The Delaware Division of the Arts’ Mezzanine Gallery presents 2022 DDOA Individual Artist Fellow Aaron Terry’s exhibition, “Patterns for Saturn,” running June 2-July 28, 2023.  Guests are invited to attend a Meet-the-Artist Reception on Friday, June 2 from 5:00-7:00 p.m.

As in previous years, the Office of Veterans Services (OVS) and the Delaware Commission of Veterans Affairs (DCVA) will host a ceremonial event in observance of Veterans Day on Saturday, November 11, 2023, at 10:30 a.m. at the Delaware War Memorial Plaza (163 Cherry Lane, New Castle, DE 19720) in New Castle. The event will […]

Governor Markell signed House Bill 175 which will place tighter controls on workers compensation medical costs, while improving the state’s workplace safety program and more effectively encouraging injured individuals to return to work.

WILMINGTON, Del. – After reviewing customer feedback from three Community Conversations in Wilmington and Newark last week, DART will make a series of improvements. The recent Community Conversations offered DART riders, and the general public, the opportunity to provide feedback and share their experiences since DART’s service changes in mid-December. “The Community Conversations were intended […]

Expo to expose students, career-seekers to careers in construction WILMINGTON, Del. – On Friday and Saturday at the Chase Center on the Riverfront, Governor John Carney and a dozen partner organizations will host the first Governor’s Construction Career Expo to expose Delaware students and Delawareans exploring a career change to careers in construction. The construction […]

Delaware’s Birth to Three Program is proud to announce a dynamic and engaging virtual event, “Explore Delaware’s Birth to Three Journey with Special Guest Ms. Rachel,” scheduled for December 6, 2023, from 6:00 PM to 7:00 PM (EST) via Zoom. This one-hour live event is divided into two captivating segments, designed to educate, inspire and […]

The Delaware Department of Elections (DOE) informs eligible Delaware residents who are not yet registered to vote in Delaware and who wish to vote in the November 5, 2024, General Election that they must register to vote on or before Saturday, October 12, 2024 at 11:59 p.m. in order to vote in the General Election.

Microsoft announced it has acquired Semantic Machines, a conversational AI startup providing chatbots and AI chat apps founded in 2014 having $20.9 million in funding from investors. The acquisition will help Microsoft catch up with Amazon Alexa, though the latter is more focused on enabling consumer applications of conversational AI.

Microsoft will use Semantic Machine’s acquisition to establish a conversational AI center of excellence in Berkeley to help it innovate in natural language interfaces.

Microsoft has been stepping up its products in conversational AI. It launched the digital assistant Cortana in 2015, as well as social chatbots like XiaoIce. The latest acquisition can help Microsoft beef up its ‘enterprise AI’ offerings.

As the use of NLP (natural language processing) increases in IoT products and services, more startups are getting traction from investors and established players. In June last year, Josh.ai, avoice-controlled home automation software has raised $8M.

Followed by it was SparkCognition that raised $32.5M Series B for its NLP-based threat intelligence platform.

It appears Microsoft’s acquisition of Semantic Machines was motivated by the latter’s strong AI team. The team includes technology entrepreneur Daniel Roth who sold his previous startups Voice Signal Technologies and Shaser BioScience for $300M and $100M respectively. Other team members include Stanford AI Professor Percy Liang, developer of Google Assistant Core AI technology and former Apple chief speech scientist Larry Gillick.

[COSATU] The Congress of South African Trade Unions (COSATU) is deeply concerned by the Minister for Communications and Digital Technologies, Mr. S. Malatsi's sudden withdrawal of the South African Broadcasting Corporation (SABC) SOC Ltd Bill from Parliament where it was being engaged upon by the National Assembly's Portfolio Committee: Communications and Digital Technologies.

[COSATU] The Congress of South African Trade Unions (COSATU) welcomes the slight drop in the expanded unemployment rate from 42.6% in the second quarter to 41.9% in the third quarter of this year.

DDR5 DIMM Architectures The DDR5 generation of Double Data Rate DRAM memories has experienced rapid adoption in recent years. In particular, the JEDEC-defined DDR5 Dual Inline Memory Module (DIMM) cards have become a mainstay for systems looking for high-density, high-bandwidth, off-chip random access memory[1]. Within a short time, the DIMM architecture evolved from an interconnected hierarchy of only SDRAM memory devices (UDIMM[2]) to complex subsystems of interconnected components (RDIMM/LRDIMM/MRDIMM[3]). DIMM Designs and Popular Verification Use Cases The growing complexity of the DIMMs presented a challenge for pre-silicon verification engineers who could no longer simply validate against single DDR5 SDRAM memory models. They needed to consider how their designs would perform against DIMMs connected to each channel and operating at gigahertz clock speeds. To address this verification gap, Cadence developed DDR5 DIMM Memory Models that encapsulated all of the architectural complexities presented by real-world DIMMs based on a robust, easy-to-use, easy-to-debug, and easy-to-reconfigure methodology. This memory-subsystem-in-a-single-instance model has seen explosive adoption among the traditional IP Developer and SOC Integrator customers of Cadence Memory Models. The Cadence DIMM models act as a single unit with all of the relevant DIMM components instantiated and interconnected within, and with all AC/Timing parameters among the various components fully matched out-of-the-box, based on JEDEC specifications as well as datasheets of actual devices in the market. The typical use-case for the DIMM models has been where the DUT is a DDR5 Memory Controller + PHY IP stack, and the validation plan mandated compliance with the JEDEC standards and Memory Device vendor datasheets. Unique Use Case for the DIMM Discrete Component Models Although the Cadence DIMM models have enjoyed tremendous proliferation because of their cohesive implementation and unified user API, the actual DIMM Models are built on top of powerful, flexible discrete component models, each of which was designed to stand on its own as a complete SystemVerilog UVM-based VIP. All of these discrete component models exist in the Cadence VIP Catalog as standalone VIPs, complete with their own protocol compliance checking capabilities and their own configuration mappings comprehensively modeling individual AC/Timing parameters. Because of this deliberate design decision, the Cadence DIMM Discrete Component Models can support a unique use-case scenario. Some users seek to develop IC Designs for the various DIMM components. Such users need verification environments that can model the individual components of a DIMM and allow them the option to replace one or another component with their Component Design IP. They can then validate that their component design is fully compatible with the rest of the components on the DIMM and meets the integrity of the overall DIMM compliance with JEDEC standards or Memory Vendor datasheets. The Cadence Memory VIP portfolio today includes various examples that demonstrate how customers can create DIMM “wrappers” by selecting from among the available DIMM discrete component models and “stitching” them together to build their own custom testbench around their specific Component Design IP. A Solution for Unique Component Scenarios The Cadence DDR5 DIMM Memory Models and DIMM Discrete Component Models can provide users with a flexible approach to validating their specific component designs with a fully populated pre-silicon environment. Augmented Verification Capabilities When the DIMM “wrapper” model is augmented with the Cadence DFI VIP[4] that can simulate an MC+PHY stack and offers a SystemVerilog UVM test API to the verification engineer, the overall testbench transforms into a formidable pre-silicon validation vehicle. The DFI VIP is designed as a combination of an independent DFI MC VIP and a DFI PHY VIP connected to each other via the DFI Standard Interface and capable of operating seamlessly as a single unit. It presents a UVM Sequence API to the user into the DFI MC VIP with the Memory Interface of the PHY VIP connected to the DIMM “wrapper” model. With this testbench in hand, the user can then fully take advantage of the UVM Sequence Library that comes with the DFI VIP to enable deep validation of their Component Design inside the DIMM “wrapper” model. Verification Capabilities Further Enhanced A possible further enhancement comes with the potential addition of an instance of the Cadence DIMM Memory Model in a Passive Monitor mode at the DRAM Memory Interface. The DIMM Passive Monitor consumes the same configuration describing the DIMM “wrapper” in the testbench, and thus can act as a reference model for the DIMM wrapper. If the DIMM Passive Monitor responds successfully to accesses from the DFI VIP, but the DIMM wrapper does not, then it exposes potential bugs in the DUT Components or in the settings of their AC/Timing parameters inside the DIMM wrapper. Debuggability, Interface Visibility, and Protocol Compliance One of the key benefits of the DIMM Discrete Component Models that become manifest, whether in terms of the unique use-case scenario described here, or when working with the wholly unified DDR5 DIMM Memory Models, is the increased debuggability of the protocol functionality. The intentional separation of the discrete components of a DIMM allows the user to have full visibility of the memory traffic at every datapath landmark within a DIMM structure. For example, in modeling an LRDIMM or MRDIMM, the interface between the RCD component and the SDRAM components, the interface between the RCD component and the DB components, and the interface between the SDRAM components and the DB components—all are visible and accessible to the user. The user has full access to dump the values and states of the wire interconnects at these interfaces to the waveform viewer and thus can observe and correlate the activity against any protocol violations flagged in the trace logs by any one or more of the DIMM Discrete Component Models. Access to these interfaces is freely available when using the DIMM Discrete Component Models. On the unified DDR5 DIMM Memory Models, a feature called Debug Ports enables the same level of visibility into the individual interconnects amidst the SDRAM components, RCD components, and DB components. When combined with the Waveform Debugger[5] capability that comes built-in with the VIPs and Memory Models offered by Cadence and used with the Cadence Verisium Debug[6] tool, the enhanced debuggability becomes a powerful platform. With these debug accesses enabled, the user can pull out transaction streams, chip state and bank state streams, mode register streams, and error message streams all right next to their RTL signals in the same Verisium Debug waveform viewer window to debug failures all in one place. The Verisium Debug tool also parses all of the log files to probe and extract messages into a fully integrated Smart Log in a tabbed window fully hyperlinked to the waveform viewer, all at your fingertips. A Solution for Every Scenario Cadence's DDR5 DIMM Memory Models and DIMM Discrete Component Models , partnered with the Cadence DFI VIP, can provide users with a robust and flexible approach to validating their designs thoroughly and effectively in pre-silicon verification environments ahead of tapeout commitments. The solution offers unparalleled latitude in debuggability when the Debug Ports and Waveform Debugger functions of the Memory Models are switched on and boosted with the use of the Cadence Verisium Debug tool. [1] Shyam Sharma, DDR5 DIMM Design and Verification Considerations , 13 Jan 2023. [2] Shyam Sharma, DDR5 UDIMM Evolution to Clock Buffered DIMMs (CUDIMM) , 23 Sep 2024. [3] Kos Gitchev, DDR5 12.8Gbps MRDIMM IP: Powering the Future of AI, HPC, and Data Centers , 26 Aug 2024. [4] Chetan Shingala and Salehabibi Shaikh, How to Verify JEDEC DRAM Memory Controller, PHY, or Memory Device? , 29 Mar 2022. [5] Rahul Jha, Cadence Memory Models - The Gold Standard , 15 Apr 2024. [6] Manisha Pradhan, Accelerate Design Debugging Using Verisium Debug , 11 Jul 2023.

This is the 23rd installment of The Rationalist, my column for the Times of India.

I had a strange dream last night. I dreamt that the government had passed a law that made using laptops illegal. I would have to write this column by hand. I would also have to leave my home in Mumbai to deliver it in person to my editor in Delhi. I woke up trembling and angry – and realised how Indian farmers feel every single day of their lives.

My column today is a tale of two satyagrahas. Both involve farmers, technology and the freedom of choice. One of them began this month – but first, let us go back to the turn of the millennium.

As the 1990s came to an end, cotton farmers across India were in distress. Pests known as bollworms were ravaging crops across the country. Farmers had to use increasing amounts of pesticide to keep them at bay. The costs of the pesticide and the amount of labour involved made it unviable – and often, the crops would fail anyway.

Then, technology came to the rescue. The farmers heard of Bt Cotton, a genetically modified type of cotton that kept these pests away, and was being used around the world. But they were illegal in India, even though no bad effects had ever been recorded. Well, who cares about ‘illegal’ when it is a matter of life and death?

Farmers in Gujarat got hold of Bt Cotton seeds from the black market and planted them. You’ll never guess what happened next. As 2002 began, all cotton crops in Gujarat failed – except the 10,000 hectares that had Bt Cotton. The government did not care about the failed crops. They cared about the ‘illegal’ ones. They ordered all the Bt Cotton crops to be destroyed.

It was time for a satyagraha – and not just in Gujarat. The late Sharad Joshi, leader of the Shetkari Sanghatana in Maharashtra, took around 10,000 farmers to Gujarat to stand with their fellows there. They sat in the fields of Bt Cotton and basically said, ‘Over our dead bodies.’ ¬Joshi’s point was simple: all other citizens of India have access to the latest technology from all over. They are all empowered with choice. Why should farmers be held back?

The satyagraha was successful. The ban on Bt Cotton was lifted.

There are three things I would like to point out here. One, the lifting of the ban transformed cotton farming in India. Over 90% of Indian farmers now use Bt Cotton. India has become the world’s largest producer of cotton, moving ahead of China. According to agriculture expert Ashok Gulati, India has gained US$ 67 billion in the years since from higher exports and import savings because of Bt Cotton. Most importantly, cotton farmers’ incomes have doubled.

Two, GMO crops have become standard across the world. Around 190 million hectares of GMO crops have been planted worldwide, and GMO foods are accepted in 67 countries. The humanitarian benefits have been massive: Golden Rice, a variety of rice packed with minerals and vitamins, has prevented blindness in countless new-born kids since it was introduced in the Philippines.

Three, despite the fear-mongering of some NGOs, whose existence depends on alarmism, the science behind GMO is settled. No harmful side effects have been noted in all these years, and millions of lives impacted positively. A couple of years ago, over 100 Nobel Laureates signed a petition asserting that GMO foods were safe, and blasting anti-science NGOs that stood in the way of progress. There is scientific consensus on this.

The science may be settled, but the politics is not. The government still bans some types of GMO seeds, such as Bt Brinjal, which was developed by an Indian company called Mahyco, and used successfully in Bangladesh. More crucially, a variety called HT Bt Cotton, which fights weeds, is also banned. Weeding takes up to 15% of a farmer’s time, and often makes farming unviable. Farmers across the world use this variant – 60% of global cotton crops are HT Bt. Indian farmers are so desperate for it that they choose to break the law and buy expensive seeds from the black market – but the government is cracking down. A farmer in Haryana had his crop destroyed by the government in May.

On June 10 this year, a farmer named Lalit Bahale in the Akola District of Maharashtra kicked off a satyagraha by planting banned seeds of HT Bt Cotton and Bt Brinjal. He was soon joined by thousands of farmers. Far from our urban eyes, a heroic fight has begun. Our farmers, already victimised and oppressed by a predatory government in countless ways, are fighting for their right to take charge of their lives.

As this brave struggle unfolds, I am left with a troubling question: All those satyagrahas of the past by our great freedom fighters, what were they for, if all they got us was independence and not freedom?

The India Uncut Blog © 2010 Amit Varma. All rights reserved.
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FDI in the leisure and entertainment sector has risen sharply in recent years, with Asia-Pacific the leading region 

Argentina’s copper and lithium projects are rich in opportunities for Australian mining equipment, technology and services providers.

Critical Conversations on Islam and Asia Critical Conversations on Islam and Asia

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

On June 25, 2018 I woke up to yet another social media trend – a news story with the bold and quite salacious headline “How Safe Are Customer Deposits At FCMB?” had taken over the digital airwaves. Between the shares and likes and comments, a storm in a cup had brewed to great proportions in […]

The Worrisome Trend of Sensational Social Media “Journalism” and the Impact On Legitimate Business Concerns: Recent Travails of FCMB, GTBank and First Bank

SANTIAGO, Chile — It's Friday night in Santiago, and 15 people gather around a table, sharing a bottle of wine as the smell of tobacco and incense fill the air. Black candles burn on top of an altar decorated with chalices and knives. The members of the Temple of Satan are about to start a ritual.  Five years after the Satanic Temple of the United States made headlines — and unleashed a wave of panic — when it was designated a church, a similar organization in Chile, a conservative country where half of its population of 18 million identifies as Catholic, is asking the government to be recognized legally as a religious association.  Scholars, believers and residents consulted by The Associated Press note that Chile, where a long-lasting tradition of Catholicism has played a leading role in public discussions, is experiencing a crisis of faith, following revelations of multiple sexual abuse scandals within the Catholic Church over the years.  "These types of organizations now feel that they have greater support to challenge what was virtually impossible before," said Luis Bahamondes, a professor at the Center for Judaic Studies at the University of Chile. And that's because, "until very recently, the Catholic Church enjoyed an unprecedented power. It had an opinion on everything: politics, economics, geopolitics, sexuality and education."  No sacrifices, devil worship Despite its name, the Temple of Satan: Satanists and Luciferians of Chile does not embark on sacrifices nor ask its congregants to worship the devil. Among its 100 members are people who work as publicists, firefighters, police officers, lawyers and psychologists, and who have found in the organization a way to defy moral norms, dogmas and religious impositions.  While they embrace the term Satanist, they don't revere or believe in Satan. Instead, they worship rationality, individualism, pleasure and the mundane life.  Rather than gods, they praise humankind.  "You are the owner of your present and future, there is no God that makes decisions for you," said Haborym, a spokesperson for the group, during a walk through tombs and mausoleums at the General Cemetery of Santiago. He noted that the figure of Satan is purely symbolic and their rituals are performed "to bring out the emotions and leave the intellect aside."  Haborym and other members of the Temple of Satan in Chile spoke on condition their real names not be used, particularly with many holding public-facing jobs, citing growing threats.  While Hollywood movies like "Rosemary's Baby" and TV series such as "True Detective" helped to portray the idea of Satanists as linked to sacrifice, evil, pain and death, modern groups like Chile's Temple of Satan are strongly against animal abuse, prohibit the affiliation of people with criminal records, see pleasures as a delight rather than a sin, and do not express their opinions unless asked.  "We don't want people killing in the name of Satan," said Haborym.  How to join In order to join Chile's Temple of Satan, applicants are requested to go through a lengthy process that includes filling out a form, showing proof of not having a criminal record, being interviewed by a special commission and, finally, being evaluated by a psychologist.  Once they are accepted, members can choose a new name — normally that of a demon or fallen angel — with which they will be identified inside the temple and among other associates.  Founded in 2021, Chile's Temple of Satan has 100 members, and more than 400 people applied to join in the past few weeks, said Haborym. The interest spiked at the end of July, when the group formally requested that the country's Ministry of Justice legally recognize it as a religious association.  A media frenzy followed, unleashing a heated debate and causing a stir among Chile's main religious denominations.  "The history of Satanism is well known [and] it has often been the cause of tragedies," the leaders of several churches in Chile, including the Catholic, Anglican, Jewish and Evangelical, said in a joint statement.  Following in the steps of the Church of Satan, founded in 1966 by Anton Szandor LaVey, modern Satanists praise skepticism and logic over celestial or supernatural beings. Its followers are free to formulate their own beliefs, rites and spiritual practices.  Many self-described Satanists and Luciferians are atheists. Others say they are witches or believe in the power of magic.  "We do accept that there are certain bases, both academic and esoteric, that give meaning to our existence and reality," said Azazel, who quit Judaism four years ago and, one year later, founded the Temple of Satan of Chile.  His words resonate in the darkness of the chamber and are interspersed with chants, clapping, mantras and readings of passages from the Satanic Bible and the Bible of the Adversary, the main guidelines of the group.  Disappointed worshippers Just like Azazel, others have turned to the Temple of Satan out of disappointment with traditional religions. The new congregants include not only occultists and esotericists, but also Catholics, Jews, Protestants and Evangelicals.  "In Satanism there are no solutions or absolute truths. You are your own god and you create your own reality," said Kali Ma, a dentistry student who was born and raised in a Jehovah's Witness family. "If we compare both, Jehovah's Witnesses are the real sect," she said. "They don't let you do certain things, they tell you how to dress, what to do, how to behave, whether or not to grow a beard."  Nestor da Costa, an expert in secularism and religion at the Catholic University of Uruguay, said the influx of people seeking answers through different perspectives might be linked to the search for less dogmatic approaches.  "It may be a readjustment of the religious side of people who leave Catholicism but continue to believe in something," he said.  It is unclear if the Chilean government will legally recognize the Temple of Satan as a legitimate religious association, but its very existence has already helped to spark a discussion that until recently was unthinkable in this conservative society.  Demanding recognition is the ultimate expression of everything praised by Satanic aesthetics: the rebellion against the status quo and the breakup with deep-rooted traditions.  "We comply with everything that is requested of us as a religious entity," says Haborym. "So there would be no reason to reject us beyond the fact that we're a controversial figure." 

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

As of 5:00 p.m., approximately 70 rockets were fired by Hezbollah to Israel.

Satellite images show China working on nuclear reactor for new warship

The doctrine of man’s depravity, of all the cardinal biblical truths should never need to be defended. The empirical evidence for man’s sinful nature is irrefutable and ubiquitous. It is the inescapable reality of life.

Remarks by Masatsugu Asakawa, President, Asian Development Bank, at the 21st Annual Meeting of the Independent Accountability Mechanisms of Multilateral Banks and International Financial Institutions, 1 October 2024, ADB headquarters, Manila, Philippines

Remarks by Masatsugu Asakawa, President, Asian Development Bank, at the 8th Greater Mekong Subregion Summit, Plenary Session, 7 November 2024

Remarks by Masatsugu Asakawa, President, Asian Development Bank, at the 8th Greater Mekong Subregion Summit, Leaders’ Retreat, 7 November 2024

Remarks by Masatsugu Asakawa, President, Asian Development Bank, at the 30 Years of Kazakhstan-ADB Anniversary Reception, 8 November 2024

Keynote address by Masatsugu Asakawa, President, Asian Development Bank, at the 23rd Ministerial Conference of the Central Asia Regional Economic Cooperation Program, 8 November 2024

Intervention by Masatsugu Asakawa, President, Asian Development Bank, on behalf of the multilateral development banks at COP29, World Leaders Summit, 12 November 2024

Remarks by Masatsugu Asakawa, President, Asian Development Bank, at the Innovative Finance Facility for Climate in Asia and the Pacific Kick-Off Event, 12 November 2024

to write a satire paper

Could potassium fortification be the answer we're looking for when it comes to battling our unhealthy addiction to salt?

Remote sensing, including lidar, reveals that the Amazon was once home to millions of people. The emerging picture of how they lived challenges ideas of human cultural evolution

Netflix’s Ancient Apocalypse peddles the idea that we have overlooked an extraordinary ancient civilisation. Flint Dibble explains why that is wrong, and why real archaeology is more exciting

A link between volcanic activity and rising bubbles of low pressure in the ionosphere has now been proven, which may be why the colossal Tonga volcano eruption in 2022 disrupted satellite communications

A ring of asteroid debris could have orbited Earth for tens of millions of years, and perhaps even have altered the planet's climate

A stellar cast play leaders of G7 countries facing an existential crisis in Rumours, a smart film about communication, diplomatic nonsense and not coping, says Simon Ings

Remote sensing, including lidar, reveals that the Amazon was once home to millions of people. The emerging picture of how they lived challenges ideas of human cultural evolution

Netflix’s Ancient Apocalypse peddles the idea that we have overlooked an extraordinary ancient civilisation. Flint Dibble explains why that is wrong, and why real archaeology is more exciting

Title: Brain May Recover From Concussion by Compensating
Category: Health News
Created: 8/23/2013 4:35:00 PM
Last Editorial Review: 8/26/2013 12:00:00 AM

Pleiotropy, measured as expression breadth across tissues, is one of the best predictors for protein sequence and expression conservation. In this study, we investigated its effect on the evolution of cis-regulatory elements (CREs). To this end, we carefully reanalyzed the Epigenomics Roadmap data for nine fetal tissues, assigning a measure of pleiotropic degree to nearly half a million CREs. To assess the functional conservation of CREs, we generated ATAC-seq and RNA-seq data from humans and macaques. We found that more pleiotropic CREs exhibit greater conservation in accessibility, and the mRNA expression levels of the associated genes are more conserved. This trend of higher conservation for higher degrees of pleiotropy persists when analyzing the transcription factor binding repertoire. In contrast, simple DNA sequence conservation of orthologous sites between species tends to be even lower for pleiotropic CREs than for species-specific CREs. Combining various lines of evidence, we propose that the lack of sequence conservation in functionally conserved pleiotropic CREs is owing to within-element compensatory evolution. In summary, our findings suggest that pleiotropy is also a good predictor for the functional conservation of CREs, even though this is not reflected in the sequence conservation of pleiotropic CREs.

Two decades into the era of Electronic Health Records (EHRs), the promise of streamlining clinical care, reducing burden, and improving patient outcomes has yet to be realized. A cross-sectional family physician census conducted by the American Board of Family Medicine in 2022 and 2023 included self-reported physician EHR satisfaction. Of the nearly 10,000 responding family physicians, only one-in-four (26.2%) report being very satisfied and one-in-three (33.8%) were not satisfied. These low levels of satisfaction point to the need for greater transparency in the marketplace and pressure to increase user-centric EHR design.

Chronic pain conditions affect nearly 20% of the population in the United States. Current medical interventions, such as opioid drugs, are effective at relieving pain but are accompanied by many undesirable side effects. This is one reason increased numbers of chronic pain patients have been turning to Cannabis for pain management. Cannabis contains many bioactive chemical compounds; however, current research looking into lesser-studied minor cannabinoids in Cannabis lacks uniformity between experimental groups and/or excludes female mice from investigation. This makes it challenging to draw conclusions between experiments done with different minor cannabinoid compounds between laboratories or parse out potential sex differences that could be present. We chose five minor cannabinoids found in lower quantities within Cannabis: cannabinol (CBN), cannabidivarin (CBDV), cannabigerol (CBG), 8-tetrahydrocannabinol (8-THC), and 9-tetrahydrocannabivarin (THCV). These compounds were then tested for their cannabimimetic and pain-relieving behaviors in a cannabinoid tetrad assay and a chemotherapy-induced peripheral neuropathy (CIPN) pain model in male and female CD-1 mice. We found that the minor cannabinoids we tested differed in the cannabimimetic behaviors evoked, as well as the extent. We found that CBN, CBG, and high-dose 8-THC evoked some tetrad behaviors in both sexes, while THCV and low-dose 8-THC exhibited cannabimimetic tetrad behaviors only in females. Only CBN efficaciously relieved CIPN pain, which contrasts with reports from other researchers. Together these findings provide further clarity to the pharmacology of minor cannabinoids and suggest further investigation into their mechanism and therapeutic potential.

BACKGROUND AND PURPOSE:

A cleftlike nonenhancing hypointensity was observed repeatedly in the pituitary gland at the adenohypophysis/neurohypophysis border on contrast-enhanced 3D fat-saturated T1-MPRAGE using clinical 7T MRI. Our primary goal was to assess the prevalence of this finding. The secondary goals were to evaluate the frequency of other incidental pituitary lesions, MRI artifacts, and their effect on pituitary imaging on the contrast-enhanced 3D fat-saturated T1 MPRAGE at 7T.