A.F. Branco Cartoon – It’s been a lousy week for Kamala and a great week for Trump as he surges..

Kazuhiro Ishige, Paolo Salani and Asuka Takatsu
Trans. Amer. Math. Soc. 377 (), 5705-5748.
Abstract, references and article information

firehouse.ie posted a photo:

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As I walked into the embalming room at Jones Funeral Home and Supplies in Kingston on Sunday, I immediately felt the weight of the room. The air was thick with the scent of various chemicals used in the trade permeating the space. Tools such as...

Mitochondrial dysfunction is associated with a variety of human diseases including neurodegeneration, diabetes, nonalcohol fatty liver disease (NAFLD), and cancer, but its underlying causes are incompletely understood. Using the human hepatic cell line HepG2 as a model, we show here that endoplasmic reticulum-associated degradation (ERAD), an ER protein quality control process, is critically required for mitochondrial function in mammalian cells. Pharmacological inhibition or genetic ablation of key proteins involved in ERAD increased cell death under both basal conditions and in response to proinflammatory cytokines, a situation frequently found in NAFLD. Decreased viability of ERAD-deficient HepG2 cells was traced to impaired mitochondrial functions including reduced ATP production, enhanced reactive oxygen species (ROS) accumulation, and increased mitochondrial outer membrane permeability. Transcriptome profiling revealed widespread down-regulation of genes underpinning mitochondrial functions, and up-regulation of genes associated with tumor growth and aggression. These results highlight a critical role for ERAD in maintaining mitochondrial functional and structural integrity and raise the possibility of improving cellular and organismal mitochondrial function via enhancing cellular ERAD capacity.

No abstract

McKesson Medical-Surgical Inc. entered into an agreement with the Labor Department on Monday resolving employment discrimination issues involving nearly 900 Black, Hispanic, and White applicants at a distribution center

A flight of Florida-based Spirit Airlines was hit by gunfire while attempting to land in Haiti with a crew member that sustained "minor injuries."

The movement toward open source AI made progress today when the Open Source Initiative released the first Open Source AI Definition (OSAID). While the OSAID provides one step forward, the […]

The post OSI Open AI Definition Stops Short of Requiring Open Data for LLMs appeared first on HPCwire.

A federal judge has blocked a new bill in Louisiana that would require the Bible's Ten Commandments to be displayed in the state's publicly-funded schools.

The state's "Influence 100" project includes a leadership development program that will give aspiring district leaders a hands-on opportunity to work through an equity issue in their home districts.

Districts that can screen, interview, and select candidates virtually will have less disruption to their hiring, despite how coronavirus is upending every aspect of school operations.

A former high school athletic standout and homecoming king, Pedro Garcia III “could connect with anybody,” no matter the language, said a teaching colleague in Cozad, Neb.

The firing of a black staff member for repeating the n-word while telling a black student not to use it underscores how uneasy many districts, schools, and educators are with handling the use of racist language in any context.

The first plane to fly nonstop from New York to Paris will reside on the ground level of the National Air and Space Museum for the next five months as it undergoes preservation (Courtesy of the National Air and Space Museum)

More on biomimicry: http://j.mp/RI3OOB Scientists believe the iridescent wings of the morphos butterfly could be used in technology to benefit humans.

This traveling exhibit reveals the mystery behind some of the women that helped shape this country's social and cultural landscape

Experts say that the trove of silver currency is official treasure and includes coins from England and Ireland

See photographs of the beautiful natural wonders from the Smithsonian Magazine Photo Contest

Lindley's Farm and Market in Hamilton will be "winding down" operations after 180 years of operations, including selling locally grown produce and offering activities to the community.

Malloree Enoch alleges she was sexually coerced by former Whitecaps coach Hubert Busby Jr., who was recently reinstated as head coach of the Jamaican women's national team.

The Toronto Police Services Board unanimously approved a new five-year hiring plan for the force on Tuesday.

The provincial government is seeking contractors to restore hundreds of kilometres of land where fireguards were created during the 2023 wildfire season.

Students in 500 second level schools across the country will learn fundamental engineering and design skills with easy-to-learn 3D CAD software

Hospitality stakeholders and organizations can serve a significant role in the integration of people who have criminal records or histories of incarceration back into the workforce, according to a new framework created by researchers in the Penn State School of Hospitality Management.

OM and local churches see God use the Bus4Life to draw people and break down barriers in Moldovan village communities.

Short-term participants from around the world joined OM for the Impact Ireland outreach to share Jesus with the people of Ireland.

An outreach team learns the value of sharing their personal testimonies and what a little light can do to a community.

The Creative Arts team perform their Christmas show for school children all over Ireland in the course of three weeks.

An OM short-term team worships God and engages in conversations about God in the public square of a city with an Arab majority in Israel.

An OM Ukraine sports team member helps young Ukrainian women gain a healthier understanding and appreciation of the bodies God gave them.

A team of dentists and volunteers recently visited an orphanage in the Odessa province to fix 75 young smiles.

The strategy of reinforcing good behavior with praise is the least likely to be taught in teacher-prep programs, an analysis finds.

A former computer engineer turned motivational speaker will share his dynamic insights on “Bridging the Digital Divide: Unlocking Access and Opportunity in Education” during a Nov. 6 presentation of the Technology & Society Colloquia Series at Pennsylvania College of Technology.

The strategy of reinforcing good behavior with praise is the least likely to be taught in teacher-prep programs, an analysis finds.

As part of its steadfast commitment to delivering behavioral health services that are greatly needed in central Pennsylvania, Penn State Health will relocate Pennsylvania Psychiatric Institute’s inpatient services to Holy Spirit Medical Center at the end of its lease in September 2026.

English Talk Espiritual, a twice-monthly meeting in a local café in Córdoba, has become a community where people seek healing for the lives.

French OMer Andre experiences that prayer can change the hearts of authorities regarding victims of human trafficking.

For two days, the OM Chile Agape Team share with homeless people about the Holy Spirit and witness miracles.

Workers in Tajikistan long for the people of the country to replace superstition with trust in their Saviour.

A new recording studio aims to bring Central Asian musicians together for collaboration and worship.

Three children and three women are missing from Manipur's Jiribam since yesterday after an encounter broke out between suspected Kuki insurgents and the security forces.

Hundreds of members of Manipur's Meitei community came out on the streets in Delhi and other cities in a silent candlelight protest, seeking the safety of six people who have been missing since an encounter broke out between suspected Kuki militants.

Dover, DE — Gov. Jack Markell joined the Delaware Department of Labor’s Division of Vocational Rehabilitation (DVR) and the State Rehabilitation Council (SRC) at Dover Downs to celebrate workplace inclusion by honoring the value and contribution of employees with disabilities and employers who hire them. “Each year we are proud to honor businesses in our State […]