Get early Black Friday deals on headphones at Walmart. Score AirPods for under $100.

A fossil of a tadpole from Argentina is 161 million years old - and isn't that different from some modern species

A fossil of a tadpole from Argentina is 161 million years old - and isn't that different from some modern species

Just in time to watch with the whole family over Thanksgiving.

Scientists have discovered the oldest-known fossil of a tadpole, which lived among the Jurassic dinosaurs 160 million years ago.

There is already a bunch of early Black Friday deals to check out, but if you're on the lookout for a great set of wireless headphones for yourself or a loved one, here's one that's absolutely worth your attention. Sony's WH-1000XM5 headphones have dropped to $298. That's a $102 discount.

This isn't quite the lowest price we've seen for the over-ear XM5s. They dropped to $280 at one point earlier this year. However, the headphones haven't gone back down to that point since, and this is still a great deal.

The XM5s are our pick for the best wireless headphones overall. We've long been recommending Sony's 1000X line and this is the best iteration to date. They earned a score of 95 in our review.

The redesigned headphones are much more comfortable to wear for extended periods than previous models. Sony has improved the active noise cancellation (ANC) feature as well, thanks to the addition of a new chip and four more microphones. We feel that the company's current flagship headphones do a better job of blocking out high frequencies and background noise (and even human voices) than the XM4s.

The XM5s can switch between noise modes depending on your location or activity, and they can pause audio automatically when you start speaking. They deliver better call quality than rival models and, in general, you'll get clear, crisp sound, including punchy bass. You won't need to charge the XM5s too often either, as they have a 30-hour battery life.

Check out all of the latest Black Friday and Cyber Monday deals here.

This article originally appeared on Engadget at https://www.engadget.com/deals/sonys-wh-1000xm5-headphones-are-100-off-in-this-black-friday-deal-192016343.html?src=rss

Disclosure: I sit on the Planning Committee for the FDLI Ad-Promo conference. This is an unpaid, volunteer position. The contents of this post were not discussed with or influenced by any member of the FDLI staff.

This post provides some of the highlights from FDLI's ad-promo conference. An on-demand version of the conference presentations is available on-demand at: https://www.fdli.org/2023/11/advertising-promotion-for-medical-products-conference-on-demand/

The Food and Drug Law Institute's (FDLI) Advertising & Promotion for Medical Products conference wrapped up last week. I attended the conference and also moderated a panel on data privacy and concerns about the use of health data for the targeting of advertising.

The first day kicked off with a fireside chat with Arun Rao from the Department of Justice (DOJ), Lauren Roth from the Food & Drug Administration (FDA), and Serena Viswanathan from the Federal Trade Commission (FTC), led by Christine Simmon of FDLI.

FDA and FTC both noted their recent guidance updates. For FDA, that means the new Communications From Firms to Health Care Providers Regarding Scientific Information on Unapproved Uses of Approved/Cleared Medical Products Questions and Answers Guidance for Industry (SIUU) and the newly finalized Presenting Quantitative Efficacy and Risk Information in Direct-to-Consumer (DTC) Promotional Labeling and Advertisements. 

FTC has also been busy, providing updated guidance on endorsements, reviews and testimonials, and a distinct Health Products Compliance Guidance.

DOJ, FDA, and FTC also mentioned the extent to which they are still very much digging out from the backlog created by the pandemic. More than three years after COVID-19 first came to our shores, its effects are very much still being felt.

Rao also mentioned a new policy from DOJ to create a safe harbor for self-reported disclosures made in connection with a merger or acquisition. Under this new policy, companies that learn of wrongdoing at a company they have acquired can be protected from later liability if they report the wrongdoing to DOJ within six months of closing the merger or acquisition. This is as Rao described it a "very big juicy carrot" to encourage self-reporting of wrongdoing, and it also ramps up the need for effective due diligence during the M&A to ensure that all wrongdoing is uncovered and can be reported.

One final point mentioned by Roth is the importance to FDA of combatting misinformation about medical products. Commissioner Califf has repeatedly warned about the need to combat misinformation, and it is not a stretch to see FDA's SIUU guidance as one small step in that direction. By providing further guidance about exactly how sponsors can share truthful, not misleading information about unapproved uses, FDA is enabling efforts to get good information from the people who should be seen as the most reliable source of that information, the product's sponsors.

The next session of the day included an update from OPDP, APLB, CDRH, and CVM related to advertising and promotion.

Katie Gray from OPDP gave a detailed presentation on the Recorlev enforcement action from earlier this year and an overview of the SIUU guidance. Lisa Stockbridge from APLB provided a reminder on reminder advertising, indicating that this well-established category of communication continues to cause firms difficulties. Debra Wolf of CDRH emphasized that although there has not been a significant amount of publicly available enforcement actions from CDRH, the Agency continues to have many private communications with firms about their marketing efforts.

The next plenary session covered scientific exchange and pre-approval communications. Elisabethann Wright of Cooley provided particular insight into the EU's approach, which of course varies widely by country, and has been especially active on platforms such as LinkedIn. Of note is the extremely active role played by the industry's own associations in not merely promulgating guidance and establishing codes of conduct but in regularly enforcing violations of those codes against member companies.

After lunch, the first set of breakout sessions occurred including the panel I moderated on data privacy. I found the discussion very lively and enjoyed hearing from Elisa Jillson from the FTC, Lyra Correa from HHS's Office of Civil Rights, and Nancy Perkins from Arnold & Porter. I have previously opined that the 2020s will be most known for its focus on privacy, and while the cookie-less future we keep hearing about gets pushed back once again, there's growing awareness and concern about how much deeply personal information has been given up and on how companies are using (or misusing) that data.

Simultaneous sessions looked at the recently finalized guidance from the FDA on Presenting Quantitative Efficacy and Risk Information in Direct-to-Consumer (DTC) Promotional Labeling and Advertisements while another session looked more into the promotion of veterinary products. Because I was leading another session, I couldn't attend either, but I'm looking forward to using that link provided earlier to view the recordings. 

The afternoon plenary sessions resumed with a look at FTC's role in enforcement of healthcare advertising and closed out with a session on that perennial chestnut of social media usage.

Day two of the conference kicked off with an enlightening discussion of so-called CFL (Consistent with FDA-Labeling) claims. Torrey Cope of Sidley Austin provided an insightful look not just at FDA's enforcement post-guidance for claims that failed to meet the CFL standard, but also for taking the time to examine the nature and wording around the acceptance by FDA of so-called Real-World Evidence (RWE) in the context of product approvals. RWE is not the sole source of CFL claims, but Cope was able to provide some valuable lessons.

The afternoon's breakout sessions included one on artificial intelligence (which I attended), promotional challenges in rare disease treatments, and navigating accelerated approval promotion.

The closing session focused on other avenues for enforcement, including of course, the Better Business Bureau National Advertising Division's (NAD), as well as general counsel to general counsel complaint letters, filing complaints with the FDA, and perhaps even bringing a Lanham Act case.

The NAD's finding against Novartis earlier this year was of course a hot topic. But it is worth noting that in a more recent case, Viiv simply declined to participate in the NAD process. NAD referred the matter to FDA and FTC noting that decision, but as of the writing of this post, no further action by the government has been seen.

Alan Minsk of Arnall Golden Gregory noted the importance of determining your goal when looking at the appropriate path. If your goal is get a competitor in trouble then you really need to rely on the government or the courts, but if your goal is primarily to just get the company to stop the use of misleading promotion, then NAD or a direct complaint letter might be a far more cost-effective solution.

Overall, the conference was a huge success, though my opinion should be viewed as biased because I sit on the conference planning committee. FDA is definitely digging itself out from the pandemic backlog. I fully expect we'll see more from the Agency, as a very active 2023 has already demonstrated.

The Alloy Origins Core is a tenkeyless mechanical keyboard made of airplane-grade aluminum, which prompts the question: Why don't they make the whole plane out of keyboard?

A fossil of a tadpole from Argentina is 161 million years old - and isn't that different from some modern species

Having won Grammy awards in 2009 for Best Dance Recording
monster isport headphones with the song “Poker Face” and Best Electronic/Dance Album for The Fame, Lady Gaga bagged a total of 6 Grammy...

ప్రస్తుత యుగంలో దాదాపు ప్రతీ ఒక్కరి మొబైల్స్ ఉన్నాయి. దాదాపు వాటికి సమానంగా ఇయర్ ఫోన్లు, ఇయర్ బడ్స్ ఉన్నాయి. దీంతో ప్రతీ ఒక్కరు చెవిలో ఇయర్ ఫోన్స్ లేదా ఇయర్ బడ్స్ పెట్టుకుని సంగీతాన్ని ఎంజాయ్ చేస్తున్నారు. ముఖ్యంగా ప్రయాణం చేస్తున్నప్పుడు వీటిని ఎక్కువగా వాడతారు. ఇవి వాడడం వల్ల సౌండ్ ఎక్కువ వస్తుంది. డిజిటల్

Surathkal and Mulky Railway Stations will get improved platform shelters and surfaces at ₹3 crore cost, says Konkan Railway

Deadpool & Wolverine is an example of confident film-making and unbridled enthusiasm to show what the Deadpool franchise means for its fans, observes Mayur Sanap.

Mark Heard, engineering manager at Dyson on how and why the brand has journeyed from vacuum cleaners towards styling products and now headphones.

Customisation is a key aspect of OnTrac’s design philosophy. Users can personalise their headphones with customisable outer caps and ear cushions available in a range of colours and finishes

The Urbanista Los Angeles over-ears just need some light to keep them going

Deep boom for those who want that extra thump above all else

The PXC 550-II Wireless features a triple microphone array that makes it easy to stay connected while on the move.

Comic-book creator Rob Liefeld blames Marvel for the delay to Deadpool 3.

Having won Grammy awards in 2009 for Best Dance Recording
monster isport headphones with the song “Poker Face” and Best Electronic/Dance Album for The Fame, Lady Gaga bagged a total of 6 Grammy...

Vacuum manufacturer Dyson drops a patent for headphones that filter air to an integrated mouthpiece.

Cleer, Inc Announces New Bluetooth Wireless Headphone line-up Cleer EDGE Voice and EDGE Pulse based on Qualcomm Bluetooth Audio SoCs

ADP is the highest level of partner recognition from ForgeRock

Intention to use planes significantly decreased, traveling by car expected to surge for 2020.

The present invention generally relates to use of compounds and compositions as a chemosensitizers and/or radiosensitizers and/or inhibitors of PNKP phosphatase activity. The present invention provides pharmaceutical combinations and/or a pharmaceutically acceptable salt thereof, kits containing such compounds and/composition and methods of using such compounds and/or compositions.

A mobile device case includes a reel assembly, including a reel, a supporting plate, and a hub between the reel and the supporting plate. The hub includes a first cavity between the hub and the supporting plate for housing a spring, and a second cavity between the hub and the reel for housing a flat flexible cable (FFC). The spring is wound in a first direction, while the FFC is wound in a second direction. The FFC includes a first end for electrically coupling to a female jack connector of a device. A female connector is electrically coupled to a second end of the FFC for engaging a male jack connector of user-provided headphones. When the reel rotates in the first direction, the spring tightens and the FFC loosens. When the reel rotates in the second direction, the spring loosens and the FFC tightens.

A locking headplate for an adjustable saddle tree includes opposed, hingedly connected plates for securing to a saddle tree head portion, a rotatable displacing element for displacing the hingedly connected plates inwardly or outwardly, and at least one supplemental locking mechanism for selectively preventing rotation of the rotatable displacing element. The hingedly connected plates include apertures for receiving a portion of the rotatable displacing element therethrough, the apertures defining at least one cross-sectional dimension that is greater than a corresponding cross-sectional dimension of the rotatable displacing element. Saddle trees and saddles incorporating the locking headplate are provided.

The producers for the Ryan Reynolds-fronted superhero movie have been punished with fine for failing to provide a safe workplace for the fallen stuntwoman.

The producers for the Ryan Reynolds-fronted superhero movie have been punished with fine for failing to provide a safe workplace for the fallen stuntwoman.

Sonarworks has announced SoundID Listen, a desktop application that brings personalized sound to anyone listening to their headphones on Mac or Windows, using their perfect personal sound profile called SoundID. SoundID represents a paradigm shift in audio quality, moving away from the traditional one-size-fits-all approach, to personalizing sound for everyone as an individual. SoundID unlocks […]

The post SoundID brings the first truly personalized sound to your headphones appeared first on rekkerd.org.

BALTIMORE (AP) — U.S. businesses cut an unprecedented 20.2 million jobs in April, an epic collapse with coronavirus outbreak closing the offices, factories, schools, construction sites and stores that propel the U.S. economy. The Wednesday report from payroll company ADP showed the tragic depth and scale of job losses that left no part of the […]

И бюджетный планшет Surface Go 2.

Apple has been selling audio accessories since December 2016 when the original AirPods launched. We now have the ‌AirPods‌ 2 and the AirPods Pro, and Apple is planning to add to its lineup with new over-ear Apple-branded headphones.

Apple already sells over-ear headphones under its Beats brand, but as with the ‌AirPods‌, Apple is also working on headphones that will be Apple branded rather than Beats branded. These headphones are said to be aimed at the high-end market.

Design

The headphones will feature an all-new design, and while we don't know a lot about it, we do know some details shared by Bloomberg.

Apple is said to be working on two versions of the high-end over-ear headphones, including a premium version with leather-like fabrics and a fitness-focused model that uses lighter, breathable materials with small perforations for better airflow.

Prototypes of the headphones have been described as having a retro-like look with over-ear cups that swivel along with a headband connected with thin metal arms.

Apple is planning to attach the ear pads and the head padding to the headphone's frame magnetically, allowing users to swap different colors and variants in and out for customization purposes.

An icon representing the headphones was found in the code in a leaked version of iOS 14, but little detail can be gleaned from the imagery.

Rumored Features

According to Apple analyst Ming-Chi Kuo, Apple's over-ear headphones will feature Active Noise Cancellation, a high-end feature baked into the Beats Studio 3 headphones, Solo Pro headphones, and the ‌AirPods Pro‌.

Active Noise Cancellation is designed to cut down on ambient noise so you can focus on what you're listening to. If it mimics ANC on the ‌AirPods Pro‌, there will be a transparency mode that will enable noise cancelling features, but with an option to continue to hear what's going on around you.

Sound quality is expected to be better than the sound quality of the ‌AirPods‌.

Pricing

Apple could price the new headphones at around $350.

Launch Date

Current rumors indicate the headphones will launch at some point in 2020, though a specific date has not yet been nailed down. Mass production on the headphones is scheduled to begin in mid-2020, which perhaps suggests a fall 2020 launch.

There were rumors indicating that Apple initially planned to launch the headphones at some point in 2019, but that did not happen.

Over-Ear Headphones Rumor History

• Mass Production on Apple's High-End Headphones Rumored to Start in Mid-2020


• Apple to Unveil High-End Over-Ear Wireless Headphones With Magnetically Swappable Parts Later This Year


• Apple Reportedly Targeting WWDC for Over-Ear Headphones Launch, New 'AirPods X' Later in the Year


• Icon for Apple's Rumored Over-Ear Noise Canceling Headphones Discovered in Leaked iOS 14 Code


• Apple-Branded Over-Ear Headphones Said to Launch as Early as Second Half of 2019


• Apple's Upcoming Over-Ear Wireless Headphones to Target High-End Noise-Canceling Market


• KGI: Apple Developing High-End Over-Ear Headphones, Launching Late 2018 at the Earliest

Guide Feedback

Have a question about Apple's over-ear headphones, know of something we left out, or want to offer feedback? Send us an email here.
This article, "Apple's Work on High-End Over-Ear Headphones: Everything We Know" first appeared on MacRumors.com

Discuss this article in our forums

Apple's rumored high-end over-ear headphones may be called "AirPods Studio" and retail for $349, according to Jon Prosser of YouTube channel Front Page Tech.


In keeping with the successful ‌AirPods‌ brand, the rumored "Studio" over-ear headphones would significantly diversify Apple's ‌AirPods‌ lineup, which last added the in-ear AirPods Pro in October 2019. The supposed price of $349 would place "‌AirPods‌ Studio" as a direct competitor to high-end noise-canceling over-ear headphones from Bose and Sony.

Looks like Apple is sticking with the “‌AirPods‌” branding for their new over-ear headphones.

‌AirPods‌ Studio
Codename: B515
$349

— Jon Prosser (@jon_prosser) May 9, 2020

Prosser has previously accurately leaked the April 15 launch date of the new iPhone SE and, most recently, the May 4 launch date of the refreshed 13-inch MacBook Pro.

Apple analyst Ming-Chi Kuo expects Apple's over-hear headphones to enter mass production in mid-2020, which may suggest a fall 2020 launch.
This article, "Apple's Over-Ear Headphones May Be Called 'AirPods Studio' and Cost $349" first appeared on MacRumors.com

Discuss this article in our forums

Real women have curvy headphones.

Trapped! https://ift.tt/3aDPZSz

Hand sanitizer is not the only coronavirus necessity. Students stuck at home in close and noisy quarters could use headphones to keep out distractions and allow them to focus on their studies.

BEST DEALS ON HEADPHONES:

• Jaybird - RUN XT Sport True Wireless In-Ear Headphones — $179.99

• Plantronics - Backbeat FIT 3150 True Wireless Sport Headphones — $99.99 (save $50)

• Bose - SoundSport Free True Wireless Headphones — $149.99 (save $50)

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The only thing more important to runners than their sneakers is a quality pair of headphones and a killer playlist. Running without music is like some form of medieval torture: it sucks. And cheap, crappy headphones just aren't going to cut it.

When shopping for a quality pair of headphones to wear while running, you'll want to look at a few key factors: Are they sweatproof/waterproof? Will they stay in your ears? Are the volume controls easily accessible? If you answer no to any of these questions, then you know the headphones aren't going to work. Read more...

More about Running, Headphones, Bluetooth Headphones, Mashable Shopping, and Culture

IMAGE: Amazon

BEST FOR WORKOUT TRACKERS

Bose SoundSport Pulse Wireless

While sound quality and flexibility are always good features, a great pair of headphones will do more than that.

$129 from Amazon

IMAGE: Amazon

BEST MID-PRICED WIRELESS OPTION

Jabra Elite 45e

The Elite 45e headphones are an example of quality at an affordable price.

$86.53 from Amazon

IMAGE: Amazon

BEST TRULY WIRELESS EARBUDS

Bose SoundSport Free Wireless

These truly wireless ear buds can charge while you're using them, and the app can help you locate them in the event that they fall out.

$199 from Amazon

IMAGE: Amazon

BEST BUDGET WIRED HEADPHONES

JBL Endurance RUN

These are the kind of headphones you buy in multiples so you don't have to fret once you've inevitably lost a pair.

$19.95 from Amazon

IMAGE: Amazon

BEST NO-FRILLS OPTION

ROVKING Sport Headphones

These super-cheap headphones have an earhook design that keeps them on your ears, and are also sweatproof.

$14.99 from Amazon

IMAGE: Amazon

MOST FIT OPTIONS FOR WIRED HEADPHONES

Sony MDRXB510AS/B

These Sony earbuds offer multiple sets of covers and hooks to hold the earbuds securely in place.

$29.99 from Amazon

IMAGE: Amazon

BEST AUDIO QUALITY FOR WIRED HEADPHONES

Bose SoundSport

Bose SoundSport are a great set of headphones to buy when the clarity of audio really matters to you.

$99 from Amazon

IMAGE: Amazon

BEST OVER-EAR OPTION

Levin Bluetooth 4.1 Wireless Headphones

The Levin Bluetooth 4.1 Wireless Headphones deliver an affordable and reliable option for anyone who prefers over-ear headphones.

$29.99 from Amazon

This week Ashleigh Allsopp is simultaneously fascinated and worried by the UK launch of Amazon's Dash buttons, and discusses the many wonderful and not-so-wonderful things they enable you to buy on a drunken whim. Then David Price takes his turn to shine a spotlight on Apple's mysterious tax affairs (12:20) and tries to explain why the Irish government doesn't want to be given 13 billion euros. Finally a surprisingly riled-up Neil Bennett explains why women wearing headphones are not fair game for dimwitted pick-up artists (25:00), and ponders the social conventions surrounding the place of technology in each of our lives.  

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NADPH facilitates glucose-stimulated insulin secretion (GSIS) in pancreatic islet (PI) β-cells by an as yet unknown mechanism. We found NADPH oxidase, isoform-4 (NOX4), to be the major producer of cytosolic H₂O₂, essential for GSIS, while the increase in ATP/ADP alone was insufficient. The fast GSIS phase was absent in PIs from NOX4-null, β-cell-specific knockout mice (NOX4βKO) (not NOX2KO), and NOX4-silenced or catalase-overexpressing INS-1E cells. Lentiviral NOX4 overexpression or H₂O₂ rescued GSIS in PIs from NOX4βKO mice. NOX4 silencing suppressed Ca²⁺ oscillations and the patch-clamped ATP-sensitive potassium channel (K_ATP) opened more frequently at high glucose. Mitochondrial H₂O₂, decreasing upon GSIS, provided an alternative redox signaling when 2-oxo-isocaproate or fatty acid oxidation formed superoxide by electron-transport flavoprotein:Q-oxidoreductase. Unlike GSIS, this ceased with mitochondrial antioxidant SkQ1. Both NOX4KO and NOX4βKO strains exhibited impaired glucose tolerance and peripheral insulin resistance. Thus the redox signaling previously suggested to cause β-cell-self-checking – hypothetically induces insulin resistance when absent. In conclusion, ATP plus H₂O₂ elevations constitute an essential switch-on signal of insulin exocytosis for glucose and branched-chain oxoacids as secretagogues (partly for fatty acids). Redox signaling could be impaired by cytosolic antioxidants, hence those targeting mitochondria should be preferred for clinical applications to treat (pre)diabetes at any stage.

Diabetes triggers peripheral nerve alterations at a structural and functional level, collectively referred to as diabetic peripheral neuropathy (DPN). This work highlights the role of the liver X receptor (LXR) signaling pathway and the cross talk with the reactive oxygen species (ROS)–producing enzyme NADPH oxidase-4 (Nox4) in the pathogenesis of DPN. Using type 1 diabetic (T1DM) mouse models together with cultured Schwann cells (SCs) and skin biopsies from patients with type 2 diabetes (T2DM), we revealed the implication of LXR and Nox4 in the pathophysiology of DPN. T1DM animals exhibit neurophysiological defects and sensorimotor abnormalities paralleled by defective peripheral myelin gene expression. These alterations were concomitant with a significant reduction in LXR expression and increase in Nox4 expression and activity in SCs and peripheral nerves, which were further verified in skin biopsies of patients with T2DM. Moreover, targeted activation of LXR or specific inhibition of Nox4 in vivo and in vitro to attenuate diabetes-induced ROS production in SCs and peripheral nerves reverses functional alteration of the peripheral nerves and restores the homeostatic profiles of MPZ and PMP22. Taken together, our findings are the first to identify novel, key mediators in the pathogenesis of DPN and suggest that targeting LXR/Nox4 axis is a promising therapeutic approach.

Apple's next release in the AirPods family could be its long-rumored over-ear headphones, a leaker claims, with the larger personal audio accessory tipped to have the name "AirPods Studio."

With iOS 13.1 and iPadOS, Apple adds an Audio Sharing feature that lets you share with a friend what you're listening to on your Apple AirPods or select Beats headphones.

Tired of tangled cords? Cut yourself some slack and switch to Bluetooth headphones. Whether you're looking for earbuds, on-ears, or to go completely wire-free, start with the best wireless headphones we've tested.

Whether you're looking for sleek AirPods or big over-ear models, these are the best headphones and earbuds we've tested, with advice for finding just the right pair for you.

Noise cancellation removes unwanted sounds. The best noise-cancelling headphones let you block out the world around you to enjoy your music...or the sweet sound of silence.