Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

One of the most important things that you need to do while you are at university is turn your assignments in on time. Your professor will give you a syllabus and it will tell you the plan for the semester. You will know when you have to do reading, when you have papers due, and when you have exams. Some weeks, you may have more than you can do. You can either plan ahead or get some help from essay writing services or a friend. The key is to make sure that you turn your work in on time. Continue […]

Rwandans should be proud of the immense progress they have made since the genocide, but economic inequality and political abuses still plague the country.

Reichman University launches a new medical school to address Israel's doctor shortage, with hands-on training from day one.

Thousands masquerade as Carnival season starts with festivals across Germany

“For all have sinned and fall short of the glory of God.” Most Christians are familiar with Romans 3:23—perhaps too familiar. Many of us have quoted it while sharing the “Roman Road” gospel presentation. It also serves as a quick-fire explanation for why we can never find any sinless people. But how many of us have truly comprehended the devastating truth of our universal guilt?

Yale University introduces Beyoncé course: Deets insideBeyoncé’s fans are in for a surprise as Yale University has announced a new course centering on the singer and her iconic legacy.According to Yale Daily News, the new students will “dive deep” into...

Remarks by Masatsugu Asakawa, President, Asian Development Bank, at the 30 Years of Kazakhstan-ADB Anniversary Reception, 8 November 2024

university paper application

university board of trustees 2011

See the circle of galaxy clusters and voids that surround us in this map of the nearby cosmos, extending 200 million light years in each direction

We may never know what lies beyond the boundaries of the observable universe, but the fabric of the cosmos can tell us whether the universe is infinite or not

Through science, we are striving for objective knowledge about the universe around us. But physicists increasingly believe achieving this will never be possible

Almost all the stars that will ever exist have already been born, and they have been around long enough for life to evolve on planets that orbit them

Research has found the universe is remarkably similar in structure to the human brain. But does this mean the cosmos has a consciousness of its own?

The first generation of stars changed the course of cosmic history. Now, thanks to the James Webb Space Telescope, we have a real chance of spotting them

Astronomer Jo Dunkley is planning to use the Simons Observatory to snare evidence for inflation, the theory that the universe expanded at incredible speed after its birth

The physicist Peter Higgs quietly revolutionised quantum field theory, then lived long enough to see the discovery of the Higgs boson he theorised. Despite receiving a Nobel prize, he remained in some ways as elusive as the particle that shares his name

One way to explain why time only moves forward is the quantum arrow of time, and it has major implications for both the universe's early period and its eventual demise

Through science, we are striving for objective knowledge about the universe around us. But physicists increasingly believe achieving this will never be possible

Almost all the stars that will ever exist have already been born, and they have been around long enough for life to evolve on planets that orbit them

Research has found the universe is remarkably similar in structure to the human brain. But does this mean the cosmos has a consciousness of its own?

In order to figure out how something came from nothing, we first need to explore the different types of nothing

Introduction

Exacerbation of COPD complicated by respiratory acidaemia is the commonest indication for noninvasive ventilation (NIV). The NIV outcomes (NIVO) score offers the best estimate of survival for those ventilated. Unfortunately, two-thirds of cases of COPD are unrecognised, and patients may present without COPD having been confirmed by spirometry.

Karolinska Institutet is a medical university encompassing 21 departments distributed across three departmental or campus groups. Pharmacological research has a long and successful tradition at the institute with a multitude of seminal findings in the areas of neuronal control of vasodilatation, cardiovascular pharmacology, neuropsychopharmacology, receptor pharmacology, and pharmacogenomics that resulted in, among many other recognitions, two Nobel prizes in Physiology and Medicine, one in 1970 to Ulf von Euler for his discovery of the processes involved in storage, release, and inactivation of neurotransmitters and the other in 1982 to Sune Bergström and Bengt Samuelsson for their work on prostaglandins and the discovery of leukotrienes. Pharmacology at Karolinska Institutet has over the last decade been ranked globally among the top 10 according to the QS World University Ranking. With the Department of Physiology and Pharmacology now celebrating its 75-year anniversary, we wanted to take this as an opportunity to showcase recent research achievements and how they paved the way for current activities at the department. We emphasize examples from preclinical and clinical research where the dpartment's integrative environment and robust infrastructure have successfully facilitated the translation of findings into clinical applications and patient benefits. The close collaboration between preclinical scientists and clinical researchers across various disciplines, along with a strong network of partnerships within the department and beyond, positions us to continue leading world-class pharmacological research at the Department of Physiology and Pharmacology for decades to come.

Hearing disorders pose significant challenges to individuals experiencing them and their overall quality of life, emphasizing the critical need for advanced pharmacological approaches to address these conditions. Current treatment options often focus on amplification devices, cochlear implants, or other rehabilitative therapies, leaving a substantial gap regarding effective pharmacological interventions. Advancements in our understanding of the molecular and cellular mechanisms involved in hearing disorders induced by noise, aging, and ototoxicity have opened new avenues for drug development, some of which have led to numerous clinical trials, with promising results. The development of optimal drug delivery solutions in animals and humans can also enhance the targeted delivery of medications to the ear. Moreover, large genome studies contributing to a genetic understanding of hearing loss in humans combined with advanced molecular technologies in animal studies have shown a great potential to increase our understanding of the etiologies of hearing loss. The auditory system exhibits circadian rhythms and temporal variations in its physiology, its vulnerability to auditory insults, and its responsiveness to drug treatments. The cochlear clock rhythms are under the control of the glucocorticoid system, and preclinical evidence suggests that the risk/benefit profile of hearing disorder treatments using chronopharmacological approaches would be beneficial. If translatable to the bedside, such approaches may improve the outcome of clinical trials. Ongoing research into the molecular and genetic basis of auditory disorders, coupled with advancements in drug formulation and delivery as well as optimized timing of drug administration, holds great promise of more effective treatments.

Nitric oxide (NO) from endothelial NO synthase importantly contributes to vascular homeostasis. Reduced NO production or increased scavenging during disease conditions with oxidative stress contribute to endothelial dysfunction and NO deficiency. In addition to the classical enzymatic NO synthases (NOS) system, NO can also be generated via the nitrate-nitrite-NO pathway. Dietary and pharmacological approaches aimed at increasing NO bioactivity, especially in the cardiovascular system, have been the focus of much research since the discovery of this small gaseous signaling molecule. Despite wide appreciation of the biological role of NOS/NO signaling, questions still remain about the chemical nature of NOS-derived bioactivity. Recent studies show that NO-like bioactivity can be efficiently transduced by mobile NO-ferroheme species, which can transfer between proteins, partition into a hydrophobic phase, and directly activate the soluble guanylyl cyclase-cGMP-protein kinase G pathway without intermediacy of free NO. Moreover, interaction between red blood cells and the endothelium in the regulation of vascular NO homeostasis have gained much attention, especially in conditions with cardiometabolic disease. In this review we discuss both classical and nonclassical pathways for NO generation in the cardiovascular system and how these can be modulated for therapeutic purposes.

The class F of G protein-coupled receptors (GPCRs) consists of 10 Frizzleds (FZD_1–10) and Smoothened (SMO). FZDs bind and are activated by secreted lipoglycoproteins of the Wingless/Int-1 (WNT) family, and SMO is indirectly activated by the Hedgehog (Hh) family of morphogens acting on the transmembrane protein Patched. The advance of our understanding of FZDs and SMO as dynamic transmembrane receptors and molecular machines, which emerged during the past 14 years since the first-class F GPCR IUPHAR nomenclature report, justifies an update. This article focuses on the advances in molecular pharmacology and structural biology providing new mechanistic insight into ligand recognition, receptor activation mechanisms, signal initiation, and signal specification. Furthermore, class F GPCRs continue to develop as drug targets, and novel technologies and tools such as genetically encoded biosensors and CRISP/Cas9 edited cell systems have contributed to refined functional analysis of these receptors. Also, advances in crystal structure analysis and cryogenic electron microscopy contribute to the rapid development of our knowledge about structure-function relationships, providing a great starting point for drug development. Despite the progress, questions and challenges remain to fully understand the complexity of the WNT/FZD and Hh/SMO signaling systems.

Both preclinical and clinical studies implicate functional impairments of several neuroactive metabolites of the kynurenine pathway (KP), the major degradative cascade of the essential amino acid tryptophan in mammals, in the pathophysiology of neurologic and psychiatric diseases. A number of KP enzymes, such as tryptophan 2,3-dioxygenase (TDO2), indoleamine 2,3-dioxygenases (IDO1 and IDO2), kynurenine aminotransferases (KATs), kynurenine 3-monooxygenase (KMO), 3-hydroxyanthranilic acid oxygenase (3-HAO), and quinolinic acid phosphoribosyltransferase (QPRT), control brain KP metabolism in health and disease and are therefore increasingly considered to be promising targets for the treatment of disorders of the nervous system. Understanding the distribution, cellular expression, and regulation of KP enzymes and KP metabolites in the brain is therefore critical for the conceptualization and implementation of successful therapeutic strategies.

Jade Ho explains what is possible for university students when they are given opportunities to learn about –and get involved with– social justice and labour issues in their own communities.

The post Students can be agents of change: Talking about activism in universities with Jade Ho appeared first on rabble.ca.

Chris realizes WoW is the new Diablo. Phil bakes a potato into two. Kelley becomes a cat in a frog suit. And we're dressing beds with old t-shirts.

The post RPG Cast – Episode 726: “Princes of the Mew-niverse” appeared first on RPGamer.

Beloved roguelike traumatic-childhood-em-up The Binding Of Issac: Rebirth turned 10 yesterday, and it’s half off on Steam to celebrate. What’s more, maker Edmund McMillen has announced that the foretold online co-op update is due on the 18th of this month, alongside a “considerable” balance update. Consider me considering the considerability of said considerable update!

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We’re still a week away from Blizzard’s Warcraft 30th Anniversary Direct next Wednesday the 13th of November, but art from an apparent remaster of 1995 real time strategy game Warcraft II: Tides Of Darkness has leaked online, via Xibbly user Stiven. It’s a thin one, as far as leaks go, but does show what looks to be cover, logo art, and a Battle.net icon. Thanks for the spot, Percy Coswald Gamer.

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The first generation of stars changed the course of cosmic history. Now, thanks to the James Webb Space Telescope, we have a real chance of spotting them

The long-standing mystery of how supermassive black holes grew so huge so quickly could be solved by decaying dark matter

These dazzling images taken by NASA's Hubble Space Telescope are from the upcoming book Cosmos: Explore the wonders of the universe, which has a foreword by astrophysicist Becky Smethurst

Astronomer Jo Dunkley is planning to use the Simons Observatory to snare evidence for inflation, the theory that the universe expanded at incredible speed after its birth

The Euclid space telescope's massive “cosmic atlas” promises to shed light on fundamental questions in physics and cosmology

In order to figure out how something came from nothing, we first need to explore the different types of nothing

Zeiger is president of the Jack Miller Center, an educational venture to advance the history, documents and ideals we hold in common as Americans.As a nation, we are failing to prepare citizens for leadership in our constitutional republic. According to a September 2023 Pew Research Center study, 72...

As artificial intelligence becomes more common in university classrooms, some professors are weighing the benefits — and downsides — of students using it for research projects.

The standard model predicted that the NASA/ESA/CSA James Webb Space Telescope would see dim signals from small, primitive galaxies.

The post New Research Questions Standard Theory of How Galaxies Formed in Early Universe appeared first on Sci.News: Breaking Science News.