A l'Arxiu Històric de Barcelona acaba d'ingressar tota la documentació del Projecte d'un Ferrocarril Metropolità Circular per a Barcelona, que proposava una xarxa a partir d'anelles que s'entrellacen, amb un abast descomunal. via Pocket

For this edition of Passport, Kevin Wierzbicki tells us about new releases from Esbe, Cathy Fink & Marcy Marxer with Chao Tian, Les Arrivants, and Tasha Smith Godinez

What has the Agenda Been Like Okay, recently there have been significant changes going on behind the scenes for the company. Not only has the company created new added features to the custom content management system, a new invoice system has been created as well. The new editions to the system required some intensive Cold […]

velocityconf: New #velocityconf CA program preview is up: http://t.co/rKjf91RXdD @ariyahidayat on End-to-End JS Quality Analysis.

RUTHERFORD, N.J., Dec. 5, 2023 — Intelligent Light has announced it has been selected by AFWERX for a Direct-to-Phase II contract in the amount of $1.15 Million focused on IntelliTwin […]

The post AFWERX Selects IntelliTwin as the Realizable Digital Thread for HPC-scale CFD appeared first on HPCwire.

Smithsonian magazine covers history, science and culture in the way only it can — through a lens on the world that is insightful and grounded in richly reported stories. On There's More to That, meet the magazine's journalists and hear how they discover the forces behind the biggest issues of our time. 

Read the in depth Review of Sapphire PULSE AMD Radeon RX 5600 XT 6G GDDR6 PC Components. Know detailed info about Sapphire PULSE AMD Radeon RX 5600 XT 6G GDDR6 configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

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Read the in depth Review of AMD Radeon RX 7900 XTX Graphics Card PC Components. Know detailed info about AMD Radeon RX 7900 XTX Graphics Card configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

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The CPIM lost one of its pillars today as Sitaram Yechury, the party's three-time general secretary, strategist, think tank, author and editor of its mouthpiece People's Democracy, died at the age of 72.

Title: Why Aren't Rx Weight-Loss Drugs More in Demand?
Category: Health News
Created: 8/28/2014 11:01:00 AM
Last Editorial Review: 8/28/2014 12:00:00 AM

The transcription factor (TF) cone-rod homeobox (CRX) is essential for the differentiation and maintenance of photoreceptor cell identity. Several human CRX variants cause degenerative retinopathies, but most are variants of uncertain significance. We performed a deep mutational scan (DMS) of nearly all possible single amino acid substitutions in CRX using a cell-based transcriptional reporter assay, curating a high-confidence list of nearly 2000 variants with altered transcriptional activity. In the structured homeodomain, activity scores closely aligned to a predicted structure and demonstrated position-specific constraints on amino acid substitution. In contrast, the intrinsically disordered transcriptional effector domain displayed a qualitatively different pattern of substitution effects, following compositional constraints without specific residue position requirements in the peptide chain. These compositional constraints were consistent with the acidic exposure model of transcriptional activation. We evaluated the performance of the DMS assay as a clinical variant classification tool using gold-standard classified human variants from ClinVar, identifying pathogenic variants with high specificity and moderate sensitivity. That this performance could be achieved using a synthetic reporter assay in a foreign cell type, even for a highly cell type-specific TF like CRX, suggests that this approach shows promise for DMS of other TFs that function in cell types that are not easily accessible. Together, the results of the CRX DMS identify molecular features of the CRX effector domain and demonstrate utility for integration into the clinical variant classification pipeline.

$329/£300 graphics card is said to be "future ready" for your 1080p gaming needs.

• Johnson & Johnson Innovative Medicines gives a peek inside its $43 billion gross-to-net bubble

• Optum Rx joins the private label biosimilar bandwagon

• Biosimilars boom for provider-administered drugs

• Fresh evidence of how copay accumulators hurt patients

There’s still time to request an invite to the inaugural Drug Channels Leadership Forum. Attendance will be highly limited. We have already begun extending invitations, so apply now to be considered. Click here to view the full agenda.

VolitionRx�s Nucleosomics� diagnostic platform detects epigenetic changes to fragments of chromosomes, called nucleosomes, that circulate in the blood of cancer patients. Credit: VolitionRx.

The Alloy Origins Core is a tenkeyless mechanical keyboard made of airplane-grade aluminum, which prompts the question: Why don't they make the whole plane out of keyboard?

ADVENTRX Pharmaceuticals Announces Closing of Financing

Bitcoin was inching towards its March 2024 all-time-high price of $73,750.07, but those whose crypto assets are locked with the WazirX exchange after a cyberattack are anxious about missing out

New York, NY : Oxford University Press, [2024]

WazirX proposed launching a decentralised exchange as well as a recovery token for outstanding debt settlement, as users are unable to access their existing crypto

Groucho, Harpo, Chico, and Zeppo will soon be seen in 4K quality. Here’s a look at some of their most tireless routines

MS Dhoni and his love affair with motorcycles need no introduction. Here we shed some light on Mahi's Yamaha RX135 that was one of his first bikes!

https://c2n.me/47rgOtW.jpg

Александр Понятов (1892–1980) — американский инженер, основатель и президент компании Ampex, которая выпустила в 1956 году первый коммерческий видеомагнитофон. До появления этого изобретения единственным способом записи телепередач была съемка кинескопа на пленку, что давало посредственное качество изображения и было дорогостоящим. Так многие ранние телепередачи вообще не попали в архивы. С помощью видеомагнитофона стало возможным записывать передачи и транслировать их через несколько часов в другом часовом поясе. Изобретение было настолько революционным, что коллектив авторов VRX–1000 получил в 1957 году премию «Эмми».

Александр Матвеевич — выходец из крестьянской (позже купеческой) семьи Казанской губернии, учился в ИМТУ и в Германии, ветеран Первой мировой, воевал в Белой армии, иммигрировал в Китай, позже жил во Франции, затем стал гражданином США. Будучи уже 50–летним инженером, в 1944 организовал в своем гараже в Сан–Франциско фирму AMPEX (Alexander М. Poniatoff EXcellence), которая сначала работала на оборонку. После войны Ampex занялась выпуском аудиомагнитофонов. С 1951 года фирма вела разработку технологии записи видео на магнитную ленту и к 1956 представила первый серийный коммерческий образец видеомагнитофона, который опережал прототипы конкурентов: в Ampex VRX–1000 вместо того, чтобы увеличивать скорость движения магнитной ленты, магнитные головки в видеокамере и видеомагнитофоне закреплены на вращающемся с высокой скоростью барабане, что позволило значительно снизить скорость лентопротяжного механизма (а значит, и расход ленты).

На видеопленку Ampex в частности записаны «кухонные дебаты» Никсона и Хрущева (ч1 ч2).
В самом СССР из–за эмбарго пришлось самостоятельно разработать свой видеомагнитофон в 1958–1960 гг.

Написал Fenix на historyporn.d3.ru / комментировать

Chance found me, three years ago, at the end of a brilliant summer day in Leeds, seated at dinner next to a distinguished gentleman, vice-chair of a venerable UK bank.

Aerobic thermoacidophilic archaea belonging to the genus Sulfolobus harbor peroxiredoxins, thiol-dependent peroxidases that assist in protecting the cells from oxidative damage. Here, the crystal structure of the 1-Cys peroxiredoxin from Sulfolobus islandicus, named 1-Cys SiPrx, is presented. A 2.75 Å resolution data set was collected from a crystal belonging to space group P212121, with unit-cell parameters a = 86.8, b = 159.1, c = 189.3 Å, α = β = γ = 90°. The structure was solved by molecular replacement using the homologous Aeropyrum pernix peroxiredoxin (ApPrx) structure as a search model. In the crystal structure, 1-Cys SiPrx assembles into a ring-shaped decamer composed of five homodimers. This quaternary structure corresponds to the oligomeric state of the protein in solution, as observed by size-exclusion chromatography. 1-Cys SiPrx harbors only a single cysteine, which is the peroxidatic cysteine, and lacks both of the cysteines that are highly conserved in the C-terminal arm domain in other archaeal Prx6-subfamily proteins such as ApPrx and that are involved in the association of dimers into higher-molecular-weight decamers and dodecamers. It is thus concluded that the Sulfolobus Prx6-subfamily protein undergoes decamerization independently of arm-domain cysteines.

Artisanal ice cream maker offers frozen cocktail cure that contains bourbon, cayenne, lemon and honey.

Leaders of the team that created DestinationRx or DRX Medicare sales tools have launched the MMB Medicare Sales Platform to help health plans deliver an omni channel consumer experience across their web, telesales and broker channels.

The OCMX™ is pleased to announce the listing of Rx-Precision, Inc. to its online portal which offers Investors and Advisors the ability to participate in this opportunity.

Unification and Integration is key in the fragmented digital health ecosystem

RxBioLabs has started production of CimexiShield the only topical Bed Bug repellent for skin and features 2 types of Bed Bug Relief for travel.

The initiative will support free and unlimited secure virtual visits, appointment scheduling and digital prescription of GI education modules in collaboration with AGA

COVID-19 is creating an imperative to avoid putting entire healthcare facilities and populations at risk. Traditional delivery of face-to-face screening and care can result in contamination, exposing many more patients and healthcare workers

There is no firm timeline in place for the resumption of racing at Parx, but when it does happen, it's going to look quite different. That's the word from Sal DeBunda, president of the Pennsylvania Thoroughbred Horsemen's Association in a video update posted on the group's Facebook page last week. DeBunda explained that Pennsylvania Gov. […]

The post Parx Has Several Hurdles To Clear Before Racing Can Resume appeared first on Horse Racing News | Paulick Report.

We provide an explicit construction for a class of commutative, non-associative algebras for each of the simple Chevalley groups of simply laced type. Moreover, we equip these algebras with an associating bilinear form, which turns them into Frobenius algebras. This class includes a 3876-dimensional algebra on which the Chevalley group of type E8 acts by automorphisms. We also prove that these algebras admit the structure of (axial) decomposition algebras.

We study two notions of topological entropy of correspondences introduced by Friedland and Dinh-Sibony. Upper bounds are known for both. We identify a class of holomorphic correspondences whose entropy in the sense of Dinh-Sibony equals the known upper bound. This provides an exact computation of the entropy for rational semigroups. We also explore a connection between these two notions of entropy.

Let $mathrm{rex}(n, F)$ denote the maximum number of edges in an $n$-vertex graph that is regular and does not contain $F$ as a subgraph. We give lower bounds on $mathrm{rex}(n, F)$, that are best possible up to a constant factor, when $F$ is one of $C_4$, $K_{2,t}$, $K_{3,3}$ or $K_{s,t}$ when $t>s!$.

We prove a Marstrand type slicing theorem for the subsets of the integer square lattice. This problem is the dual of the corresponding projection theorem, which was considered by Glasscock, and Lima and Moreira, with the mass and counting dimensions applied to subsets of $mathbb{Z}^{d}$. In this paper, more generally we deal with a subset of the plane that is $1$ separated, and the result for subsets of the integer lattice follow as a special case. We show that the natural slicing question in this setting is true with the mass dimension.

We give a complete (and surprisingly simple) description of the affine Hecke category for $ ilde{A}_2$ in characteristic zero. More precisely, we calculate the Kazhdan-Lusztig polynomials, give a recursive formula for the projectors defining indecomposable objects and, for each coefficient of a Kazhdan-Lusztig polynomial, we produce a set of morphisms with such a cardinality.

In this paper, we generalize the finiteness of models theorem in [BCHM06] to Kawamata log terminal pairs with fixed Kodaira dimension. As a consequence, we prove that a Kawamata log terminal pair with $mathbb{R}-$boundary has a canonical model, and can be approximated by log pairs with $mathbb{Q}-$boundary and the same canonical model.

This paper begins the project of defining Arthur packets of all unipotent representations for the $p$-adic exceptional group $G_2$. Here we treat the most interesting case by defining and computing Arthur packets with component group $S_3$. We also show that the distributions attached to these packets are stable, subject to a hypothesis. This is done using a self-contained microlocal analysis of simple equivariant perverse sheaves on the moduli space of homogeneous cubics in two variables. In forthcoming work we will treat the remaining unipotent representations and their endoscopic classification and strengthen our result on stability.