We present a unique case of a single patient presenting with two mutationally distinct, PD-L1⁺ diffuse large B-cell lymphomas (DLBCLs). One of these DLBCLs demonstrated exceptionally high mutational burden (eight disease-associated variants and 41 variants of undetermined significance) with microsatellite instability (MSI) and an acquired PMS2 mutation with loss of PMS2 protein expression, detected postchemotherapy. This report, while highlighting the extent of possible tumor heterogeneity across separate clonal expansions as well as possible syndromic B-cell neoplasia, supports the notion that, although rare, PD-L1 expression and associated states permissive of high mutational burden (such as mismatch repair gene loss of function/MSI) should be more routinely considered in DLBCLs. Appropriate testing may be predictive of outcome and inform the utility of targeted therapy in these genetically diverse and historically treatment-refractory malignancies.

One of my favourite satires is the Screwtape Letters, an epistolary novel by Narnia scribe C.S. Lewis. It consists of messages from an oily elder demon to his nephew about how to correctly groom the soul of an unsuspecting human being. It's a claustrophobic send-up of managerial politics and nepotism, with World War 1 unfolding in the background. A real pick-me-up. Sintopia is the Two Point incarnation of that premise - in other words, brighter and breezier and definitely more slapstick than Christian. It puts you in charge of a world divided between Earth and hell, and challenges you to ensure a steady movement of optimally sinful souls between one and the other. Say your prayers and watch the trailer.

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Radio astronomers teamed up with SpaceX to find a promising solution for helping expensive telescopes avoid interference from thousands of Starlink satellites

A chance to observe the high-speed re-entry of a falling satellite will give researchers important insights on how debris burns up in our atmosphere

Five satellites due to launch this week could be brighter than most stars, and astronomers fear the growth of such constellations could have a catastrophic impact

My first sight of Saturn through a telescope inspired my love of space. Dig out your telescopes or visit your local astronomy club, and you may be lucky enough to spot our sixth planet's stunning thick band of rings, says Leah Crane

Archaeologists are using AI and US spy satellite imagery from the cold war to find ancient underground aqueducts that helped humans survive in the desert

NASA said Thursday that the study of UFOs will require new scientific techniques, including advanced satellites as well as a shift in how unexplained sightings are perceived.

People report greater life satisfaction six months after starting Parkrun events, which could partly be due to the supportive environment

Scientists continue to learn new things about the planet, its sweeping rings and its many moons

"A satellite is always coming over an area within a given reasonable amount of time."

Peruvanam Satheesan Marar recalls his initiation into the percussion ensemble and how he gained expertise in playing different instruments

Meta has long been at loggerheads with European Union officials over its approach to targeted Facebook and Instagram ads. The company is hoping to placate regulators with some changes to its ad model in the bloc, which includes lowering the price of its ad-free subscription. Starting November 13, the plan will cost 40 percent less — €6 ($6.36) per month for signups via the web and €8 ($8.48) for those who subscribe on an iOS or Android device. The fee for each additional Facebook and Instagram account is €4 per month on the web and €5 via mobile.

The company will automatically drop current subscribers down to the lower pricing. It says that it will once again ask users in the bloc if they'd like to sign up.

When they see this prompt (which can only be ignored for a certain period of time), there will be a third option for EU Facebook and Instagram users to choose from. Those who don't want to pay for a subscription can instead opt to only view ads that are based on what they see in a given session in the apps. Meta will also factor in a few key data markers such as "a person’s age, location, gender and how a person engages with ads."

These less-personalized ads naturally won't be as tailored to a given user's interests, the company notes. As such, people are perhaps less likely to click on such ads. To make up for that (and make sure this option doesn't hit Meta in the pocket too hard), folks who choose the less-personalized ads option will sometimes encounter unskippable ads. According to The Wall Street Journal, these will be displayed full screen.

"Such ad breaks are common across other services, and are already offered by many of our competitors," Meta argues. "This change will help us continue to provide value to advertisers which ensures we can offer people a less personalized ads experience at no charge."

Targeted ads are Meta's biggest revenue driver, but EU officials have reportedly been pressuring the company to offer a free, less-personalized option in its apps. Meta has argued that would negatively impact its bottom line. Although it has seemingly caved to officials' requests, the unskippable ad aspect may be construed as malicious compliance, as it worsens the user experience.

Meta claims that these changes to its ad model "meet EU regulator demands and go beyond what’s required" by the bloc's laws. The company introduced its ad-free subscription a year ago to comply with laws such as the Digital Markets Act (DMA), as well as stricter interpretations of the General Data Protection Regulation. It was previously ordered to seek permission from users in the bloc before showing them personalized ads.

The EU didn't take too kindly to the paid ad-free approach, however. An investigation into the "consent or pay" model is ongoing. In July, the EU said that in its preliminary findings, Meta was violating the DMA with this plan.

These latest changes are said to be Meta's attempt to settle the case, but according to the Journal, the EU's discussions with the company haven't concluded. The bloc's regulatory body has until late March to finish its investigation and make a final decision. If it determines that Meta has indeed violated the DMA, the company could be on the hook for a fine of up to 10 percent of its annual global revenue. Based on its total revenue for 2023, it could have to pay up as much as $13 billion or so.

Los Angeles CA (SPX) Nov 09, 2024
Data from NISAR will improve our understanding of such phenomena as earthquakes, volcanoes, and landslides, as well as damage to infrastructure. Earth's surface is in a state of continuous motion, although often unnoticed. Scientists have utilized satellite and ground-based technology to observe movements linked to geological events such as earthquakes, landslides, and volcanic activity. A

Paris, France (SPX) Nov 03, 2024
ESA's Proba-3 mission, designed to create a solar eclipse in space, is leaving Europe to head to its Indian launch site. The mission's two spacecraft, designed to align precisely in orbit so one will block the Sun for the other, have departed from Redwire Space's facilities in Kruibeke, Belgium. The pair will be transported to the Satish Dhawan Space Centre near Chennai, India, to prepare for th

À l’exception notable des électeurs conservateurs.

ADELAIDE’S Mark Ricciuto has denied orchestrating a campaign to cut dollars from the contract of one of his star players.

Gros succès en France, le drame biographique est présenté samedi au Festival Cinemania.

James Hicks, healthcare application development and processing engineer at Syensqo explores the latest trends, challenges and solutions in sterilisation.

Ampacet has introduced ProVital+ Gamma-Protect, a medical-grade additive designed to preserve mechanical and optical properties of polypropylene-based medical and pharmaceutical articles during gamma and e-beam sterilisation processes.

A few dozen ChatGPT queries cost a bottle’s worth of water. Tech firms should consider simpler solutions, such as harvesting rainwater, to meet AI’s needs

Droughts in 48 of 50 U.S. states, evidence of microplastics mucking up wastewater recycling and the science of a baseball mud bath in this week’s news roundup.

Dec 1, 2022

A conversation hosted by the Faultlines Podcast with Ambassador Paula J. Dobriansky covering her career at the U.S. State Department and current geopolitical issues like the Russia-China strategic alignment.

Sep 8, 2023

Energy economist Severin Borenstein, Professor of the Graduate School at the Haas School of Business at the University of California, Berkeley, discussed the many significant challenges facing the nation’s electricity power sector in the latest episode of “Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program.

Oct 10, 2023

Michael Toffel, Senator John Heinz Professor of Environmental Management and Professor of Business Administration at Harvard Business School (HBS), discusses the many ways in which business and governments can and are working together to address climate change in the latest episode of “Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program.” The podcast is produced by the Harvard Environmental Economics Program.

Nov 27, 2023

With the start of the 28th Conference of the Parties (COP 28) of the United Nations Framework Convention on Climate Change just days away, environmental economist Nat Keohane is expressing optimism that the new global stocktake will incentivize participating nations to step up their collective efforts to slow the rise of global temperatures. Keohane is the guest in a special pre-COP episode of “Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program.” The podcast is produced by the Harvard Environmental Economics Program.

Dec 8, 2023

With 28th Conference of the Parties (COP 28) of the United Nations Framework Convention on Climate Change well underway, Jonathan Banks, the global director of the Methane Pollution Prevention Program at the Clean Air Task Force (CATF), is the guest in a special mid-COP episode of “Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program.” The podcast is produced by the Harvard Environmental Economics Program.

Dec 20, 2023

Amy Harder, the founding Executive Editor of the climate policy publication Cipher News, expressed her surprise with several positive outcomes from the recent 28th Conference of the Parties of the United Nations Framework Convention on Climate Change (COP 28) in Dubai during a special episode of “Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program.”

Feb 8, 2024

Eminent Harvard economist Richard Zeckhauser presented arguments for additional climate adaptation measures in the latest episode of “Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program.” The podcast is produced by the Harvard Environmental Economics Program.

Mar 4, 2024

UCLA Law School Professor Kimberly Clausing gives the Biden Administration high praise for its climate policies in the latest episode of “Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program.” The podcast is produced by the Harvard Environmental Economics Program.

Mar 7, 2024

Tarek Masoud, who questioned Iriqat’s views of Oct. 7 and how a two-state solution could be achieved during the event, said in an interview later on Thursday that he was “reasonably confident and hopeful” the discussion was an opportunity for learning, and added he appreciated that Iriqat “did not deny the atrocities of Oct. 7.” Understanding the Palestinian perspective is critical for moving toward peace and a two-state solution, Masoud said. Masoud and Iriqat agreed to discuss her controversial social media posts during the dialogue. Iriqat said that she did not intend to justify the violence on Oct. 7, which included kidnappings of children and elderly, beheadings, and massacres of civilians, but meant to place the attack in the context of a decades-long conflict. She was intensely critical of Israel throughout the conversation, saying the “settler-colonial project started 76 years ago.”

Apr 22, 2024

On March 05, 2024, the European Commission unveiled its first-ever European Defense Industry Strategy (EDIS). This announcement comes at an unprecedented moment in history.  In Ukraine, the situation remains a dire tactical stalemate, while belligerent Russia seems more threatening than ever to the European bloc. In the US, despite the efforts of the Biden administration, aid to Ukraine stalled for months and remains a contentious issue in Congress. Across Europe, EU Member States are trying to fill the gap in aid, but are struggling to supply Ukraine with the defense systems it urgently needs. On February 10, at a rally in South Carolina, former President and presidential candidate Donald Trump cast doubt on whether he would defend or surrender to Russia any European country that would fail to achieve NATO’s 2%-of-GDP target for defense spending.

Mar 28, 2024

Confronted by the accelerating climate crisis, Western governments, NGOs, and academia are grappling with a difficult question: Should the West engage with Russia on science and conservation, at a time when Russia is waging an unjust and violent war on a sovereign nation?

This study group, led by Arctic Initiative Senior Fellow Margaret Williams, is evaluating the costs and benefits of renewing cooperation with Russia on science and conservation issues.

Jun 18, 2024

The rise of political populism and economic protectionism are serious barriers impeding efforts to combat global climate change. Robert Lawrence, the Albert Williams Professor of International Trade and Investment at Harvard Kennedy School, expressed those concerns in the latest episode of “Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program.”

Jul 8, 2024

The ways in which land use and environmental policies intersect with natural resource sustainability and climate change was the focus of discussion in the latest episode of “Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program” featuring Charles Taylor, assistant professor of public policy at Harvard Kennedy School. The podcast is produced by the Harvard Environmental Economics Program.

Apr 8, 2024

Behavioral economist Hunt Allcott, Professor of Global Environmental Policy at the Doerr School of Sustainability at Stanford University, questioned the impact of new and used electric vehicle (EV) subsidies in the latest episode of “Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program.”

May 6, 2024

International relations expert Meghan O'Sullivan, the Jeane Kirkpatrick Professor of the Practice of International Affairs at Harvard Kennedy School, expressed her hopes for achieving successful international climate policy solutions in the latest episode of “Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program.”

Genworth Breaks Down the Basics of Long Term Care

Settlement Overview Video. If you lived at Huronia, Rideau, or Southwestern Regional Centres, you may be eligible to make a claim.

Singer Austin Mahone teams up with The Allstate Foundation to encourage smart teen driving through its #GetThereSafe program.

Trans-Atlantic Information Flow

Volvo V90 Reveal

Elecnor Deimos publica las primeras imágenes del satélite DEIMOS-2

This Saturday is a brand new episode of “Home Sweet Home” on Food Network. My kids are helping me shoot it, my production company in the UK is editing it together, and it’s been a great team effort! I just wanted to show you the dishes I’ll be making—it’s a fun, exciting, food-centric show! I’m […]

8006/20947Another 9/11 passes by with barely anyone recognising it at all. It seems to be only me and Harriet Harman who remember that fateful day at all (thanks to @BookHonest for the clip). I guess the world moves on, but I will remember them. The rest of you should be ashamed.I was hoping to get to Park Run this morning, but Catie took the early shift with the kids (I am usually the one who gets up to do this, as I generally wake up before the children) and I slept in til after 9am. I don't remember the last time this happened.

Toshiyuki Morikawa stars as titular dog in 12 episodes now streaming

This Saturday, May 18, starting at 10AM Pacific time, I’ll be doing a live “Ask Me Anything” on /r/comics. I’ve been informed that the mods will make the actual post a few hours earlier, for questions to start rolling in. UPDATE: Here is the link to the thread! I will of course (as is tradition) award a prize to the best question asked during the AMA. I’ve done a few AMAs before, and topics previously discussed include: ➡️ In 2018: ➡️ In 2013: Super interesting to see how things have changed and evolved since I gave those answers. Most of ... Read more