FileJump's 2TB Cloud Storage Lifetime Subscription is a permanent solution for file storage, and it's on sale for £69.82 (reg. £366.34).

Australian food and beverage were a hit at HOTEC, Fiji's premium tourism and hospitality trade event.

The Federal Energy Regulatory Commission has received two applications for preliminary permits for a pumped storage project at Lake Elsinore in California.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

Bandits, on Sunday night, attacked two villages – Kwaga and Ungwan Zako – in Birnin-Gwari Local Government Area of Kaduna State, setting fire to harvested maize on six farms. The devastating attacks caused anger in the villages as locals lamented their losses. The PUNCH learnt that the attack came barely 48 hours after a peace

In a tragic incident in Rawalpindi’s Shah Khalid Colony, three siblings, 2-year-old Zohan, 6-year-old Saira, and 7-year-old Faria, lost their lives after being confined in a box. The children were left alone at home, intensifying the sorrow of the situation. According to reports from a Rescue spokesperson, the parents, who were employed in different jobs—the ... Read more

The post Tragedy Strikes as Three Siblings Found Dead Locked in Box appeared first on Pakistan Tribune.

According to an analysis by the Urban Institute, between 2010 and 2015, more than 19 million non-elderly people gained health insurance under the  Affordable Care Act. The top 10 states that ranked the highest based on percent of total population insured through the A.C.A. are Nevada (1), California (2), Oregon (3), Kentucky (4), New Mexico (5), West Virginia (6), Florida (7), Arkansas (8), Colorado (9), and Washington (10).

Ukraine and Russia barrage each other with dozens of drone attacks

Spain's Climate Floods Tragedy in Pictures

Queen Camilla has sparked a surge of support for a cause close to her heart, following in the footsteps of Prince William with a powerful new documentary. Her Majesty The Queen: Behind Closed Doors, which aired on ITV on Monday evening, offered a deeply personal look at her first year as...

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Title: Mellow Music May Help Stave Off Road Rage
Category: Health News
Created: 8/30/2013 9:35:00 AM
Last Editorial Review: 8/30/2013 12:00:00 AM

Title: Average Lifespan Longer for Twins
Category: Health News
Created: 8/23/2016 12:00:00 AM
Last Editorial Review: 8/24/2016 12:00:00 AM

Title: Monitoring System for Underage Tobacco Sales Falls Short: Study
Category: Health News
Created: 8/29/2018 12:00:00 AM
Last Editorial Review: 8/30/2018 12:00:00 AM

Obidoxime chloride is an antidote for nerve gas intoxication. As an emergency medicine, it is being stored by the Israel Defense Forces (IDF) scattered throughout Israel in depots without a controlled environment (field conditions), thus being exposed to high and fluctuating temperatures. These conditions do not meet the manufacturer’s requirements. In addition, due to possible supply shortages, the utilization of expired batches was suggested. The current work investigated these matters. Long-term (15 years) storage under different conditions was initiated. Chemical stability and toxicity in rats were assessed. No difference was found between field conditions vs the controlled environment. The obidoxime assay remained >95% for 5 years and >90% for 7 years. The pH remained above the lower specification limit for 7–8 years. The major degradation product, 4-pyridinealdoxime, surpassed the allowed limit at 5 years. The content of total unknown impurities reached its maximum allowed by the IDF limit at 4–5 years. Threefold higher than clinically utilized doses of valid-to-date Toxogonin batches administered to rats did not cause any abnormality. However, expired batches produced significant toxic effects. Although no difference was found between storage of obidoxime ampoules when adhering to manufacturer’s recommendations vs field conditions, accumulation of degradants over the limit allowed by the IDF at 4–5 years of storage and the toxicity of the expired batches observed in rats led the IDF to a decision to shorten the shelf-life of this product from 5 to 4 years when stored in an uncontrolled environment of the Mediterranean climate.

Oxidative stress, fibrosis, and inflammasome activation from advanced glycation end product (AGE)–receptor of advanced glycation end product (RAGE) interaction contribute to diabetic cardiomyopathy (DCM) formation and progression. Our study revealed the impact of β-caryophyllene (BCP) on activating cannabinoid type 2 receptors (CB2Rs) against diabetic complication, mainly cardiomyopathy and investigated the underlying cell signaling pathways in mice. The murine model of DCM was developed by feeding a high-fat diet with streptozotocin injections. After the development of diabetes, the animals received a 12-week oral BCP treatment at a dose of 50 mg/kg/body weight. BCP treatment showed significant improvement in glucose tolerance and insulin resistance and enhanced serum insulin levels in diabetic animals. BCP treatment effectively reversed the heart remodeling and restored the phosphorylated troponin I and sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2a expression. Ultrastructural examination showed reduced myocardial cell injury in DCM mice treated with BCP. The preserved myocytes were found to be associated with reduced expression of AGE/RAGE in DCM mice hearts. BCP treatment mitigated oxidative stress by inhibiting expression of NADPH oxidase 4 and activating phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/nuclear factor erythroid 2–related factor 2 (Nrf2) signaling. Also, BCP suppressed cardiac fibrosis and endothelial-to-mesenchymal transition in DCM mice by inhibiting transforming growth factor β (TGF-β)/suppressor of mothers against decapentaplegic (Smad) signaling. Further, BCP treatment suppressed nucleotide-binding domain, leucine-rich–containing family, pyrin domain–containing-3 (NLRP3) inflammasome activation in DCM mice and alleviated cellular injury to the pancreatic tissues evidenced by significant elevation of the number of insulin-positive cells. To demonstrate a CB2R-dependent mechanism of BCP, another group of DCM mice were pretreated with AM630, a CB2R antagonist. AM630 was observed to abrogate the beneficial effects of BCP in DCM mice. Taken together, BCP demonstrated the potential to protect the myocardium and pancreas of DCM mice mediating CB2R-dependent mechanisms.

BACKGROUND AND PURPOSE:

A cleftlike nonenhancing hypointensity was observed repeatedly in the pituitary gland at the adenohypophysis/neurohypophysis border on contrast-enhanced 3D fat-saturated T1-MPRAGE using clinical 7T MRI. Our primary goal was to assess the prevalence of this finding. The secondary goals were to evaluate the frequency of other incidental pituitary lesions, MRI artifacts, and their effect on pituitary imaging on the contrast-enhanced 3D fat-saturated T1 MPRAGE at 7T.

Sega are delisting several bundles of 'classic' games from digital stores, along with "select individual" games. On Steam specifically, this adds up to over 60 games in total, including several actual classics including the original Streets Of Rage trilogy, Crazy Taxi, and Jet Set Radio.

The games will be removed on December 6th but will remain playable to those who already own them.

Read more

A Labour minister confirmed that the application process for Personal Independence Payment is being 'kept under review'

Despite being an engaging watch, ‘I Am Kathalan’ hits a little below the mark compared to director Girish A.D’s previous outings

For our last full controller review on TouchArcade, I’ve been using the Victrix Pro BFG Tekken 8 Rage Art Edition …

Continue reading "Victrix Pro BFG Tekken 8 Rage Art Edition Controller Review – Customizable, Comfortable, but Lacking in Ways"

The United States has a wide range of climate zones, from the subtropical to the arctic. On the low end of the thermometer, there are plenty of options for a deep winter chill. Here, we look at a couple different ways to determine the coldest state in the U.S. — and by both definitions, there's one winner.

CBC has announced it's investing more in local and regional news. The coverage includes up to 25 journalists in more than a dozen communities and four new daily local podcasts.

The Indian pharmaceutical industry is advocating for enhanced fire safety measures and improved insurance coverage for employees working in pharmaceutical facilities.

NPR's Leila Fadel talks with actor Patrick Dempsey about his efforts to raise money for cancer treatment and prevention.

Between 1999 and 2014, opioid use disorder (OUD) among pregnant women more than quadrupled, risking the health of the women—before and after giving birth—and their infants. As states grapple with COVID-19’s exacerbation of the opioid crisis, several are taking innovative steps to address the needs of high-risk groups, including low-income, postpartum patients with OUD.

MLAs in Karnataka have on average assets worth ₹34.6 crore, the highest among all the States

Sep 2, 2023

Amid the global energy transition, investors are anxious to pour billions of dollars into many of these countries to turn the new fossil fuel finds into hydrogen. The element is the key feedstock for fuel cells, which use chemical reactions to generate electricity cleanly, with water as the main byproduct. Notwithstanding the considerable technological challenges ahead, demand for the gas in Europe and elsewhere is widely expected to surge as vehicles, factories, and other energy users seek to reduce greenhouse gas emissions.

For Southern Rim nations, however, this tantalizing opportunity for economic development risks turning into just another Sahara mirage. That’s because the hype surrounding hydrogen may continue to distract the regions’ leaders from addressing the tough domestic social issues that are behind the migration crisis. If the technology does become viable, revenue from hydrogen exports to Europe could just perpetuate rent-seeking behavior by political and economic elites at the expense of their own citizens.

This #AutismAwarenessMonth we encourage families with special needs to take steps now to plan for their loved ones� futures. Our Director of Advanced Planning, Ruthann Driscoll, discusses the importance of planning to secure long-term security and quality of life for your family. Learn more: http://u.nm.com/1AQBAsN

With the support of mentor Orbi Rosario, Hannah Strope overcame financial and family instability to become the first in her family to graduate high school. She is currently a college student.

Virginia Bioinformatics Institute Video Case Study

Eva Longoria :30 English

Visit FuelUpToPlay60.com to access new Spanish-language materials and get your school involved.

Video of legally-blind photographer living his Whole Day, as he captures a celebration of senses and movement

Ask About the Curve Public Service Announcement

The national average decreased 6.2 cents, to $4.185, following a 3.5-cent decline, to $4.247, for the week of March 13.

More than 500 fires have burned across Colombia, including in its delicate and unique highland wetlands, one of the fastest evolving ecosystems on Earth