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Most Americans Hit Hard by Medical Bills

By www.medicinenet.com
Published On :: Sat, 9 May 2020 00:00:00 PDT

Title: Most Americans Hit Hard by Medical Bills
Category: Health News
Created: 5/2/2019 12:00:00 AM
Last Editorial Review: 5/2/2019 12:00:00 AM


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Gene Therapy May Help Fight Tough-to-Treat Blood Cancer

By www.medicinenet.com
Published On :: Sat, 9 May 2020 00:00:00 PDT

Title: Gene Therapy May Help Fight Tough-to-Treat Blood Cancer
Category: Health News
Created: 5/1/2019 12:00:00 AM
Last Editorial Review: 5/2/2019 12:00:00 AM


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Breast Implants Linked to Cancer Can Still be Sold in U.S.: FDA

By www.medicinenet.com
Published On :: Sat, 9 May 2020 00:00:00 PDT

Title: Breast Implants Linked to Cancer Can Still be Sold in U.S.: FDA
Category: Health News
Created: 5/3/2019 12:00:00 AM
Last Editorial Review: 5/3/2019 12:00:00 AM


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For People With Autism, Encounters With Police Can Turn Dangerous

By www.medicinenet.com
Published On :: Sat, 9 May 2020 00:00:00 PDT

Title: For People With Autism, Encounters With Police Can Turn Dangerous
Category: Health News
Created: 5/3/2019 12:00:00 AM
Last Editorial Review: 5/3/2019 12:00:00 AM


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Device Spots Lymphedema Early in Breast Cancer Patients, to Help Stop It

By www.medicinenet.com
Published On :: Sat, 9 May 2020 00:00:00 PDT

Title: Device Spots Lymphedema Early in Breast Cancer Patients, to Help Stop It
Category: Health News
Created: 5/2/2019 12:00:00 AM
Last Editorial Review: 5/3/2019 12:00:00 AM


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Red Tape Means Many Cancer Patients Get Radiation Treatments Late

By www.medicinenet.com
Published On :: Sat, 9 May 2020 00:00:00 PDT

Title: Red Tape Means Many Cancer Patients Get Radiation Treatments Late
Category: Health News
Created: 5/2/2019 12:00:00 AM
Last Editorial Review: 5/3/2019 12:00:00 AM


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You Can't Get Coronavirus Through Sex, Study Suggests

By www.medicinenet.com
Published On :: Sat, 9 May 2020 00:00:00 PDT

Title: You Can't Get Coronavirus Through Sex, Study Suggests
Category: Health News
Created: 4/27/2020 12:00:00 AM
Last Editorial Review: 4/27/2020 12:00:00 AM


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He Recovered From COVID-19. Can His Blood Help Others?

By www.medicinenet.com
Published On :: Sat, 9 May 2020 00:00:00 PDT

Title: He Recovered From COVID-19. Can His Blood Help Others?
Category: Health News
Created: 4/27/2020 12:00:00 AM
Last Editorial Review: 4/27/2020 12:00:00 AM


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Costs Would Keep 1 in 7 Americans From Seeking COVID-19 Treatment

By www.medicinenet.com
Published On :: Sat, 9 May 2020 00:00:00 PDT

Title: Costs Would Keep 1 in 7 Americans From Seeking COVID-19 Treatment
Category: Health News
Created: 4/28/2020 12:00:00 AM
Last Editorial Review: 4/29/2020 12:00:00 AM


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Pandemic Delaying Medical Care of Older Americans

By www.medicinenet.com
Published On :: Sat, 9 May 2020 00:00:00 PDT

Title: Pandemic Delaying Medical Care of Older Americans
Category: Health News
Created: 4/30/2020 12:00:00 AM
Last Editorial Review: 4/30/2020 12:00:00 AM


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ECMO: Technology That Might Help COVID Patients When Ventilators Can't

By www.medicinenet.com
Published On :: Sat, 9 May 2020 00:00:00 PDT

Title: ECMO: Technology That Might Help COVID Patients When Ventilators Can't
Category: Health News
Created: 5/1/2020 12:00:00 AM
Last Editorial Review: 5/1/2020 12:00:00 AM


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AHA News: How Pregnant Woman's High Blood Pressure Can Change Shape of Baby's Heart

By www.medicinenet.com
Published On :: Fri, 1 May 2020 00:00:00 PDT

Title: AHA News: How Pregnant Woman's High Blood Pressure Can Change Shape of Baby's Heart
Category: Health News
Created: 4/30/2020 12:00:00 AM
Last Editorial Review: 5/1/2020 12:00:00 AM


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Many Americans in the Dark About Eye Health

By www.medicinenet.com
Published On :: Mon, 27 Jan 2020 00:00:00 PDT

Title: Many Americans in the Dark About Eye Health
Category: Health News
Created: 1/26/2020 12:00:00 AM
Last Editorial Review: 1/27/2020 12:00:00 AM


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With Macular Degeneration, 1 Missed Visit to Eye Doc Can Mean Vision Loss

By www.medicinenet.com
Published On :: Mon, 10 Feb 2020 00:00:00 PDT

Title: With Macular Degeneration, 1 Missed Visit to Eye Doc Can Mean Vision Loss
Category: Health News
Created: 2/7/2020 12:00:00 AM
Last Editorial Review: 2/10/2020 12:00:00 AM


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Rising Number of Older Americans at Risk of Vision Loss

By www.medicinenet.com
Published On :: Fri, 13 Mar 2020 00:00:00 PDT

Title: Rising Number of Older Americans at Risk of Vision Loss
Category: Health News
Created: 3/12/2020 12:00:00 AM
Last Editorial Review: 3/13/2020 12:00:00 AM


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During Droughts, Many Poor Americans Will Lack Clean Tap Water: Study

By www.medicinenet.com
Published On :: Fri, 1 May 2020 00:00:00 PDT

Title: During Droughts, Many Poor Americans Will Lack Clean Tap Water: Study
Category: Health News
Created: 4/30/2020 12:00:00 AM
Last Editorial Review: 5/1/2020 12:00:00 AM


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I Want to Retire, But Just Can't Say Goodbye

By www.webmd.com
Published On :: Wed, 06 May 2020 12:44:11 EST

Many doctors are considering retiring, but fear they'll miss the patient interaction, mental stimulation, and income. There are ways to have it all.


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EuroPCR 2020 Canceled as SCAI, SCCT, TVT Go Virtual

By www.webmd.com
Published On :: Wed, 06 May 2020 13:07:16 EST

In a sign of the times and things to come, in-person cardiovascular society meetings pivot to virtual events.


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COMMENTARY: COVID-19: Why We Can't Test Our Way Out of This

By www.webmd.com
Published On :: Thu, 07 May 2020 13:46:17 EST

Calls to relax social distancing policies emphasize the need for increased testing, but a closer look at current SARS-CoV-2 tests leaves Anish Koka, MD, doubtful that more tests will be the solution.


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COMMENTARY: Can We Measure COVID-19 Seroprevalence With a Flawed Ruler?

By www.webmd.com
Published On :: Fri, 08 May 2020 13:03:00 EST

Just as an imperfect ruler can measure accurately if its error is constant and known, serology need not have perfect sensitivity and specificity to estimate COVID's prevalence, write Drs Jha and Murthy.


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Americans' Cholesterol Levels Decline: Study

By www.medicinenet.com
Published On :: Wed, 13 Nov 2019 00:00:00 PDT

Title: Americans' Cholesterol Levels Decline: Study
Category: Health News
Created: 11/12/2019 12:00:00 AM
Last Editorial Review: 11/13/2019 12:00:00 AM


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AHA News: Statins May Do Double Duty on Heart Disease and Cancer

By www.medicinenet.com
Published On :: Tue, 7 Jan 2020 00:00:00 PDT

Title: AHA News: Statins May Do Double Duty on Heart Disease and Cancer
Category: Health News
Created: 1/6/2020 12:00:00 AM
Last Editorial Review: 1/7/2020 12:00:00 AM


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Fewer Americans Have High Cholesterol

By www.medicinenet.com
Published On :: Thu, 23 Apr 2020 00:00:00 PDT

Title: Fewer Americans Have High Cholesterol
Category: Health News
Created: 4/22/2020 12:00:00 AM
Last Editorial Review: 4/23/2020 12:00:00 AM


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PMC Canada to Start in Fall 2009

By www.ncbi.nlm.nih.gov
Published On :: Mon, 6 Jul 2009 08:00:00 EST

Canada is soon expected to join the international effort to provide access to health research through the PMC International network of digital archives. PMC Canada is the result of a three-way collaborative effort by the National Library of Medicine (NLM), the Canadian Institutes of Health Research (CIHR), and the National Research Council's Canada Institute for Scientific and Technical Information (NRC-CISTI). Similar to UK PubMed Central, PMC Canada will include most of the health and life sciences literature available through the U.S. PMC. PMC Canada will also include research resulting from funding through the Canadian Institutes of Health Research (CIHR). Components of the new repository will include a bilingual interface as well a manuscript submission system for CIHR researchers.


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PMC Canada is Launched!

By www.ncbi.nlm.nih.gov
Published On :: Wed, 21 Oct 2009 08:00:00 EST

The newest addition to the PMC International effort, PubMed Central Canada has now been made public. Stay tuned for the launch of PMC Canada's manuscript submission system later this year.


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PMC Canada's Manuscript Submission System Goes Live!

By www.ncbi.nlm.nih.gov
Published On :: Thu, 29 Apr 2010 08:00:00 EST

The PMC Canada manuscript submission system was released on April 28, 2010. The system will enable researchers funded by the Canadian Institutes of Health Research to deposit their peer-reviewed research publications, in compliance with CIHR's Policy on Access to Research Outputs.


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PMC Canada Status Update

By www.ncbi.nlm.nih.gov
Published On :: Mon, 18 Dec 2017 08:00:00 EST

PMC Canada, sponsored by the Canadian Institutes of Health Research (CIHR), with operational support provided by the National Research Council (NRC), has been a valued partner in the PMC International network since 2009. CIHR and NRC have now notified NLM of their decision to permanently take PubMed Central Canada (PMC Canada) offline on February 23, 2018. Details of this decision are available on the PMC Canada website.

The decision to decommission PMC Canada does not affect the status or operations of NIH’s PubMed Central (US) or Europe PubMed Central. PMC Canada content will remain in the PMC archive and be publicly searchable on NLM’s PubMed Central (US) and through Europe PMC. CIHR researchers who publish in journals that deposit their articles directly into NIH’s PubMed Central or deposit manuscripts co-funded with current PMC-participating funders will continue to be considered in compliance with the Tri-Agency Open Access Policy on Publications.

NIH and NLM have appreciated our cooperation with CIHR and NRC over the last several years and will continue to identify new opportunities to work together to support open access and research excellence.


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Intense Exercise Can Trigger Heart Trouble in the Unprepared

By www.medicinenet.com
Published On :: Tue, 3 Mar 2020 00:00:00 PDT

Title: Intense Exercise Can Trigger Heart Trouble in the Unprepared
Category: Health News
Created: 3/2/2020 12:00:00 AM
Last Editorial Review: 3/3/2020 12:00:00 AM


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Can AI Predict Who Will Develop Diabetes?

By www.medicinenet.com
Published On :: Tue, 31 Mar 2020 00:00:00 PDT

Title: Can AI Predict Who Will Develop Diabetes?
Category: Health News
Created: 3/31/2020 12:00:00 AM
Last Editorial Review: 3/31/2020 12:00:00 AM


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Thrush (Oral Candidiasis)

By www.medicinenet.com
Published On :: Fri, 27 Mar 2020 00:00:00 PDT

Title: Thrush (Oral Candidiasis)
Category: Diseases and Conditions
Created: 1/31/2005 12:00:00 AM
Last Editorial Review: 3/27/2020 12:00:00 AM


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Modern Livestock Farming Can Pose Public Health Risk

By www.medicinenet.com
Published On :: Fri, 8 May 2020 00:00:00 PDT

Title: Modern Livestock Farming Can Pose Public Health Risk
Category: Health News
Created: 5/7/2020 12:00:00 AM
Last Editorial Review: 5/8/2020 12:00:00 AM


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Prescription-Strength Steroid Creams Sold Over-the-Counter Can Be Dangerous

By www.medicinenet.com
Published On :: Fri, 24 Jan 2020 00:00:00 PDT

Title: Prescription-Strength Steroid Creams Sold Over-the-Counter Can Be Dangerous
Category: Health News
Created: 1/23/2020 12:00:00 AM
Last Editorial Review: 1/24/2020 12:00:00 AM


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AHA News: Being an African American 'Superwoman' Might Come With a Price

By www.medicinenet.com
Published On :: Wed, 12 Feb 2020 00:00:00 PDT

Title: AHA News: Being an African American 'Superwoman' Might Come With a Price
Category: Health News
Created: 2/11/2020 12:00:00 AM
Last Editorial Review: 2/12/2020 12:00:00 AM


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Endometriosis Risk Can Be Predicted in Young Girls: Study

By www.medicinenet.com
Published On :: Tue, 10 Mar 2020 00:00:00 PDT

Title: Endometriosis Risk Can Be Predicted in Young Girls: Study
Category: Health News
Created: 3/10/2020 12:00:00 AM
Last Editorial Review: 3/10/2020 12:00:00 AM


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One Dose of HPV Vaccine May Protect Against Cervical Cancer

By www.medicinenet.com
Published On :: Mon, 10 Feb 2020 00:00:00 PDT

Title: One Dose of HPV Vaccine May Protect Against Cervical Cancer
Category: Health News
Created: 2/10/2020 12:00:00 AM
Last Editorial Review: 2/10/2020 12:00:00 AM


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Can Men Dine Their Way to Higher Sperm Counts?

By www.medicinenet.com
Published On :: Mon, 24 Feb 2020 00:00:00 PDT

Title: Can Men Dine Their Way to Higher Sperm Counts?
Category: Health News
Created: 2/21/2020 12:00:00 AM
Last Editorial Review: 2/24/2020 12:00:00 AM


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How Pets Can Be True Lifesavers for Seniors

By www.medicinenet.com
Published On :: Fri, 3 Apr 2020 00:00:00 PDT

Title: How Pets Can Be True Lifesavers for Seniors
Category: Health News
Created: 4/3/2020 12:00:00 AM
Last Editorial Review: 4/3/2020 12:00:00 AM


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Welcome to the 'Smart Toilet' That Can Spot Disease

By www.medicinenet.com
Published On :: Fri, 17 Apr 2020 00:00:00 PDT

Title: Welcome to the 'Smart Toilet' That Can Spot Disease
Category: Health News
Created: 4/17/2020 12:00:00 AM
Last Editorial Review: 4/17/2020 12:00:00 AM


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Broiling in a Heat Wave? Wet T-shirt Can Safely Cool You Down

By www.medicinenet.com
Published On :: Tue, 14 Apr 2020 00:00:00 PDT

Title: Broiling in a Heat Wave? Wet T-shirt Can Safely Cool You Down
Category: Health News
Created: 4/13/2020 12:00:00 AM
Last Editorial Review: 4/14/2020 12:00:00 AM


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Tukysa Approved for Unresectable, Metastatic HER2-Positive Breast Cancer

By www.medicinenet.com
Published On :: Tue, 21 Apr 2020 00:00:00 PDT

Title: Tukysa Approved for Unresectable, Metastatic HER2-Positive Breast Cancer
Category: Health News
Created: 4/20/2020 12:00:00 AM
Last Editorial Review: 4/21/2020 12:00:00 AM


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Parent or Sibling With Colon Cancer? You May Need Colonoscopy Earlier

By www.medicinenet.com
Published On :: Tue, 21 Apr 2020 00:00:00 PDT

Title: Parent or Sibling With Colon Cancer? You May Need Colonoscopy Earlier
Category: Health News
Created: 4/20/2020 12:00:00 AM
Last Editorial Review: 4/21/2020 12:00:00 AM


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Bacterial Blood Infections Tied to Heightened Colon Cancer Risk

By www.medicinenet.com
Published On :: Thu, 23 Apr 2020 00:00:00 PDT

Title: Bacterial Blood Infections Tied to Heightened Colon Cancer Risk
Category: Health News
Created: 4/22/2020 12:00:00 AM
Last Editorial Review: 4/23/2020 12:00:00 AM


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FDA Approves Trodelvy for Metastatic Triple-Negative Breast Cancer

By www.medicinenet.com
Published On :: Fri, 24 Apr 2020 00:00:00 PDT

Title: FDA Approves Trodelvy for Metastatic Triple-Negative Breast Cancer
Category: Health News
Created: 4/24/2020 12:00:00 AM
Last Editorial Review: 4/24/2020 12:00:00 AM


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Could AI Help Doctors Map Out Treatments for Brain Cancers?

By www.medicinenet.com
Published On :: Mon, 27 Apr 2020 00:00:00 PDT

Title: Could AI Help Doctors Map Out Treatments for Brain Cancers?
Category: Health News
Created: 4/24/2020 12:00:00 AM
Last Editorial Review: 4/27/2020 12:00:00 AM


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Shun the Sun to Prevent Skin Cancer

By www.medicinenet.com
Published On :: Mon, 4 May 2020 00:00:00 PDT

Title: Shun the Sun to Prevent Skin Cancer
Category: Health News
Created: 5/2/2020 12:00:00 AM
Last Editorial Review: 5/4/2020 12:00:00 AM


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Fewer Kids in Cancer Trials, Which Might Not Be a Bad Thing

By www.medicinenet.com
Published On :: Wed, 6 May 2020 00:00:00 PDT

Title: Fewer Kids in Cancer Trials, Which Might Not Be a Bad Thing
Category: Health News
Created: 5/5/2020 12:00:00 AM
Last Editorial Review: 5/6/2020 12:00:00 AM


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Some Cities' Smog Can Ruin Your Vacation

By www.medicinenet.com
Published On :: Tue, 3 Dec 2019 00:00:00 PDT

Title: Some Cities' Smog Can Ruin Your Vacation
Category: Health News
Created: 12/3/2019 12:00:00 AM
Last Editorial Review: 12/3/2019 12:00:00 AM


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Too Much Super Bowl Can Mean Too Little Sleep

By www.medicinenet.com
Published On :: Fri, 31 Jan 2020 00:00:00 PDT

Title: Too Much Super Bowl Can Mean Too Little Sleep
Category: Health News
Created: 1/31/2020 12:00:00 AM
Last Editorial Review: 1/31/2020 12:00:00 AM


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Restful Romance: Smelling Your Lover's Shirt Can Help You Sleep

By www.medicinenet.com
Published On :: Fri, 14 Feb 2020 00:00:00 PDT

Title: Restful Romance: Smelling Your Lover's Shirt Can Help You Sleep
Category: Health News
Created: 2/14/2020 12:00:00 AM
Last Editorial Review: 2/14/2020 12:00:00 AM


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SLFN11 Expression in Advanced Prostate Cancer and Response to Platinum-based Chemotherapy

By mct.aacrjournals.org
Published On :: 2020-05-04T05:39:42-07:00

Expression of the DNA/RNA helicase schlafen family member 11 (SLFN11) has been identified as a sensitizer of tumor cells to DNA-damaging agents including platinum chemotherapy. We assessed the impact of SLFN11 expression on response to platinum chemotherapy and outcomes in patients with metastatic castration-resistant prostate cancer (CRPC). Tumor expression of SLFN11 was assessed in 41 patients with CRPC treated with platinum chemotherapy by RNA sequencing (RNA-seq) of metastatic biopsy tissue (n = 27) and/or immunofluorescence in circulating tumor cells (CTC; n = 20). Cox regression and Kaplan–Meier methods were used to evaluate the association of SLFN11 expression with radiographic progression-free survival (rPFS) and overall survival (OS). Multivariate analysis included tumor histology (i.e., adenocarcinoma or neuroendocrine) and the presence or absence of DNA repair aberrations. Patient-derived organoids with SLFN11 expression and after knockout by CRISPR-Cas9 were treated with platinum and assessed for changes in dose response. Patients were treated with platinum combination (N = 38) or platinum monotherapy (N = 3). Median lines of prior therapy for CRPC was two. Median OS was 8.7 months. Overexpression of SLFN11 in metastatic tumors by RNA-seq was associated with longer rPFS compared with those without overexpression (6.9 vs. 2.8 months, HR = 3.72; 95% confidence interval (CI), 1.56–8.87; P < 0.001); similar results were observed for patients with SLFN11-positive versus SLFN11-negative CTCs (rPFS 6.0 vs. 2.2 months, HR = 4.02; 95% CI, 0.77–20.86; P = 0.002). A prostate-specific antigen (PSA) decline of ≥50% was observed in all patients with SLFN11 overexpression. No association was observed between SLFN11 expression and OS. On multivariable analysis, SLFN11 was an independent factor associated with rPFS on platinum therapy. Platinum response of organoids expressing SLFN11 was reduced after SLFN11 knockout. Our data suggest that SLFN11 expression might identify patients with CRPC with a better response to platinum chemotherapy independent of histology or other genomic alterations. Additional studies, also in the context of PARP inhibitors, are warranted.


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