A new study found that as Central Valley residents go about their day, they regularly breathe in pesticides, including one banned in California.

People hospitalized for COVID-19 early in the pandemic suffered an increased risk of heart attacks, strokes and other serious "cardiac events," researchers say.

The nation's capital Washington, D.C., is the least festive of the United States, according to a study.

A study published in JAMA Pediatrics found cohesive links between prenatal cannabis use and poor thinking skills, lack of impulse control, issues with planning and paying attention and an increase in aggressive behavior among preschool-aged children…

The Carol Hathaway depicter reveals in a new interview with Oprah Winfrey that she rejected a huge payday for TV return and chose to embark on spiritual journey instead.

The University of Warwick has extended its open access courses and offers a taster in Acocks Green this coming weekend.

How do women who mud wrestle or take regular mud baths (esp. naked, say at a spa) avoid getting mud in their, er, orifices—or do they avoid it? Would tampons be useful in preventing such an occurrence? Or is that even necessary?

And if mud is allowed into the vagina or anus, does that lead to an increased incidence of infection (whether by yeast or bacteria)? How would one go about (or, ladies, how have you gone about) preventing such resultant infections? And do spas have problems with the transmission of such infections in their mud baths?

I've found an abstract from a study in the Journal of the American Medical Association that found a greater incidence of pustular follicular dermatitis outbreaks among mud-wrestling college students (no joke) at the University of Washington in Seattle—but that doesn't speak to the question of vaginal, anal or urethral irritation stemming from prolonged mud exposure.

(And yes, this is a serious question, I promise—the topic came up during a conversation I was party to a while back about, well, vaginal irritation/infections. Fun stuff, huh?)

A group of H1N1 swine influenza viruses have essential hallmarks of being highly adapted to infect humans and are of potential pandemic concern, health officials say. These viruses — referred to as G4 Eurasian (EA) avian-like H1N1 viruses — have been spreading in pigs in China since 2016 and are now the predominant set of genes that can be passed down from parents to offspring , according to the Centers for Disease Control and Prevention.

It can be expensive to install rooftop solar panels, but they do pay for themselves over time. Not only does it save on energy costs, but a new University of Michigan study says the value of rooftop solar panels will continue to increase. It will also be vital as the climate continues to warm, and we will need more energy to keep cool. WEMU's David Fair was joined by U-M Energy Systems Assistant Professor Dr. Michael Craig to learn more about the research.

PFAS contamination has already been a significant concern. Now, there may be reason to add to the worry. A study funded by the Ann Arbor-based Ecology Center finds there is an array of PFAS chemical profiles in rainwater falling over Ann Arbor and Southeast Michigan. WEMU's David Fair spoke with the center’s Erica Bloom about the findings and what it means to the environment and public health.

We all know that air pollution is bad for the environment and our health. A new study out of the University of Michigan now shows that it is contributing to a loss of independence among older adults. The study also shows that the economic impact of that loss comes in at an estimate of over $11 billion. WEMU's David Fair spoke with the lead author of the study, Dr. Sara Adar, about the findings.

Over the summer, the Huron River Watershed Council conducted an extensive survey of freshwater mussels in the Huron River to determine potential impacts when the Peninsular Paper Dam is removed. It found that removing the Pen Dam could release sediment, potentially smothering downstream mussel populations. Once the dam is removed, though, the river will return to a more natural state, benefiting mussel species over time. WEMU's David Fair looked at the research and its implications with Huron River Watershed Council Ecologist Dr. Paul Steen.

ARI SHAPIRO, HOST: A bipartisan delegation of Congresspeople is just back from Ukraine. It was a trip designed to strengthen the U.S.-Ukraine alliance, and it was planned before news broke of the whistleblower complaint against President Trump involving that same country. Congressman John Garamendi led the delegation as a senior member of the House Armed Services Committee. And the Democrat from California joins us now. Welcome, Congressman. JOHN GARAMENDI: Good to be with you. SHAPIRO: One central question in the impeachment inquiry is whether President Trump demanded help investigating a political rival in exchange for U.S. aid to Ukraine. And I know that aid was a central topic on your trip, so what did you learn about Ukraine's reliance on American assistance? GARAMENDI: Well, first of all, Ukraine is an extraordinary country. These citizens of that country are determined to be independent. They have been fighting a war against Russia for the last five years. They've lost 13- to 14

Updated at 6:34 p.m. ET In a swift reversal, the Trump administration has agreed to rescind a directive that would have barred international college students from the U.S. if their colleges offered classes entirely online in the fall semester. The U.S. Immigration and Customs Enforcement rule change , released last week, would have prohibited foreign students from entering or remaining in the country to take fully online course loads. A number of colleges and universities had already announced plans to offer online-only classes because of the coronavirus pandemic. The agency's July 6 announcement was met with immediate backlash. Harvard University and the Massachusetts Institute of Technology sued the U.S. government in federal court two days later, calling the directive "arbitrary and capricious" and seeking to have it reversed and declared unlawful. Many colleges, universities, municipalities and tech companies expressed their support for the legal challenge in their own court

A new study published by the American Cancer Society reveals that nearly half of all cancer deaths are attributable to lifestyle factors. Would a return to God’s original health plan make a difference?

The spread of COVID19 put a lot of extra work on emergency doctors, due to increased visits as a result of respiratory failure and other consequences caused by the infection. .

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As public support for marijuana decriminalization grows, new research is shedding light on the drug’s impact on sleep and memory.

Had Denver matched the regional average gain, it would have seen an additional $646 million more in taxable sales revenues, the report estimates.

“A 60MW offshore wind farm could generate up to 40% of Bermuda’s electricity,” according to a new study released by Greenrock into Offshore Wind Feasibility. A spokesperson said, “After completing an independent review of work carried out to date a few months ago, Greenrock is pleased to announce the release of an Offshore Wind detailed […]

Greenrock announced the release of the fourth study in our offshore wind feasibility study series – a Wind Speed and Annual Energy Production Analysis. A spokesperson said, “This study was commissioned to understand more accurately how much electricity could be generated by an offshore wind farm in Bermuda. “Key points from the study are as follows: […]

Research published this week in the journal “Science” involving a population of humpback whales which spends time in Bermuda’s waters every year adds further evidence to the theory the giant mammals are able to learn from one other, in this case passing on a hunting technique suited to a particular type of prey. The authors […]

Sebastian Kempe, one of the top Bermudian sailing competitors, has secured his place to study yacht design and production at Solent University in Southampton. Kempe, who previously attended the Royal Hospital School in Suffolk, England, became the youth world sailing champion in the ILCA 6 class in 2021 and was named the Bermudian Junior Male […]

Five years of data collected on reefs and offshore in Bermuda shows that coral reef chemistry – and perhaps the future success of corals – is tied not only to the human carbon emissions causing systematic ocean acidification, but also to seasonal and decadal cycles in the open waters of the Atlantic, and the balance […]

A new three-year NASA field expedition gets underway this year to survey more of the world’s coral reefs, with Dr Eric Hochberg from the Bermuda Institute of Ocean Sciences set to be involved in the study. NASA said, “Coral reefs, sometimes called the rainforests of the sea, are home to a quarter of all ocean […]

Regular readers will know that I was recruited via my doctor’s surgery to take part in the Fenland Study. The study is taking a sample of the population in this area born between 1950 and 1975, and carrying out a raft of blood tests, body stature measurements, DEXA body fat and bone density and tests … Continue reading "Back in the Fenland Study"

Seeking a balance between personal life and educational pursuits is a nuanced art for students enrolled in online learning programs. Without the physical separation of classrooms and the distinct routine of in-person education, online learners often struggle to create... Tagged as:

The European Space Agency’s Hera spacecraft launched on Oct. 7, 2024, from Cape Canaveral, Florida. It will travel to the Didymos-Dimorphos asteroid system to study the aftermath of the first-ever field test of an asteroid deflection technique.

This research was undertaken by Stuart Fordyce as part of an MSc in Integrated Service Improvement (Health and Social Care) at the University of Edinburgh. It considers the impact of a rapidly ageing population on a Scottish local authority and its attempt to shift the focus to a more contemporary service provision. The aim is to explore what factors are inhibiting the effectiveness of enablement. Using a case study approach the research explored whether: (i) enablement is wholly effective in addressing the increase in current service demands; (ii) the approach adopted by the local authority is undermined as services are now over extended and are attempting to address competing objectives, and; (iii) the paradigmatic change across the sector in the future will materialise if organisations cannot create the capacity and infrastructure to enable change to occur

You probably haven’t given a lot of thought to the damaging effects of tire wear, at least when it comes to our food supply. But a study out of the University of Vienna (UV) will likely change your perspective on that. [...]

The clonal quaking aspen known as Pando is between 16,000 and 80,000 years old.

The landmark 2022 Inflation Reduction Act (IRA) has committed nearly $400 billion to mitigating climate change. Nine research teams across the U.S, including a Princeton team led by Jesse Jenkins, have now modeled the law's effect on U.S. carbon emissions.

Research on a massive storm at Gorongosa National Park offers strategies for wildlife managers around the world.

A new report led by Emily Carter and Elizabeth Zeitler *14 offers research and policy ideas, including carbon fiber replacements for rebar in construction and titanium in high-tech applications.

As followers may recall, I started hand stitching hexies for a Grandmother's Flower Garden quilt in March, 2012... three years ago. Watching my friend, Christy, basting sweet, reproduction fabrics around paper forms, making little stacks of 3/4-inch hexagons, I just couldn't resist! These Beadlust posts show the various steps to making the quilt top and the start of  hand-quilting in more detail than this post.

Although I'm still hand-quilting, the end is in sight now. I'm hoping to finish in time for our County Fair in August.

In this post, I thought it might interest you to look at how much time it takes to complete each of the steps in hand piecing and quilting a 3/4" hexie quilt, and the total number of hours involved. I'm basing time estimates for all of the repetitive steps on how long it takes me to do a large number in one sitting, after having practiced... in other words, at my best speed.

Step 1 - Planning the Quilt and Getting Fabrics - time: 20 hours

I decided to make a version of the traditional 1930's Grandmother's Flower Garden quilt that is less common than the one with a path or ring around each of the flowers. I chose this design. Note the green hexie leaves, which form a vertical-horizontal grid.


The final size is 72 x 92 inches, a comfortable size for a twin bed, a total of 4,694 hexies. I wanted to use as many different fabrics in this quilt as possible.

• flowers = 280 different print fabrics with any background color except green or white.
• leaves = 150 different print fabrics in green
• flower centers (repeats OK) = 25 different solids
• double border = 1 print + 1 solid

Although I had collected 30's reproduction fabrics for a few years, I certainly needed more. From a selection of fabrics given to me, fabrics purchased in an eBay auction, and my stash, I found enough to make each of the flowers unique. Although there were not enough greens to make the leaves unique, I had about 60 different green prints, such that each is not repeated more than 3 times in the quilt. So, in the end the quilt includes more than 360 unique fabrics!

Step 2 - Wash and Iron all of the Fabrics - time: 15 hours

Yikes! A few of the fabrics I wanted to use were already washed; most were not. Knowing it should be consistent, and worrying that the reds might bleed, I decided to pre-wash and iron all of the fabrics. Doing this step in stages, as I acquired fabrics, I'm not really sure how long it took, perhaps quite a bit more than the above estimate.

Step 3 - Cutting and Trimming all of the Hexies - time: 28 hours

For each of the  4,694 hexies, I cut a 2" square of fabric, and trimmed off the four corners. Of course, I cut and trimmed in multiples, except for a few that I fussy cut individually. Again, since I did this step in stages, the above time estimate is a bit rough.

Step 4 - Basting the Fabric to the Paper Hexie Forms - time: 235 hours

Once I learned that using YLI quilting thread for basting makes it go much faster than using regular sewing thread, I was able to baste 20 hexies per hour.

Step 5 - Stitching Hexies Together to Make Flowers - time: 105 hours

Averaging 2.5 complete flowers per hour, it took me about two and a half 40-hour-work-weeks to whip-stitch all 238 full and 42 partial flowers. There are 14-17 whip-stitches per 3/4 inch seam.

Step 6 - Stitching a White Hexie Ring Around 130 of the Flowers - time: 130 hours

On average, it takes me 1 hour to whip-stitch 12 white hexies around each flower.

Step 7 - Layout Flowers for Quilt Top; Note Position on Each - time: 4 hours

I didn't fuss too much about the layout, spreading out the flowers randomly, making sure the red ones were evenly spaced, and that no areas were overly dominated by one color. Assigning each row a letter and each position within the row a number, I marked each flower on the back (writing on the center paper piece).

Step 7a - Half Flowers and Double Border All Around - time 90 hours

This is an update, added Feb. 2018. (I can't believe I forgot this important step when writing the original time line.) To make 42 partial flowers to fill in the gaps around the edges of the top, I cut fabrics, basted hexies, joined petals, and then stitched the partials into the gaps. To make the outer border, I made 522 individual hexies, stitched them into rows, and then stitched the rows onto the top.

Step 8 - Sew Flowers into Small Groups - time: 90 hours

To assemble the quilt top, I grouped 8-12 flowers, and whip-stitched them into a solid piece. There were 30 pieces, which took about 3 hours each to complete.

Step 9 - Sew Small Groups Together to Complete Quilt Top - time: 123 hours

I first sewed the small groups into rows, then stitched the rows together. As the sections got larger, the stitching took longer, making it difficult to estimate the time with total accuracy. I did a couple of time tests at different stages of the process in order to figure the above total. I completed this step on March 1st, 2013, one year after basting the first hexie.

Step 10 - Iron/Starch Top, Remove Papers and Basting Stitches - time: 33 hours

Removing all the basting stitches and papers took a lot longer than I would have guessed. But when I look at the pile of basting threads, it begins to make sense.

Step 11 - Assemble Quilt Layers, and Baste - time: 12 hours

Christy and Lunnette helped me layout the back, batting, and top on the floor; then baste in a 4 inch grid. I think we pinned it first, then basted, then removed the pins. On our knees for most of the time, it sure was wonderful to have their help!

Step 10 - Quilt and Embroider the Flower Centers - time: 70 hours

Choosing a floss in a similar color to each flower center, I embroidered a flower. Intentionally, some of the stitches act as quilting stitches, while others slip between the layers and don't show on the back. Around the edges of the quilt, it took about 15 minutes per flower center. Toward the middle of the quilt, it took about 20 minutes per flower center.

Step 11 - Quilt Flower Petals - time: 106 hours

Quilting around the petals of each flower requires turning the quilt 270 degrees for each petal, which is why it takes at least 20 minutes per flower, longer toward the middle of the quilt when the whole weight of the quilt must be constantly shifted. There are 238 whole and 42 partial flowers. I'm figuring an average of 25 minutes per whole and 10 minutes per partial flower.

Step 12 - Quilt Around White Rings - time: 65 hours

Like quilting the flower petals, quilting around the outside edge of each of the 130 white rings requires turning the whole quilt as I work, which adds a lot to the time it takes. I believe quilting the entire top in a diagonal grid of straight lines would take about half the time it takes to follow the curved, zig-zagging path of the hexie flowers, leaves, and rings.

Step 13 - Quilt Around Each of the Leaves - time: 79 hours

Not only does this step require turning the quilt as I stitch 360 degrees around each leaf, it also requires knotting and burying the tail at the start and finish of each leaf. Also I'm changing color of thread to more or less match the fabric color for each set of 4 leaves. Around the edge, it takes about 9 minutes per leaf; toward the center 11 minutes per leaf. There are 474 leaves total, at an average of 10 minutes/leaf.

Step 14 - Assemble Hexies for the Border Facing - time: 37 hours

To face the double (print + blue) border on the back of the quilt requires 522 hexies. To sew them together, forming the border strips, takes about 1 hour per 14 hexies.

Step 15 - Trim Backing and Batting; Blind-stitch Facing to Border - time: 13 hours

There are 264 hexies around the outside edge of the quilt top. Since I have not done this step yet, the time estimate (blind-stitching 20 hexies together per hour) is somewhat rough.

Step 16 - Remove Paper Pieces and Basting from Border and Facing - time: 10 hours

Again, since I have not done this step yet, the time estimate is based on the time it took to remove paper pieces and basting threads from the quilt top.

Step 17 - Blind-stitch Facing to Quilt Back - time: 13 hours

Step 18 - Quilt Around Print Fabric Border - time: 13 hours

Step 19 - Blanket Stitch Around Outside Edge of Quilt - time: 10 hours

* * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * *

Total Time to Complete Hand-Piecing the Quilt Top: 873 hours

This is equivalent to nearly 20 weeks or 5 months on a 40 hours/week job. It took me a year. Mostly the time flew by as I basted and hand-stitched the little hexies together. Always there was a new print to enjoy, a new stack mounting in size to admire, a growing quilt top to thrill me.

Total Time to Complete Hand-Quilting: 428 hours

Since this job isn't completed yet, the time is only a rough estimate, based on the times it took to do some of the already completed steps. In all, hand quilting will take the equivalent to 10 or 11 weeks of full-time work. I find the quilting rather very boring. After taking a break for more than a year, I started working on it again and hope to be finished by August this year. Audio books are the answer to the tedium for me.

Total Time, Start to Finish: 1,301 hours

With Steps15-19 still to complete, the total is a rough estimate. Still, it is obvious that making a quilt like this, start to finish, requires more than 1,300 hours or the equivalent of over 8 months of full time work. If I were to be paid only minimum wages (2015, Seattle, WA - $11/hr.), the cost of the quilt would be $14,311 + about $500 in materials, or a total of $14,800.  Good thing I intend to keep and use it myself!

UPDATE, July 4, 2016

By June, 2015, I completely finished one corner, an area big enough to photograph so I could submit an entry form to the 2015 La Conner Quilt Festival, sponsored by the La Conner Quilt & Textile Museum. On August 7th, 2015, I received notice that it was juried into the show. Wow! That sent me into high gear for sure. After working non-stop, 7 days a week, and an average of 10 hours per day, I inserted my needle into that quilt for the last/final time on Aug. 24th, 2015, just days before delivering it to the museum. It took me 3 years and 3 months, start to finish!


I was surprised, honored, and incredibly pleased to find out it won the Curator's Award of Excellence, one of the top awards, which then qualified it to be shown at the museum for the month following the Festival. Note, the finished size is 71 x 93 inches, and there are 4,700 individual hexagons in it.


Big work for both hands, but sooooo satisfying!


In fact it was so satisfying that I've started another hexie quilt... Can you believe it? So far, I've made 733 hexie flowers for it! Although they are the same size hexies, there are no reproduction fabrics and the arrangement will be anything but traditional. Don't know why I love the hexagon shape so much... but it's certain that I do.

CSDP brings voices from across the political spectrum into conversation with Princeton social scientists and students. 

Join the Study Abroad team at Princeton to learn about undergraduate summer study abroad opportunities!

All professors, postdocs and staff are invited to this interdenominational Christian Bible study and community. The meeting is available via Zoom also.

Join the Study Abroad Program to learn more about undergraduate summer study abroad at the London School of Economics. We will discuss the application process, credit transfer, and funding.

Minerallac Company, an electrical construction hardware manufacturer, find Repeat Signage software a useful tool for keeping staff updated on events and information. Staff is their satellite office, 2000 miles away, now feel more connected since digital signage was utilised.

The percentage of workers in the U.S. who say they are using AI at work has remained largely flat over the last three months, according to a new study commissioned by Slack. From a report: If AI's rapid adoption curve slows or flattens, a lot of very rosy assumptions about the technology -- and very high market valuations tied to them -- could change. Slack said its most recent survey found 33% of U.S. workers say they are using AI at work, an increase of just a single percentage point. That represents a significant flattening of the rapid growth noted in prior surveys. Global adoption of AI use at work, meanwhile, rose from 32% to 36%. Between the lines: Slack also found that globally, nearly half of workers (48%) said they were uncomfortable telling their managers they use AI at work. Among the top reasons cited were a fear of being seen as lazy, cheating or incompetent.

Read more of this story at Slashdot.

Thanks for joining us today about what the New Testament has to say about how to please God. If you missed last week’s study concerning the Old Testament, please read it now. While we wait, here is a “pleasing” song. Last week I offered my take on pleasing God which is always at the top […]

The post A Quick Bible Study Vol. 240: What the Old Testament Says About How to Please God appeared first on Liberty Unyielding.

The planet Uranus and its five biggest moons may not be the sterile worlds scientists have long thought.

TNF is a highly pro-inflammatory cytokine that contributes not only to the regulation of immune responses but also to the development of severe inflammatory diseases. TNF is synthesized as a transmembrane protein, which is further matured via proteolytic cleavage by metalloproteases such as ADAM17, a process known as shedding. At present, TNF is mainly detected by measuring the precursor or the mature cytokine of bulk cell populations by techniques such as ELISA or immunoblotting. However, these methods do not provide information on the exact timing and extent of TNF cleavage at single-cell resolution and they do not allow the live visualization of shedding events. Here, we generated C-tag TNF as a genetically encoded reporter to study TNF shedding at the single-cell level. The functionality of the C-tag TNF reporter is based on the exposure of a cryptic epitope on the C terminus of the transmembrane portion of pro-TNF on cleavage. In both denatured and nondenatured samples, this epitope can be detected by a nanobody in a highly sensitive and specific manner only upon TNF shedding. As such, C-tag TNF can successfully be used for the detection of TNF cleavage in flow cytometry and live-cell imaging applications. We furthermore demonstrate its applicability in a forward genetic screen geared toward the identification of genetic regulators of TNF maturation. In summary, the C-tag TNF reporter can be employed to gain novel insights into the complex regulation of ADAM-dependent TNF shedding.

Visual Abstract

Visual Abstract

Visual Abstract

The tenovins are a frequently studied class of compounds capable of inhibiting sirtuin activity, which is thought to result in increased acetylation and protection of the tumor suppressor p53 from degradation. However, as we and other laboratories have shown previously, certain tenovins are also capable of inhibiting autophagic flux, demonstrating the ability of these compounds to engage with more than one target. In this study, we present two additional mechanisms by which tenovins are able to activate p53 and kill tumor cells in culture. These mechanisms are the inhibition of a key enzyme of the de novo pyrimidine synthesis pathway, dihydroorotate dehydrogenase (DHODH), and the blockage of uridine transport into cells. These findings hold a 3-fold significance: first, we demonstrate that tenovins, and perhaps other compounds that activate p53, may activate p53 by more than one mechanism; second, that work previously conducted with certain tenovins as SirT1 inhibitors should additionally be viewed through the lens of DHODH inhibition as this is a major contributor to the mechanism of action of the most widely used tenovins; and finally, that small changes in the structure of a small molecule can lead to a dramatic change in the target profile of the molecule even when the phenotypic readout remains static.