Parents, kids: Fear not the silica gel pack. Sure it says DO NOT EAT and THROW AWAY. But you should only follow one of those rules.    Instead, save the packs and use them a whole lot of ways: Place them on the car dashboard by the windshield to keep it from fogging up.   […]

Arterial cardiovascular events are the leading cause of death in patients with JAK2V617F myeloproliferative neoplasms (MPNs). However, their mechanisms are poorly understood. The high prevalence of myocardial infarction without significant coronary stenosis or atherosclerosis in patients with MPNs suggests that vascular function is altered. The consequences of JAK2V617F mutation on vascular reactivity are unknown. We observe here increased responses to vasoconstrictors in arteries from Jak2V617F mice resulting from a disturbed endothelial NO pathway and increased endothelial oxidative stress. This response was reproduced in WT mice by circulating microvesicles isolated from patients carrying JAK2V617F and by erythrocyte-derived microvesicles from transgenic mice. Microvesicles of other cellular origins had no effect. This effect was observed ex vivo on isolated aortas, but also in vivo on femoral arteries. Proteomic analysis of microvesicles derived from JAK2V617F erythrocytes identified increased expression of myeloperoxidase as the likely mechanism accounting for their effect. Myeloperoxidase inhibition in microvesicles derived from JAK2V617F erythrocytes suppressed their effect on oxidative stress. Antioxidants such as simvastatin and N-acetyl cysteine improved arterial dysfunction in Jak2V617F mice. In conclusion, JAK2V617F MPNs are characterized by exacerbated vasoconstrictor responses resulting from increased endothelial oxidative stress caused by circulating erythrocyte-derived microvesicles. Simvastatin appears to be a promising therapeutic strategy in this setting.

Chronic pancreatitis (CP) is considered an irreversible fibroinflammatory pancreatic disease. Despite numerous animal model studies, questions remain about local immune characteristics in human CP. We profiled pancreatic immune cell characteristics in control organ donors and CP patients including those with hereditary and idiopathic CP undergoing total pancreatectomy with islet autotransplantation. Flow cytometric analysis revealed a significant increase in the frequency of CD68+ macrophages in idiopathic CP. In contrast, hereditary CP samples showed a significant increase in CD3+ T cell frequency, which prompted us to investigate the T cell receptor β (TCRβ) repertoire in the CP and control groups. TCRβ sequencing revealed a significant increase in TCRβ repertoire diversity and reduced clonality in both CP groups versus controls. Interestingly, we observed differences in Vβ-Jβ gene family usage between hereditary and idiopathic CP and a positive correlation of TCRβ rearrangements with disease severity scores. Immunophenotyping analyses in hereditary and idiopathic CP pancreases indicate differences in innate and adaptive immune responses, which highlights differences in immunopathogenic mechanisms of disease among subtypes of CP. TCR repertoire analysis further suggests a role for specific T cell responses in hereditary versus idiopathic CP pathogenesis, providing insights into immune responses associated with human CP.

IL-17–producing RORγt+ γδ T cells (γδT17 cells) are innate lymphocytes that participate in type 3 immune responses during infection and inflammation. Herein, we show that γδT17 cells rapidly proliferate within neonatal lymph nodes and gut, where, upon entry, they upregulate T-bet and coexpress IL-17, IL-22, and IFN-γ in a STAT3- and retinoic acid–dependent manner. Neonatal expansion was halted in mice conditionally deficient in STAT5, and its loss resulted in γδT17 cell depletion from all adult organs. Hyperactive STAT5 mutant mice showed that the STAT5A homolog had a dominant role over STAT5B in promoting γδT17 cell expansion and downregulating gut-associated T-bet. In contrast, STAT5B preferentially expanded IFN-γ–producing γδ populations, implying a previously unknown differential role of STAT5 gene products in lymphocyte lineage regulation. Importantly, mice lacking γδT17 cells as a result of STAT5 deficiency displayed a profound resistance to experimental autoimmune encephalomyelitis. Our data identify that the neonatal microenvironment in combination with STAT5 is critical for post-thymic γδT17 development and tissue-specific imprinting, which is essential for infection and autoimmunity.

Facioscapulohumeral muscular dystrophy (FSHD) is caused by loss of repression of the DUX4 gene; however, the DUX4 protein is rare and difficult to detect in human muscle biopsies, and pathological mechanisms are obscure. FSHD is also a chronic disease that progresses slowly over decades. We used the sporadic, low-level, muscle-specific expression of DUX4 enabled by the iDUX4pA-HSA mouse to develop a chronic long-term muscle disease model. After 6 months of extremely low sporadic DUX4 expression, dystrophic muscle presented hallmarks of FSHD histopathology, including muscle degeneration, capillary loss, fibrosis, and atrophy. We investigated the transcriptional profile of whole muscle as well as endothelial cells and fibroadiopogenic progenitors (FAPs). Strikingly, differential gene expression profiles of both whole muscle and, to a lesser extent, FAPs, showed significant overlap with transcriptional profiles of MRI-guided human FSHD muscle biopsies. These results demonstrate a pathophysiological similarity between disease in muscles of iDUX4pA-HSA mice and humans with FSHD, solidifying the value of chronic rare DUX4 expression in mice for modeling pathological mechanisms in FSHD and highlighting the importance FAPs in this disease.

BACKGROUND Mirabegron is a β3-adrenergic receptor (β3-AR) agonist approved only for the treatment of overactive bladder. Encouraging preclinical results suggest that β3-AR agonists could also improve obesity-related metabolic disease by increasing brown adipose tissue (BAT) thermogenesis, white adipose tissue (WAT) lipolysis, and insulin sensitivity.METHODS We treated 14 healthy women of diverse ethnicities (27.5 ± 1.1 years of age, BMI of 25.4 ± 1.2 kg/m2) with 100 mg mirabegron (Myrbetriq extended-release tablet, Astellas Pharma) for 4 weeks in an open-label study. The primary endpoint was the change in BAT metabolic activity as measured by [18F]-2-fluoro-d-2-deoxy-d-glucose (18F-FDG) PET/CT. Secondary endpoints included resting energy expenditure (REE), plasma metabolites, and glucose and insulin metabolism as assessed by a frequently sampled intravenous glucose tolerance test.RESULTS Chronic mirabegron therapy increased BAT metabolic activity. Whole-body REE was higher, without changes in body weight or composition. Additionally, there were elevations in plasma levels of the beneficial lipoprotein biomarkers HDL and ApoA1, as well as total bile acids. Adiponectin, a WAT-derived hormone that has antidiabetic and antiinflammatory capabilities, increased with acute treatment and was 35% higher upon completion of the study. Finally, an intravenous glucose tolerance test revealed higher insulin sensitivity, glucose effectiveness, and insulin secretion.CONCLUSION These findings indicate that human BAT metabolic activity can be increased after chronic pharmacological stimulation with mirabegron and support the investigation of β3-AR agonists as a treatment for metabolic disease.TRIAL REGISTRATION Clinicaltrials.gov NCT03049462.FUNDING This work was supported by grants from the Intramural Research Program of the NIDDK, NIH (DK075112, DK075116, DK071013, and DK071014).

For this week's giveaway, we've once again teamed up with Throwboy to offer MacRumors readers a chance to win one of Throwboy's plushes modeled after classic Apple products and icons.


Throwboy makes a whole range of different plush pillow options priced at $30 to $40, with each one designed to look like an Apple product of some kind, including classic Macs, the iPod, the iPhone, and more. Each pillow features detailed embroidery and careful construction to highlight each component and to accurately represent Apple's designs.

The 1998 pillow, for example, is modeled after Apple's original iMac with its bright Bondi Blue design, while the 2001 pillow modeled after the original iPod comes complete with a screen and click wheel embroidery.


The 2007 pillow looks like the original ‌iPhone‌ with black bezels and a silver backing, and the Icon Pillow looks like Apple's classic happy Finder icon.


There's even a rainbow-colored Spinning Wheel Pillow that's designed to look like the dreaded spinning pinwheel that the cursor morphs into when an application is busy.


All of Throwboy's plushes are soft, squishy, huggable, and the perfect accent piece for an Apple fan. Each pillow is the ideal size to be used as a comfortable throw pillow for a couch or a chair. Photos of the pillows in action can be seen on Throwboy's Instagram account.


We have 10 of Throwboy's pillows to give away to MacRumors readers, and each winner will be able to pick their favorite pillow: ‌iMac‌, iPod, classic ‌iPhone‌, Finder Icon, or Spinning Wheel.

To enter to win our ‌giveaway‌, use the Gleam.io widget below and enter an email address. Email addresses will be used solely for contact purposes to reach the winners and send the prizes. You can earn additional entries by subscribing to our weekly newsletter, subscribing to our YouTube channel, following us on Twitter, following us on Instagram, or visiting the MacRumors Facebook page.

Due to the complexities of international laws regarding giveaways, only U.S. residents who are 18 years or older and Canadian residents (excluding Quebec) who have reached the age of majority in their province or territory are eligible to enter. To offer feedback or get more information on the ‌giveaway‌ restrictions, please refer to our Site Feedback section, as that is where discussion of the rules will be redirected.

Dan Avidan, after years of dancing around topic of being a furry and which he would be, seems to have settled on his fursona of a cyberpunk wolf in a recently released music video. The video features animal characters with trans-humanist enhancements. The coloration has a signature bleed of 80s style animation.

The story portrays a pack of wolves seeking vengeance against a stag mogul after having their kin slaughtered at his hand. The style of animation and situation has some striking similarities to that of Caravan Palace's music video for Lone Digger.

This was brought to my attention by Majira Strawberry who asked why know one was talking about it. The answer to that in my case is object pertinence.

For those who are fans of cyberpunk and animation this is certainly worth the watch.

Are accountants destined to be the anthropologists of the cyber era? Gillian Tett appears to suspect such. Continue reading →

The Vermont senator and presidential candidate talks to Chris Hayes about his differences with Hillary Clinton and the prospects for his presidential candidacy. Continue reading →

Chris Hedges speaks the truth about American politics while Robert Reich shows that he is still an establishment Democrat after all, like Bernie Sanders. Continue reading →

"Well, reducing the election to personalities is kind of infantile at this point. The fact is, we live in a system that Sheldon Wolin calls inverted totalitarianism. It’s a system where corporate power has seized all of the levers of control. There is no way to vote against the interests of Goldman Sachs or ExxonMobil or Raytheon." Continue reading →

Noor asks Hedges how the presidential nominees should respond to these types of terrorist attacks in the U.S. “Their response should be the end of the occupation in the Middle East and the cessation of saturation bombing by drones and military aircrafts and missiles in parts of Iraq and Syria and Pakistan and Yemen and Somalia,” Hedges responds. He goes on to explain how decades of foreign policy decisions made by both parties have created the circumstances for terrorist attacks. Continue reading →

"And you know, we have to stop looking beyond this election cycle and see that this corporate driven ideology, you know, this commodification of the culture, this constant extracting of blood from us as citizens to pay what in essence were private debts of the banks which engaged in casino capitalism, has political consequences. History has taught us that. And Hillary Clinton is only going to further that process." Continue reading →

CYHRA опубликовали 40+ минутный документальный фильм о том, как создавался альбом No Halos In Hell, выпущенный в ноябре прошлого года.

Трек-лист:

01. Out Of My Life

02. No Halos In Hell

03. Battle From Within

04. I Am The One

05. Bye Bye Forever

06. Dreams Gone Wrong

07. Lost In Time

08. Kings Tonight

09. I Had Your Back

10. Blood Brothers

11. Hit Me

12. Man Of Eternal Rain

В диджипак-издание альбома вошло на шесть песен больше, три из которых — в акустике. #Cyhra #MelodicMetal #Melodic_Metal

IBM Security, Packet Clearing House (PCH) and The Global Cyber Alliance (GCA) today launched a free service designed to give consumers and businesses added privacy and security protection as they access the internet. The new Quad9 Domain Name System (DNS) service helps protect users from accessing millions of malicious internet sites known to steal personal information, infect users with ransomware and malware, or conduct fraudulent activity.

At the International Supercomputing Conference in Frankfurt, The Weather Company, an IBM Business, today announced a plan to help improve weather prediction globally via a new collaboration with the University Corporation for Atmospheric Research (UCAR) and the National Center for Atmospheric Research (NCAR), a federally funded research and development center for the atmosphere and Earth’s geospace systems.

IBM today announced that it will help deliver a tailored fan experience through the IBM Cloud at Atlanta’s new Mercedes-Benz Stadium, scheduled to open later this month.

Forty-one years ago this summer I was a young investigator working in Harrisburg, Pennsylvania and Washington, DC for the President’s Commission on the Accident at Three Mile Island, a big federal investigation chaired by Dartmouth Professor John Kemeny, who is best known as the father of the BASIC programming language. I learned a lot that summer and fall not only about nuclear accidents but about how governments and industries respond to crises. Some of those lessons apply to the current COVID-19 pandemic, which is also being poorly managed. This may surprise you (that 41-year-old lessons can still apply) but governments, especially, change at a glacial pace. The two federal agencies with which I mainly dealt were the Federal Emergency Management Agency (FEMA) and the Nuclear […]






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My last column was about crisis management lessons I learned back in 1979 while investigating the Federal Emergency Management Agency for the President’s Commission on the Accident at Three Mile Island (TMI). Let’s just say that FEMA wasn’t ready for a nuclear meltdown. Today we turn to the other federal agency I investigated at that same time — the Nuclear Regulatory Commission (NRC). While FEMA was simply unprepared and incompetent, the NRC was unprepared and lied about it. Like FEMA, the NRC had recently undergone a rebranding from its previous identity as the Atomic Energy Commission — a schizoid agency that had been charged with both regulating nuclear power and promoting it. It’s difficult to be the major booster of technology while at the same […]






Digital Branding
Web Design
Marketing

Mayo Clinic and IBM Watson Health today unveiled results from early use of the Watson for Clinical Trial Matching, an IBM cognitive computing system. Use of this system in the Mayo Clinic oncology practice has been associated with more patients enrolled in Mayo’s breast cancer clinical trials.

Highlights  IBM scientists have measured how long information can stay in an individual atom  IBM breakthrough enables ability to actually record, study and visualize the magnetism of individual atoms at staggering speeds – one million times faster than previously possible  Could be valuable tool to study solar cells, quantum computing and storage-class memory at the nanoscale Today IBM researchers published a breakthrough technique in the peer-reviewed journal Science that measures how long a single atom can hold information, and giving scientists the ability to record, study and "visualize" extremely fast phenomena inside these atoms.

IBM's World Community Grid, a worldwide network of PC owners helping scientists solve humanitarian challenges, today announced several computing projects aimed at developing techniques to produce cleaner and safer water, an increasingly scarce commodity eluding at least 1.2 billion people worldwide.

Today on Data Privacy Day, IBM is announcing an innovative cloud-based technology for developers to help consumers better protect their personal data online such as their date of birth, home address and credit card numbers. As cybersecurity threats and identity theft continue to threaten both consumers and businesses, IBM scientists have been developing a clever cryptographic algorithm which enables transactions to occur without involuntarily sharing any personal data.

Country Energy, manager of Australia's largest power network, today announced a global collaboration with IBM (NYSE: IBM) aimed at developing and deploying an Intelligent Network in Australia.

Méně stolů a větší rozestupy. Jihomoravské restaurace v pondělí otevřou své zahrádky. Musí dodržet přísná opatření proti šíření koronaviru, přesto nemají alternativu pro špatné počasí.

Hospody a restaurace Češi prostřednictvím projektu Zachraň hospodu podpořili deseti miliony korun. Poukazy do více než 1 500 podniků si od začátku dubna, kdy byl projekt spuštěn, koupilo přes devět tisíc lidí. Stravovací zařízení budou moci od pondělí obsluhovat hosty na zahrádkách, iniciativa se tím však nezastaví.

Koronavirová krize výrazně ovlivnila český pracovní trh. Ve srovnání s loňským rokem evidují personální agentury v posledních měsících přibližně poloviční nabídku nových pracovních pozic. Ubylo práce v gastronomii a cestovním ruchu, naopak logistika zažívá žně. Pro firmy zůstávají nejcennějšími pracovníky lidé z oblasti IT.

Istrie patří k nejoblíbenějším částem Chorvatska. Jako skoro všude na světě se tam hoteliérský a restaurační byznys letos v březnu úplně zastavil, což si ještě nedávno nikdo nedokázal představit. Teď se ale blíží oživení. „Ani přinejmenším ale neočekáváme, že zopakujeme výsledky loňského roku,“ říká v rozhovoru šéf turistického sdružení celé oblasti Denis Ivošević.

Hafthor Bjornsson set a world record in the deadlift on Saturday, hoisting 1,104.52 pounds (501 kilograms).

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Děti se v online světě pohybují naprosto přirozeně a svými technickými znalostmi často předčí své rodiče. Na druhou stranu jsou právě ony nejohroženější skupinou čelící útokům internetových predátorů a kyberšikaně. Rodiče často o hrozbách ani netuší. Vyzkoušejte si náš kvíz a zjistěte, jak jste na tom s digitálními znalostmi právě vy.

So this is week…4 (I think?) of self-isolation.   The days blend in together.  I look through the news to see when this will all pass but there are no clear answers.  Lately though I’ve read small hints about the … Continue reading →