Douglas Owsley, the division head for physical anthropology at the Smithsonian’s National Museum of Natural History, presented today a forensic analysis of 17th-century human remains […]

The post Forensic analysis of 17th-century human remains at Jamestown, Va., reveals evidence of survival cannibalism appeared first on Smithsonian Insider.

Hot spots of mercury pollution in aquatic sediments and soils can contaminate local food webs and threaten ecosystems, but cleaning them up can be expensive […]

The post Toxicity of mercury hot spots can be reduced with application of activated carbon, researchers discover appeared first on Smithsonian Insider.

The scale of the universe can be difficult to comprehend. Pretend you are going to make a scale model with a basketball representing the Earth […]

The post Can iPads help students learn science? appeared first on Smithsonian Insider.

The report card is in for the state of the birds in the USA. So how did we do? Certainly not an A+ or even […]

The post Our birds are in real trouble. Can we fix it? Yes we can! appeared first on Smithsonian Insider.

To paraphrase Mark Twain, the report of the Kepler spacecraft’s death was greatly exaggerated. Despite a malfunction that ended its primary mission in May 2013, […]

The post Kepler spacecraft proves it can still find planets appeared first on Smithsonian Insider.

Native Americans and America’s early colonists ate many more blue crabs than modern researchers previously thought, according to a team of scientists studying crab remains […]

The post American Indians, colonists had healthy appetite for crabs, study shows appeared first on Smithsonian Insider.

Yabbies, mudbugs, crayfish, crawdads, call them what you will, but one-third of the world’s crayfish species are facing extinction according to a recent report by […]

The post Coming soon: Vacancy at the crawdad hole? appeared first on Smithsonian Insider.

Bald from snout to tail with baggy wrinkled skin and beady eyes, eastern African naked mole rats (Heterocephalus glaber) are subterranean mammals long credited with […]

The post Rare cancer cells discovered in naked mole rats appeared first on Smithsonian Insider.

Seven fossil teeth exposed by the Panama Canal expansion project are the first evidence of a monkey on the North American continent before the Isthmus […]

The post First North American Monkey Fossils Found in Panama Canal Excavation appeared first on Smithsonian Insider.

Higher acidity in coastal waters can make fish more sensitive to low oxygen, causing them to become debilitated and suffocate in water with oxygen levels […]

The post Acidification, Low Oxygen Can be Deadly Combination for Fish appeared first on Smithsonian Insider.

Thanks to a recent reassessment of specimens preserved in jars of alcohol at the Smithsonian’s National Museum of Natural History, New Hampshire is now on […]

The post Discovery in Smithsonian collection broadens understanding of rare North American leech appeared first on Smithsonian Insider.

In an age of one-hour delivery and overnight shipping, a corner of the country still gets its mail by mule. That’s right. For a small […]

The post In the Grand Canyon, the U.S. Postal Service still delivers mail by mule appeared first on Smithsonian Insider.

In 1935, 101 cane toads from Hawaii were set loose in Australia to help control beetles that were decimating the Australian sugar crop. But instead […]

The post Discovery: Australia’s invasive cane toads modify their bodies to conquer new territory faster appeared first on Smithsonian Insider.

Recent underwater photographs and video from the National Marine Park of the southern Caribbean island of Bonaire has led to the discovery of a new species […]

The post Meet the candy striped hermit crab, a new Caribbean species appeared first on Smithsonian Insider.

For centuries, cultures around the world have used masks in ritual dances and festivals to represent traditional characters. This copper mask, found in the Smithsonian’s […]

The post Mexican Masks: Tales Through Dance appeared first on Smithsonian Insider.

“Think of a lion shrunk to the size of a mouse that needs to eat every 20 minutes or so.” That is a shrew, says […]

The post New Costa Rican shrew species named from a single specimen found 44 years ago appeared first on Smithsonian Insider.

Today’s cutting-edge laboratories rely on ultra-cold refrigeration to keep delicate cells like sperm viable for use in the future. But a new technique using microwaves […]

The post What does candied, microwaved sperm have to do with saving endangered species? appeared first on Smithsonian Insider.

In 1854, a curious-looking spider was found preserved in 50 million-year-old amber. With an elongated neck-like structure and long mouthparts that protruded from the “head” […]

The post These newly discovered pelican spiders will make you want to visit Madagascar appeared first on Smithsonian Insider.

“Somber” is the adjective Smithsonian beetle expert Terry Erwin uses to describe the insects he collects on the forest floor in Peru and Ecuador. “They […]

The post Meet the newest New World canopy beetle species. ‘Gazillions’ await discovery. appeared first on Smithsonian Insider.

Animal species can become endangered, but what about languages? Around 80 percent of the world’s population speaks just 20 percent of its 7,000 languages. That […]

The post Why languages become endangered, and how we can keep them alive appeared first on Smithsonian Insider.

In the early 20th century, Canada geese were considered endangered in the U.S. So in the 1950s and 1960s, birds from the Midwest were released […]

The post Study of bacteria inside guts of wild Canada geese shows greater danger than earlier studies exposed appeared first on Smithsonian Insider.

The new book Subsistence Economies of Indigenous North American Societies provides a comprehensive and in-depth documentation of how Native American societies met the challenges of […]

The post New book: “The Subsistence Economies of Indigenous North American Societies: A Handbook” appeared first on Smithsonian Insider.

Warner’s narrative covers the major natural sweeteners, including sugar, molasses from cane, beet sugar, corn syrup, honey and maple, as well as artificial sweeteners such as saccharin, cyclamate, aspartame and sucralose.

The post New Book: “Sweet Stuff: An American History of Sweeteners from Sugar to Sucralose” appeared first on Smithsonian Insider.

Photographs, by virtue of their static nature, not only allow us to look back to a fixed point in time, but also give us a […]

The post Book Review: Double Exposure: photos of African American History & Culture appeared first on Smithsonian Insider.

For the first time in its history the Smithsonian’s National Museum of African Art opened an exhibition on the continent of Africa. “Chief S.O. Alonge: […]

The post A first: Smithsonian’s African Art Museum opens exhibition in Africa appeared first on Smithsonian Insider.

Kasun Buddika, Ishara S. Ariyapala, Mary A. Hazuga, Derek Riffert, and Nicholas S. Sokol

Stressed cells downregulate translation initiation and assemble membrane-less foci termed stress granules (SGs). Extensively characterized in cultured cells, the existence of such structures in stressed adult stem cell pools remain poorly characterized. Here we report that Drosophila orthologs of mammalian SG components AGO1, ATX2, CAPRIN, eIF4E, FMRP, G3BP, LIN-28, PABP, and TIAR are enriched in adult intestinal progenitor cells where they accumulate in small cytoplasmic messenger ribonucleoprotein complexes (mRNPs). Treatment with sodium arsenite or rapamycin reorganized these mRNPs into large cytoplasmic granules. Formation of these intestinal progenitor stress granules (IPSGs) depended on polysome disassembly, led to translational downregulation, and was reversible. While canonical SG nucleators ATX2 and G3BP were sufficient for IPSG formation in the absence of stress, neither of them, nor TIAR, either individually or collectively, were required for stress-induced IPSG formation. This work therefore finds that IPSGs do not assemble via a canonical mechanism, raising the possibility that other stem cell populations employ a similar stress-response mechanism.

Karolina Losenkova, Mariachiara Zuccarini, Marika Karikoski, Juha Laurila, Detlev Boison, Sirpa Jalkanen, and Gennady G. Yegutkin

Extracellular adenosine mediates diverse anti-inflammatory, angiogenic and vasoactive effects and becomes an important therapeutic target for cancer, which has been translated into clinical trials. This study was designed to comprehensively assess adenosine metabolism in prostate and breast cancer cells. We identified cellular adenosine turnover as a complex cascade, comprised of (a) the ectoenzymatic breakdown of ATP via sequential nucleotide pyrophosphatase/phosphodiesterase-1, ecto-5’-nucleotidase/CD73 and adenosine deaminase reactions, and ATP re-synthesis through counteracting adenylate kinase and nucleoside diphosphokinase; (b) the uptake of nucleotide-derived adenosine via equilibrative nucleoside transporters; and (c) the intracellular adenosine phosphorylation into ATP by adenosine kinase and other nucleotide kinases. The exposure of cancer cells to 1% O₂ for 24 hours triggered ~2-fold up-regulation of CD73, without affecting nucleoside transporters, adenosine kinase activity and cellular ATP content. The ability of adenosine to inhibit the tumor-initiating potential of breast cancer cells via receptor-independent mechanism was confirmed in vivo using a xenograft mouse model. The existence of redundant pathways controlling extracellular and intracellular adenosine provides a sufficient justification for reexamination of the current concepts of cellular purine homeostasis and signaling in cancer.

Ganlu Deng, Yihong Chen, Cao Guo, Ling Yin, Ying Han, Yiyi Li, Yaojie Fu, Changjing Cai, Hong Shen, and Shan Zeng

Epithelial-mesenchymal transition (EMT) is a crucial process for cancer cells to acquire metastatic potential, which primarily causes death in gastric cancer (GC) patients. Bone morphogenetic protein 4 (BMP4) is a member of the TGF-β family that plays an indispensable role in human cancers. However, little is known about its roles in GC metastasis. In this study, BMP4 was found to be frequently overexpressed in GC tissues and was correlated with patient's poor prognosis. BMP4 was upregulated in GC cell lines and promoted EMT and metastasis of GC cells both in vitro and in vivo, while knockdown of BMP4 significantly inhibited EMT and metastasis of GC cells. Meanwhile, the inhibitor of DNA binding 1 (Id1) was identified as a downstream target of BMP4 by PCR arrays and upregulated via Smad1/5/8 phosphorylation. Id1 knockdown attenuated BMP4-induced EMT and invasion in GC cells. Moreover, Id1 overexpression in BMP4 knockdown cells restored the promotion of EMT and cell invasion. In summary, BMP4 induced EMT to promote GC metastasis by upregulating Id1 expression. Antagonizing BMP4 may be a potential therapeutic strategy in GC metastasis.

Richard Wunderman is managing editor of the Bulletin of the Global Volcanism Network and a geologist in the Division of Mineral Sciences at the Smithsonian’s […]

The post Q&A: Smithsonian volcanologist Richard Wunderman answers questions about the Aug. 23, East Coast earthquake appeared first on Smithsonian Insider.

Restless volcano. This Feb. 10 satellite radar image shows the summit of Alaska’s Cleveland Volcano and a new lava dome within the volcano’s summit crater […]

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According to the weekly report of the Smithsonian’s Global Volcanism Program, gas-and-ash plumes rose nearly one mile above the crater of Mexico’s Popocatépetl volcano from […]

The post Mexico’s Popocatepetl volcano active again appeared first on Smithsonian Insider.

Miniature camels and horses, a rhinoceros and a giant bear-dog are among fossils unearthed in the recent excavations of the Panama Canal expansion project. These […]

The post First five years of Panama Canal excavations reveal fossil finds appeared first on Smithsonian Insider.

Volcanoes are a source of fascination for many, attracting a steady stream of visitors worldwide. While the danger of sudden eruptions may add to the […]

The post When will a volcano explode, ooze or lie silent? appeared first on Smithsonian Insider.

Oysters are keystone organisms in estuaries around the world, influencing water quality, constructing habitat and providing food for humans and wildlife. Yet their populations in […]

The post Ancient Native-American methods may be key to sustainable oyster harvests appeared first on Smithsonian Insider.

Looking for another Earth? An international team of researchers has pinpointed which of the more than 4,000 exoplanets discovered by NASA’s Kepler mission are most […]

The post Another Earth? Kepler astronomers pinpoint likeliest candidates appeared first on Smithsonian Insider.

To the Hopewell Culture, ancient Native Americans who sought out the exotic from near and far, metal was a rare and precious resource. Copper, found […]

The post Ancient Native American beads traced to otherworldy source: an iron meteorite appeared first on Smithsonian Insider.

The Jamaican golden swallow was last seen in 1982. From 1994 to 2012, Smithsonian ornithologist Gary Graves combed the island of Jamaica to document several […]

The post After a nearly 20-year search, this Jamaican bird is probably extinct appeared first on Smithsonian Insider.

To get a better idea of just what is going on with the current volcanic eruption of Kilauea on the island of Hawaii, take a […]

The post Kilauea’s activity is nothing new, says a Smithsonian volcano expert appeared first on Smithsonian Insider.

A hunter touches an infected animal’s blood, a farmer breathes the moist air exhaled by sick cows, contaminated meat is served at an outdoor market—these […]

The post What causes disease outbreaks and how can we stop them? appeared first on Smithsonian Insider.

Forensic anthropologists from the Smithsonian's National Museum of Natural History discover African remains at a Colonial burial site in Maryland. Follow them as they study the remains, reconstruct the face and body, and share what they learn about the African experience in the Chesapeake in the 1600s.

The post Smithsonian team examines African remains from a colonial burial site in Maryland appeared first on Smithsonian Insider.

Rick Wunderman of the Global Volcanism Program at the Smithsonian's National Museum of Natural History talks about the current volcanic activity in Iceland.

The post Smithsonian volcanologist Rick Wunderman talks about volcanos and the recent eruptions in Iceland appeared first on Smithsonian Insider.

Smithsonian Scientist Helen James dives into dormant Hawaiian volcanoes to find bird fossils. Her work to identify these species (some new species, some extinct) helps us learn about the past--specifically, how humans might have caused the extinction of certain bird species.

The post Meet Our Scientist–Helen James dives into dormant Hawaiian volcanoes to find bird fossils appeared first on Smithsonian Insider.

Tom Crouch, Senior curator in the National Air and Space Museum's Aeronautics Division, discusses Thaddeus Lowe and the birth of American aerial reconnaissance during the Civil War. This presentation was recorded on May 11, 2011 on the National Mall.

The post Tom Crouch, Senior curator in the National Air and Space Museum’s Aeronautics Division, discusses Thaddeus Lowe and the birth of American aerial reconnaissance appeared first on Smithsonian Insider.

The post Learn about the ash that comes from volcanoes with Dr. Liz Cottrell, a geologist from the National Museum of Natural History appeared first on Smithsonian Insider.

The post Smithsonian conservators open 2001 Jim Thorpe Wheaties Box from the Smithsonian’s National Museum of the American Indian appeared first on Smithsonian Insider.

The post 3-D laser scanning is helping solve ancient mysteries at the Smithsonian appeared first on Smithsonian Insider.