Need for Surface Surface Modelling is a method used to create and represent complex shapes with high curvature controls. Generally, surfaces are used as an alternative where a particular feature is difficult to create using solid modeling. It is helpful

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Learn how to easily delete a face from a solid or surface body when modeling in SOLIDWORKS. Our #TechTip this week is by Training Manager John Setzer. Video Transcript Hi and welcome to another GSC tech tip. Today we’re going

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If you need a last-minute gift, you can grab a $50 Apple iTunes gift card for $42.50. Plus, you can save $250 on the Microsoft Surface Pro 6 and $100 on the iRobot Roomba 675.

The cartridge was meant to upgrade the processor and GPU in the Surface Hub 2S so as to allow rotation and multiple hubs to work together.

Talk to school and district leaders and you’ll hear worries about the next recession, spending restrictions, and a public that knows little about worries that lawmakers and elected officials who know little about their funding needs.

Pertussis is a poorly controlled vaccine-preventable disease. Verifying outbreaks is challenging owing to nonspecific clinical presentations and imperfect diagnostic tests. Exclusive reliance on highly sensitive polymerase chain reaction has been associated with pseudo-outbreaks.

Contamination of specimens with vaccine derived Bordetella pertussis DNA from pediatric clinic surfaces likely resulted in misdiagnoses. Standard practices, liquid transport medium, and lack of polymerase chain reaction cutoffs for discerning weakly positive (contaminant) DNA are contributory, but modifiable factors. (Read the full article)

Although China has the largest birth population in the world and a number of multicenter studies of neonatal respiratory failure are reported, there is a paucity of data regarding outcome measurement of very premature neonates requiring respiratory care and surfactant therapy.

This study is the largest survey, to date, in a Chinese network of 55 NICUs that presents the incidence, morbidity, and mortality rates, with risk factors of neonatal respiratory failure, with special emphasis on surfactant-treated very immature infants. (Read the full article)

A policy of intubation, mechanical ventilation, and surfactant administration is commonly used for the treatment of respiratory distress syndrome worldwide; however subsequent development of bronchopulmonary dysplasia remains as risk with this standard approach.

Noninvasive surfactant administration technique during spontaneous breathing (Take Care) along with nasal continuous positive airway pressure support successfully reduces the need for further respiratory support and bronchopulmonary dysplasia rate in very low birth weight infants. (Read the full article)

Redmond's pitch for its latest tablet is a crazy man screaming at himself.

Agency: DOT Closing Date: 5/19/2020

DNREC the Delaware Division of Public Health are now accepting project proposals from state, county and municipal governments, and conservation districts, for matching grants for wastewater, surface water, and drinking water project planning.

DNREC, with the Division of Public Health, is now accepting project proposals for matching grants for waste, surface, and drinking water project planning.

Tallyville --

Location: Ramsey Road between Creek Road and Thompsons Bridge Road, Talleyville.

Dates and Times: 7:00 a.m. until 7:00 p.m. each day starting on April 8, 2020 through April 16, 2020, pending weather.

There will be no work on Easter Weekend. [More]

Wilmington --

Location: Smith Bridge Road between Montchanin Road and Brandywine Creek Road, Wilmington.

Dates and Times: 7:00 a.m. until 7:00 p.m. each day, beginning on April 14, 2020 and ending on April 23, 2020, pending weather

Traffic Information: The Delaware Department of Transportation (DelDOT) announces that Smith Bridge Road will be closed during the day for the milling and resurfacing of the roadway.

Residential traffic destined for addresses between the closure points will be permitted access and directed by flaggers on-site. [More]

Wilmington --

Location: North Harrison Street from Delaware Avenue to Pennsylvania Avenue, Wilmington.

Times and Dates: 7:00 a.m. on Monday, May 4, 2020 until 5:00 p.m. on Thursday, May 7, 2020, pending weather.

Traffic Information: DelDOT announces to motorists that North Harrison Street will be closed for the roadway surface to be replaced with concrete to eliminate the deterioration of the roadway. [More]

Out-of-state visitors must self-quarantine for 14 days before engaging in fishing, hunting, golf, visiting state parks and wildlife areas.

The report claims that the development could help seismologists detect earthquakes of even very small magnitude, signals of which were earlier drowned in the cacophony produced by various activities.

Have you ever manufactured a printed circuit board (PCB) without analyzing all the routed signal traces? Most designers will say “yes, all the time.” Trace widths and spacing are set by constraints,...

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If I talk about my life, it was much simpler when I used to live with my parents. They took good care of whatever I wanted - in fact, they still do. But now, I am living alone, and sometimes I buy...

[[ Click on the title to access the full blog on the Cadence Community site. ]]

When you design a rigid-flex board, the focus is, of course, on the bend. Your design might be bend to install (stable flexion) - it will be bent only a few times while installing. Or it might be dynamic - it will be bent regularly. It's important to...(read more)

You must deal with many reports in your daily life – for your health, financial accounts, credit, your child’s academic records, and the count goes on. Ever noticed that these reports contain many details, most of which you don’t wa...(read more)

With ECAD-MCAD Library Creator, you can easily create footprints for your parts using thousands of ready-to-use templates that are provided with the tool.(read more)

Longfellow's metaphorical footprints on the sands of time is more profound and eternal no doubt but a footprint for silicon (a form of sand isn't it?) is as important for PCB designers. So, here we will list the steps to create a fo...(read more)

All PCB designers know the importance of proper power delivery for successful board design. Integrated circuits need the power to turn on, and ICs with marginal power delivery will not operate reliably. Since power planes can...(read more)

Imagine you are on a vacation with your family, and suddenly, your phone starts buzzing. You pick it up and what are you looking at is a bunch of pending, unanswered e-mails. You start recollecting the checklist you had made before taking off only to realize that you haven’t put on the automatic replies! (read more)

In my previous blog, I talked about creating a footprint using an existing template in Allegro ECAD-MCAD Library Creator and explained how easily you can access an existing template and create a package from it by just clicking a button. In this blog...(read more)

What is a Power Distribution Network (PDN) after all but resistance, inductance, and capacitance in the PCB and components? And, of course, it is there to deliver the right current and voltage to each component on your PCB. But is that all? Are there oth...(read more)

Have you ever manufactured a printed circuit board (PCB) without analyzing all the routed signal traces? Most designers will say “yes, all the time.” Trace widths and spacing are set by constraints, and many designers simply don’t h...(read more)

So, what if you can figure out all that can go wrong when your product is being assembled early on? Not guess but know and correct at an early stage – not wait for the fabricator or manufacturer to send you a long report of what needs to change. That’s why Design for Assembly (DFA) rules(read more)

Whale in a win32 attack surface toolkit written in C#. It's capable of monitoring many of different areas of the Windows for new and removed kernel objects, open ports, drivers, services and much more. It also allows a user to test for different bug classes and has found a few interesting issues across the sub-systems.

Computer and network security is an ever-evolving field. As technology advances, cybercriminals find new ways to exploit vulnerabilities in order to get at your personal, financial, or organizational data. We recently spoke with Symantec's Director of Security Response Kevin Haley to get an idea of what threats you'll face in the next year or two.

In short, expect a continuation of common threats like ransomware, as well as the emergence of new threats from connected devices and the so-called Internet of Things. Plus, keep an eye out for the resurgence of an old threat made new.

Ransomware with a Twist

Ransomware — malicious software that locks your data or otherwise compromises your computer in an attempt to extort money — is not a new threat. It's been around for a number of years in various forms. But according to Haley, a new form of ransomware doesn't just lock your files; instead, it threatens to publicly release your data unless you pay up.

For many individuals, this may simply mean an embarrassing leakage of personal data — browser history, emails, photos, and so on. For a nonprofit, especially one that deals with sensitive sociopolitical issues, the possibility of data leakage can have more serious ramifications. It could pose a threat to the community you serve.

Email That Looks Like It Came from a Co-worker

In traditional phishing attempts, scammers create an email that appears to be from a legitimate source — say, Google, Amazon, or Apple. Then they attempt to steal account information, such as usernames and passwords. But in an emerging form of phishing, hackers may use emails purportedly from co-workers or business associates to try to steal information from your organization.

For example, Haley says, you may receive an email from a vendor or a colleague asking for specific pieces of information (such as tax forms) or for money outright. The only problem is that these emails originate from scammers, not your colleagues. And once you email an important piece of information to these impersonators, there's no way to get it back.

With proper data handling, though, you can avoid these sorts of nightmares. See our recent post, 5 Data Security Risks for Nonprofits (and How to Fix Them), to learn more.

The Internet of Things Can Make People Vulnerable

From smart locks to Internet-connected appliances, the Internet of Things promises to change the way we interact with all sorts of items within our homes and offices. But with this comes the potential for security headaches.

According to Haley, these "smart" devices are rarely protected properly, and are easy to infect with malware. And this isn't just an issue that may cause problems some years down the line. Last year, as CNET reported, a network of malware-infected DVRs and webcams overloaded a number of popular websites and online services, temporarily knocking them offline.

Word Macro Viruses Make a Comeback

Perhaps the most surprising threat Haley warned about was the revival of Word macro viruses.

Macro viruses use Microsoft Word's macro programming feature — typically used to automate certain tasks within Word — to infect your computer. Macro viruses have been around for many, many years. And Word disables macros by default: If you open a Word document with a macro, you'll have to click a button to tell Word to turn on any macros within that document.

With this new wave of macro viruses, however, criminals employ social engineering trickery to goad you into turning on macros, allowing the macro virus to do its thing.

Fortunately, you can easily protect yourself from getting infected. First, don't open file attachments from people you don't know. If you receive a Word document with macros from someone you do know, confirm with that person to make sure that they intended to send the macros and that they are safe to run.

As Always, Vigilance Is Key

Although specific threats may evolve over time, good security practices never go out of style. Use a security software package and keep it updated. Enforce good account security practices within your organization.

Don't open file attachments from people you don't know, and don't open unexpected file downloads. Secure all your devices as best you can. And if something seems fishy — perhaps that email from your boss doesn't seem quite right — don't be afraid to question it.

By taking small steps like these, you might save yourself — and your organization — some serious pain.

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A "mass of surfers" have converged on one of Wellington's most popular surf beaches.A Wellington local, who wanted to be known only as Brendan, said he was in the area for work when he decided to stop and see what was happening...

Reforming state-owned enterprises can be an extraordinarily complex activity but it is underpinned by a single clear goal.

AN3433 - Touchpad With Built-In Surface Gesture Recognition Using Peripheral Touch Controller

Mudskippers are known for their unusual ability to climb trees, but now they have been spotted hopping across water. They are thought to be a living example of how fish transitioned to land

Most tadpoles breathe air but they are too weak to break the elastic "skin" on top of ponds created by water tension – so they suck air bubbles from the surface

Title: Laser Process May Kill Bacteria on Metal Surfaces
Category: Health News
Created: 4/16/2020 12:00:00 AM
Last Editorial Review: 4/17/2020 12:00:00 AM

ABSTRACT

Pneumocystis, a major opportunistic pathogen in patients with a broad range of immunodeficiencies, contains abundant surface proteins encoded by a multicopy gene family, termed the major surface glycoprotein (Msg) gene superfamily. This superfamily has been identified in all Pneumocystis species characterized to date, highlighting its important role in Pneumocystis biology. In this report, through a comprehensive and in-depth characterization of 459 msg genes from 7 Pneumocystis species, we demonstrate, for the first time, the phylogeny and evolution of conserved domains in Msg proteins and provide a detailed description of the classification, unique characteristics, and phylogenetic relatedness of five Msg families. We further describe, for the first time, the relative expression levels of individual msg families in two rodent Pneumocystis species, the substantial variability of the msg repertoires in P. carinii from laboratory and wild rats, and the distinct features of the expression site for the classic msg genes in Pneumocystis from 8 mammalian host species. Our analysis suggests multiple functions for this superfamily rather than just conferring antigenic variation to allow immune evasion as previously believed. This study provides a rich source of information that lays the foundation for the continued experimental exploration of the functions of the Msg superfamily in Pneumocystis biology.

IMPORTANCE Pneumocystis continues to be a major cause of disease in humans with immunodeficiency, especially those with HIV/AIDS and organ transplants, and is being seen with increasing frequency worldwide in patients treated with immunodepleting monoclonal antibodies. Annual health care associated with Pneumocystis pneumonia costs ~$475 million dollars in the United States alone. In addition to causing overt disease in immunodeficient individuals, Pneumocystis can cause subclinical infection or colonization in healthy individuals, which may play an important role in species preservation and disease transmission. Our work sheds new light on the diversity and complexity of the msg superfamily and strongly suggests that the versatility of this superfamily reflects multiple functions, including antigenic variation to allow immune evasion and optimal adaptation to host environmental conditions to promote efficient infection and transmission. These findings are essential to consider in developing new diagnostic and therapeutic strategies.

ABSTRACT

The appressoria that are generated by the rice blast fungus Magnaporthe oryzae in response to surface cues are important for successful colonization. Previous work showed that regulators of G-protein signaling (RGS) and RGS-like proteins play critical roles in appressorium formation. However, the mechanisms by which these proteins orchestrate surface recognition for appressorium induction remain unclear. Here, we performed comparative transcriptomic studies of Morgs mutant and wild-type strains and found that M. oryzae Aa91 (MoAa91), a homolog of the auxiliary activity family 9 protein (Aa9), was required for surface recognition of M. oryzae. We found that MoAA91 was regulated by the MoMsn2 transcription factor and that its disruption resulted in defects in both appressorium formation on the artificial inductive surface and full virulence of the pathogen. We further showed that MoAa91 was secreted into the apoplast space and was capable of competing with the immune receptor chitin elicitor-binding protein precursor (CEBiP) for chitin binding, thereby suppressing chitin-induced plant immune responses. In summary, we have found that MoAa91 is a novel signaling molecule regulated by RGS and RGS-like proteins and that MoAa91 not only governs appressorium development and virulence but also functions as an effector to suppress host immunity.

IMPORTANCE The rice blast fungus Magnaporthe oryzae generates infection structure appressoria in response to surface cues largely due to functions of signaling molecules, including G-proteins, regulators of G-protein signaling (RGS), mitogen-activated protein (MAP) kinase pathways, cAMP signaling, and TOR signaling pathways. M. oryzae encodes eight RGS and RGS-like proteins (MoRgs1 to MoRgs8), and MoRgs1, MoRgs3, MoRgs4, and MoRgs7 were found to be particularly important in appressorium development. To explore the mechanisms by which these proteins regulate appressorium development, we have performed a comparative in planta transcriptomic study and identified an auxiliary activity family 9 protein (Aa9) homolog that we named MoAa91. We showed that MoAa91 was secreted from appressoria and that the recombinant MoAa91 could compete with a chitin elicitor-binding protein precursor (CEBiP) for chitin binding, thereby suppressing chitin-induced plant immunity. By identifying MoAa91 as a novel signaling molecule functioning in appressorium development and an effector in suppressing host immunity, our studies revealed a novel mechanism by which RGS and RGS-like proteins regulate pathogen-host interactions.

ABSTRACT

Dermonecrotic toxin (DNT) is one of the representative toxins produced by Bordetella pertussis, but its role in pertussis, B. pertussis infection, remains unknown. In this study, we identified the T-type voltage-gated Ca²⁺ channel Ca_V3.1 as the DNT receptor by CRISPR-Cas9-based genome-wide screening. As Ca_V3.1 is highly expressed in the nervous system, the neurotoxicity of DNT was examined. DNT affected cultured neural cells and caused flaccid paralysis in mice after intracerebral injection. No neurological symptoms were observed by intracerebral injection with the other major virulence factors of the organisms, pertussis toxin and adenylate cyclase toxin. These results indicate that DNT has aspects of the neurotropic virulence factor of B. pertussis. The possibility of the involvement of DNT in encephalopathy, which is a complication of pertussis, is also discussed.

IMPORTANCE Bordetella pertussis, which causes pertussis, a contagious respiratory disease, produces three major protein toxins, pertussis toxin, adenylate cyclase toxin, and dermonecrotic toxin (DNT), for which molecular actions have been elucidated. The former two toxins are known to be involved in the emergence of some clinical symptoms and/or contribute to the establishment of bacterial infection. In contrast, the role of DNT in pertussis remains unclear. Our study shows that DNT affects neural cells through specific binding to the T-type voltage-gated Ca²⁺ channel that is highly expressed in the central nervous system and leads to neurological disorders in mice after intracerebral injection. These data raise the possibility of DNT as an etiological agent for pertussis encephalopathy, a severe complication of B. pertussis infection.

ABSTRACT

The human gut microbiota (HGM) has far-reaching impacts on human health and nutrition, which are fueled primarily by the metabolism of otherwise indigestible complex carbohydrates commonly known as dietary fiber. However, the molecular basis of the ability of individual taxa of the HGM to address specific dietary glycan structures remains largely unclear. In particular, the utilization of β(1,3)-glucans, which are widespread in the human diet as yeast, seaweed, and plant cell walls, had not previously been resolved. Through a systems-based approach, here we show that the symbiont Bacteroides uniformis deploys a single, exemplar polysaccharide utilization locus (PUL) to access yeast β(1,3)-glucan, brown seaweed β(1,3)-glucan (laminarin), and cereal mixed-linkage β(1,3)/β(1,4)-glucan. Combined biochemical, enzymatic, and structural analysis of PUL-encoded glycoside hydrolases (GHs) and surface glycan-binding proteins (SGBPs) illuminates a concerted molecular system by which B. uniformis recognizes and saccharifies these distinct β-glucans. Strikingly, the functional characterization of homologous β(1,3)-glucan utilization loci (1,3GUL) in other Bacteroides further demonstrated that the ability of individual taxa to utilize β(1,3)-glucan variants and/or β(1,3)/β(1,4)-glucans arises combinatorially from the individual specificities of SGBPs and GHs at the cell surface, which feed corresponding signals to periplasmic hybrid two-component sensors (HTCSs) via TonB-dependent transporters (TBDTs). These data reveal the importance of cooperativity in the adaptive evolution of GH and SGBP cohorts to address individual polysaccharide structures. We anticipate that this fine-grained knowledge of PUL function will inform metabolic network analysis and proactive manipulation of the HGM. Indeed, a survey of 2,441 public human metagenomes revealed the international, yet individual-specific, distribution of each 1,3GUL.

IMPORTANCE Bacteroidetes are a dominant phylum of the human gut microbiota (HGM) that target otherwise indigestible dietary fiber with an arsenal of polysaccharide utilization loci (PULs), each of which is dedicated to the utilization of a specific complex carbohydrate. Here, we provide novel insight into this paradigm through functional characterization of homologous PULs from three autochthonous Bacteroides species, which target the family of dietary β(1,3)-glucans. Through detailed biochemical and protein structural analysis, we observed an unexpected diversity in the substrate specificity of PUL glycosidases and glycan-binding proteins with regard to β(1,3)-glucan linkage and branching patterns. In combination, these individual enzyme and protein specificities support taxon-specific growth on individual β(1,3)-glucans. This detailed metabolic insight, together with a comprehensive survey of individual 1,3GULs across human populations, further expands the fundamental roadmap of the HGM, with potential application to the future development of microbial intervention therapies.

In order to establish sustainable heat loading (heat removal and storage) in abandoned flooded mine workings it is important to understand the geomechanical impact of the cyclical heat loading caused by fluid injection and extraction. This is particularly important where significantly more thermal loading is planned than naturally occurs. A simple calculation shows that the sustainable geothermal heat flux from abandoned coal mines can provide less than a tenth of Scotland's annual domestic heating demand. Any heat removal greater than the natural heat flux will lead to heat mining unless heat storage options are also considered.

As a first step, a steady-state, fully saturated, 2D coupled hydromechanical model of a generalized section of pillar-and-stall workings has been created. Mine water rebound was modelled by increasing the hydrostatic pressure sequentially, in line with monitored mine water-level data from Midlothian, Scotland. The modelled uplift to water-level rise ratio of 1.4 mm m^–1 is of the same order of magnitude (1 mm m^–1) as that observed through interferometric synthetic aperture radar (InSAR) data in the coalfield due to mine water rebound. The modelled magnitude of shear stress at the pillar corners, as a result of horizontal and vertical displacement, is shown to increase linearly with water level. Mine heat systems are expected to cause smaller changes in pressure than those modelled but the results provide initial implications on the potential geomechanical impacts of mine water heat schemes which abstract or inject water and heat into pillar-and-stall coal mine workings.

Thematic collection: This article is part of the SJG Collection on Early-Career Research available at: https://www.lyellcollection.org/cc/SJG-early-career-research

Studies of the former NE England coalfield in Tyneside demonstrated that heat flow perturbations in boreholes were due to the entrainment and lateral dispersion of heat from deeper in the subsurface through flooded mine workings. This work assesses the influence of historical mining on geothermal observations across Greater Glasgow. The regional heat flow for Glasgow is 60 mW m^–2 and, after correction for palaeoclimate, is estimated as c. 80 mW m^–2. An example of reduced heat flow above mine workings is observed at Hallside (c. 10 km SE of Glasgow), where the heat flow through a 352 m deep borehole is c. 14 mW m^–2. Similarly, the heat flow across the 199 m deep GGC01 borehole in the Glasgow Geothermal Energy Research Field Site is c. 44 mW m^–2. The differences between these values and the expected regional heat flow suggest a significant component of horizontal heat flow into surrounding flooded mine workings. This deduction also influences the quantification of deeper geothermal resources, as extrapolation of the temperature gradient above mine workings would underestimate the temperature at depth. Future projects should consider the influence of historical mining on heat flow when temperature datasets such as these are used in the design of geothermal developments.

Supplementary material: Background information on the chronology of historical mining at each borehole location and a summary of groundwater flow in mine workings beneath Glasgow are available at https://doi.org/10.6084/m9.figshare.c.4681100

Thematic collection: This article is part of the ‘Early Career Research’ available at: https://www.lyellcollection.org/cc/SJG-early-career-research

Key Points