Geologic mapping has been one of the most fundamental mandates of the U.S. Geological Survey (USGS) since its establishment in 1879. Congress created the USGS to "classify the public lands and examine the geological structure, mineral resources, and products within and outside the national domain."

A study published in eLife provides new insights on how bats recognise their surroundings to help them build mental maps.

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Creative use of modern tools can throw light on the meaning of Scripture in ways that enhance faith

Tags: election, metaphor, Washington Post

In 2007 the University of St Andrews Web Team (of two) was faced with the daunting task of managing the migration of 4,000+ Web pages from 35 individual Web sites into one new Web site within a content management system. Having explored various methods we settled on using mind maps to successfully the complete the task within 4 months. In this workshop we will begin with an overview of mind mapping before sharing what we did and looking at how you can use this tool to efficiently organise and manage your own content. The session was facilitated by Stephen Evans and Gareth Saunders, St Andrews.

How can we improve global crop mapping? IFPRI’s Spatial Production Allocation Model (SPAM)

Accessibility to consistent, subnational, spatial information on crops globally will be hugely beneficial to  researchers and policy makers. Researchers need this data to evaluate the benefits and costs of adopting new crop and livestock technologies, estimate the impact of climate change on agriculture calculate yield gaps, and analyze the historical evolution of farming systems. Policymakers, […]

The post How can we improve global crop mapping? IFPRI’s Spatial Production Allocation Model (SPAM) appeared first on IFPRI.

Nanoparticle enrichment mass-spectrometry proteomics identifies protein-altering variants for precise pQTL mapping  Nature.com

A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell  Nature.com

The aerospace industry relies on advanced nondestructive testing (NDT) to ensure safety and reliability. Automated technologies, such as phased arrays and 3D scanning, enhance defect detection in aircraft structures, reducing human error. This overview emphasizes the importance of these advancements.

Process mapping is a method to visualize and understand manufacturing processes, similar to a flowchart. It helps identify inefficiencies and delays in the workflow. For example, it can pinpoint the source of delays in an assembly line.

Azuga studied 3.6 million driver behavior datasets from its GPS fleet tracking devices over the first five months of 2019.

Testing and Test Control Notation version 3: The IDL to TTCN-3 mapping

Royal Bermuda Regiment divers are to join forces with an environmental watchdog to help protect the Island’s reef system. And the Regiment and the Bermuda Reef Ecosystem Analysis and Monitoring Programme [BREAM] appealed for volunteer divers and snorkelers to join them in a major reef mapping programme at Elbow Beach in Paget on Sunday. The […]

Mapping Black London — which is led by Northeastern University and aims to “visualise the multi-racial foundations and histories of London and the UK” — has created an interactive map chronicling the life of Bermudian Mary Prince. The organization said, “This exhibit traces the life of Mary Prince through the locations she described in her […]

Cold Fusion 9 Mappings I have been trying to tackle this problem for some time now and have had little to no success with mapping directories directly in the Application.cfc. Trying to extend the Application.cfc seems to be an answer at this time, but not sure just yet. A particular post brought about the ideal […]

Two projects — one that maps the function of the brain’s neuronal network in unprecedented detail and another that combines robotics and light-based computer circuits to create safe self-driving vehicles — have been awarded funding through Princeton’s Eric and Wendy Schmidt Transformative Technology Fund.

An international team of researchers and gamers, led by Princeton’s Mala Murthy and Sebastian Seung, mapped every neuron and every synaptic connection in an adult fruit fly's brain, building a comprehensive “connectome” that represents a massive step toward understanding the human brain.

An anonymous reader quotes a report from 404 Media: Flock is one of the largest vendors of automated license plate readers (ALPRs) in the country. The company markets itself as having the goal to fully "eliminate crime" with the use of ALPRs and other connected surveillance cameras, a target experts say is impossible. [...] Flock and automated license plate reader cameras owned by other companies are now in thousands of neighborhoods around the country. Many of these systems talk to each other and plug into other surveillance systems, making it possible to track people all over the country. "It went from me seeing 10 license plate readers to probably seeing 50 or 60 in a few days of driving around," [said Alabama resident and developer Will Freeman]. "I wanted to make a record of these things. I thought, 'Can I make a database of these license plate readers?'" And so he made a map, and called it DeFlock. DeFlock runs on Open Street Map, an open source, editable mapping software. He began posting signs for DeFlock (PDF) to the posts holding up Huntsville's ALPR cameras, and made a post about the project to the Huntsville subreddit, which got good attention from people who lived there. People have been plotting not just Flock ALPRs, but all sorts of ALPRs, all over the world. [...] When I first talked to Freeman, DeFlock had a few dozen cameras mapped in Huntsville and a handful mapped in Southern California and in the Seattle suburbs. A week later, as I write this, DeFlock has crowdsourced the locations of thousands of cameras in dozens of cities across the United States and the world. He said so far more than 1,700 cameras have been reported in the United States and more than 5,600 have been reported around the world. He has also begun scraping parts of Flock's website to give people a better idea of where to look to map them. For example, Flock says that Colton, California, a city with just over 50,000 people outside of San Bernardino, has 677 cameras. People who submit cameras to DeFlock have the ability to note the direction that they are pointing in, which can help people understand how these cameras are being positioned and the strategies that companies and police departments are using when deploying them. For example, all of the cameras in downtown Huntsville are pointing away from the downtown core, meaning they are primarily focused on detecting cars that are entering downtown Huntsville from other areas.

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The “Reading Peaceniks” The authors of this article are a group of researchers and practitioners who are looking to end the divisiveness of the “reading wars” — and help children learn to read and write with competence and pleasure. See the list of contributing editors as well as the 25 nationally recognized colleagues who support this effort.

Defining discontinuous antigenic epitopes remains a substantial challenge, as exemplified by the case of lipid transfer polyproteins, which are common pollen allergens. Hydrogen/deuterium exchange monitored by NMR can be used to map epitopes onto folded protein surfaces, but only if the complex rapidly dissociates. Modifying the standard NMR-exchange measurement to detect substoichiometric complexes overcomes this time scale limitation and provides new insights into recognition of lipid transfer polyprotein by antibodies. In the future, this new and exciting development should see broad application to a range of tight macromolecular interactions.

Christoforos Neofytidis
Trans. Amer. Math. Soc. 377 (), 5289-5321.
Abstract, references and article information

Intrinsically disordered protein domains often have multiple binding partners. It is plausible that the strength of pairing with specific partners evolves from an initial low affinity to a higher affinity. However, little is known about the molecular changes in the binding mechanism that would facilitate such a transition. We previously showed that the interaction between two intrinsically disordered domains, NCBD and CID, likely emerged in an ancestral deuterostome organism as a low-affinity interaction that subsequently evolved into a higher-affinity interaction before the radiation of modern vertebrate groups. Here we map native contacts in the transition states of the low-affinity ancestral and high-affinity human NCBD/CID interactions. We show that the coupled binding and folding mechanism is overall similar but with a higher degree of native hydrophobic contact formation in the transition state of the ancestral complex and more heterogeneous transient interactions, including electrostatic pairings, and an increased disorder for the human complex. Adaptation to new binding partners may be facilitated by this ability to exploit multiple alternative transient interactions while retaining the overall binding and folding pathway.

Diana Samodova
Dec 1, 2020; 19:2139-2156
Technological Innovation and Resources

Kir2.1, a strong inward rectifier potassium channel encoded by the KCNJ2 gene, is a key regulator of the resting membrane potential of the cardiomyocyte and plays an important role in controlling ventricular excitation and action potential duration in the human heart. Mutations in KCNJ2 result in inheritable cardiac diseases in humans, e.g. the type-1 Andersen-Tawil syndrome (ATS1). Understanding the molecular mechanisms that govern the regulation of inward rectifier potassium currents by Kir2.1 in both normal and disease contexts should help uncover novel targets for therapeutic intervention in ATS1 and other Kir2.1-associated channelopathies. The information available to date on protein-protein interactions involving Kir2.1 channels remains limited. Additional efforts are necessary to provide a comprehensive map of the Kir2.1 interactome. Here we describe the generation of a comprehensive map of the Kir2.1 interactome using the proximity-labeling approach BioID. Most of the 218 high-confidence Kir2.1 channel interactions we identified are novel and encompass various molecular mechanisms of Kir2.1 function, ranging from intracellular trafficking to cross-talk with the insulin-like growth factor receptor signaling pathway, as well as lysosomal degradation. Our map also explores the variations in the interactome profiles of Kir2.1^WT versus Kir2.1^314-315, a trafficking deficient ATS1 mutant, thus uncovering molecular mechanisms whose malfunctions may underlie ATS1 disease. Finally, using patch-clamp analysis, we validate the functional relevance of PKP4, one of our top BioID interactors, to the modulation of Kir2.1-controlled inward rectifier potassium currents. Our results validate the power of our BioID approach in identifying functionally relevant Kir2.1 interactors and underline the value of our Kir2.1 interactome as a repository for numerous novel biological hypotheses on Kir2.1 and Kir2.1-associated diseases.

Trypsin is the protease of choice in bottom-up proteomics. However, its application can be limited by the amino acid composition of target proteins and the pH of the digestion solution. In this study we characterize ProAlanase, a protease from the fungus Aspergillus niger that cleaves primarily on the C-terminal side of proline and alanine residues. ProAlanase achieves high proteolytic activity and specificity when digestion is carried out at acidic pH (1.5) for relatively short (2 h) time periods. To elucidate the potential of ProAlanase in proteomics applications, we conducted a series of investigations comprising comparative multi-enzymatic profiling of a human cell line proteome, histone PTM analysis, ancient bone protein identification, phosphosite mapping and de novo sequencing of a proline-rich protein and disulfide bond mapping in mAb. The results demonstrate that ProAlanase is highly suitable for proteomics analysis of the arginine- and lysine-rich histones, enabling high sequence coverage of multiple histone family members. It also facilitates an efficient digestion of bone collagen thanks to the cleavage at the C terminus of hydroxyproline which is highly prevalent in collagen. This allows to identify complementary proteins in ProAlanase- and trypsin-digested ancient bone samples, as well as to increase sequence coverage of noncollagenous proteins. Moreover, digestion with ProAlanase improves protein sequence coverage and phosphosite localization for the proline-rich protein Notch3 intracellular domain (N3ICD). Furthermore, we achieve a nearly complete coverage of N3ICD protein by de novo sequencing using the combination of ProAlanase and tryptic peptides. Finally, we demonstrate that ProAlanase is efficient in disulfide bond mapping, showing high coverage of disulfide-containing regions in a nonreduced mAb.

Antibodies play essential roles in both diagnostics and therapeutics. Epitope mapping is essential to understand how an antibody works and to protect intellectual property. Given the millions of antibodies for which epitope information is lacking, there is a need for high-throughput epitope mapping. To address this, we developed a strategy, Antibody binding epitope Mapping (AbMap), by combining a phage displayed peptide library with next generation sequencing. Using AbMap, profiles of the peptides bound by 202 antibodies were determined in a single test, and linear epitopes were identified for >50% of the antibodies. Using spike protein (S1 and S2)-enriched antibodies from the convalescent serum of one COVID-19 patient as the input, both linear and conformational epitopes of spike protein specific antibodies were identified. We defined peptide-binding profile of an antibody as the Binding Capacity (BiC). Conceptually, the BiC could serve as a systematic and functional descriptor of any antibody. Requiring at least one order of magnitude less time and money to map linear epitopes than traditional technologies, AbMap allows for high-throughput epitope mapping and creates many possibilities.

Subsidies and Sustainable Agriculture: Mapping the Policy Landscape Research paper sysadmin 10 December 2019

Agricultural subsidies shape production and consumption patterns, with potentially significant effects on poverty, nutrition and other sustainability concerns. This paper maps the different types of support provided by governments to the agricultural sector, and highlights some of the complex political economy dynamics that underpin the relevant policies.

Summary

• Agricultural subsidies, a mainstay of government policy, have a large part in shaping production and consumption patterns, with potentially significant effects as regards poverty, food security, nutrition, and other sustainability concerns such as climate change, land use practices and biodiversity.
• There are multiple types of direct and indirect support provided by governments to various actors in the agricultural sector; and in terms of political economy, there are complex dynamics underpinning the policies that sustain these subsidies.
• Overall, subsidies targeting producers have the most significant effect on production, and the greater trade-distorting effect. These subsidies promote domestic production and discourage imports, leading to overproduction that is largely disposed of on the international market, with the help of export subsidies. This can tend to intensify negative environmental agricultural practices, such as cultivating marginal land, unsustainable types of intensification, or incentivizing excessive pesticide and fertilizer use.
• On the other hand, producer subsidies that are not tied to output of a specific commodity (i.e. delinked) have far fewer distorting impacts and could help to deliver sustainable outcomes. For example, this type of subsidies can require crop diversification or be linked to conservation of permanent grassland.
• Subsidies that enable transfers to consumers, for example through food stamp programmes, also serve to delink production from consumption, can foster healthier diets, can play an important role in delivering food accessibility and security among low-income groups, and can represent one of the less trade-distorting subsidies.
• If subsidies are to be reformed to help promote healthier diets and encourage more sustainable production, it is essential to understand not only the type and amount of support that key countries provide, but also the domestic dynamics that can shape such policies.
• While price support, input subsidies or investment aids remain the central pillars of programmes in large developing countries such as Brazil, China or India, other economies – notably including the EU and Japan – focus on direct payments, support for general services and set-aside schemes, as well as significant border protection. The US, for its part, has tended to focus on subsidized insurance schemes and food programmes for poorer consumers.
• If subsidies are to deliver policy objectives, their design and implementation should delink production from consumption. For example, consumer subsidies designed to deliver nutrition and food security, or payments for environmental services to enable more environmentally friendly production systems, could prove to be the most effective, least trade-distorting means of achieving more sustainable and equitable agricultural production.
• The political economy of food means that the removal of subsidies is often highly sensitive, and tends to be met with significant resistance. However, reform that delinks support from production through a gradual transition process could ultimately prove successful in delivering effective subsidy schemes.
• Effective subsidy schemes must by design be truly result- and performance-based, supported by robust and objective indicators. At the same time, engaging multiple actors along key commodity value chains – including leading importing and exporting countries, traders and transporters – could lead to the development of international, commodity-specific arrangements that are able to deliver effective nutrition and sustainability goals.

Yulia Lerner
Feb 23, 2011; 31:2906-2915
BehavioralSystemsCognitive

Matthew F. Glasser
Aug 10, 2011; 31:11597-11616
BehavioralSystemsCognitive

A team of researchers led by Nanyin Zhang, the Dorothy Foehr Huck and J. Lloyd Huck Chair in Brain Imaging and professor of biomedical engineering at Penn State, recently published their findings about how blood flow changes to different brain regions relate to what is happening with the brain's neurons.

Secretary of Education Mark Holodick is pleased to recognize the following students for their submissions in this year’s Esri’s 2024 ArcGIS webapp competition. Students were challenged to create and share interactive mapping projects using ESRI ArcGIS software. Delaware entrants to this national competition must create a digital Storymap that explores some aspect of life in Delaware.

DNREC announced today the 2025 Community Environmental Project Fund (CEPF) grants will have a focus on equity. This change comes after the CEPF grant process was revamped to better address community needs and strengthen partnerships.

Hi,

i am compiling firmware under Windows transfer the binaries and the sources to Linux to simulate/debug there. The problem is that the paths in the DWARF debug info of the .elf file are the absolute Windows paths as set by the compiler so they are useless under Linux. Is it possible to configure mappings of these paths to the Linux paths when simulating/debugging like with e.g. GDB (https://sourceware.org/gdb/current/onlinedocs/gdb/Source-Path.html#index-set-substitute_002dpath)?

thx,

Peter

Using a laser-based detection system, archaeologists have discovered over 6,500 pre-Hispanic structures -- including a previously unknown Maya city named Valeriana -- in Campeche, Mexico.

The post Laser Mapping Reveals Previously Unknown Maya City with Stone Pyramids in Mexico appeared first on Sci.News: Breaking Science News.

Apr 22, 2024

For most of this century, the Arctic has been a place of peaceful cooperation in science and environmental protection, an approach built on a foundation of multiple agreements reached in the twentieth century. The Russian invasion of Ukraine and the geopolitical reverberations of the war have disrupted or outright halted most collaboration between Western and Russian scientists and conservationists.

Mar 19, 2024

Africa is home to approximately 1.4 billion people[1], about 16 percent of the world’s population, yet its continental share in global trade remains below 3 percent[2], according to the World Trade Organization (WTO). This suboptimal proportion of world trade is compounded by Africa's limited intra-continental trade. During the 26th Africa Business Conference (ABC) held at Harvard Business School (HBS) on the 17^th of February 20, 2024, industry experts, policymakers, students, faculty members, and entrepreneurs converged to interrogate these concerns and explore opportunities for improving intra-African trade. 

How live updating of online maps is helping humanitarian work around the world.

The medical devices industry in India is experiencing remarkable growth, with 2023 revenues reaching approximately (and) #8377;1,04,760 crores (US (Dollor) 12.8 billion).

IWMI and GWP partner with Bhutan’s Department of Water to advance efforts including mapping surface water bodies.

The post Cutting-edge mapping techniques are crucial for managing water storage in South Asia first appeared on International Water Management Institute (IWMI).

medlinkPregnant women/medlink with high levels of certain genetic mutations- especially those associated with involuntary muscle contraction - were less likely to respond to preterm treatment.

Manchester : Manchester University Press, [2018]

Manchester : Manchester University Press, [2018]

The Zoological Survey of India will use eDNA for mapping, monitoring wildlife; help in biodiversity assessments & eradication of aquatic invasive species

Produced by WIRED Brand Lab with Expedia Group | Over the past 10 years, how we travel has been completely transformed by social media, technology, and the gig economy. With the proliferation of short-term rentals, we’ve seen a shift in the way housing in communities operates. Your neighbor could change every weekend, and your little corner bodega is now a travel hot spot. Short-term rentals open up local tourism in a new way. But with new regulations severely limiting short-term rentals in one of the largest cities in the world, what does the future of the industry look like?

BrandXcel’s research reveals changing Indian consumer trends, from pride in Indian products to premiumisation and individualistic decision-making