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Placental microphysiological systems: new advances on promising platforms that mimic the microenvironment of the human placenta

Lab Chip, 2025, Advance Article
DOI: 10.1039/D4LC00500G, Critical Review
Inês M. Gonçalves, Muhammad Afzal, Nithil Kennedy, Ana Moita, Rui Lima, Serge Ostrovidov, Takeshi Hori, Yuji Nashimoto, Hirokazu Kaji
This review presents new advancements in placental MPS models for toxicological screening, preeclampsia assessment, and embryo uterine implantation and an overview of bioprinting technology and current advances in endometrial MPSs.
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A paper-in-polymer-pond (PiPP) hybrid microfluidic microplate for multiplexed ultrasensitive detection of cancer biomarkers

Lab Chip, 2024, 24,4962-4973
DOI: 10.1039/D4LC00485J, Paper
Sanjay S. Timilsina, XiuJun Li
A reusable and cost-effective paper-in-polymer-pond (PiPP) hybrid microfluidic microplate with unique features for ultrasensitive and high-throughput multiplexed detection of disease biomarkers within an hour without using specialized instruments.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Artificial intelligence performance in testing microfluidics for point-of-care

Lab Chip, 2024, 24,4998-5008
DOI: 10.1039/D4LC00671B, Paper
Open Access
Mert Tunca Doganay, Purbali Chakraborty, Sri Moukthika Bommakanti, Soujanya Jammalamadaka, Dheerendranath Battalapalli, Anant Madabhushi, Mohamed S. Draz
AI is revolutionizing medicine by enhancing diagnostics and patient care. Our study showed ML and DL AI models excel in microchip testing, underscoring AI's potential to improve precision medicine and POC diagnostics.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Exploring cancer-associated fibroblast-induced resistance to tyrosine kinase inhibitors in hepatoma cells using a liver-on-a-chip model

Lab Chip, 2024, 24,5043-5054
DOI: 10.1039/D4LC00624K, Paper
Madhu Shree Poddar, Yu-De Chu, Gaurav Pendharkar, Cheng-Hsien Liu, Chau-Ting Yeh
3D liver-on-a-chip reveals AHSG and CLEC3B to mediate cancer-associated fibroblast-induced resistance to TKIs in hepatoma cells.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Correction: Deciphering hepatoma cell resistance to tyrosine kinase inhibitors: insights from a Liver-on-a-Chip model unveiling tumor endothelial cell mechanisms

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC90093F, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Madhu Shree Poddar, Yu-De Chu, Chau-Ting Yeh, Cheng-Hsien Liu
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A gravity-driven tissue chip to study the efficacy and toxicity of cancer therapeutics

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00404C, Paper
Open Access
Pouria Rafsanjani Nejad, Astha Lamichhane, Prasiddha Guragain, Gary Luker, Hossein Tavana
A 96-well plate format, fully-automated multi-organ tissue chip array with gravity-driven flow for cancer research.
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Real-time impedance-activated dielectrophoretic actuation for reconfigurable manipulation of single flowing particles

Lab Chip, 2024, 24,5145-5154
DOI: 10.1039/D4LC00622D, Paper
Alexis Lefevre, Cristian Brandi, Adele De Ninno, Filippo Ruggiero, Enrico Verona, Michaël Gauthier, Paolo Bisegna, Aude Bolopion, Federica Caselli
We present an original all-electrical platform that combines MIC-sensing and DEP-actuation for precise and selective trajectory control of single flowing particles.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Microstring-engineered tension tissues: a novel platform for replicating tissue mechanics and advancing mechanobiology

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00753K, Paper
Zixing Zhou, Tingting Li, Wei Cai, Xiaobin Zhu, Zuoqi Zhang, Guoyou Huang
A simple, cost-effective approach for fabricating soft microstring chips that enables precise engineering of tension tissues (METTs), advancing research in mechanobiology and biomedical applications.
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HC declines former Chief Secretary’s plea seeking exemption from personal appearance

Court exempts Palakkad Collector from personal appearance on condition that she will appear through virtual mode




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HC allows medical termination of pregnancy of minor rape survivor

Division Bench passed the order while allowing an appeal filed against a single judge’s order declining permission. Medical board said that termination of pregnancy was most appropriate




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Gold Ride, Vivaldi, Royal Defender and Supreme Dance impress




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Golden Dancer and Mothers Grace impress




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India steps up critical mineral acquisition plans in Africa, challenging China’s dominance

Race for critical minerals primarily focuses on cobalt and copper – key EV battery making metals, apart from lithium.




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Finance Minister is now final authority to grade CPSEs

Proposals for upgrade or downgrade CPSEs need no longer be referred to Cabinet Secretariat and Public Enterprises Service Board




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Cabinet clears ₹2,254 crore for national forensic infra enhancement scheme

Under this scheme, the MHA will establish campuses of the National Forensic Sciences University and central forensic science laboratories in the country




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Govt hikes NDRF risk and hardship allowance by 40%: Amit Shah

Union Home Minister Amit Shah made the announcement at the Flag-in ceremony of the NDRF’s Mountaineering Expedition Vijay, emphasising the crucial role NDRF plays in national and international disaster response




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Budget 2024: ₹5,000 monthly internship allowance announced for 1 crore youth

Internship scheme aims to create job opportunities in top 500 companies over next five years




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Entering a decade of financial inclusion: PMJDY reaches 53 crore beneficiaries and ₹2.28 lakh crore in deposits

The scheme has largely been women-centric with 29.48 crore beneficiaries while 35.27 crore of total accounts are from rural and semi-urban branches




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Govt to provide financial assistance to North Eastern States for hydro power development

This scheme has an outlay of ₹4,136 crore to be implemented from FY25 to FY32




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Centre Notifies NaBFID as a ‘Public Financial Institution’

NaBFID expects its total sanctions loan book to touch ₹2 lakh crore by March 2025, while disbursements are likely to be around ₹ 1 lakh crore



  • Money & Banking

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Finance Ministry notifies new rules for compounding under FEMA

The new rules aim to further promote ease of investment




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GoM for freeing health insurance for senior citizens, all policies up to ₹5-lakh cover from GST burden

GoM suggests rate hike on high-end wrist watches, shoes; GST on packaged water to be cut




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Invoice Management System may add compliance for GST assesses, say tax experts

First GSTR-2B based on IMS to be generated for October on November 14.




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No merger of 50% DA into basic, as finance ministry issues order payment for 53% DA

DA to central government employees was enhanced from 50 per cent to 53 per cent of the basic pay with effect from July 1, 2024




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Mid-tier exuberance: Range Rover Velar

Land Rover’s straightforward segmentation puts its mid-tier Velar in the spotlight




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Renault Kiger 2024 Review: Compact SUV’s pricing, performance and features explained

Renault’s sub-four-metre Kiger is refreshed with added vigour for 2024




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Special puja at Kamala Harris' ancestral village for her win in US Prez polls




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Tamil Nadu Artificial Intelligence Mission to focus on research, developing AI-driven governance




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'Sad & dejected': Pall of gloom over Kamala Harris's ancestral village in TN after electoral defeat




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TN Health Dept to launch 25 bike ambulances with Rs 1.60 crore allocation




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Bengal govt to bring exams in medical colleges under CCTV surveillance, live-streaming




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What is saree, petticoat cancer? From causes, symptoms to prevention, all you need to know

Research shows that tight petticoats worn with sarees may increase the risk of skin cancer in women due to constant....




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NIH study links neighborhood environment to prostate cancer risk in men with West African genetic ancestry

A new study suggests, for men with West African genetic ancestry, living in a disadvantaged neighborhood was associated with a higher risk of prostate cancer. The researchers posit that chronic stress—such as from racial profiling, housing discrimination, and exposure to violence—may be a possible driver.




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Immunotherapy after surgery helps people with high-risk bladder cancer live cancer-free longer

An NCI trial shows that giving patients pembrolizumab after surgery for high-risk muscle invasive bladder cancer doubles the median length of time that they remain cancer free, compared with observation alone after surgery.




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New cancer diagnoses did not rebound as expected following pandemic

While new cancer diagnoses largely returned to pre-pandemic levels in 2021, they don’t account for the missed diagnoses in early 2020 that resulted from disruptions in cancer screening and other medical care.




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NIH clinical trial will test precision medicine treatments for myeloid cancers

NCI has launched myeloMATCH, a precision medicine treatment trial that will test treatment combinations targeting specific genetic changes in people with acute myeloid leukemia and myelodysplastic syndromes.




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NIH-funded scientists uncover clues to precancer and tumor biology

New studies released by NCI’s Human Tumor Atlas Network explore the role of the tumor microenvironment and the immune system in promoting the spread of cancer and its resistance to treatment. The studies appear across several Nature journals.




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Researchers uncover new role of mutant RAS proteins in some of the deadliest cancers

A new study led by NCI researchers shows that mutant RAS proteins help release a nuclear protein from a complex transported from the nucleus to the cytoplasm, kicking off a series of events that lead to the breakdown of a tumor suppressor protein.




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Data | The risk of small States’ heavy reliance on the Union government

Small States must prioritise raising their own revenue to reduce their vulnerabilities in the future




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Opposition MLAs allege attacks amid formation of gram panchayat boards in West Bengal

The State has been hit by violence since the notification for the three-tier panchayat polls was issued on June 8




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Alliance between parties key for ousting Jaganmohan Reddy, says JSP chief Pawan Kalyan

It all depends on the top leaders of BJP and TDP; if they decide not to come together, it might aid YSR Congress for another five-year term, which would take the State backwards by another five years, said the Jana Sena Party chief




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Panchayats in India earn only one per cent of their revenue through taxes: Data

Most of their revenue comes from the Centre and the States as grants




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Over 20,000 FCRA licences cancelled till date, most from Tamil Nadu | Data

If cancellations are expressed as a share of FCRA licences given, then Uttar Pradesh tops the list




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The enormity of the Indian electorate and its State-wise variances | Data

The prospect of delimitation based on electorate variances in States will have to grapple with federal questions




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India’s dominance at Chess Olympiad, a pleasant surprise, says Praggnanandhaa

“I knew if we gave our best we would be the favourites to win the gold, but I didn’t think we would win 10 out of 11 matches”




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WFI decides not to field team in Worlds in present circumstances

The WFI had announced that it would hold the trials in New Delhi on October 6 and 7 to select teams for the World under-23 championships and World championships respectively.




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Women’s T20 World Cup: It may have been different if we took some chances, says India coach Muzumdar after Australia defeat

The Indian team delivered a lackluster performance on the field, ultimately resulting in a nine-run loss to defending champions Australia in their must-win game on Sunday (October 14, 2024)




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We have to go all the way back to Karpov and Kasparov on the top two boards to find something like India’s dominance: Peter Svidler

In this chat, Russian GM Svidler talks about India’s historic Olympiad, his experience of coaching Praggnanandhaa, his love affair with Test cricket and his assessment of the Global Chess League, not just as a chess player but also as a cricket fan who follows the IPL




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Indian wrestlers to participate in World championships after Minister’s assurance

‘Wrestlers’ interest is the priority,’ assures Union Minister Mansukh Mandviya




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Israel urges fans to skip France-Israel football match in Paris

The National Security Council called on Israelis to “avoid attending sports games/cultural events involving Israelis