What do locksmiths have to do with photography? How about expoplanets? Find out on today’s episode. (Episode artwork: DALL-E 2) Topics: [TOOL] SD Recovery : An amazing look at the technology that is used in data recovery to read a broken SD card. [SPACE, PHOTO] Finding Exo Planets : Finding exoplanets has everything to do … Continue reading "912 The Locksmith’s Paradox"

The post 912 The Locksmith’s Paradox appeared first on PHOTOGRAPHY TIPS FROM THE TOP FLOOR.

An organization should be at least at level 3, Defined Systems Approach, of the Management System Maturity Model to reap the rewards of a culture of excellence.

Characteristics of MPLS-TP equipment functional blocks

Characteristics of MPLS-TP equipment functional blocks supporting ITU-T G.8113.1/Y.1372.1 OAM mechanisms

What it is: Recently, the good people at SAM Labs sent me an Alpha Kit to play with and review. You guys, this is such a cool product! I love that as soon as students open it up, it puts them in charge of the learning. Best of all, it encourages the learning to happen...

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Bringing Locks to Life With Strand Hair Technology in Dragon Age: The Veilguard  Electronic Arts Home Page

Interface interoperability is becoming closer to reality, but more work is needed.

LineView Solutions, provider of manufacturing optimisation solutions, has unlocked £5.4M in capacity increase at Britvic’s factory in Rugby, UK through Line Balancing Optimisation (LBO). LineView worked with the leading British beverage manufacturer to execute a comprehensive LBO training project over a two-week period.

President Joe Biden on Monday issued an order blocking a Chinese-backed cryptocurrency mining firm from owning land near a Wyoming nuclear missile base, calling its proximity to the base a “national security risk.” The order forces the divestment of property operated as a crypto mining facility near the Francis E. Warren Air Force Base. It also forces the removal of certain equipment owned by MineOne Partners Ltd., a firm that is partly owned by the Chinese state. The move was made in coordination with the U.S. Committee on Foreign Investment in the United States.

The post Biden blocks Chinese-backed crypto mining firm from land ownership near Wyoming missile base first appeared on Federal News Network.

A federal judge in Idaho issued a block on a state law that would ban gender transitions for children before it was set to go into effect Jan. 1.

AB 2839 aimed to label AI-generated content in political ads as "manipulated." A federal judge says the law violates the 1st Amendment.

Richard Weatherly has always had time on his side…

Locksley Cummings was sentenced to 35 years in prison for multiple counts of sexual exploitation, with the police commending his young victims for their  ”courage in coming forward to bring this situation to the attention of the police.” Acting Assistant Commissioner of Police [Crime] Sean Field-Lament said, “The Bermuda Police Service notes the historic sentence handed […]

The Department of Parks advised the public of a “temporary road obstruction within the Botanical Gardens,” noting that a ”large tree, located near Camden House, suddenly snapped, blocking the roadway within the Botanical Gardens.” A spokesperson said, “A Department of Parks crew is working expeditiously to clear the obstruction and ensure the safety and accessibility of […]

Photo by Elliott Stallion Last week, Georgia blocked Trump-backed election rules that had been recently passed by the State Election Board. Of the seven rules implemented, three gained immense pushback, which included one that required ballots to be counted by hand after polls close and two that dealt with the certification of election results.  Fulton County […]

The post Georgia Judge Blocks Trump’s Election Rules appeared first on Feminist Majority Foundation.

The law requires public schools to display a poster of the Ten Commandments in every classroom.

A Louisiana law that sought to post the Ten Commandments in every schoolroom in the state has been shelved by a federal judge. U.S. District Court Judge John W. deGravelles, […]

The post Obama-Appointed Federal Judge Temporarily Blocks Ten Commandments Law appeared first on The Western Journal.

The dimeric ectonucleotidase CD73 catalyzes the hydrolysis of AMP at the cell surface to form adenosine, a potent suppressor of the immune response. Blocking CD73 activity in the tumor microenvironment can have a beneficial effect on tumor eradication and is a promising approach for cancer therapy. Biparatopic antibodies binding different regions of CD73 may be a means to antagonize its enzymatic activity. A panel of biparatopic antibodies representing the pairwise combination of 11 parental monoclonal antibodies against CD73 was generated by Fab-arm exchange. Nine variants vastly exceeded the potency of their parental antibodies with ≥90% inhibition of activity and subnanomolar EC50 values. Pairing the Fabs of parents with nonoverlapping epitopes was both sufficient and necessary whereas monovalent antibodies were poor inhibitors. Some parental antibodies yielded potent biparatopics with multiple partners, one of which (TB19) producing the most potent. The structure of the TB19 Fab with CD73 reveals that it blocks alignment of the N- and C-terminal CD73 domains necessary for catalysis. A separate structure of CD73 with a Fab (TB38) which complements TB19 in a particularly potent biparatopic shows its binding to a nonoverlapping site on the CD73 N-terminal domain. Structural modeling demonstrates a TB19/TB38 biparatopic antibody would be unable to bind the CD73 dimer in a bivalent manner, implicating crosslinking of separate CD73 dimers in its mechanism of action. This ability of a biparatopic antibody to both crosslink CD73 dimers and fix them in an inactive conformation thus represents a highly effective mechanism for the inhibition of CD73 activity.

A federal judge has blocked a new bill in Louisiana that would require the Bible's Ten Commandments to be displayed in the state's publicly-funded schools.

The judge said the law likely discriminates on the basis of transgender status in violation of the equal-protection clause of the U.S. Constitution.

The U.S. Supreme Court blocked an injunction that had allowed a group backing an Idaho education spending measure to collect electronic signatures because of the coronavirus pandemic.

For over 80 years, the Scurlock photography studio catalogued the lives of the black middle class of Washington, D.C (The exhibit, The Scurlock Studio and Black Washington: Picturing the Promise, is on view at the National Museum of American History through November 15, 2009. Thanks to Lonnie Bunch, Director of the National Museum of African American History and Culture, which co-organized the exhibit). Read more at http://www.smithsonianmag.com/people-places/The-Scurlock-Studio-Picture-of-Prosperity.html

John Hopfield and Geoffrey Hinton shared the award for their work on artificial neural networks and machine learning

Across the country, revelers are dressing in costumes and gliding across bodies of water on stand-up paddleboards to ring in the spooky season

As a troubled local gym goes dark, some members and the landlord say they haven’t heard from the owner about the future of the business in Thunder Bay, Ont.

'EFAB Access' fuels development of miniaturized mechanical structures

A US order to TSMC to cut AI chip supplies to China over Huawei sanctions won't cause problems for Apple. However, Taiwan's prohibition of TSMC producing 2-nanometer chips elsewhere could make an impact.

U.S. sanctions against Huawei has caused problems for TSMC over attempts by intermediaries to order certain AI-based chip designs on Huawei's behalf. From Monday, TSMC is suspending shipments of the AI-focused chips to China, on the orders of the United States.

The Department of Commerce imposed export restrictions of select chip designs that were intended to be shipped to China, an unnamed source of Reuters claims. The shipment ban, which kicks in from Monday, affects certain types of chips made with 7-nanometer processes or advanced designs, intended for AI or graphics processing.


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SARS continues to deny amaBhungane and the Financial Mail's requests for access to former president Jacob Zuma's tax records despite the seminal judgment of the Constitutional Court handed down in May 2023.

The court rules that the decision to unwind deportation relief for nearly 700,000 undocumented immigrants who came to the U.S. as children was done in an “arbitrary and capricious” manner.

The judge said the law likely discriminates on the basis of transgender status in violation of the equal-protection clause of the U.S. Constitution.

Smart Lock Company LockState raised $5.8M Series A in new investment to fund its aggressive sales and marketing and partner development plan. The company previously raised $740K seed round and $1M in a round led by angel investors. The lead investor in latest round was Iron Gate Capital. Other investors include Kozo Keikaku Engineering Inc, Nelnet and Service Provider Capital.

The company’s Wi-Fi-enabled RemoteLock is used by 1000s of Airbnb and other vacation rental hosts. It helps hosts remotely provide access to guests. Locking/unlocking codes can be generated via a host’s computer or smartphone.

RemoteLock’s prices start at $299 which is its algorithmic ResortLock. The most pricey lock by LockState is its ‘RemoteLock 7i Black WiFi Commercial Smart Lock’ which costs $479.

Another core product of LockState is its cloud-based remote access platform for internet-enabled locks. It implies users can remotely manage their (internet-enabled) locks via LockState’s cloud platform.

Unlike smartphones and watches, customers don’t look forward to upgrading their smart locks or buying one when new models are launched. Thus, smart lock companies offset this disadvantage by partnering with property management and short-term rental companies to get new customers.

LockState has partnered with vacation rental brands like Airbnb, HomeAway, and other listing partners to automate guest access.

“We are expanding our footprint and moving into a new warehouse office that is more than twice the size of our current office. We’re also staffing up our sales and marketing teams. We’ve accomplished a lot without investing heavily in marketing so we’ll support that area to keep our momentum going. We intend to expand into new business-to-business and enterprise verticals where we’re seeing the market grow. We are also dedicating budget toward development.” Nolan Mondrow, CEO of LockState in a statement released to news site Venture Beat

Igloohome a Singapore-based smart lock company also raised an investment of $4M in April this year.

In most vertebrates, a pattern of chemical marks on the genome is a reliable indicator of age, but in axolotls this clock seems to stop after the first four years of life

An AI-assisted robot can listen to spoken commands and assemble 3D objects such as chairs and tables out of reusable building blocks

Comprehensive maps of neuronal connectivity provide a foundation for understanding the structure of neural circuits. In a circuit, neurons are diverse in morphology, electrophysiology, gene expression, activity, and other neuronal properties. Thus, constructing a comprehensive connectivity map requires associating various properties of neurons, including their connectivity, at cellular resolution. A commonly used approach is to use the gene expression profiles as an anchor to which all other neuronal properties are associated. Recent advances in genomics and anatomical techniques dramatically improved the ability to determine and associate the long-range projections of neurons with their gene expression profiles. These studies revealed unprecedented details of the gene–projection relationship, but also highlighted conceptual challenges in understanding this relationship. In this article, I delve into the findings and the challenges revealed by recent studies using state-of-the-art neuroanatomical and transcriptomic techniques. Building upon these insights, I propose an approach that focuses on understanding the gene–projection relationship through basic features in gene expression profiles and projections, respectively, that associate with underlying cellular processes. I then discuss how the developmental trajectories of projections and gene expression profiles create additional challenges and necessitate interrogating the gene–projection relationship across time. Finally, I explore complementary strategies that, together, can provide a comprehensive view of the gene–projection relationship.

An AI-assisted robot can listen to spoken commands and assemble 3D objects such as chairs and tables out of reusable building blocks

Modern life disrupts the circadian rhythms controlling our biology – increasing our risk of developing conditions ranging from diabetes to dementia. Lynne Peeples's new book The Inner Clock explores and offers solutions

The new Louisiana requirement that the Ten Commandments be displayed in every public classroom by Jan. 1 was temporarily blocked Tuesday. The judge said the law is "unconstitutional on its face."

Starring Tamannaah Bhatia, Jimmy Shergill, and Avinash Tiwary, ‘Sikandar Ka Muqaddar’ is directed by Neeraj Pandey

Sweat: We all do it. It plays an essential role in controlling body temperature by cooling the skin through evaporation. But it can also carry salts and other molecules out of the body in the process. In medieval Europe, people would lick babies; if the skin was salty, they knew that serious illness was likely. (We now know that salty skin can be an indicator for cystic fibrosis.)

Scientists continue to study how the materials in sweat can reveal details about an individual’s health, but often they must rely on gathering samples from subjects during strenuous exercise in order to get samples that are sufficiently large for analysis.

Now researchers in China have developed a wearable sensor system that can collect and process small amounts of sweat while providing continuous detection. They have named the design a “skin-interfaced intelligent graphene nanoelectronic” patch, or SIGN for short. The researchers, who described their work in a paper published in Advanced Functional Materials, did not respond to IEEE Spectrum’s interview requests.

The SIGN sensor patch relies on three separate components to accomplish its task. First, the sweat must be transported from the skin into microfluidic chambers. Next, a special membrane removes impurities from the fluid. Finally, this liquid is delivered to a bioreceptor that can be tuned to detect different metabolites.

The transport system relies on a combination of hydrophilic (water-attracting) and hydrophobic (water-repelling) materials. This system can move aqueous solutions along microchannels, even against gravity. This makes it possible to transport small samples with precision, regardless of the device’s orientation.

The fluid is transported to a Janus membrane, where impurities are blocked. This means that the sample that reaches the sensor is more likely to produce accurate results.

Finally, the purified sweat arrives at a flexible biosensor. This graphene sensor is activated by enzymes designed to detect the desired biomarker. The result is a transistor that can accurately measure the amount of the biomarker in the sample.

At its center, the system has a membrane that removes impurities from sweat and a biosensor that detects biomarkers.Harbin Institute of Technology/Shenyang Aerospace University

One interesting feature of the SIGN patch is that it can provide continuous measurements. The researchers tested the device through multiple cycles of samples with known concentrations of a target biomarker, and it was about as accurate after five cycles as it was after just one. This result suggests that it could be worn over an extended period without having to be replaced.

Continuous measurements can provide useful longitudinal data. However, Tess Skyrme, a senior technology analyst at the research firm IDTechEx, points out that continuous devices can have very different sampling rates. “Overall, the right balance of efficient, comfortable, and granular data collection is necessary to disrupt the market,” she says, noting that devices also need to optimize “battery life, calibration, and data accuracy.”

The researchers have focused on lactate—a metabolite that can be used to assess a person’s levels of exercise and fatigue—as the initial biomarker to be detected. This function is of particular interest to athletes, but it can also be used to monitor the health status of workers in jobs that require strenuous physical activity, especially in hazardous or extreme working conditions.

Not all experts are convinced that biomarkers in sweat can provide accurate health data. Jason Heikenfeld, director of the Novel Device Lab at the University of Cincinnati, has pivoted his research on wearable biosensing from sweat to the interstitial fluid between blood vessels and cells. “Sweat glucose and lactate are way inferior to measures that can be made in interstitial fluid with devices like glucose monitors,” he tells Spectrum.

The researchers also developed a package to house the sensor. It’s designed to minimize power consumption, using a low-power microcontroller, and it includes a Bluetooth communications chip to transmit data wirelessly from the SIGN patch. The initial design provides for 2 hours of continuous use without charging, or up to 20 hours in standby mode.

An AI-assisted robot can listen to spoken commands and assemble 3D objects such as chairs and tables out of reusable building blocks

“My very first experience was in asking the cards about a novel I was writing at the time and it wasn’t going anywhere," says Chelsey Pippin Mizzi in an interview with Lauren Parker. “Up until that point, so much of my writing had been informed by visuals. And then suddenly there were these three pocket-sized pictures that were inviting me to consider creative ideas.” 

Continue reading “Tarot for Creativity” helps writers and artists get through creative blocks at The Wild Hunt.

Employees must stick to official channels to make sure their messages are fully retrievable.

Shahid Kapoor and Kareena Kapoor were once the hottest love birds of Bollywood, but something went wrong in their relationship, leading them to part ways. However, before breaking-up, they had hit more headlines than any other couple in B-town. Notably, over their on-screen and off-screen kisses!

Citadel: Honey Bunny intertwines elements of romance, humour, and suspense, navigating between the 1990s and 2000s, highlighting the lead actors' chemistry and action sequences. Directed by Raj & DK, the series also stars Kay Kay Menon.