gate A reaction based carbazole–indolium conjugate probe for the selective detection of environmentally toxic ions By pubs.rsc.org Published On :: Anal. Methods, 2024, Advance ArticleDOI: 10.1039/D4AY00301B, PaperJayasudha Palanisamy, Mansour K. Gatasheh, Ashraf Atef HatamlehCarbazole–indolium based colorimetric probe was designed for detecting cyanide ions in various water samples. An outstanding response was shown by paper test strips prepared using the probe for the easy detection of cyanide in real time.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
gate Design, synthesis, inhibitory activity, and molecular simulations study for D-glucose-conjugated thioureas containing pyrimidine ring as multitarget inhibitors against α-amylase, α-glucosidase, DDP-4, and PTP1B in Type 2 diabetes mellitus By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3395-3417DOI: 10.1039/D4MD00334A, Research ArticleVu Ngoc Toan, Do Son Hai, Hoang Thi Kim Van, Nguyen Minh Tri, Duong Ngoc Toan, Nguyen Thi Thanh Mai, Nguyen Dinh ThanhD-Glucose-conjugated thioureas from 2-aminopyrimidines had inhibitory activity against α-amylase, α-glucosidase, DPP-4, PTP1B. The cytotoxicity, inhibitory kinetics, and molecular simulations of the most potent inhibitors 8k, 8j, 8f, and 8h were studied.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
gate Synthesis and cytotoxic activity of madecassic acid–silybin conjugate compounds in liver cancer cells By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3418-3432DOI: 10.1039/D4MD00170B, Research Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Chien Van Tran, Thao Thi Phuong Tran, Anh The Nguyen, Loc Van Tran, Ninh Thi Pham, Luu Thi Nguyen, Dung Thi Nguyen, Michelle D. Garrett, Nga Thi Nguyen, Thao Thi Do, Christopher J. Serpell, Sung Van TranMadecassic acid and silybin have been conjoined to produce hybrid compounds with improved and different activity against liver cancer cells.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
gate Design, synthesis and biological evaluation of a novel PSMA–PI3K small molecule drug conjugate By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3485-3494DOI: 10.1039/D4MD00246F, Research ArticleShouguo Peng, Haixia Li, Weilu Cui, Tianning Xiong, Jiaqi Hu, Haixiang Qi, Songwen Lin, Deyu Wu, Ming Ji, Heng XuA novel PSMA–PI3K small molecule drug conjugate has been prepared, highlighting its potential in targeted cancer therapy.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
gate Inhibition of monoamine oxidases by heterocyclic derived conjugated dienones: synthesis and in vitro and in silico investigations By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00608A, Research ArticleSunil Kumar, Bishnu Prasad Pandey, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Rania B. Bakr, Hoon Kim, Bijo MathewA total of 18 heterocyclic derived conjugated dienones (CD1–CD18) were evaluated for their potential monoamine oxidase (MAO)-A/-B inhibitory activity.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
gate Technical, preclinical, and clinical developments of Fc-glycan-specific antibody–drug conjugates By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00637B, Review Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Qiang Yang, Yunpeng LiuFc-glycan-specific ADC is a significant advance in site-specific ADCs for cancer therapy. Notably, JSKN003 and IBI343 have demonstrated promising results in phase 1 clinical trials and are advancing into phase 3 studies.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
gate Uppiliyapuram, gateway to scenic Pachamalai, lacks bus stand with passengers left to fight the elements By www.thehindu.com Published On :: Fri, 08 Nov 2024 19:20:03 +0530 Buses stop at a busy junction making it difficult for commuters as well as local businessmen; a site is yet to be identified for the bus stand Full Article Tiruchirapalli
gate Aggregated customer power By www.thehindubusinessline.com Published On :: Sun, 13 Oct 2024 20:00:00 +0530 User-friendly financial services are a click away with account aggregators Full Article Current Account
gate Coimbatore car blast: NIA interrogates three accused of raising funds for operation By www.thehindu.com Published On :: Mon, 11 Nov 2024 13:28:18 +0530 The NIA sleuths will interrogate them in custody till November 14, said a source privy to the investigation Full Article Tamil Nadu
gate Reversible pH-responsive supramolecular aggregates from viologen based amphiphiles – A molecular design perspective By pubs.rsc.org Published On :: Soft Matter, 2024, Accepted ManuscriptDOI: 10.1039/D4SM00695J, PaperRedhills L. Narendran, Archita PatnaikpH responsive self-assembled supramolecular systems in water hold tremendous promise spanning across the various realms of science and technology. Herein, we report the design and synthesis of benzyl viologen (BV)...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
gate Palakkad division commissions first of 30 electric lifting barriers at level-crossing gates By www.thehindu.com Published On :: Fri, 08 Nov 2024 07:00:00 +0530 LC gate at Jokatte and LC gates between Mangaluru Central and Kannur to be upgraded to EOLBs in a phased manner Full Article Mangaluru
gate A 10-step guide to navigate the MBA journey By www.thehindu.com Published On :: Sun, 03 Nov 2024 18:30:00 +0530 As students embark on a journey towards an MBA degree, here are some tips to help them onwards Full Article Education
gate Isomeric diazapyrene–thiophene conjugated systems: synthesis, characterization, and transport properties By pubs.rsc.org Published On :: Org. Chem. Front., 2024, Advance ArticleDOI: 10.1039/D4QO01305K, Research Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Honglei Li, Guodong Zhao, Qingxin Tang, Hongkun Tian, Lixiang WangThree key dihalogenated diazapyrene intermediates were synthesized and the corresponding isomeric co-oligomers with bithiophene demonstrated distinct position-dependence in the crystal structures, and optoelectronic and charge transport properties.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
gate Dendron-mediated control over self-assembly of chlorophyll rosettes into columnar vs. discrete aggregates By pubs.rsc.org Published On :: Org. Chem. Front., 2024, 11,6304-6310DOI: 10.1039/D4QO01629G, Research Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ryo Kudo, Hiroki Hanayama, Balaraman Vedhanarayanan, Hitoshi Tamiaki, Nobuyuki Hara, Sarah E. Rogers, Martin J. Hollamby, Biplab Manna, Koji Harano, Shiki YagaiBy controlling the π-π stacking of chlorophyll supramolecular rosettes through steric hindrance of alkyl dendrons, it become possible to create chlorophyll tubes and discrete rings that resemble to natural chlorophyll assemblies.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
gate Synthesis and in vitro assessment of gold nanoparticles conjugated with extracts, sterols and pure compounds derived from marine sponges from the Indian and Pacific Oceans By pubs.rsc.org Published On :: RSC Adv., 2024, 14,36115-36131DOI: 10.1039/D4RA04068F, Paper Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Avin Ramanjooloo, Devesh Bekah, Samson A. Adeyemi, Philemon Ubanako, Lindokuhle Ngema, Yahya E. Choonara, David E. Williams, Elena A. Polishchuk, Raymond J. Andersen, Archana Bhaw-LuximonThe synthesis of gold nanoparticles using extracts, sterols and pure compounds from marine sponges.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
gate Multi-functional biotinylated platinum(IV)–SAHA conjugate for tumor-targeted chemotherapy By pubs.rsc.org Published On :: Dalton Trans., 2024, 53,17829-17840DOI: 10.1039/D4DT01571A, PaperAjay Gupta, Pijus K. SasmalHerein, we have developed a hydrolytically stable biotinylated Pt(IV) complex conjugated with a histone deacetylase inhibitor (SAHA) as a multi-functional tumour targeted chemotherapeutic agent.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
gate Fluorescent molecular systems based on carborane-perylenediimide conjugates By pubs.rsc.org Published On :: Dalton Trans., 2024, 53,17841-17851DOI: 10.1039/D4DT02477J, Paper Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Ruben Rodriguez-Madrid, Sohini Sinha, Laura Parejo, Jordi Hernando, Rosario Núñezo-Carborane–perylenediimide conjugates exhibit exceptional fluorescence properties in solution, while red-light excimer emission is observed in their aggregated forms and in dispersible nanoparticles.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
gate Synthesis and relaxivity of gadolinium-based DOTAGA conjugated 3-phosphoglycerate By pubs.rsc.org Published On :: Dalton Trans., 2024, 53,17777-17782DOI: 10.1039/D4DT02766C, Communication Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Andrew R. Brotherton, Shifa Noor Mohamed, Thomas J. MeadeA Gd-DOTAGA based MR contrast agent conjugated to 3-phosphoglycerate for enhanced relaxivity and investigation into its metabolism.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
gate Aldgate, Czar and Flight Of Fancy shine By www.thehindu.com Published On :: Sat, 09 Nov 2024 19:20:25 +0530 Full Article Races
gate Zydus Lifesciences gets WHO prequalification for Typhoid Vi conjugate vaccine By www.thehindu.com Published On :: Wed, 23 Oct 2024 15:49:21 +0530 Zydus Lifesciences’ ZyVac TCV receives WHO prequalification, eligible for U.N. procurement, combating typhoid fever in high-risk regions Full Article Industry
gate LTTS to acquire California firm Intelliswift for an aggregate consideration of $110 million By www.thehindu.com Published On :: Mon, 11 Nov 2024 19:22:34 +0530 As per the filing, Intelliswift services four of the top five hyperscalers and caters to over 25 Fortune 500 companies including five of the top 10 ER&D spenders in Software and Technology Full Article Industry
gate Row over relocation of school gate, allegedly for a bar hotel to get licence By www.thehindu.com Published On :: Fri, 08 Nov 2024 19:40:32 +0530 Full Article Kerala
gate The art of Gatescrashing democracy By www.thehindu.com Published On :: Fri, 12 Apr 2024 09:01:00 +0530 Journalist Tim Schwab says his book probing the Gates Foundation is a case study for the larger problem of extreme wealth and how it threatens democracy Full Article Interview
gate A robust data analytical method to investigate sequence dependence in flow-based peptide synthesis By pubs.rsc.org Published On :: React. Chem. Eng., 2024, 9,825-832DOI: 10.1039/D3RE00494E, Paper Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Bálint Tamás, Pietro Luigi Willi, Héloïse Bürgisser, Nina HartrampfA new data analytical method for flow-based peptide synthesis enables robust and quantitative analysis of sequence-dependent difficult couplings.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
gate The quercetin metabolite 4-methylcatechol causes vasodilation via voltage-gated potassium (KV) channels By pubs.rsc.org Published On :: Food Funct., 2024, 15,11047-11059DOI: 10.1039/D3FO04672A, Paper Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Patrícia Dias, Rudy Salam, Jana Pourová, Marie Vopršalová, Lukáš Konečný, Eduard Jirkovský, Jurjen Duintjer Tebbens, Přemysl MladěnkaOne of important metabolites of dietary polyphenols is 4-methylcatechol (4-MC). This compounds causes vasodilation likely due to an effect on voltage-dependent potassium channels (KV) as suggested by our ex vivo and in silico docking study.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
gate Exosome-like nanoparticles from Arbutus unedo L. mitigate LPS-induced inflammation via JAK-STAT inactivation By pubs.rsc.org Published On :: Food Funct., 2024, 15,11280-11290DOI: 10.1039/D4FO03646H, PaperCristian Martínez Fajardo, Lucía Morote, Elena Moreno-Giménez, Susana López-López, Ángela Rubio-Moraga, María José M. Díaz-Guerra, Gianfranco Diretto, Alberto J. López Jiménez, Oussama Ahrazem, Lourdes Gómez-GómezExosomes have garnered attention as a potential cell-free therapy for inflammatory diseases due to their immunomodulatory and anti-inflammatory properties.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
gate Your gateway to the social world By www.thehindu.com Published On :: Sun, 23 Oct 2016 17:00:54 +0530 Delve into sociology, criminology and deviance to challenge your critical thinking. Full Article Education Plus
gate Metamagnetic transition and meta-stable magnetic state in Co-doped Fe3GaTe2 By pubs.rsc.org Published On :: Nanoscale, 2024, 16,20252-20259DOI: 10.1039/D4NR02622E, PaperHyo-Bin Ahn, Hyunjong Lim, Jaegu Song, Jisung Lee, Seung-Young Park, Minwoong Joe, Chang-Jong Kang, Kyoung-Whan Kim, Tae-Eon Park, Tuson Park, Changgu LeeThe phase diagram and M–H curves of the metamagnetic regime of (Fe1−xCox)3GaTe2 with x = 0.19–0.26 at various temperatures were studied.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
gate Correction: Ce6-Conjugated and polydopamine-coated gold nanostars with enhanced photoacoustic imaging and photothermal/photodynamic therapy to inhibit lung metastasis of breast cancer By pubs.rsc.org Published On :: Nanoscale, 2024, 16,20354-20355DOI: 10.1039/D4NR90194K, Correction Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ziwei Li, Fan Yang, Di Wu, Yanhong Liu, Yang Gao, Haichen Lian, Hongxin Zhang, Zhibin Yin, Aiguo Wu, Leyong ZengThe content of this RSS Feed (c) The Royal Society of Chemistry Full Article
gate Retraction: Enhanced activity of vancomycin by encapsulation in hybrid magnetic nanoparticles conjugated to a cell-penetrating peptide By pubs.rsc.org Published On :: Nanoscale, 2024, 16,20356-20356DOI: 10.1039/D4NR90195A, Retraction Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Wenjie Zhang, Reza Taheri-Ledari, Zoleikha Hajizadeh, Ehsan Zolfaghari, Mohammad Reza Ahghari, Ali Maleki, Michael R. Hamblin, Ye TianThe content of this RSS Feed (c) The Royal Society of Chemistry Full Article
gate Refined Design of DNA Logic Gate for Implementing DNA-based Three-level Circuit By pubs.rsc.org Published On :: Nanoscale, 2024, Accepted ManuscriptDOI: 10.1039/D4NR03606A, PaperYuanpeng Zhang, Bei Yan, Xingge Li, Huan Liu, Xiao Liu, Xianjin Xiao, Zenghui Mao, Zhihao MingDNA computing circuits are favored by researchers due to their high density, high parallelism, and biocompatibility. However, compared with electronic circuits, current DNA circuits have significant errors in understanding the...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
gate DON encapsulated carbon dot–vesicle conjugate in therapeutic intervention of lung adenocarcinoma by dual targeting of CD44 and SLC1A5 By pubs.rsc.org Published On :: Nanoscale, 2024, Advance ArticleDOI: 10.1039/D4NR00426D, PaperAfreen Zaman, Aparajita Ghosh, Anup Kumar Ghosh, Prasanta Kumar DasHACD–TMAV, a carbon dot–vesicle conjugate, selectively delivered glutamine inhibitor DON to CD44-enriched cancer cells, inducing ROS triggered apoptosis by dual targeting CD44 and SLC1A5 through downregulation of PI3K/AKT/mTOR signalling cascade.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
gate Ultra-efficient delivery of CRISPR/Cas9 using ionic liquid conjugated polymers for genome editing-based tumor therapy By pubs.rsc.org Published On :: Biomater. Sci., 2024, 12,1716-1725DOI: 10.1039/D3BM01981K, PaperZhongming Huang, Tongren Yang, Jie Yu, Yijian Gao, Yuhua Weng, Yuanyu Huang, Shengliang LiThrough molecular screening, ionic liquid-conjugated polymers (IL-CPs) are developed for highly efficient delivery of CRISPR/Cas9 system, which demonstrated high-performance genome editing-based tumor therapy.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
gate French politicians navigate evolving fashion rules By www.thehindu.com Published On :: Sat, 22 Jun 2024 12:18:23 +0530 Women politicians in France have largely abandoned the neat designer outfits of the past in a bid to look less elitist Full Article Fashion
gate Death in Gujarat Refinery fire rises to 2; IOCL constitutes team to investigate By www.thehindubusinessline.com Published On :: Tue, 12 Nov 2024 10:59:20 +0530 The fire that began on Monday afternoon with a blast in a benzene storage tank of the refinery later spread to two other adjoining tanks, Jawahar Nagar police station inspector A B Mori said Full Article Companies
gate HC grants time to authorities to repair damaged sluice gate at an irrigation tank in Sattur By www.thehindu.com Published On :: Thu, 07 Nov 2024 21:17:15 +0530 Full Article Madurai
gate Inside the gated glens and glades By www.thehindu.com Published On :: Fri, 13 Dec 2013 16:51:30 +0530 If your heart aches for a piece of green, landscaping can be of help Full Article Gardens
gate Enzyme conjugate synthesizes DNA By cen.acs.org Published On :: 20 Jun 2018 21:13:26 +0000 Method is possible replacement for phosphoramidite-based DNA synthesis Full Article
gate EC investigates sale of Solvay’s nylon unit to BASF By cen.acs.org Published On :: 30 Jun 2018 13:15:47 +0000 Full Article
gate Bill Gates backs Alzheimer’s diagnostics with new Diagnostics Accelerator venture fund By cen.acs.org Published On :: 20 Jul 2018 16:15:55 +0000 Full Article
gate Injections of botulinum conjugate relieves chronic pain in mice By cen.acs.org Published On :: 25 Jul 2018 21:01:00 +0000 Modified toxin targets and silences nerves that transmit pain, offering a potential nonaddictive alternative to opioids Full Article
gate Urgent need for climate services to mitigate intensifying climate threats, says World Meteorological Organization By www.thehindubusinessline.com Published On :: Fri, 08 Nov 2024 15:53:03 +0530 World Meteorological Organization says big gaps exist and investments lag far behind Full Article Agri Business
gate One-pot synthesis of conjugated vinylene-extended viologen ionic radical polyacetylenes for visible light-promoted photocatalytic CO2 cycloaddition By pubs.rsc.org Published On :: Green Chem., 2024, 26,10876-10885DOI: 10.1039/D4GC03683B, PaperYanan Chang, Shuo Wang, Juan Chen, Zixuan Xu, Qing Shi, Yunjie Mao, Yanli Gai, Zhouyang Long, Guojian ChenIn situ synthesis of a conjugated vinylene-extended viologen ionic radical polyacetylene (VIRP-2) for visible light-promoted photocatalytic CO2 cycloaddition under ambient conditions.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
gate Stationary PMPML bus catches fire at Pune’s Swargate depot By indianexpress.com Published On :: Sat, 09 Nov 2024 10:03:07 +0000 Full Article Cities Pune
gate COVID-19 crisis set to spur M&A in SE Asia, says Golden Gate’s Lauria By www.dealstreetasia.com Published On :: Tue, 24 Mar 2020 21:53:21 +0000 The M&A wave is seen as startups begin to struggle with the virus' impact on their cashflows. The post COVID-19 crisis set to spur M&A in SE Asia, says Golden Gate’s Lauria appeared first on DealStreetAsia. Full Article golden gate ventures
gate Thai Airways to seek $1.8b emergency loan to navigate COVID-19 impact By www.dealstreetasia.com Published On :: Thu, 30 Apr 2020 13:35:13 +0000 After the loan, the money-losing national carrier plans to raise 77.04 billion baht in capital. The post Thai Airways to seek $1.8b emergency loan to navigate COVID-19 impact appeared first on DealStreetAsia. Full Article Thai Airways
gate Reinvent, smartly: A Gates Foundation-led rethink of New York public schools has promise and risks By www.nydailynews.com Published On :: Sun, 10 May 2020 08:05:00 +0000 A state full of parents who, having been suddenly forced to help homeschool youngsters, have by the millions grown more appreciative of the work of professional teachers in actual classrooms, had reason to worry when they heard how Gov. Cuomo trotted out plans for a Gates Foundation reinvention of public education statewide. Full Article
gate Police investigate death on Indianapolis' near northeast side By rssfeeds.indystar.com Published On :: Sat, 09 May 2020 20:22:06 +0000 Indianapolis Metropolitan Police Department are on the scene in the area of East 32nd Street and Baltimore Avenue. Full Article
gate Police investigate death on Indianapolis' near northeast side By rssfeeds.indystar.com Published On :: Sat, 09 May 2020 20:22:06 +0000 Indianapolis Metropolitan Police Department are on the scene in the area of East 32nd Street and Baltimore Avenue. Full Article
gate Frigatebirds sleep in mid-flight By www.theguardian.com Published On :: 2016-08-05T15:00:07Z New research shows that frigatebirds can sleep on the wing, with just one or both halves of their brainWhen Charles Darwin arrived at the Galápagos Islands in 1839, he had the opportunity to observe the habits of frigatebirds, and marvelled at their graceful flight manoeuvres and their ability to soar up high. “When it sees any object on the surface of the water,” he wrote, “[it] descends from a great height… with the swiftness of an arrow; and at the instant of seizing with its long beak and outstretched neck, the floating morsel, it turns upwards, with extraordinary dexterity, by the aid of its forked tail, and its long, powerful wings.” Related: Sleepy brains neglect half the world | Mo Costandi Related: Birds pack more cells into their brains than mammals Continue reading... Full Article Science Neuroscience
