Auger/internal conversion [IC] electrons and β^– particles) were computed via Monte Carlo simulations, while considering spheric cells. Once the absorbed dose to the cell nucleus was calculated, survival curves were fitted to the appropriate linear or linear-quadratic model and corresponding relative biological effectiveness was evaluated. Results: Although the radiopeptide uptake was independent of the radionuclide, [¹⁶¹Tb]Tb-DOTATATE and [¹⁶¹Tb]Tb-DOTA-LM3 delivered a 3.6 and 3.8 times higher dose to the nucleus, respectively, than their ¹⁷⁷Lu-labeled counterparts on saturated receptor binding. This increased nucleus-absorbed dose was mainly due to the additional emission of IC and not Auger electrons by ¹⁶¹Tb. When activity concentrations were considered, both [¹⁶¹Tb]Tb-DOTATATE and [¹⁶¹Tb]Tb-DOTA-LM3 showed a lower survival fraction than did labeling with ¹⁷⁷Lu. When the absorbed dose to the nucleus was considered, no significant difference could be observed between the dose–response curves for [¹⁶¹Tb]Tb- and [¹⁷⁷Lu]Lu-DOTATATE. [¹⁶¹Tb]Tb-DOTA-LM3 showed a linear-quadratic dose response, whereas [¹⁶¹Tb]Tb-DOTATATE showed only a linear dose response within the observed dose range, suggesting additional cell membrane damage by Auger electrons. Conclusion: The IC, rather than Auger, electrons emitted by ¹⁶¹Tb resulted in a higher absorbed dose to the cell nucleus and lower clonogenic survival for [¹⁶¹Tb]Tb-DOTATATE and [¹⁶¹Tb]Tb-DOTA-LM3 than for the ¹⁷⁷Lu-labeled analogs. In contrast, [¹⁶¹Tb]Tb-DOTATATE showed no higher dose response than [¹⁷⁷Lu]Lu-DOTATATE, whereas for [¹⁶¹Tb]Tb-DOTA-LM3 an additional quadratic response was observed. Because of this quadratic response, potentially caused by cell membrane damage, [¹⁶¹Tb]Tb-DOTA-LM3 is a more effective radiopeptide than [¹⁶¹Tb]Tb-DOTATATE for labeling with ¹⁶¹Tb.

Read the in depth Review of Sony WF-1000XM3 Audio Video. Know detailed info about Sony WF-1000XM3 configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of Poco M3 Mobile Phones. Know detailed info about Poco M3 configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of Oppo Enco M32 Audio Video. Know detailed info about Oppo Enco M32 configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of Samsung Galaxy M34 5G Mobile Phones. Know detailed info about Samsung Galaxy M34 5G configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

The rapid rise in size and sophistication of AI/ML training models requires increasingly powerful hardware deployed in the data center and at the network edge. This growth in complexity and data stresses the existing infrastructure, driving the need for new and innovative processor architectures and associated memory subsystems. For example, even GPT-3 at 175 billion parameters is stressing the bandwidth, capacity, training time, and power of the most advanced GPUs on the market.

To this end, Cadence has shown our HBM3E memory subsystem running at 12.4Gbps at nominal voltages, demonstrating the PHY’s robustness and performance margin. The production version of our latest HBM3E PHY supports DRAM speeds of up to 10.4Gbps or 1.33TB/s per DRAM device. This speed represents a >1.6X bandwidth increase over the previous generation, making it ideal for LLM training.

Cadence has been the HBM performance leader since 2021, when we announced our first 8.4Gbps HBM3E PHY supporting >1TB/s of memory bandwidth per HBM DRAM. Customers building advanced AI processors have used this speed while building margin into their systems. Recall that HBM3E is a 3D stacked DRAM with 1024-bit wide data (16 64-bit channels). While this wide data bus enables high data transfer, routing these signals requires interposer technology (2.5D) capable of routing close to 2000 signals (data and control), including silicon, RDL, and silicon bridges.

The interposer design is critical for the system to operate at these data rates. Cadence provides 2.5D reference designs, including the interposer and package, as part of our standard IP package. As demonstrated in our test silicon, these designs give customers confidence they will meet their memory bandwidth requirements. The reference design is also a good starting point, helping to reduce development time and risk. Our expert SI/PI and system engineers work closely with customers to analyze their channels to ensure the best system performance.

Even as HBM3E delivers the highest memory bandwidth today, the industry keeps pushing forward. JEDEC recently announced that HBM4, the next version of the HBM DRAM standard, is nearing completion. JEDEC calls HBM4 an “evolutionary step beyond the currently published HBM3 standard.” They also claim HBM4 “enhancements are vital for applications that require efficient handling of large datasets and complex calculations.” HBM4 will support AI training applications, high-performance computing (HPC), and high-end graphics cards.

Cadence will continue to push the HBM performance boundaries to ensure designers of these data-intensive systems can take advantage of the highest memory bandwidth available.

Learn more about Cadence HBM PHY IP products.

Hey, is it suitable to post here? I wanted a small yet robust amp for practicing while I travel. I wanted something that would fit in my pocket yet still be loud enough to hear.

Presented here is a amplifier based upon the LM386 Audio Amplifier.

There is a standard circuit in the data sheet that is an excellent place to start.

Materials needed:
1 - HM359 project box
1 - 668-1237 speaker
1 - BS6I battery conn
1 - CP1-3515 stereo jack
1 - SC1316 stereo jack
2 - 450-1742 knob
1 - 679-1856 switch
1- 3mm LED
1 - 10 ohm 1/4W resistor
1 - 10uF ceramic cap
1 - .05 uF ceramic cap
1 - 420 uF electrolytic cap
1 - 8 ohm resistor
2 - 51AADB24 10K pot
1 - HM1252 circuit board
1 - LM386N-4 amplifier

Wire and Solder
Step 1: Prep the enclosure

Careful planning is required the first time you free build a circuit. The circuit board has solder pads but not traces. You will have to use thin wire to make the connections for the circuit to work.

Begin by laying out the components on the circuit board that will need to pass through the enclosure. This enclosure has a removable top panel which will be used for the volume, gain and 1/4 inch stereo jack.

Space is limited to check for fit before drilling.

All drilling of the plastic should be done with a step drill bit. This will make the cleanest holes without breaking the plastic.

Lay out the pots a few spaces back but still in line with the desired position. mark the center of each pot shaft then drill with a step drill tot he tightest fitting hole size. Make a center mark between the pot holes then drill for the stereo jack

On the inside of the top cover position and mark where the speaker will go.

Make a template on grid paper the same size as the speaker.

Tape the template to the inside of the cover as shown then use a step bit to drill holes on the center of every square in the grid. This will form the speaker grille. clean up the holes.

Step 2: place the major components

Solder the pots to the circuit board as shown. then place the stereo jack(note in order to get the final fit I had to trim and modify the stereo jack housing a little)

Next, position and solder the switch on the circuit board and mark a space on the top cover that will need to be cut for the switch opening. Use a small file to cut the opening.

Use a sharp knife to bevel the edges of the switch hole to allow for easier operation.

Drill a hole in the side of the upper case for the headphone jack and fasten it in place. ( I had to recess the hole a bit for the retaining nut to grab)

Step 3: Build the circuit

The speaker is held in place by using 2 small brackets that come with the serial cable connector hood. ( I had a bunch around that would never be used)

Refer the the circuit shown from the datasheet and the datasheet for the LM386. The basic circuit only has the volume control while the datasheet shows how to add a gain control across pins 1 and 8 of the amplifier.

The speaker is wired in series with the headphone jack. The headphone jack has internal switches that shut the speaker off when the phones are plugged in.

I chose to use a chip socket for the amplifier which make prototyping easier since you do not have to worry about solder heating as much.

Carefully lay the circuit out on the board and begin wiring components together. I added a second pot and cap in series between pins 1 and 8 of the amp to be able to manually set the gain in addition to volume.

Check you connections with a multimeter before adding the amplifier.

I chose to add a LED indicator for power. This was done by using one side of switch contacts from the battery. The LED is in series with a 220 ohm resistor.

Assemble the case and insert the battery.

Step 4: Final notes

If the speaker is noisy while the headphones work normally, try reversing the speaker connections. If it does not correct the issue, connect a 8 ohm resistor across the speaker contacts.

You may have to place an insulating layer between the speaker and the place where the stereo jack comes through to prevent contact. This will be noted by a loud buzz.

You may have to add some foam in the battery compartment to stop the battery from banging around.

For reference, I've also read an article about amplifiers: http://www.apogeeweb.net/article/60.html

Thanks for reading!
​

As of Nov. 12, Apple’s 2024 MacBook Air with the new M3 chip is $200 off at Amazon, priced at $899.

We identified a de novo heterozygous transient receptor potential cation channel subfamily M (melastatin) member 3 (TRPM3) missense variant, p.(Asn1126Asp), in a patient with developmental delay and manifestations of cerebral palsy (CP) using phenotype-driven prioritization analysis of whole-genome sequencing data with Exomiser. The variant is localized in the functionally important ion transport domain of the TRPM3 protein and predicted to impact the protein structure. Our report adds TRPM3 to the list of Mendelian disease–associated genes that can be associated with CP and provides further evidence for the pathogenicity of the variant p.(Asn1126Asp).

It's rare that you'll find discounts on Apple products through the company's own retail channels, but other storefronts are often happy to slash prices on such wares. You can find early Black Friday deals on a bunch of Apple products, including MacBooks. The M3 MacBook Air with 16GB of RAM has dropped to its lowest price to date at Amazon. The laptop will run you $899, which is $200 off the list price.

This is a 13-inch MacBook Air with 256GB of storage. Other configurations with more storage space are on sale too. One with 8GB of RAM and a 512GB SSD is $300 off at $999, though we'd recommend having at least 16GB of memory. It's not possible to upgrade the RAM in an Apple Silicon MacBook, but you can always add external storage if need be.

To that end, you can snag a 13-inch M3 MBA with 16GB of RAM and 512GB of built-in storage for $1,099. If a model with 24GB and the same SSD is what you're looking for, you can snap one up for $1,299. Both are $200 off.

Apple just released its first M4-powered Macs, but it has yet to slot the latest chip into the MacBook Air. To that end, we reckon the 13-inch M3 MacBook Air is the best laptop for most people. It's our pick for the best laptop for college students too.

The 13-inch MBA's blend of power and portability makes it a potent choice and we gave it a score of 90 in our review. It delivers fast performance and has a killer display. The design is sleek and sturdy and it sounds great thanks to a quad-speaker array. We like the trackpad and keyboard as well, while the upgrade to Wi-Fi 6E connectivity is a definite plus. Our main quibble is that the USB-C ports are on the same side of the unit as the one for the charger — having even one USB-C on the right side would be handy. But that's a minor complaint about an otherwise excellent laptop.

Check out all of the latest Black Friday and Cyber Monday deals here.

Apple is gearing up for a significant update across its Mac computer range, focusing on the integration of artificial intelligence (AI) capabilities through its upcoming M4 chipset. The tech giant, headquartered in Cupertino, California, has already introduced its M3 chip in

ASUS recently launched the new all-in-one (AIO) PC, the M3702. This AIO computer combines a stylish design with a capable processor, aiming to be a functional and attractive solution for both home and office environments. Let's delve into what the M3702

Don’t let the sedan shape fool you, for the BMW M340i is a sports car in disguise

A versatile powerhouse with a stunning display, smooth gaming experience and long-lasting battery

Powerful, portable, and long-lasting battery, perfect for productivity on the go

NetBIOS Enumeration Utility (NBTEnum) is a utility for Windows that can be used to enumerate NetBIOS information from one host or a range of hosts. The enumerated information includes the network transports, NetBIOS name, account lockout threshold, logged on users, local groups and users, global groups and users, and shares. If run under the context of a valid user account additional information is enumerated including operating system information, services, installed programs, Auto Admin Logon information and encrypted WinVNC/RealVNC passwords. This utility will also perform password checking with the use of a dictionary file. Runs on Windows NT 4.0/2000/XP/2003. PERL source included.

A WOMAN has been banned from the road for drug driving.

Perma.cc archive of http://curia.europa.eu/jurisp/cgi-bin/form.pl?lang=en created on 2020-05-08 17:25:36+00:00..

This item belongs to: web/perma_cc.

This item has files of the following types: Metadata

Recently I stumbled across a Youtube channel that was filled with nothing but videos that had been taken from other YouTubers, uploaded onto his site and claimed for his own. There were no descriptions as to where these videos came from, no link pointing back to their original creators. And to top it off at the end of each video was a quick blurb about religion.

oscon: RT @oreillyanimals Vote Instant Wild's Digital Eyes & Ears for Wildlife Protection to win Google Global Impact Award http://t.co/BM3qufX1PF

Marilyn Goudreault
Jan 1, 2009; 8:157-171
Research

Mitochondrial protein FAM3A suppresses hepatic gluconeogenesis and lipogenesis. This study aimed to screen drug(s) that activates FAM3A expression and evaluate its effect(s) on hyperglycemia and steatosis. Drug-repurposing methodology predicted that antidepressive drug doxepin was among the drugs that potentially activated FAM3A expression. Doxepin was further validated to stimulate the translocation of transcription factor HNF4α from the cytoplasm into the nucleus, where it promoted FAM3A transcription to enhance ATP synthesis, suppress gluconeogenesis, and reduce lipid deposition in hepatocytes. HNF4α antagonism or FAM3A deficiency blunted doxepin-induced suppression on gluconeogenesis and lipid deposition in hepatocytes. Doxepin administration attenuated hyperglycemia, steatosis, and obesity in obese diabetic mice with upregulated FAM3A expression in liver and brown adipose tissues (BAT). Notably, doxepin failed to correct dysregulated glucose and lipid metabolism in FAM3A-deficient mice fed on high-fat diet. Doxepin’s effects on ATP production, Akt activation, gluconeogenesis, and lipogenesis repression were also blunted in FAM3A-deficient mouse livers. In conclusion, FAM3A is a therapeutic target for diabetes and steatosis. Antidepressive drug doxepin activates FAM3A signaling pathways in liver and BAT to improve hyperglycemia and steatosis of obese diabetic mice. Doxepin might be preferentially recommended as an antidepressive drug in potential treatment of patients with diabetes complicated with depression.

Cisco Content Security Virtual Appliance M380 IronPort remote cross site host modification demo exploit.

CryptoAuthSSH-XSTK (DM320109) - Latest Firmware

Physical and chemical DNA-damaging agents are used widely in the treatment of cancer. Double-strand break (DSB) lesions in DNA are the most deleterious form of damage and, if left unrepaired, can effectively kill cancer cells. DNA-dependent protein kinase (DNA-PK) is a critical component of nonhomologous end joining (NHEJ), one of the two major pathways for DSB repair. Although DNA-PK has been considered an attractive target for cancer therapy, the development of pharmacologic DNA-PK inhibitors for clinical use has been lagging. Here, we report the discovery and characterization of a potent, selective, and orally bioavailable DNA-PK inhibitor, M3814 (peposertib), and provide in vivo proof of principle for DNA-PK inhibition as a novel approach to combination radiotherapy. M3814 potently inhibits DNA-PK catalytic activity and sensitizes multiple cancer cell lines to ionizing radiation (IR) and DSB-inducing agents. Inhibition of DNA-PK autophosphorylation in cancer cells or xenograft tumors led to an increased number of persistent DSBs. Oral administration of M3814 to two xenograft models of human cancer, using a clinically established 6-week fractionated radiation schedule, strongly potentiated the antitumor activity of IR and led to complete tumor regression at nontoxic doses. Our results strongly support DNA-PK inhibition as a novel approach for the combination radiotherapy of cancer. M3814 is currently under investigation in combination with radiotherapy in clinical trials.

In vitro and mouse studies suggest inhibiting TRIM37 could help treat breast cancer.

Money Supply M3 in Cyprus increased to 23374 EUR Thousand in December from 22649 EUR Thousand in November of 2007. Money Supply M3 in Cyprus averaged 11203.29 EUR Thousand from 1993 until 2007, reaching an all time high of 23374 EUR Thousand in December of 2007 and a record low of 4451 EUR Thousand in January of 1993. Cyprus Money Supply M3 includes M2 plus long-term time deposits in banks. This page provides - Cyprus Money Supply M3 - actual values, historical data, forecast, chart, statistics, economic calendar and news.