Hurricane Ian has caused catastrophic damage to life, property, and infrastructure across Florida, and it is headed toward Georgia and the Carolinas. The National Academies have many resources aimed at better understanding hurricanes, how climate change may be affecting their intensity and frequency, and how communities can become more resilient to extreme events.

For the first time, researchers from the Wellcome Trust Sanger Institute and their collaborators have been able to identify in human cancers two characteristic patterns of DNA damage caused by ionising radiation. These fingerprint patterns may now enable doctors to identify which tumours have been caused by radiation, and investigate if they should be treated differently.

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An innovative underground radar technology developed at Louisiana Tech University is helping the City of Slidell in south Louisiana to identify and document underground infrastructure damage that had gone undetected in the months and years following Hurricane Katrina.

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We are a full service plumbing company. There are times when we have to gain access to the roof of million dollar homes. 

Damage Control now Manufactures 3D Printed Mouth Guards.

After a storm, it is vital to check your home and property as soon as possible. If you find that you did suffer damage, it is in your best interest to file a homeowners insurance claim as soon as possible.

Tips to avoid costly water damage

Avoid costly property damage with these tips

For homeowners, spring can be a beautiful time of the year, but damaging spring storms can spring up at any time and if your property is not prepared, springtime can be costly.

Here a 5 ways to minimize wind and rain damage to your property.

The Rise in Pandemic Injuries

Complaint alleges that Kasamba misclassified the Plaintiff and other Readers as independent contractors, seeking to avoid various duties and obligations owed to employees under California's Labor Code and wage orders

Fast Guard Service Provides Critical Support to Flash Flooding Victims in Hurricane's Path

A New York appellate court ruled that the defendants in a Labor Law action were entitled to a trial, but they could not have a jury’s determination on damages set…

The U.S. 10th Circuit Court of Appeals ruled that an employer was entitled to more than $541,000 in damages for its insurance carrier’s breach of contract. Case: MVT Services LLC v. Great…

A New York appellate court overturned an award of damages after a defendant’s default in a Labor Law case, finding the award inadequate. Case: Sharif v. Pritam Property Inc., Nos. 2021-09103…

Prevention is better than cure, we all know this, and this is true not only for people, but also for the health of your electrical and electronic components and equipment. Smart and cost-effective strategies demand an investment in surge protection.... Read more

The post How to handle overvoltages before any damage is done? Surge protection in a nutshell. appeared first on EEP - Electrical Engineering Portal.

Michael Vervena gives us tips on navigating water damage restoration and the adoption of technology to document the damage and streamline insurance claims.

Understanding how water behaves during freezing and thawing is essential for effective water damage restoration during the winter months.

Insurer provides complimentary smart home kit, premium discount to customers.

We delve into the challenges insurance company’s face when categorizing the different levels of water intrusion and the importance of why this is a big issue if done incorrectly.

A new paper presents the first clear evidence that the relationship between fog levels and vegetation status is measurable using remote sensing. The discovery opens up the potential to easily and rapidly assess fog's impact on ecological health across large land masses -- as compared to painstaking ground-level observation.

The post Hydrologists show environmental damage from fog reduction is observable from outer space appeared first on GeoSpace.

At #COP29Azerbaijan, Jeroom Remmers says “Producers of meat & dairy should pay for the damage they cause [to climate]. It’s normal, when I damage the window of my neighbor, I have to repair this damage, but meat & dairy processors also have to repair the damage they cause” pic.twitter.com/91XX5zm6fI — Tom Elliott (@tomselliott) November 12, […]

Thanks to polyurethane foam and Polyglass silicone coating, this 1-million-square-foot warehouse in Texas took on the brunt of an EF2 tornado.

Solar panels have shown remarkable resilience in severe weather, but falling debris or installation issues can sometimes cause damage; Panasonic offers some steps to prepare and protect solar panels from severe storms.

Labor law can be confusing and may lead a company into unintentional non-compliance. Work “prep” time, like training,  is technically considered "work" by the Wage and Hour Division of the U.S. Department of Labor.

Kyiv battles fires and damage after multiple drone blitzes

Judge calls for a swift end to experts secretly using AI to sway cases.

Location: Engineering Library- TA656.N53 2016

Location: Engineering Library- TA409.L346 2016

http://www.musicxray.com/xrays/2672475 Carolyn202 - Broken Damaged Defective

How a unique wilderness in the Democratic Republic of Congo is being revived and preserved for future generations.

A unique wilderness in the Democratic Republic of Congo is being revived and preserved for future generations.

The Canadian Pharmacy Spammers are at it again, or should we say still at it again.

A Delta Airlines flight flying from Detroit landed safely at Denver International Airport on Monday after a mid-flight mechanical issue damaged the plane’s nose.

A wildfire northwest of Fort Collins on Tuesday burned 15 to 30 acres.

A man who pleaded guilty to willful damage in connection with car fires was given a suspended sentence, with the Judge noting the accused was the recent victim of a burgled home shortly prior to his commission of the offence and he was unable to retrieve his medication. Justis Iris appeared before the Court for sentence following […]

Teacher question: I understand your claims that teaching students with grade-level texts instead of instructional level texts increases children’s opportunities to learn. However, what about children’s emotional needs, self-esteem, motivation, and self-starting skills when text is challenging. Children who struggle with sight words or sounding out words who are given a hard piece of text will shut down and refuse to try or will act out in the classroom.

Loss and damage: Where are we now and what happens next? 25 January 2022 — 1:00PM TO 2:00PM Anonymous (not verified) 17 January 2022 Online

This event discusses the progress of the loss and damage agenda within climate negotiations. 

Loss and damage refers to harms and destruction caused by climate change impacts that cannot be avoided through mitigation or adaptation.

While it has gained increasing recognition in international climate change negotiations, turning the concept of loss and damage into tangible action for climate-vulnerable countries has been contentious.

Loss and damage is interwoven with issues of fairness and equity. The issue is highly disputed due to its connection with the historical responsibility of developed countries in causing climate change, as well as associated calls for compensation from developing countries.

At COP26, Scotland became the first government to pledge funds for loss and damage for countries in the Global South. However, most climate-vulnerable countries left disappointed by the failure of the Glasgow Climate Pact to secure the establishment of a dedicated loss and damage financing facility.

Developing countries have made it clear that they will continue to push for a new financing facility in the Glasgow Dialogue, a set of international discussions on loss and damage kicking off in June.

The Environment and Society Discussion Series is hosting two events on loss and damage ahead of that date. This first event outlines the key debates and discuss what progress has been made on advancing the loss and damage agenda within climate negotiations to date.

The second event focuses on solutions and possible ways forward, looking ahead to the COP27 negotiations in Egypt later in 2022, where loss and damage is expected to be a high-profile agenda item.

A deep dive into loss and damage solutions 8 February 2022 — 1:00PM TO 2:15PM Anonymous (not verified) 31 January 2022 Online

This second event of our loss and damage series cuts through polarized debate by bringing together international experts to discuss innovative legal and financial approaches.

This event will focus on a deep dive into constructive solutions and progress made to address loss and damage.

Following the first event of this two-part series, ‘Loss and Damage – where are we now and what happens next’, this event focuses on a deep dive into constructive solutions and progress made to address loss and damage.

Loss and damage refers to harms and destruction caused by climate change impacts that cannot be avoided through mitigation or adaptation. While it has gained increasing recognition in international climate change negotiations, turning the concept of loss and damage into tangible action for climate-vulnerable countries has been contentious.

Loss and damage is interwoven with issues of fairness and equity. The issue is highly disputed due to its connection with the historical responsibility of developed countries in causing climate change, as well as associated calls for compensation from developing countries.

At COP26, Scotland became the first government to pledge funds for loss and damage for countries in the Global South. However, most climate-vulnerable countries left disappointed by the failure of the Glasgow Climate Pact to secure the establishment of a dedicated loss and damage financing facility.

Developing countries have made it clear that they will continue to push for a new financing facility in the Glasgow Dialogue, a set of international discussions on loss and damage kicking off in June. The Environment and Society Discussion Series is hosting two events on loss and damage ahead of that date.

This second event convenes a deep dive into the progress and potential on loss and damage solutions, while also examining the hurdles that are still to overcome to make loss and damage support a reality.

We have observed overexpression of PACS-1, a cytosolic sorting protein in primary cervical tumors. Absence of exonic mutations and overexpression at the RNA level suggested a transcriptional and/or posttranscriptional regulation. University of California Santa Cruz genome browser analysis of PACS-1 micro RNAs (miR), revealed two 8-base target sequences at the 3' terminus for hsa-miR-34a and hsa-miR-449a. Quantitative RT-PCR and Northern blotting studies showed reduced or loss of expression of the two microRNAs in cervical cancer cell lines and primary tumors, indicating dysregulation of these two microRNAs in cervical cancer. Loss of PACS-1 with siRNA or exogenous expression of hsa-miR-34a or hsa-miR-449a in HeLa and SiHa cervical cancer cell lines resulted in DNA damage response, S-phase cell cycle arrest, and reduction in cell growth. Furthermore, the siRNA studies showed that loss of PACS-1 expression was accompanied by increased nuclear γH2AX expression, Lys382-p53 acetylation, and genomic instability. PACS-1 re-expression through LNA-hsa-anti-miR-34a or -449a or through PACS-1 cDNA transfection led to the reversal of DNA damage response and restoration of cell growth. Release of cells post 24-h serum starvation showed PACS-1 nuclear localization at G1-S phase of the cell cycle. Our results therefore indicate that the loss of hsa-miR-34a and hsa-miR-449a expression in cervical cancer leads to overexpression of PACS-1 and suppression of DNA damage response, resulting in the development of chemo-resistant tumors.

In nucleotide excision repair, bulky DNA lesions such as UV-induced cyclobutane pyrimidine dimers are removed from the genome by concerted dual incisions bracketing the lesion, followed by gap filling and ligation. So far, two dual-incision patterns have been discovered: the prokaryotic type, which removes the damage in 11–13-nucleotide-long oligomers, and the eukaryotic type, which removes the damage in 24–32-nucleotide-long oligomers. However, a recent study reported that the UvrC protein of Mycobacterium tuberculosis removes damage in a manner analogous to yeast and humans in a 25-mer oligonucleotide arising from incisions at 15 nt from the 3´ end and 9 nt from the 5´ end flanking the damage. To test this model, we used the in vivo excision assay and the excision repair sequencing genome-wide repair mapping method developed in our laboratory to determine the repair pattern and genome-wide repair map of Mycobacterium smegmatis. We find that M. smegmatis, which possesses homologs of the Escherichia coli uvrA, uvrB, and uvrC genes, removes cyclobutane pyrimidine dimers from the genome in a manner identical to the prokaryotic pattern by incising 7 nt 5´ and 3 or 4 nt 3´ to the photoproduct, and performs transcription-coupled repair in a manner similar to E. coli.

Timely repair of DNA double-strand breaks (DSBs) is essential to maintaining genomic integrity and preventing illnesses induced by genetic abnormalities. We previously demonstrated that the E3 ubiquitin ligase SMURF2 plays a critical tumor suppressing role via its interaction with RNF20 (ring finger protein 20) in shaping chromatin landscape and preserving genomic stability. However, the mechanism that mobilizes SMURF2 in response to DNA damage remains unclear. Using biochemical approaches and MS analysis, we show that upon the onset of the DNA-damage response, SMURF2 becomes phosphorylated at Ser384 by ataxia telangiectasia mutated (ATM) serine/threonine kinase, and this phosphorylation is required for its interaction with RNF20. We demonstrate that a SMURF2 mutant with an S384A substitution has reduced capacity to ubiquitinate RNF20 while promoting Smad3 ubiquitination unabatedly. More importantly, mouse embryonic fibroblasts expressing the SMURF2 S384A mutant show a weakened ability to sustain the DSB response compared with those expressing WT SMURF2 following etoposide treatment. These data indicate that SMURF2-mediated RNF20 ubiquitination and degradation controlled by ataxia telangiectasia mutated–induced phosphorylation at Ser384 constitutes a negative feedback loop that regulates DSB repair.