sm Donald Trump Jr. is tweeting about Jussie Smollett. Again. By www.washingtonpost.com Published On :: Wed, 12 Feb 2020 22:54:59 +0000 The president's son mocked the former "Empire" actor's legal troubles in numerous tweets this week. And not for the first time. Full Article
sm The inherently, intrinsically and inevitably flawed case for American nationalism By www.washingtonpost.com Published On :: Thu, 31 Oct 2019 14:00:07 +0000 Review of 'The Case for Nationalism: How It Made Us Powerful, United, and Free' by Rich Lowry Full Article
sm So much for the ‘small government’ GOP By www.washingtonpost.com Published On :: Fri, 26 Jul 2019 17:10:28 +0000 Government spending grew at its fastest pace since the Great Recession. Full Article
sm Trump has a dream team for mismanaging a recession By www.washingtonpost.com Published On :: Thu, 15 Aug 2019 21:45:29 +0000 If we have an economic downturn, it will be bad. Full Article
sm Officials have spent the last few years dismantling anti-recession measures By www.washingtonpost.com Published On :: Thu, 12 Mar 2020 22:49:43 +0000 And now, we’re woefully unprepared. Full Article
sm strataconf: A roundup from the data journalism beat http://t.co/y8RVUwHO4G Global open data, scholarships, mapping a civil war & more #strataconf By twitter.com Published On :: Thu, 06 Jun 2013 21:36:47 +0000 strataconf: A roundup from the data journalism beat http://t.co/y8RVUwHO4G Global open data, scholarships, mapping a civil war & more #strataconf Full Article
sm Fin24.com | EXPLAINER | 5 questions about virus 'tracing' by smartphone By www.fin24.com Published On :: Thu, 16 Apr 2020 19:30:13 +0200 Can an app contain the pandemic? Interest is growing in smartphone technology as a potential key to ending lockdowns and reopening economies around the world. Full Article
sm NAR Leadership and Staff Named Real Estate’s 2019 Newsmakers By feedproxy.google.com Published On :: Wed, 05 Dec 2018 16:41:58 +0000 NAR Leadership and Staff Named Real Estate’s 2019... More than 230 real estate professionals were named as “newsmakers” for their role as influencers, crusaders, and trailblazers in the industry.... By: Cole Henry Full Article
sm Shopify launches post-COVID POS, Yelp rolls out omnichannel tools for SMBs By feeds.searchengineland.com Published On :: Mon, 04 May 2020 17:56:32 +0000 The companies are part of a shift toward deeper integration between online and offline operations. Please visit Search Engine Land for the full article. Full Article
sm Advertisers signal glimmers of optimism, start spending again By feeds.searchengineland.com Published On :: Tue, 05 May 2020 13:08:05 +0000 Despite numerous unknowns and continued challenges, many agencies and advertisers say they have shifted gears for the next phase. Please visit Search Engine Land for the full article. Full Article
sm Less than essential: Why smart speakers are like smartwatches, not smartphones By feeds.searchengineland.com Published On :: Wed, 06 May 2020 08:40:25 +0000 The devices have reached 50% of US homes, but fallen flat as a channel Please visit Search Engine Land for the full article. Full Article
sm Attend SMX June 23-24… for free! By feeds.searchengineland.com Published On :: Wed, 06 May 2020 10:00:00 +0000 Join us online for SMX Next, a free virtual event designed to equip you with actionable SEO and SEM tactics that can drive more traffic, leads, and sales. Please visit Search Engine Land for the full article. Full Article
sm Nokia World: Very quick hands-on impressions of Nokia’s three new smartphones By feedproxy.google.com Published On :: Wed, 15 Sep 2010 17:49:26 +0000 Yesterday was a really fun day spent at Nokia World, the Finnish handset maker’s annual shindig. Conveniently, this year it was held in my home city of London and I got to cover the event for TechCrunch Europe. On day one, Nokia unveiled three new smartphones running Symbian^3, the C6, C7 and E7, which I [...] Full Article Mobile Nokia Nokia World
sm velocityconf: RT @suzaxtell: #WomeninTech You're invited to a women's meetup on Tues May 28 in SF w/ @courtneynash @mjawili, more http://t.co/MsMZ0IK8L2 By feedproxy.google.com Published On :: Tue, 21 May 2013 20:27:27 +0000 velocityconf: RT @suzaxtell: #WomeninTech You're invited to a women's meetup on Tues May 28 in SF w/ @courtneynash @mjawili, more http://t.co/MsMZ0IK8L2 Full Article
sm AT#125 - Volunteer Travel / Voluntourism By traffic.libsyn.com Published On :: Sat, 16 Feb 2008 13:57:00 +0000 Volunteer Travel / Voluntourism Full Article
sm AT#142 - Traveling with Small Children By traffic.libsyn.com Published On :: Sat, 05 Jul 2008 11:00:00 +0000 Traveling with Small Children Full Article
sm AT#21 - Cruising - Alaska by Small Boat By traffic.libsyn.com Published On :: Sun, 16 Nov 2008 07:47:27 +0000 The Amateur Traveler talks to Deanna about cruising to Alaska aboard a small boat from Cruise West In a nights ashore / days at sea program. Full Article
sm AT#345 - Travel to Great Smoky Mountains National Park and Western North Carolina By usa.amateurtraveler.com Published On :: Sat, 27 Oct 2012 12:30:00 +0000 The Amateur Traveler talks to Nathan from Wand’rly Magazine about Great Smoky Mountains National Park and about his current home of Western North Carolina. The Great Smoky Mountains National Park is the most visited U.S. National Park. Full Article
sm AT#426 - Travel to Tasmania, Australia By australia.amateurtraveler.com Published On :: Sat, 28 Jun 2014 19:00:12 +0000 Hear about travel to Tasmania in Australia as the Amateur Traveler talks to Robert Reid, the Offbeat Observer for National Geographic Traveler, about his recent trip to Van Diemen’s Land. Full Article
sm Predictions Review: Trump, Zuck Crush My Optimism In 2019 By feedproxy.google.com Published On :: Fri, 27 Dec 2019 18:08:18 +0000 This past year, I predicted the fall of both Zuck and Trump, not to mention the triumph of cannabis and rationale markets. But in 2019, the sociopaths won – bigly. Damn, was I wrong. One year ago this week, I sat down to write my annual list of ten or so predictions for the coming … Continue reading "Predictions Review: Trump, Zuck Crush My Optimism In 2019" Full Article Uncategorized 2019 Election 2020 facebook politics predictions tech technology Trump
sm An Open Letter To American Corporations: It’s Good Business (and Smart Marketing) To Support Quality Journalism By feedproxy.google.com Published On :: Mon, 06 Apr 2020 15:32:15 +0000 “Outbreaks have sparked riots and propelled public-health innovations, prefigured revolutions and redrawn maps.” – The New Yorker, April 2020 “Nothing will be the same.” That’s the overwhelming takeaway I’ve heard from dozens of conversations I’ve had with C-suite leaders, physicians, policy experts and media professionals these past few weeks. When it comes to the business … Continue reading "An Open Letter To American Corporations: It’s Good Business (and Smart Marketing) To Support Quality Journalism" Full Article Internet Big Five Media/Tech Business Models The Conversation Economy branding brands journalism marketing media news
sm Cobie Smulders sings social distance 'Let's Go to the Mall' parody By feedproxy.google.com Published On :: Sat, 09 May 2020 14:49:55 +0000 The coronavirus pandemic has many of us nostalgic for a simpler time — maybe when we were teenagers and/or watching our favorite early oughts sitcoms. Actress Cobie Smulders seems to be feeling that itch, and sensed we are too. The former How I Met Your Mother actress decided to recreate her character Robin Scherbatsky's hit song from the series, "Let's Go to The Mall." For those who need a refresher, "Let's Go to The Mall" was released during Robin's short career as a pop star (under the name Robin Sparkles) in her homeland of Canada. While it has all the flair of an '80s banger — jelly bracelets, worshipping the mall — it was released in the '90s because apparently that's when '80s culture reached Canada. Read more...More about How I Met Your Mother, Cobie Smulders, Movies Tv Shows, Social Distancing, and Entertainment Full Article How I Met Your Mother Cobie Smulders Movies Tv Shows Social Distancing Entertainment
sm Soap promises to make you smell like "Naval Supremacy" By feedproxy.google.com Published On :: Fri, 08 May 2020 08:04:35 PDT Ironic toxic masculinity is in fashion! The Duke Cannon Naval Supremacy Big Brick of Bar Soap for Men [Amazon] promises that those thusly-soaped will smell of "naval supremacy", "productivity" or other humorously-abstract scents. (More traditionally "manly" odors such as tobacco, leather, burned vegetation, etc. are also available). The veil of humor is threadbare -- "get clean and smell good without using feminine shower gels and accessories" -- but I'll admit that I do bathe in warm turpentine and it really helps. Are you ready for images of the best “soap but for MEN” product you’ve ever seen? pic.twitter.com/kVAWb57UlF — Shayna Moon, Unity Lich (@qorquiq) May 8, 2020 UPDATE: Here's a balding treatment called "Lethal Uprising", spotted by Greg Sideyr. I'll see your Naval Supremacy, and raise you pic.twitter.com/UJE9wxeRvp — ????Greg | Applied Eschatology ???? (@Greg_Sideyr) May 8, 2020 Looking forward to Internecine Violence Toothpaste, Shambolic Venezeulan Coup Ice Cream, and Silently Endure Prison Abuse Hemmorhoid Cream with Aloe Vera. Read the rest Full Article Post self care
sm Watch Meet the Smiths Online | Season 1 Full Episodes Video Streaming & Torrent Search By www.webtvwire.com Published On :: Wed, 29 Apr 2015 04:40:17 +0000 Meet the Smiths Synopsis Meet the Smiths is a scripted reality television series produced by TBS that premiered in April of 2015. Meet the Smiths follows the daily lives of Kenny Smith, an NBA analyst for TNT and his wife Gwendolyn Osborne-Smith, a model for The Price is Right. The couple has five children together […] Full Article TV Shows
sm Northern Pudu - the World's Smallest Deer By feedproxy.google.com Published On :: Tue, 07 Jul 2015 13:25:00 +0200 The Northern Pudu (Pudu mephistophiles) is the world's smallest deer. This little inhabitant of the Andes Mountains weighs in at only 3 to 6 kg, or 7 to 13 pounds. The Northern Pudu lives and plays across Columbia, Ecuador, and Peru. They prefer to stay in the higher elevations of the Andes Mountain range. Most of them live at least 2000 meters above sea level. The climate here is a temperate rainforest, with a wet winter and arid summer. What Do They Look Like? These little deer have a stocky body and slim legs. They average 32 - 35 cm, or 13 - 14 inches tall. They are approximately 85 cm or 33 inches long. They are slightly larger than a small house dog or a large cat. They have a Southern branch of the family that lives in Chili and Argentina. This species is slightly larger. Their fur is thick, stiff and lays close to the body. They range in color from a reddish brown to a darker brown. The males sport backward curving antlers that do not split. How Do They Survive? The Pudu is a solitary animal interacting socially only to mate. They are nocturnal by nature and thrive on leaves, shrubs, sprouts, blossoms and bark. They do not eat meat. They are adept at climbing, jumping and sprinting which helps them evade predators. They tend to move slowly and purposefully through the lush climate, utilizing dense vegetation to hide. Predators include owls, foxes, and large wild cats. How Many Young Do They Have? Mating season is short, lasting from April to May each year. Once done they return to their solitary existence. The female Pudu carries her young six to seven months. Most mothers have only one baby, but twins do occur with some regularity. Pudu young will stay with their Mommas for between 8 - 12 months before heading out on their own. Most of them have an average lifespan of 8 - 10 years. Why Are They Endangered? The Pudu is listed as vulnerable on the ICUN red list. The main causes of death are disease, loss of habitat, and over hunting. The Pudu is prone to become infected with various types of worms such as the round worm and heart worms. The worms multiply rapidly overcoming their small bodies. Loss of habitat has lead to a decline in mating and death from road accidents. Adding to the problem are hunters. The Pudu is eagerly sought due to the skill needed to track and kill them. Conservationist are working to restore and preserve the habitat for these precious little deer. Full Article default
sm The New Macroeconomics of Populism By feedproxy.google.com Published On :: Mon, 17 Jun 2019 07:23:37 +0000 17 June 2019 David Lubin Associate Fellow, Global Economy and Finance Programme @davidlubin The nationalist urge to keep the world off your back extends to foreign finance. 2019-06-17-AMLO.jpg Mexican president Andrés Manuel López Obrador throws out the first pitch at a baseball game in March. Photo: Getty Images. It is nearly 30 years since Rudiger Dornbusch and Sebastian Edwards published a seminal book, The Macroeconomics of Populism. Their conclusion back then was that the economic policies of populist leaders were quintessentially irresponsible. These governments, blinded by an aim to address perceived social injustices, specialised in profligacy, unbothered by budget constraints or whether they might run out of foreign exchange.Because of this disregard for basic economic logic, their policy experiments inevitably ended badly, with some combination of inflation, capital flight, recession and default. Salvador Allende’s Chile in the 1970s, or Alan García’s Peru in the 1980s, capture this story perfectly.These days, the macroeconomics of populism looks different. Of course there are populist leaders out there whose policies follow, more or less, the playbook of the 1970s and 1980s. Donald Trump may prove to be one of those, with a late-cycle fiscal expansion that seemed to have no basis in economic reasoning; Recep Tayyip Erdogan, by some accounts, may be another.But a much more interesting phenomenon is the apparent surge in populist leaders whose economic policies are remarkably disciplined.Take Mexico’s president, Andrés Manuel López Obrador. When it comes to fiscal policy, it is odd indeed that this fiery critic of neoliberalism seems fully committed to austerity. His budget for 2019 targets a surplus before interest payments of 1 per cent of GDP, and on current plans he intends to increase that surplus next year to 1.3 per cent of GDP. He has upheld the autonomy of the central bank and, so far at least, his overall macroeconomic framework is anything but revolutionary.Hungary’s prime minister Viktor Orban offers another example of conservative populism. Under his watch, budget deficits have been considerably lower than they had been previously, helping to push the stock of public debt down from 74 per cent of GDP in 2010, the year Orban took over, to 68 per cent last year.This emphasis on the virtues of fiscal prudence is also visible in Poland, where Jaroslaw Kaczynski’s PiS has managed public finances with sufficient discipline in the past few years to push the debt/GDP ratio below 50 per cent last year, the first time this has happened since 2009.The obvious question is: what has changed in the decades since Dornbusch and Edwards went into print?One answer is that today’s populists tend to strive for national self-reliance, which encourages them to avoid building up any dependence on foreign capital. And since that goal is achieved by keeping a tight rein on macro policy, fiscal indiscipline is avoided in order to limit vulnerability to foreign influences.Perhaps this is because the 'them', or the perceived enemy, for many of today’s populists tends to be outside the country rather than inside. Broadly speaking, it is the forces of globalisation — and global capital in particular — that are the problem for these leaders, and self-reliance is the only way to keep those forces at arm’s length. This helps to explain why, for example, Orban has been so keen to repay debt to Hungary’s external creditors. He has relied instead on selling bonds to Hungarian households to finance his deficits, even though the interest rates on those bonds are much higher than he would pay to foreign creditors. It also helps explain why the PiS in Poland has presided over a decline in foreign holdings of its domestic bonds. Foreign investors owned 40 per cent of Poland’s domestic government debt back in 2015, but only 26 per cent now.In other words, among many of today’s populists there is a blurring of the distinction between populism and nationalism. And the nationalistic urge to keep the rest of the world off your back seems to dominate the populist urge to spend money. The perfect example of that instinct is Vladimir Putin: not necessarily a populist, but his administration has been emphatic about the need to keep public spending low and to build solid financial buffers. National self-reliance is an economic obsession for the Russian government, and provides a model for other countries who wish to insulate themselves from international finance.One of the reasons why the macroeconomics of populism have changed in this way is the historical legacy of economic disaster. If you are a populist leader in a country where financial crisis is part of living memory — as it is in Mexico, Hungary and Russia, say — you might do well to err on the side of conservatism for fear of repeating the mistakes of your predecessors.But another reason why populism looks different for countries like Poland, Hungary, Mexico and Russia has to do with mere luck. Hungary and Poland, in particular, enjoy the luck of geography: having been absorbed into the EU, they have received financial transfers from Brussels averaging some 3-4 per cent of GDP in the past few years, so that populism in these countries has been solidly underpinned by the terms of their EU membership. López Obrador is enjoying the inheritance of his predecessor’s sound macro policy, together with a buoyant US economy and low US interest rates. Russia has had the good fortune of oil exports to rely on.The thing about luck is that it can run out. So maybe it’s not quite time yet to bury the old macroeconomics of populism. But for the time being, it seems true to say that many of today’s populists have an unexpectedly robust sense of economic discipline.This article was originally published in the Financial Times. Full Article
sm A peroxisome deficiency-induced reductive cytosol state up-regulates the brain-derived neurotrophic factor pathway [Metabolism] By feedproxy.google.com Published On :: 2020-04-17T00:06:05-07:00 The peroxisome is a subcellular organelle that functions in essential metabolic pathways, including biosynthesis of plasmalogens, fatty acid β-oxidation of very-long-chain fatty acids, and degradation of hydrogen peroxide. Peroxisome biogenesis disorders (PBDs) manifest as severe dysfunction in multiple organs, including the central nervous system (CNS), but the pathogenic mechanisms in PBDs are largely unknown. Because CNS integrity is coordinately established and maintained by neural cell interactions, we here investigated whether cell-cell communication is impaired and responsible for the neurological defects associated with PBDs. Results from a noncontact co-culture system consisting of primary hippocampal neurons with glial cells revealed that a peroxisome-deficient astrocytic cell line secretes increased levels of brain-derived neurotrophic factor (BDNF), resulting in axonal branching of the neurons. Of note, the BDNF expression in astrocytes was not affected by defects in plasmalogen biosynthesis and peroxisomal fatty acid β-oxidation in the astrocytes. Instead, we found that cytosolic reductive states caused by a mislocalized catalase in the peroxisome-deficient cells induce the elevation in BDNF secretion. Our results suggest that peroxisome deficiency dysregulates neuronal axogenesis by causing a cytosolic reductive state in astrocytes. We conclude that astrocytic peroxisomes regulate BDNF expression and thereby support neuronal integrity and function. Full Article
sm Structure-based discovery of a small-molecule inhibitor of methicillin-resistant Staphylococcus aureus virulence [Molecular Biophysics] By feedproxy.google.com Published On :: 2020-05-01T00:06:09-07:00 The rapid emergence and dissemination of methicillin-resistant Staphylococcus aureus (MRSA) strains poses a major threat to public health. MRSA possesses an arsenal of secreted host-damaging virulence factors that mediate pathogenicity and blunt immune defenses. Panton–Valentine leukocidin (PVL) and α-toxin are exotoxins that create lytic pores in the host cell membrane. They are recognized as being important for the development of invasive MRSA infections and are thus potential targets for antivirulence therapies. Here, we report the high-resolution X-ray crystal structures of both PVL and α-toxin in their soluble, monomeric, and oligomeric membrane-inserted pore states in complex with n-tetradecylphosphocholine (C14PC). The structures revealed two evolutionarily conserved phosphatidylcholine-binding mechanisms and their roles in modulating host cell attachment, oligomer assembly, and membrane perforation. Moreover, we demonstrate that the soluble C14PC compound protects primary human immune cells in vitro against cytolysis by PVL and α-toxin and hence may serve as the basis for the development of an antivirulence agent for managing MRSA infections. Full Article
sm Webinar: Federalism in a Fragmented State: Rethinking Decentralization in Yemen By feedproxy.google.com Published On :: Tue, 07 Apr 2020 11:40:01 +0000 Research Event 15 April 2020 - 1:00pm to 2:00pm Event participants Osamah Al Rawhani, Deputy Director, Sana’a Center for Strategic StudiesModerator: Nadim Houry, Executive Director, Arab Reform Initiative Yemen suffered from the excessive control of the central government prior to the current conflict. Federalism has been put forward by many Yemeni political parties since the National Dialogue Conference (NDC) as the supposed magic cure for this significant problem. Today, Yemen is more fragmented than ever, its state central institutions have been scattered and lack leadership and the state has lost most of its sovereignty. The prevailing narrative that decentralization through federalism is Yemen’s inevitable path post-conflict often fails to acknowledge that there are prerequisites for effective local governance, beyond political will. In a recent article, Osamah Al Rawhani addressed how the weakness of central state institutions is the key challenge to proceeding with federalism in Yemen and highlighted prerequisites and contextual factors that need to be addressed before reforming the structure of the state. He argued that the viability of decentralization relies on the presence of a functioning, representative central government that is capable of devolving power but also able to keep the state from further fragmentation. In this webinar, part of the Chatham House project on The Future of the State in the Middle East and North Africa, the article’s author will discuss recent developments in Yemen, where shifting frontlines and regional divisions are fragmenting the country in new ways. The speaker will explore alternative approaches to pursue the path of federalism that recognize the current realities and the critical need for strong central institutions. He will also survey the internal and external factors that must be considered to rebuild a stable state in Yemen.You can express your interest in attending by following this link. You will receive a Zoom confirmation email should your registration be successful. Alternatively, you can watch the event live on the MENA Programme Facebook page. Department/project Middle East and North Africa Programme, The Future of the State in the Middle East Reni Zhelyazkova Programme Coordinator, Middle East and North Africa Programme +44 (0)20 7314 3624 Email Full Article
Reni Zhelyazkova Programme Coordinator, Middle East and North Africa Programme +44 (0)20 7314 3624 Email
sm Biosynthesis of depsipeptides with a 3-hydroxybenzoate moiety and selective anticancer activities involves a chorismatase [Metabolism] By feedproxy.google.com Published On :: 2020-04-17T00:06:05-07:00 Neoantimycins are anticancer compounds of 15-membered ring antimycin-type depsipeptides. They are biosynthesized by a hybrid multimodular protein complex of nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS), typically from the starting precursor 3-formamidosalicylate. Examining fermentation extracts of Streptomyces conglobatus, here we discovered four new neoantimycin analogs, unantimycins B–E, in which 3-formamidosalicylates are replaced by an unusual 3-hydroxybenzoate (3-HBA) moiety. Unantimycins B–E exhibited levels of anticancer activities similar to those of the chemotherapeutic drug cisplatin in human lung cancer, colorectal cancer, and melanoma cells. Notably, they mostly displayed no significant toxicity toward noncancerous cells, unlike the serious toxicities generally reported for antimycin-type natural products. Using site-directed mutagenesis and heterologous expression, we found that unantimycin productions are correlated with the activity of a chorismatase homolog, the nat-hyg5 gene, from a type I PKS gene cluster. Biochemical analysis confirmed that the catalytic activity of Nat-hyg5 generates 3-HBA from chorismate. Finally, we achieved selective production of unantimycins B and C by engineering a chassis host. On the basis of these findings, we propose that unantimycin biosynthesis is directed by the neoantimycin-producing NRPS–PKS complex and initiated with the starter unit of 3-HBA. The elucidation of the biosynthetic unantimycin pathway reported here paves the way to improve the yield of these compounds for evaluation in oncotherapeutic applications. Full Article
sm Economic Populism: A Transatlantic Perspective By feedproxy.google.com Published On :: Mon, 10 Oct 2016 14:53:00 +0000 Invitation Only Research Event 30 November 2016 - 9:00am to 5:15pm Chatham House, London Meeting Summarypdf | 164.3 KB Economic populism is on the rise on both sides of the Atlantic. In the US, both Donald Trump and Bernie Sanders have made protectionist arguments and appealed to voters who feel left behind by globalization. In Europe, left-wing groups like Syriza in Greece and Podemos in Spain as well as far-right groups like France’s Front National, Germany’s Alternative für Deutschland (AfD) and the UK Independence Party are capitalizing on the anti-globalization mood.Manifestations of the current anti-trade and anti-globalization movements include opposition to trade initiatives like the Transatlantic Trade and Investment Partnership (TTIP) and the Trans-Pacific Partnership (TPP) as well as populist calls for an end to the austerity measures and economic reforms that were introduced in the wake of the euro crisis. There have been questions regarding whether capitalism can respond to the rise in inequality seen in many Western states. Many populists also share a distrust of those they perceive as elite policy-makers and a desire to reclaim national sovereignty from international institutions. Thus, the rise of populism could have far-reaching consequences for trade and economic policy-making and the existing trade and broader economic architectures.The US and the Americas Programme at Chatham House and the German Marshall Fund of the United States in cooperation with the Konrad Adenauer Stiftung will convene an expert roundtable to provide insight and analysis geared towards examining key drivers behind the rise of economic populism, its implications for the international economic system, and possible ways to mitigate the effects of populism in the economic arena.Attendance at this event is by invitation only. The Chatham House RuleTo enable as open a debate as possible, this event will be held under the Chatham House Rule. Department/project US and the Americas Programme, US Geoeconomic Trends and Challenges US and Americas Programme Email Full Article
sm Liberalism in Retreat By feedproxy.google.com Published On :: Tue, 13 Dec 2016 09:54:55 +0000 13 December 2016 Robin Niblett Director and Chief Executive, Chatham House @RobinNiblett With the liberal international order under threat, democracies will need to find a way to coexist with their ideological foes. 2016-12-13-EUUS.jpg Photo by Getty Images. The liberal international order has always depended on the idea of progress. Since 1945, Western policymakers have believed that open markets, democracy and individual human rights would gradually spread across the entire globe. Today, such hopes seem naïve.In Asia, the rise of China threatens to challenge US military and economic hegemony. In the Middle East, the United States and its European allies have failed to guide the region toward a more liberal and peaceful future in the wake of the Arab Spring. And Russia’s geopolitical influence has reached heights unseen since the Cold War, as it attempts to roll back liberal advances around its periphery.But the more important threats to the order are internal. For the past half-century, the European Union has seemed to represent the advance guard of a new liberalism in which nations pool sovereignty and cooperate ever more closely with one another. Today, as it reels from one crisis to the next, the EU has stopped expanding.Other countries will probably not follow the United Kingdom out of the EU. But few European leaders appear willing to continue relinquishing sovereignty, whether to manage flows of refugees or to ensure the long-term viability of the single currency. Many European politicians are demanding more national sovereign control over their destinies rather than more integration.Across the Atlantic, the US commitment to global leadership, which until now has sustained the liberal international order through good times and bad, looks weaker than at any point since the Second World War. After the costly wars in Afghanistan and Iraq and the chaos that followed the intervention in Libya, President Barack Obama consistently encouraged allies in Europe and the Middle East to take greater responsibility for their own security. In his presidential campaign, President-elect Donald Trump twisted this argument into an explicitly transactional bargain: America would become a mercenary superpower, protecting only those countries that paid, so that it could focus on making itself great again at home. In so doing, he ignored the hard-won lesson that investing in the security of its allies is the best way of protecting America’s own security and economic interests.Meanwhile, America’s rebalance to Asia is in jeopardy. With Trump promising to roll back the Trans-Pacific Partnership, Beijing has wasted no time in laying out its own vision for a more integrated Eurasia that may exclude America and in which China will play the leading role. We may be on the brink of a Eurasian century, rather than a Pacific century.Sustaining an international liberal economic orderIn the past, as other political systems have crumbled, the liberal international order has risen to face its challenges. Yet so long as the economies of its leading members remain fragile and their political institutions divided, the order they have championed is unlikely to regain the political momentum that helped democracy spread across the globe. Instead, it will evolve into a less ambitious project: an international liberal economic order that encompasses states with diverse domestic political systems.This need not be bad news if it allows democracies and their illiberal counterparts to find ways to coexist. Non-Western rising powers, China chief among them, will remain committed to sustaining the international economic order of open markets and free flows of investment. After all, only through continued integration into the global supply chains of goods, services, people and knowledge can emerging markets meet the aspirations of their growing middle classes.It is in the West’s interests that China’s economic development continues smoothly. US and European markets for goods, services and infrastructure should remain open to Chinese trade and foreign direct investment, as long as Chinese companies abide by their WTO commitments and by US and European rules on security and transparency and the protection of intellectual property. European countries should take the same approach toward Russia, on the condition that Russian companies abide by EU rules. A mutual commitment to the international liberal economic order would help Western governments and their illiberal counterparts keep open other avenues for cooperation on shared challenges, such as terrorism and nuclear proliferation.Meanwhile, European governments and businesses should take part in the Chinese-led strategy to connect northeast Asia with Europe across the Eurasian continent, a component of a series of regional infrastructure investments known as the Belt and Road Initiative. Today, the world is experiencing a structural decline in growth rates of trade, as emerging markets like China make more of their own products and developed countries bring some production back on-shore. Against this backdrop, ramping up investment in infrastructure that can connect the thriving coastal areas of Asia to their underdeveloped hinterlands and then to Europe could create new opportunities for economic growth in both the liberal and the illiberal worlds.Similar cooperation will be harder to build with Russia. Russia’s system of centralized, opaque political and economic governance makes deeper integration incompatible with the EU’s market and rules-based system. And NATO members have begun a much-needed upgrading of their military readiness in the face of recent Russian provocations. EU and NATO tensions with Russia will likely persist. However, the initiative to build new Eurasian economic inter-connections could provide an alternative way for the United States and Europe to engage Russia in the future.A period of awkward coexistenceThe countries that built the liberal international order are weaker today than they have been for three generations. But liberal policymakers would be wrong to hunker down or resort to containment. An extended stand-off with those who contest a liberal international order may accidentally lead to outright conflict. A better approach would be for liberal countries to prepare themselves for a period of awkward coexistence with illiberal ones, cooperating on some occasions and competing on others. Time will then tell whose form of government is more resilient. If history is any guide, liberal democracy remains the best bet.An extended version of this article appears in Foreign Affairs.To comment on this article, please contact Chatham House Feedback Full Article
sm Up in smoke? Global tobacco advocacy and local mobilization in Africa By feedproxy.google.com Published On :: Wed, 04 Sep 2019 14:05:11 +0000 4 September 2019 , Volume 95, Number 5 Amy S. Patterson and Elizabeth Gill Read online Even though most African states have signed and ratified the Framework Convention on Tobacco Control (FCTC), a global treaty to limit tobacco use, African states have been slow to pass and implement tobacco control policies like regulations on sales, smoke-free environments and taxes. This article examines how the ineffectiveness of local tobacco-control advocacy contributes to this suboptimal outcome. It asserts that the disconnect between the global tobacco-control advocacy network and local advocates shapes this ineffectiveness. With funding and direction predominately from the Bloomberg Initiative, local advocates emulate the funders' goal of achieving quick, measurable policy results. Their reliance on the network drives African advocates to strive to pass legislation, even in difficult political climates, and to remake their agendas when funders change their priorities. They also emulate the network's focus on evidence-based arguments that stress epidemiological data and biomedical interventions, even when this issue frame does not resonate with policy-makers. Financial dependence can draw local advocates into expectations about patronage politics, undermine their ability to make principled arguments, and lead them to downplay the ways that their home country's socioeconomic and cultural contexts affect tobacco use and control. Based on key informant interviews with African advocates, media analysis and the case-studies of Ghana and Tanzania, the article broadens the study of philanthropy in global health, it adds an African perspective to the literature on global health advocacy, and it deepens knowledge on power dynamics between external funders and local actors in the realms of health and development. Full Article
sm The mRNA levels of heat shock factor 1 are regulated by thermogenic signals via the cAMP-dependent transcription factor ATF3 [Metabolism] By feedproxy.google.com Published On :: 2020-05-01T00:06:09-07:00 Heat shock factor 1 (HSF1) regulates cellular adaptation to challenges such as heat shock and oxidative and proteotoxic stresses. We have recently reported a previously unappreciated role for HSF1 in the regulation of energy metabolism in fat tissues; however, whether HSF1 is differentially expressed in adipose depots and how its levels are regulated in fat tissues remain unclear. Here, we show that HSF1 levels are higher in brown and subcutaneous fat tissues than in those in the visceral depot and that HSF1 is more abundant in differentiated, thermogenic adipocytes. Gene expression experiments indicated that HSF1 is transcriptionally regulated in fat by agents that modulate cAMP levels, by cold exposure, and by pharmacological stimulation of β-adrenergic signaling. An in silico promoter analysis helped identify a putative response element for activating transcription factor 3 (ATF3) at −258 to −250 base pairs from the HSF1 transcriptional start site, and electrophoretic mobility shift and ChIP assays confirmed ATF3 binding to this sequence. Furthermore, functional assays disclosed that ATF3 is necessary and sufficient for HSF1 regulation. Detailed gene expression analysis revealed that ATF3 is one of the most highly induced ATFs in thermogenic tissues of mice exposed to cold temperatures or treated with the β-adrenergic receptor agonist CL316,243 and that its expression is induced by modulators of cAMP levels in isolated adipocytes. To the best of our knowledge, our results show for the first time that HSF1 is transcriptionally controlled by ATF3 in response to classic stimuli that promote heat generation in thermogenic tissues. Full Article
sm The Human Plasma Proteome: A Nonredundant List Developed by Combination of Four Separate Sources By feedproxy.google.com Published On :: 2004-04-01 N. Leigh AndersonApr 1, 2004; 3:311-326Research Full Article
sm In Vivo Identification of Human Small Ubiquitin-like Modifier Polymerization Sites by High Accuracy Mass Spectrometry and an in Vitro to in Vivo Strategy By feedproxy.google.com Published On :: 2008-01-01 Ivan MaticJan 1, 2008; 7:132-144Research Full Article
sm Quantitative, Multiplexed Assays for Low Abundance Proteins in Plasma by Targeted Mass Spectrometry and Stable Isotope Dilution By feedproxy.google.com Published On :: 2007-12-01 Hasmik KeshishianDec 1, 2007; 6:2212-2229Research Full Article
sm Quantitative Mass Spectrometric Multiple Reaction Monitoring Assays for Major Plasma Proteins By feedproxy.google.com Published On :: 2006-04-01 Leigh AndersonApr 1, 2006; 5:573-588Research Full Article
sm The Human Plasma Proteome: History, Character, and Diagnostic Prospects By feedproxy.google.com Published On :: 2002-11-01 N. Leigh AndersonNov 1, 2002; 1:845-867Reviews/Perspectives Full Article
sm Small-molecule agonists of the RET receptor tyrosine kinase activate biased trophic signals that are influenced by the presence of GFRa1 co-receptors [Neurobiology] By feedproxy.google.com Published On :: 2020-05-08T03:41:14-07:00 Glial cell line–derived neurotrophic factor (GDNF) is a growth factor that regulates the health and function of neurons and other cells. GDNF binds to GDNF family receptor α1 (GFRa1), and the resulting complex activates the RET receptor tyrosine kinase and subsequent downstream signals. This feature restricts GDNF activity to systems in which GFRa1 and RET are both present, a scenario that may constrain GDNF breadth of action. Furthermore, this co-dependence precludes the use of GDNF as a tool to study a putative functional cross-talk between GFRa1 and RET. Here, using biochemical techniques, terminal deoxynucleotidyl transferase dUTP nick end labeling staining, and immunohistochemistry in murine cells, tissues, or retinal organotypic cultures, we report that a naphthoquinone/quinolinedione family of small molecules (Q compounds) acts as RET agonists. We found that, like GDNF, signaling through the parental compound Q121 is GFRa1-dependent. Structural modifications of Q121 generated analogs that activated RET irrespective of GFRa1 expression. We used these analogs to examine RET–GFRa1 interactions and show that GFRa1 can influence RET-mediated signaling and enhance or diminish AKT Ser/Thr kinase or extracellular signal-regulated kinase signaling in a biased manner. In a genetic mutant model of retinitis pigmentosa, a lead compound, Q525, afforded sustained RET activation and prevented photoreceptor neuron loss in the retina. This work uncovers key components of the dynamic relationships between RET and its GFRa co-receptor and provides RET agonist scaffolds for drug development. Full Article
sm Roles of active-site residues in catalysis, substrate binding, cooperativity, and the reaction mechanism of the quinoprotein glycine oxidase [Enzymology] By feedproxy.google.com Published On :: 2020-05-08T03:41:14-07:00 The quinoprotein glycine oxidase from the marine bacterium Pseudoalteromonas luteoviolacea (PlGoxA) uses a protein-derived cysteine tryptophylquinone (CTQ) cofactor to catalyze conversion of glycine to glyoxylate and ammonia. This homotetrameric enzyme exhibits strong cooperativity toward glycine binding. It is a good model for studying enzyme kinetics and cooperativity, specifically for being able to separate those aspects of protein function through directed mutagenesis. Variant proteins were generated with mutations in four active-site residues, Phe-316, His-583, Tyr-766, and His-767. Structures for glycine-soaked crystals were obtained for each. Different mutations had differential effects on kcat and K0.5 for catalysis, K0.5 for substrate binding, and the Hill coefficients describing the steady-state kinetics or substrate binding. Phe-316 and Tyr-766 variants retained catalytic activity, albeit with altered kinetics and cooperativity. Substitutions of His-583 revealed that it is essential for glycine binding, and the structure of H583C PlGoxA had no active-site glycine present in glycine-soaked crystals. The structure of H767A PlGoxA revealed a previously undetected reaction intermediate, a carbinolamine product-reduced CTQ adduct, and exhibited only negligible activity. The results of these experiments, as well as those with the native enzyme and previous variants, enabled construction of a detailed mechanism for the reductive half-reaction of glycine oxidation. This proposed mechanism includes three discrete reaction intermediates that are covalently bound to CTQ during the reaction, two of which have now been structurally characterized by X-ray crystallography. Full Article
sm The Smart Peace Initiative: An Integrated and Adaptive Approach to Building Peace By feedproxy.google.com Published On :: Tue, 11 Feb 2020 10:55:01 +0000 Invitation Only Research Event 12 May 2020 - 10:00am to 11:30amAdd to CalendariCalendar Outlook Google Yahoo Smart Peace brings together global expertise in conflict analysis and research, peacebuilding and mediation programming, and behavioural science and evaluation. Together, Smart Peace partners are developing integrated and adaptive peace initiatives, working with local partners to prevent and resolve complex and intractable conflicts in Central African Republic, Myanmar and northern Nigeria. This roundtable is an opportunity for Smart Peace partners to share the Smart Peace concept, approach and objectives, and experiences of the first phases of programme implementation. Roundtable discussions among participants from policy, practice and research communities will inform future priorities and planning for Smart Peace learning, advocacy and communication. Smart Peace partners include Conciliation Resources, Behavioural Insights Team, The Centre for Humanitarian Dialogue, Chatham House, ETH Zurich, International Crisis Group and The Asia Foundation. Nilza Amaral Project Manager, International Security Programme Email Department/project International Security Programme, Smart Peace Full Article
sm Religious violence, gender and post-secular counterterrorism By feedproxy.google.com Published On :: Wed, 04 Mar 2020 12:55:46 +0000 4 March 2020 , Volume 96, Number 2 Katherine E. Brown Read Online This article argues that despite the framing of religion in the discipline and practice of International Relations (IR) as a force for good, or a cause of evil in the world, IR fails to treat religion on its own terms (as sui generis). With a few exceptions, the discipline has pigeonholed religion as a variable of IR, one that can be discussed as one might GDP, HIV, or numbers of nuclear missiles: measurable, with causality and essential properties. IR has also tended to treat religion as equivalent to features of global politics that it already recognizes—as an institution or community or ideology, for example—but in doing so, it misses intrinsic (and arguably unique) elements of religion. Drawing on feminist insights about how gender works in IR, namely that gender is a construct, performative and structural, this article argues a similar case for religion. A reframing of religion is applied to the case of Daesh (so-called Islamic State of Iraq and Syria, ISIS) to show how our understanding of the organization changes when we view religion differently. The implications for counterterrorism policies if religion is viewed as more than a variable are explored in light of recent territorial and military losses for Daesh. The article therefore proposes a post-secular counterterrorism approach. Full Article
sm Unpacking the role of religion in political transnationalism: the case of the Shi'a Iraqi diaspora since 2003 By feedproxy.google.com Published On :: Wed, 04 Mar 2020 12:58:04 +0000 4 March 2020 , Volume 96, Number 2 Oula Kadhum Read Online This article explores the role of religion in political transnationalism using the case of the Shi'a Iraqi diaspora since 2003. The article focuses on three areas that capture important trends in Shi'a transnationalism and their implications for transnational Shi'a identity politics. These include Shi'a diasporic politics, transnational Shi'a civic activism, and the cultural production of Iraqi Shi'a identity through pilgrimages, rituals and new practices. It is argued that understanding Shi'a Islam and identity formation requires adopting a transnational lens. The evolution of Shi'a Islam is not only a result of the dictates of the Shi'a clerical centres, and how they influence Shi'a populations abroad, but also the transnational interrelationships and links to holy shrine cities, Shi'i national and international politics, humanitarianism and commemorations and rituals. The article demonstrates that Shi'a political transnationalism is unexceptional in that it echoes much of the literature on diasporic politics and development where diaspora involve themselves from afar in the politics and societies of their countries of origin. At the same time, it shows the exceptionalism of Shi'a diasporic movements, in that their motivations and mobilizations are contributing to the reification of sectarian geographical and social borders, creating a transnationalism that is defined by largely Shi'a networks, spaces, actors and causes. The case of Shi'a political transnationalism towards Iraq shows that this is increasing the distance between Shi'is and Iraq's other communities, simultaneously fragmenting Iraq's national unity while deepening Shi'a identity and politics both nationally and supra-nationally. Full Article
sm The Dangers of Tribalism in South Sudan By feedproxy.google.com Published On :: Thu, 19 Dec 2013 17:59:01 +0000 19 December 2013 Hannah Bryce @hannahekbryce LinkedIn Former Assistant Head, International Security 20131219SudanClashesTruck.jpg South Sudanese soldiers patrol the streets of Juba 2 January 2014. Thousands of people are feared to have been killed, pitting army units loyal to President Salva Kiir against ethnic militia forces and mutinous army commanders nominally headed by former vice president Riek Machar. Photo by Samir Bol/AFP/Getty Images. The violence in South Sudan this week suggests there could be worse times to come for the country. It will exacerbate the deep-rooted inter- and intra-tribal tensions that have defined the political landscape in South Sudan since it gained independence in 2011. It could also create a refugee dilemma for the country’s neighbours.The dynamics of the leadership struggle between President Salva Kiir, a Dinka, and former vice president Riek Macher, a Nuer, colours politics throughout the country, illustrating the prevalence of political tribalism at the highest office. Following Kiir’s dismissal of Machar and the entire cabinet in July, neither this week’s attempted coup nor its heavy suppression will have come as a surprise to many in South Sudan.The perception of Dinka domination pervading the Sudan People Liberation Movement (SPLM) and the Sudan People Liberation Army (SPLA) by other ethnic groups is not new. But it has become increasingly marked in a country with a fragile economy, limited opportunities for employment and deep-rooted patrimonialism throughout all tiers of government.While there is a long-standing rivalry for power between the Dinka and Nuer, South Sudan’s two largest tribal groups, others, such as the Equatorians, perceive both groups as monopolizing power. Addressing this perceived inequity within the government will be integral to move beyond political tribalism towards an inclusive system of government that guarantees minority representation. Without this change, discontent and frustrations within the disenfranchised rural communities that make up the majority of the population are liable to rise to the surface, as this week’s events demonstrate.While government policies since independence have been careful to use the language of inclusivity, the reality is very different. Jonglei, the largest of South Sudan’s ten states and home of the Nuer, has seen severe fighting between the Dinka, Nuer and Murle, for example. In December 2011 tribal attacks and counterattacks between Nuer and Murle caused at least 1,000 deaths. These tensions have been further aggravated by the failure of the central government to provide even basic levels of local governance, made worse by systemic corruption and patrimonialism. The extent of corruption, and the government’s lack of control over it, was demonstrated in 2012 when President Kiir issued a somewhat plaintive call to his government officials to return stolen cash.Government reforms and legislation have stripped traditional authorities of their former functions and roles within local society, without reintegrating them into new roles within the government apparatus or providing viable alternatives. This has resulted in inconsistent and disparate systems of local governance throughout South Sudan, contributing to existing perceptions of inequity. This is often assumed to be based on tribal factors, regardless of whether this is in fact the case.With tensions appearing to be unabated in the capital, Juba, and with the dry season approaching, which will facilitate a more mobile population, there is significant potential for security to deteriorate further. And it may not recover for a long time. Disgruntled and marginalized, the tribal populations that have felt excluded from the political process, or in the case of the Nuer, undermined in that process, may use the current political turbulence to bring matters to a head and challenge the authority of South Sudan’s leading figures.A lasting conflict in South Sudan would likely lead to further displacement of people, which would place an increased strain on host communities in neighbouring countries. Ethiopia, Kenya and Uganda already have a long history of accepting refugees from the Sudanese civil war. With the current flows of displaced populations from conflicts in Somalia, the Central African Republic and Democratic Republic of the Congo however, an additional influx of South Sudanese refugees would have the potential to overburden and destabilize the region further.To comment on this article, please contact Chatham House Feedback Full Article
sm Lesotho’s Domestic Priorities and Global Interests: Small Country Levers for International Influence By feedproxy.google.com Published On :: Tue, 01 Apr 2014 14:57:42 +0000 Research Event 7 April 2014 - 3:00pm to 4:00pm Chatham House, London Meeting Summarypdf | 59.43 KB Event participants HE Dr Motsoahae Thomas Thabane, Prime Minister of LesothoChair: Ian Lucas MP, Shadow Minister for Africa and the Middle East The landlocked southern African nation of Lesotho faces a number of domestic challenges in 2014. Reducing reliance on the agricultural sector, containing the prevalence of HIV and improving service delivery are all important issues that must be addressed to ensure sustainable growth. However, social achievements including literacy rates and levels of gender parity among the highest in Africa, the country’s potential for electricity exports, and the booming relationship between its textile industry and the United States, could mean Lesotho is well-placed for future growth and development. HE Prime Minister Tom Thabane will discuss how his government seeks to address the Lesotho’s domestic issues and how the country seeks to exert its influence in the regional Southern African Development Community. Full Article
sm Islamism and Its Alternatives in the GCC By feedproxy.google.com Published On :: Wed, 14 Jan 2015 16:15:01 +0000 Research Event 14 December 2014 - 9:00am to 15 December 2014 - 2:00pm Doha, Qatar Meeting Summarypdf | 76.75 KB This expert-level workshop will bring together around 30 Gulf scholars, experts and practitioners from a variety of professional and academic backgrounds to share their analysis and research on the role of Islam in social and political movements in the GCC countries, as well as alternatives to Islamism. It will place political Islam in historical context, explore the differences between different strands of political Islam and the ways in which different country contexts have shaped the behaviour of movements that claim to have religious legitimacy, such as the institutions and legal regulations governing political movements.This event is part of Chatham House’s Future Trends in the GCC research project, and is held in partnership with Qatar University’s Gulf Studies Center in Doha, Qatar. Event attributes External event Department/project Middle East and North Africa Programme, Future Dynamics in the Gulf Full Article
sm Syria: Destruction of Civil Society Means Dictatorship, Extremism and Displacement By feedproxy.google.com Published On :: Fri, 07 Oct 2016 08:56:47 +0000 7 October 2016 Rana Marcel Khalaf Former Academy Associate The void in governance in Syria caused by the conflict has enabled a previously oppressed civil society to rise. Now this new society is under threat. Sustained commitment from the international community is required. 2016-10-07-white-helmets-syria2.jpg Syrian civil defence volunteers, known as the White Helmets, search amid the rubble of destroyed buildings following an air strike on the rebel-held neighbourhood of Aleppo, on October 4, 2016. Photo: Getty Images. The void in governance created by the ongoing Syrian conflict has been capitalized upon by warlords, militias and extremist groups to expand and consolidate their power – but has also helped to generate activism, with new leaders born as a reaction to authoritarian governance and conflict limitations.As public social services have been taken over as war tools, local coordination committees, local councils, humanitarian support groups, citizen journalist networks, women’s groups, and more, have mushroomed across all of Syria. But this new civil society continues to be threatened by many challenges.It remains hindered by structural weakness and limited capacity - largely as a result of the legacy of Ba’athist policies, which did not allow civil society to exist in the so-called Damascus Spring, but only under the umbrella of the Government, First Lady Asma al-Assad and business NGOs (GoNGOs, FLNGOs and BoNGOs). Beyond this, civil society was limited to purely charitable and religious causes, known as “moujtamaa ahli”.In addition, Syrian civil society is often a victim of counter-terrorism legislation, with laws and regulations across many countries and institutions prohibiting Syrians from registering an organization and opening bank accounts. This makes it difficult to secure financial support in an environment where funding has already been dwindling due to a “Syria fatigue” among potential donors, and where any money available is mainly directed at large, often international, NGOs.Trust, hope and legitimacyTo reach funds, many organizations have to submit to this “NGOization” process. But even this rarely allows for civil society to foster its own interests through core funding. Civil society in Syria is treated more as a “project” with strict indicators, deals and deadlines, when working under conflict necessitates building relationships of trust with a community over time and often has to cover the direct needs on the ground to gain local legitimacy and increase effectiveness. Trust, hope and legitimacy are not aspects you can report against or cover in a sophisticated proposal.But despite such obstacles, activists and civil society groups continue to volunteer for various causes, ensuring many have not had to seek refuge elsewhere. And their work has included challenging authoritarian and extremist governance.In Aleppo in 2014, it was civil society with the support of a military faction of Jaish Al Mujahideen that helped expel ISIS. Local councils have since been providing services ranging from humanitarian aid and garbage collection to re-establishing order and resolving local conflicts, thus challenging the legitimacy of jihadist institutions.NGOs such as the Civil Defense Forces (known as the White Helmets) continually risk their lives to save others by rescuing people from bombed out buildings. On September 19, when a UN sanctioned aid convoy was attacked in Aleppo – reportedly by Russian aircraft – it was the White Helmets that responded, before then coming under attack themselves.Human rights activists, meanwhile, persist in documenting human rights abuses in the hope that the perpetrators will eventually be held accountable.However, a Syrian civil society tragedy is unfolding as their work is struggling to survive. To give but one example, Kesh Malek, one of the biggest groups running home-based schooling for children in Aleppo, has already had to close some of its schools.Lacking international protection, the fate of these children in relation to arms and radicalization is all the more alarming. Several local councils have also been much weakened, especially vis-à-vis warlords, authoritarian and/or extremists actors.At its best, the current bombing campaign serves to kill any potential alternatives to an authoritarian regime, and only boosts human suffering, radicalization and displacement.If this situation is to be reversed, international actors need to ensure security at the local Syrian level, showing that Syrian security is as important as that of Europe.This means financial security through a deeper and more sustainable capacity building and funding to civil society, and it means protecting civilians and civil society groups though the creation of a safe haven.To comment on this article, please contact Chatham House Feedback Full Article
sm Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death By feedproxy.google.com Published On :: 2006-12-01 Nica M. BorradaileDec 1, 2006; 47:2726-2737Research Articles Full Article
sm The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism By feedproxy.google.com Published On :: 2013-09-01 Gijs den BestenSep 1, 2013; 54:2325-2340Reviews Full Article