A pair of strong earthquakes has struck off the southern coast of Cuba, inflicting damage and causing landslides.

A B-2 Spirit stealth bomber made an emergency landing at Whiteman Air Force Base in Missouri earlier this week after the high-tech aircraft malfunctioned during a training flight.

Cochlear hair cells (HCs) sense sound waves and allow us to hear. Loss of HCs will cause irreversible sensorineural hearing loss. It is well known that DNA damage repair plays a critical role in protecting cells in many organs. However, how HCs respond to DNA damage and how defective DNA damage repair contributes to hearing loss remain elusive. In this study, we showed that cisplatin induced DNA damage in outer hair cells (OHCs) and promoted OHC loss, leading to hearing loss in mice of either sex. Cisplatin induced the expression of Brca1, a DNA damage repair factor, in OHCs. Deficiency of Brca1 induced OHC and hearing loss, and further promoted cisplatin-induced DNA damage in OHCs, accelerating OHC loss. This study provides the first in vivo evidence demonstrating that cisplatin mainly induces DNA damage in OHCs and that BRCA1 promotes repair of DNA damage in OHCs and prevents hearing loss. Our findings not only demonstrate that DNA damage–inducing agent generates DNA damage in postmitotic HCs but also suggest that DNA repair factors, like BRCA1, protect postmitotic HCs from DNA damage–induced cell death and hearing loss.

Home to more than 300 artists, the neighborhood was submerged under the record-high waters of the French Broad River

The sprawling estate, which is the largest privately owned home in the country, will open its doors in November after a month-long closure

Emergency officials said the fire at the Herring Pub and Restaurant on Water Street broke out around 4 p.m. and appears to have started in an air conditioning unit.   

'Breakaway link' is key feature in new, safer utility connector

Four of Fotress's properties were affected by floods. But the company said only minor flood damage and no significant structural damage has been identified so far.

WILMINGTON – The Delaware Children’s Department is reporting an incident at Ferris School that resulted in the significant damage of state property. Ferris School is a Level V locked secure facility under the Delaware Division of Youth Rehabilitative Services. Youth committed to Ferris School are identified as serious and/or chronic, repeat offenders who have been deemed […]

Palworld developer Pocketpair has shared details from the patent infringement lawsuit brought against it by Nintendo and The Pokémon Company in September, shedding light on the plaintiffs’ demands. The two companies are seeking an injunction on Palworld, a survival game with monsters that bear alleged similarities to the creatures from the Pokémon franchise.

The State of Delaware and E. I. du Pont de Nemours and Company, The Chemours Company, DuPont de Nemours, Inc. and Corteva, Inc, (the “Companies”), businesses with a long history of operations within the State, today announced a settlement agreement designed to benefit Delaware’s natural resources and the people of the State of Delaware now, […]

Smryna – The Delaware Emergency Management Agency (DEMA) Emergency Operations Center is requesting that Delaware residents with damage to their properties fill out the following survey report linked below.  This information is important to help determine eligibility for a disaster declaration.   Delaware Damage Report – Click Here Residents with severe damage or other direct evidence […]

The Delaware Emergency Management Agency (DEMA), Delaware State Police, Delaware Department of Health and Social Services, Sussex County Emergency Operations Center, DelDOT, and numerous volunteer organizations are mobilizing resources and personnel to respond to yesterday’s statewide damage from severe storms and likely tornado in Sussex County. Officials confirmed a fatality at a collapsed structure along Tuckers Road southeast of Greenwood, Sussex County. It’s the first confirmed death from a tornado in Delaware since 1983 according to the National Weather Service.

Governor John C. Carney, Jr. joined State and Sussex County officials to tour areas near Bridgeville today after a confirmed tornado tore through the region on Saturday night, April 1. Preliminary estimates show more than 60 structures were damaged or destroyed along a 14-mile-long path through the communities of Bridgeville, Greenwood, and Ellendale. The survey also included a DelDOT maintenance yard on Newton Road where several buildings were damaged and destroyed, including one where winds pulled a wooden beam out of the ground, shifting the concrete footing.

During the routine biennial inspection of the bridge carrying Route 896 over I-95, a crack was found in one beam that was caused by an oversized vehicle. As a result, the Delaware Department of Transportation (DelDOT) announces that the rightmost lane on the Route 896 southbound bridge over I-95 will remain closed indefinitely until a […]

DNREC announced that the Michael N. Castle Trail along the C&D Canal has been reopened at the South Lums Parking Area following repairs to a section of the trail damaged in March by storms.

The explosion occurred in Telangana Spice Kitchen on Road Number One Jubilee Hills. According to police, the explosion damaged the boundary wall of the hotel.

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Nintendo and The Pokémon Company in September filed a patent infringement lawsuit against Palworld developer Pocketpair. 

At the time Nintendo did not share which patents Palworld infringed on, however, Pocketpair has now revealed what patents Nintendo are claiming were infringed on.

"As announced on September 19, 2024, The Pokémon Company and Nintendo Co Ltd (hereinafter referred to as the Plaintiffs) have filed a patent infringement lawsuit against us," said Pocketpair. "We have received inquiries from various media outlets regarding the status of the lawsuit, and we would like to report the details and current status of this case as follows.

"The Plaintiffs claim that Palworld, released by us on January 19, 2024, infringes upon the following three patents held by the Plaintiffs, and are seeking an injunction against the game and compensation for a portion of the damages incurred between the date of registration of the patents and the date of filing of this lawsuit."

Nintendo and The Pokémon Company are each seeking an injunction and damages of five million yen plus late payment damages.

Pocketpair added, "We will continue to assert our position in this case through future legal proceedings. Please note that we will refrain from responding individually to inquiries regarding this case. If any matters arise that require public notice, we will announce them on our website, etc."

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463022/nintendo-and-the-pokemon-company-seeking-injunction-and-damages-from-pocketpair/

Hospitals have been forced to innovate with new ways of hydrating patients and giving them medications, after a key factory that produces IV fluid bags flooded during Hurricane Helene. (This story first aired on Morning Edition on Nov. 7, 2024.)

State Farm: Spring Home Maintenance Tips

The warming impact of the vapour trails that emerge from airplanes is being discussed at climate gathering.

Tiny, self-organized three-dimensional (3D) tissue cultures (Organoids) derived from medlinkstem cells/medlink have been developed to produce teeth-protecting

Youssef Brouziyne, IWMI Middle East and North Africa (MENA) Regional Representative, says two key questions will dominate discussions around the Loss and Damage Fund at COP28.

The post At COP28, science and research are critical to the loss and damage conversation first appeared on International Water Management Institute (IWMI).

Sickle cell disease is an inherited red blood cell disorder that affects hemoglobin, the protein carrying oxygen through the body. In this condition,

A common ingredient in plastic may cause breaks in DNA strands, leading to egg cells with an abnormal number of chromosomes in roundworms, reveals a new

New research based on patient health records on lowering high cholesterol suggests that rosuvastatin can harm the kidneys, especially at high doses of the medicine.

Roughly 50% of those diagnosed with medlinkhigh blood pressure/medlink (BP), or hypertension, face the risk of long-term kidney damage, potentially

Ayurvedic poly-herbal drug called Neeri-KFT can help in kidney recovery, reveals a new study. Patients suffering from Ascites -- a condition

Peruvian President Pedro Castillo declared an environmental emergency after an oil spill from high waves caused by the Tonga volcanic eruption contaminated several beaches. Photo: Martin Mejia/Associated Press

Satellite images show parts of the Pacific nation of Tonga before and after a tsunami triggered by an underwater volcanic eruption damaged the archipelago’s coastline. Vast areas were blanketed in ash. Photos: Maxar Technologies/Reuters

'Pandi was promised something, that is not happening, so his anger is not of a villain's.' 'That's how all normal humans would react, or they stay silent.''Our violence is our silence. So in this world, everybody is innocent.'

A disruptive technology, says researcher

While the number of lost and damaged luggage has increased over time, customer handling has become better

Before the firemen could reach the spot, the personnel put off the fire by pouring water. The two buggies were completely damaged