I recently met with one of the most actively engaged and supportive members of the American Bakers Association (ABA) and their senior management team. They asked me to provide a market and Washington update.

Even though the year started in a partial government shutdown, the government relations team from the American Bakers Association (ABA) continued to push forward on several key regulatory initiatives.

As of the last regulatory update from the American Bakers Association (ABA), we were coming out of a governmental shutdown. Now, the clock is ticking as we stare down the August recess in Congress and feel continued residual delays from that shutdown.

Hospitals, clinics and related medical centers can now choose from four new onsite consulting services introduced by  J. J. Keller & Associates, Inc.

Ingredient companies announced new hires as well as case studies detailing consumer trends influencing new product development.

New Lens Aims to Treat Contact Lens Wearers Who Suffer from Seasonal Allergies

Arun Mathew lends years of expertise to his work in quality.

Christine M. Grzywna is an expert in banking regulations and risk management in the finance industry

Carl Denny channels years of expertise into his work with Abeona Therapeutics

The Better World Regulatory Coalition Inc. ("BWRCI"), a newly formed international self-regulatory organization (SRO), is pleased to announce the publication of a groundbreaking PCT patent pending and the seating of its founding Board of Advisors.

Brian Lamont Lewis-Hardy is the senior vice president of compliance and accreditation at Intellectual Point

Rita E. Norton is a distinguished expert in public and government affairs

Update on Yeast-based Precision Biopesticide Technology 2023 Plans -- Invitation for Joint Development Partners to Accelerate Development of Multiple Products Using Sustainable Bio-based Precision Crop Protection Technology

Exploring the Impact of ETFs: Regulatory Challenges and the Market Dynamic

Hear from Crypto Vets

The removals market in Melbourne faces dual challenges: regulatory compliance and rising demand.

A federal appellate court ruled that an administrative law judge did not err in relying on a regulatory preamble to support an award of black lung benefits to a veteran…

Workers' compensation defense attorney John P. Kamin will recap the highlights from this year's legislative session during this one-hour webinar. Kamin will also bring you up to date on the…

This discussion, presented by HIRMA, will cover regulations and risk management issues impacting attendees organizations in 2024.

Mass spectrometry-based proteomic landscape of rice reveals a post-transcriptional regulatory role of N  Nature.com

Throughout every facet of the frozen food and beverage industry, companies are preparing to navigate the new food safety landscape created by the Food Safety Modernization Act (FSMA).

WASHINGTON, D.C. -- In response to an order by the Federal Communications Commission setting regulatory fees for Fiscal Year 2021, the following statement can be attributed to NAB Senior Vice President of Communications Ann Marie Cumming:

WASHINGTON, D.C. -- In response to the Federal Communications Commission's proposed regulatory fee rates for Fiscal Year 2022, the following statement can be attributed to NAB President and CEO Curtis LeGeyt:

WASHINGTON, D.C. - In response to the Federal Communications Commission's Fiscal Year 2022 Regulatory Fees Report and Order, the following statement can be attributed to NAB President and CEO Curtis LeGeyt.

WASHINGTON, D.C. – In response to the Federal Communications Commission’s (FCC) Fiscal Year 2023 Regulatory Fees Report and Order, the following statement can be attributed to NAB President and CEO Curtis LeGeyt:

The finalization of a Regulatory Reform Roadmap for Armenia was the focus of a workshop co-organized by the OSCE Office for Democratic Institutions and Human Rights (OSCE/ODIHR), the Ministry of Justice of Armenia and the OSCE Office in Yerevan on 27 and 28 May 2016 in Tsaghkadzor, Armenia.

The workshop provided an opportunity for participants from the executive branch, the legislature, civil society and international organizations to exchange views on how to improve the overall process of lawmaking in the country. Topics discussed included policy-making and legislative planning, public consultations and regulatory impact assessment, as well as monitoring and evaluation of legislation.

The purpose of the workshop was to discuss recommendations for reform from previous thematic lawmaking workshops, conducted in Armenia in 2015, and from OSCE/ODIHR’s 2014 report on the “Comprehensive Assessment of the Legislative Procedure in Armenia”. These recommendations were consolidated in a draft Regulatory Reform Roadmap with concrete action points in early 2016, and this draft provided a basis for workshop discussions.

"The recommendations in the draft Regulatory Reform Roadmap focus on identifying workable solutions and were developed by key Armenian stakeholders during a series of discussions," said Alice Thomas, Chief of ODIHR’s Legislative Support Unit. "The draft Roadmap thus constitutes a home-grown plan for action to address weaknesses identified in the Armenian lawmaking system during discussions at our 2015 workshops."

Arsen Mkrtchyan, First Deputy Minister of Justice of Armenia, said: "We have already begun initiating reforms as indicated in the draft Roadmap. This workshop will help us finalize this document, which will be very useful in helping us plan and implement additional reform processes to make our legislative process less burdensome and more planned, transparent, and participatory."

The consolidating workshop begins the final stage of the process of drafting a Regulatory Reform Roadmap for Armenia, as envisaged by the Memorandum of Understanding signed between OSCE/ODIHR and the Ministry of Justice in 2014. Once ready, the Roadmap will form the basis for future reforms of the legislative process in the country.

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J.J. Keller & Associates, Inc. introduces the 'Live Regulatory Update Service,' offering customized virtual presentations by subject matter experts in areas including FMCSA, DOT, OSHA, EPA, and more.

[This Day] On the back of galloping inflation, regulating expenses, and devaluation of the local currency, a total of 23 leading companies on the Nigeria Exchange Limited (NGX), reported a whooping N5.1 trillion operating expenses in the half year (H1) ended June 2024.

After facing several regulatory obstacles, Elon Musk's Starlink is on the brink of entering the Indian market, a move that could reshape the country's digital landscape.

The planned action signals growing regulatory scrutiny of Walmart-owned Flipkart and Amazon when their sales are rapidly growing in India's $70 billion e-commerce market. An antitrust investigation also found the two companies breached laws by favouring select sellers, Reuters has reported.

“Bermuda has taken a significant step towards sustainable energy development with the introduction of the Electricity Amendment Act 2022 [Consequential Amendments] Regulations 2023,” said Minister of Home Affairs Walter Roban regarding the act, which went into effect on 9th May 2023. “This Act paved the way for introducing the Electricity [Innovative Licence] Regulations 2023 which […]

Sebastian A. Wagner
Oct 1, 2011; 10:M111.013284-M111.013284
Research

Reactive oxygen species (ROS) are an unavoidable host environmental cue for intracellular pathogens such as Mycobacterium tuberculosis and Mycobacterium bovis; however, the signaling pathway in mycobacteria for sensing and responding to environmental stress remains largely unclear. Here, we characterize a novel CmtR-Zur-ESX3-Zn2+ regulatory pathway in M. bovis that aids mycobacterial survival under oxidative stress. We demonstrate that CmtR functions as a novel redox sensor and that its expression can be significantly induced under H2O2 stress. CmtR can physically interact with the negative regulator Zur and de-represses the expression of the esx-3 operon, which leads to Zn2+ accumulation and promotion of reactive oxygen species detoxication in mycobacterial cells. Zn2+ can also act as an effector molecule of the CmtR regulator, using which the latter can de-repress its own expression for further inducing bacterial antioxidant adaptation. Consistently, CmtR can induce the expression of EsxH, a component of esx-3 operon involved in Zn2+ transportation that has been reported earlier, and inhibit phagosome maturation in macrophages. Lastly, CmtR significantly contributes to bacterial survival in macrophages and in the lungs of infected mice. Our findings reveal the existence of an antioxidant regulatory pathway in mycobacteria and provide novel information on stress-triggered gene regulation and its association with host–pathogen interaction.

The bacterial enhancer-binding protein (bEBP) FlrC, controls motility and colonization of Vibrio cholerae by regulating the transcription of class-III flagellar genes in σ54-dependent manner. However, the mechanism by which FlrC regulates transcription is not fully elucidated. Although, most bEBPs require nucleotides to stimulate the oligomerization necessary for function, our previous study showed that the central domain of FlrC (FlrCC) forms heptamer in a nucleotide-independent manner. Furthermore, heptameric FlrCC binds ATP in “cis-mediated” style without any contribution from sensor I motif 285REDXXYR291 of the trans protomer. This atypical ATP binding raises the question of whether heptamerization of FlrC is solely required for transcription regulation, or if it is also critical for ATPase activity. ATPase assays and size exclusion chromatography of the trans-variants FlrCC-Y290A and FlrCC-R291A showed destabilization of heptameric assembly with concomitant abrogation of ATPase activity. Crystal structures showed that in the cis-variant FlrCC-R349A drastic shift of Walker A encroached ATP-binding site, whereas the site remained occupied by ADP in FlrCC-Y290A. We postulated that FlrCC heptamerizes through concentration-dependent cooperativity for maximal ATPase activity and upon heptamerization, packing of trans-acting Tyr290 against cis-acting Arg349 compels Arg349 to maintain proper conformation of Walker A. Finally, a Trp quenching study revealed binding of cyclic-di-GMP with FlrCC. Excess cyclic-di-GMP repressed ATPase activity of FlrCC through destabilization of heptameric assembly, especially at low concentration of protein. Systematic phylogenetic analysis allowed us to propose similar regulatory mechanisms for FlrCs of several Vibrio species and a set of monotrichous Gram-negative bacteria.