This is a whitepaper tutorial that describes steps taken to identify post-authentication remote code execution vulnerabilities in Symantec Web Gateway version 5.0.2.8.

Citrix Gateway versions 11.1, 12.0, and 12.1 suffer from an information disclosure vulnerability.

SAPUI5 version 1.0.0 and the SAP Gateway versions 7.5, 7.51, 7.52 and 7.53are vulnerable to content spoofing in multiple parameters.

UK company BAE Systems has been selected as preferred tenderer for the SEA 5000 program to deliver the Australian Government’s nine Future Frigates for the Royal Australian Navy.

Knight Construction & Supply Co. has won a $3.7 million contract from the U.S. Army Corps of Engineers to rehabilitate spillway gates at the Blue River Dam in Oregon.

Last Friday evening in Surprise, Arizona a storage facility owned by Arizona Public Service (APS) exploded, injuring four firefighters. Reporter for azfamily.com, Maria Hechanova, visited the scene yesterday and reported that the explosion happened while four hazmat firefighters from Peoria were working to extinguish a battery fire at the facility.

Seagate Technology ships tens of millions of hard disk drives every quarter. Ensuring the quality of each one is a top priority, but not easy. The disk drive manufacturing process is incredibly complex. For example, it takes 1,400 steps just to manufacture the drive head. Even the smallest errors can lead to product flaws. “Mistakes Read article >

The post Seagate Provides the RX to Improve Hard Drive Manufacturing appeared first on The Official NVIDIA Blog.

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Slovak-Austrian Chamber of Commerce together with law firm Eversheds Sutherland invites you to a webinar: First practical experience with measures to mitigate the economic consequences of COVID19 in Slovakia. The Slovak republic applied a number of ...

Hong Kong Courts are closed as a result of the COVID-19 pandemic and the backlog of litigation continues to grow. Does arbitration have the answers? The COVID-19 pandemic has led to the closure of the Hong Kong courts. They closed after the Chinese ...

As the government searches for alternative sources of revenue, experts say the agricultural sector remains a promising area.

The post How Nigeria can use agriculture to mitigate COVID-19 impact — Expert appeared first on Premium Times Nigeria.

The Chinese Ministry of Commerce (“MOFCOM”) recently announced the intention of the Chinese competition authorities to step up the number of their investigations into possible anti-competitive and abusive market conduct.  Chinese co...

Court of appeal overturns High Court judgment in Lloyd v Google LLC [2019] EWCA Civ 1599 Court of Appeal judgment The Court of Appeal has given the go-ahead for a representative claim to be served on Google LLC in the U.S. for alleged data breaches,...

Changes to the insolvency, civil and criminal procedural law The German Federal Government is currently planning various support measures for entrepreneurs, sole traders, other small, medium and large companies and credit institutions to mitigate t...

On Thursday, 7 May, the IOPC launched an independent investigation into the full circumstances of an incident in Haringey on 4 May in which a man sustained serious injuries. We fully support this investigation and continue to co-operate with the IOPC's...

Glenn Hutchinson has been in touch to tell us how his passion for the Spireites began when he visited Saltergate as a youngster in the mid-50s... I first visited the ground when I was about 7/8 in 1954/55 with my dad. Caught the bug and been a Spirerite ever since. When I was...

The Environmental Audit Committee (“EAC”) has launched an inquiry to investigate the impact of toxic chemicals on everyday life (launched 12 February 2019). The inquiry will focus on the use of toxic chemicals in everyday products includ...

The European Securities and Markets Authority (“ESMA”) has issued a public statement, “Actions to mitigate the impact of COVID-19 on the EU financial markets” urging national competent authorities not to prioritise supervisor...

[Premium Times] In February, PREMIUM TIMES exclusively spoke with Chris Elias, the President of the Global Development Division of the Bill and Melinda Gates Foundation and Paulin Basinga, the foundation's country director, on the role the foundation played in the eradication of wild polio in Nigeria and a range of other developmental issues.

[Dalsan Radio] The African Union Mission in Somalia, AMISOM, expresses its heartfelt condolences to the families of those who perished in the plane crash of 4th May, 2020. The aircraft which left Baidoa, had six people on board and was approaching Bardale, south of Somalia and 300km northwest of the capital Mogadishu when it crashed.

This story is published in a content partnership with POLITICO. It was originally reported by Myah Ward on politico.com on May 7, 2020.Melinda Gates on Thursday gave the Trump administration low marks for its handling of the coronavirus pandemic, adding that more money is needed for testing and vaccine development in the United States and across the world.Gates – co-chairman of the Bill & Melinda Gates Foundation, which has donated billions of dollars to health research – gave the…

The government said hospitals, long-term care homes, retirement homes, and women's shelters are in need of staff including custodial and maintenance workers. 

A unanimous Supreme Court on Thursday threw out the convictions of two political insiders involved in the "Bridgegate" scandal that ultimately derailed the 2016 presidential bid of then-New Jersey Gov. Chris Christie. The justices found evidence of deception, corruption and abuse of power in the sch...

A unanimous Supreme Court on Thursday threw out the convictions of two political insiders involved in the “Bridgegate” scandal that ultimately derailed the 2016 presidential bid of then-New Jersey Gov. Chris Christie. The justices found evidence of deception, corruption and abuse of power in the scheme, but said “not every corrupt act by state or local officials is a federal crime.”

ADB has approved $50 million in loan and grant financing to help the Government of the Kyrgyz Republic mitigate the significant negative health, social, and economic impacts of the novel coronavirus disease (COVID-19) pandemic.

In December 2006, the Asian Development Bank (ADB) approved a $900.0 million equivalent multitranche financing facility (MFF) for the Punjab Irrigated Agriculture Investment Program (PIAIP) to finance improvements to Punjab’s irrigation sector. At the same time, two loans for tranche 1 totaling $227.8 million equivalent were approved using the MFF for $217.8 million equivalent from ADB’s ordinary capital resources and $10.0 million equivalent from ADB’s Asian Development Fund (ADF).

ADB has approved $50 million in loan and grant financing to help the Kyrgyz Republic mitigate the health and socioeconomic impact of COVID-19 pandemic.

Approved project 51423-002 in Mongolia.

Healthy grey whales are four times more likely to become stranded when solar activity produces lots of radio noise, suggesting solar storms may be blinding their ability to sense magnetic fields

Three physicians describe their impressions of video-based evaluations and things to watch out for.

Key Points

Although pain is a prevalent nonmotor symptom in Parkinson’s disease (PD), it is undertreated, in part because of our limited understanding of the underlying mechanisms. Considering that the basal ganglia are implicated in pain sensation, and that their synaptic outputs are controlled by the subthalamic nucleus (STN), we hypothesized that...

Neural networks have become the method of choice in surrogate modeling because of their ability to characterize arbitrary, high-dimensional functions in a data-driven fashion. This paper advocates for the training of surrogates that are 1) consistent with the physical manifold, resulting in physically meaningful predictions, and 2) cyclically consistent with...

Deregulation of mitochondrial dynamics leads to the accumulation of oxidative stress and unhealthy mitochondria; consequently, this accumulation contributes to premature aging and alterations in mitochondria linked to metabolic complications. We postulate that restrained mitochondrial ATP synthesis might alleviate age-associated disorders and extend healthspan in mammals. Herein, we prepared a previously...

Antibody-drug conjugates (ADCs) employ overexpressed cell surface antigens to deliver cytotoxic payloads inside cancer cells. However, the relationship between target expression and ADC efficacy remains ambiguous. In this manuscript, we have addressed a part of this ambiguity by quantitatively investigating the effect of antigen expression levels on ADC exposure within cancer cells. Trastuzumab-valine-citrulline-monomethyl auristatin E was used as a model ADC, and four different cell lines with diverse levels of human epidermal growth factor receptor 2 (HER2) expression were used as model cells. The pharmacokinetics (PK) of total trastuzumab, released monomethyl auristatin E (MMAE), and total MMAE were measured inside the cells and in the cell culture media following incubation with two different concentrations of ADC. In addition, target expression levels, target internalization rate, and cathepsin B and MDR1 protein concentrations were determined for each cell line. All the PK data were mathematically characterized using a cell-level systems PK model for ADC. It was found that SKBR-3, MDA-MB-453, MCF-7, and MDA-MB-468 cells had ~800,000, ~250,000, ~50,000, and ~10,000 HER2 receptors per cell, respectively. A strong linear relationship (R² > 0.9) was observed between HER2 receptor count and released MMAE exposure inside the cancer cells. There was an inverse relationship found between HER2 expression level and internalization rate, and cathepsin B and multidrug resistance protein 1 (MDR1) expression level varied slightly among the cell lines. The PK model was able to simultaneously capture all the PK profiles reasonably well while estimating only two parameters. Our results demonstrate a strong quantitative relationship between antigen expression level and intracellular exposure of ADCs in cancer cells.

The cell surfaces of many bacteria carry filamentous polypeptides termed adhesins that enable binding to both biotic and abiotic surfaces. Surface adherence is facilitated by the exquisite selectivity of the adhesins for their cognate ligands or receptors and is a key step in niche or host colonization and pathogenicity. Streptococcus gordonii is a primary colonizer of the human oral cavity and an opportunistic pathogen, as well as a leading cause of infective endocarditis in humans. The fibrillar adhesin CshA is an important determinant of S. gordonii adherence, forming peritrichous fibrils on its surface that bind host cells and other microorganisms. CshA possesses a distinctive multidomain architecture comprising an N-terminal target-binding region fused to 17 repeat domains (RDs) that are each ∼100 amino acids long. Here, using structural and biophysical methods, we demonstrate that the intact CshA repeat region (CshA_RD1–17, domains 1–17) forms an extended polymeric monomer in solution. We recombinantly produced a subset of CshA RDs and found that they differ in stability and unfolding behavior. The NMR structure of CshA_RD13 revealed a hitherto unreported all β-fold, flanked by disordered interdomain linkers. These findings, in tandem with complementary hydrodynamic studies of CshA_RD1–17, indicate that this polypeptide possesses a highly unusual dynamic transitory structure characterized by alternating regions of order and disorder. This architecture provides flexibility for the adhesive tip of the CshA fibril to maintain bacterial attachment that withstands shear forces within the human host. It may also help mitigate deleterious folding events between neighboring RDs that share significant structural identity without compromising mechanical stability.

The global burden of disease caused by extraintestinal pathogenic Escherichia coli (ExPEC) is increasing as the prevalence of multidrug-resistant strains rises. A multivalent ExPEC O-antigen bioconjugate vaccine could have a substantial impact in preventing bacteremia and urinary tract infections. Development of an ExPEC vaccine requires a readout to assess the functionality of antibodies. We developed an opsonophagocytic killing assay (OPA) for four ExPEC serotypes (serotypes O1A, O2, O6A, and O25B) based on methods established for pneumococcal conjugate vaccines. The performance of the assay was assessed with human serum by computing the precision, linearity, trueness, total error, working range, and specificity. Serotypes O1A and O6A met the acceptance criteria for precision (coefficient of variation for repeatability and intermediate precision, ≤50%), linearity (90% confidence interval of the slope of each strain, 0.80, 1.25), trueness (relative bias range, –30% to 30%), and total error (total error range, –65% to 183%) at five serum concentrations and serotypes O2 and O25B met the acceptance criteria at four concentrations (the lowest concentration for serotypes O2 and O25B did not meet the system suitability test of maximum killing of ≥85% of E. coli cells). All serotypes met the acceptance criteria for specificity (opsonization index value reductions of ≤20% for heterologous serum preadsorption and ≥70% for homologous serum preadsorption). The assay working range was defined on the basis of the lowest and highest concentrations at which the assay jointly fulfilled the target acceptance criteria for linearity, precision, and accuracy. An OPA suitable for multiple E. coli serotypes has been developed, qualified, and used to assess the immunogenicity of a 4-valent E. coli bioconjugate vaccine (ExPEC4V) administered to humans.

The need to characterize and distinguish geographically adjacent aggregate quarry sources prompted the SEM-EDS analysis of pyrite (FeS₂) within fill material taken from eight different quarry sources. This experiment was undertaken to investigate the possibility of geochemically separating these quarry sources based on the major element concentration of their pyrite. The results show that median values for Fe and S vary by up to 7.6 and 8.55 wt% respectively. By implementing statistical methods, including k-means clustering and principal component analysis, it is possible to geochemically discriminate three of the eight sources.

Purpose:

Radium-223 is approved for metastatic castration-resistant prostate cancer (mCRPC) based on improved overall survival, and delay in skeletal related events. However, it is not associated with PSA or radiographic response, which poses a challenge in real-time assessment of its efficacy. Surrogate markers of treatment outcomes may facilitate tailoring treatment duration with radium-223, by limiting the duration of therapy with radium-223 in these patients. Here, we sought to investigate the utility of bone metabolic markers (BMMs) as surrogate markers of response to radium-223 in mCRPC.